鼻呼出气一氧化氮检测对慢性鼻窦炎临床意义的研究进展

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Abstract Chronic sinusitis is one of the most common inflammatory diseases of the nose, and it has a complicated pathogenesis, which is mostly related to the destruction of the nasal mucosa structure and ciliary dyskinesia. At present, many diagnostic methods, such as sinus imaging, sinus puncture, irrigation, are one-sided due to their complex and invasive operation, and high price. The nasal nitric oxide (nNO) measurement is a non-invasive, safe, simple, and reproducible auxiliary detection method. This method provides patients with direct detection of inflammation in the upper respiratory tract, and has important reference significance for the diagnosis of chronic sinusitis. At present, the research on differences in nNO levels in patients with different chronic sinusitis is still controversial. This article reviews the overview of nNO and its relationship with the severity of chronic sinusitis as well as its application in the diagnosis and treatment of chronic sinusitis in adults and children.

Key words： Nasal nitric oxide Chronic sinusitis Nasal polyps Inflammation response

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	CHEN Yijing YANG Jing CAO Zhiwei

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CHEN Yijing YANG Jing CAO Zhiwei. Research progress on the clinical significance of nasal nitric oxide measurement for chronic sinusitis#br#[J]. 中国医药导报, 2022, 19(9): 46-49,54.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I9/46

[1] Sedaghat AR，Gray ST，Kieff DA. In response to preapproval of sinus computed tomography for otolaryngologic evaluation of chronic rhinosinusitis does not save health care costs [J]. Laryngoscope，2014，124（12）：471-472.
[2] Ren L，Zhang W，Zhang Y，et al. Nasal Nitric Oxide Is Correlated With Nasal Patency and Nasal Symptoms [J]. Allergy Asthma Immunol Res，2019，11（3）：367-380.
[3] Lundberg J，Farkas-Szallasi T，Weitzberg E，et al. High nitric oxide production in human paranasal sinuses [J]. Nat Med，1995，1（4）：370-373.
[4] Maniscalco M，Bianco A，Mazzarella G，et al. Recent Advances on Nitric Oxide in the Upper Airways [J]. Curr Med Chem，2016，23（24）：2736-2745.
[5] Lee M，Wang C，Jin SW，et al. Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1 [J]. Free Radic Biol Med，2019，130：278-287.
[6] Heffler E，Carpagnano GE，Favero E，et al. Fractional Exhaled Nitric Oxide（FENO）in the management of asthma：a position paper of the Italian Respiratory Society（SIP/IRS）and Italian Society of Allergy，Asthma and Clinical Immunology（SIAAIC）[J]. Multidiscip Respir Med，2020，15（1）：36.
[7] Ambrosino P，Molino A，Spedicato GA，et al. Nasal Nitric Oxide in Chronic Rhinosinusitis with or without Nasal Polyps：A Systematic Review with Meta-Analysis [J]. J Clin Med，2020，9（1）：200.
[8] Krantz C，Janson C，Hollsing A，et al. Exhaled and nasal nitric oxide in relation to lung function，blood cell counts and disease characteristics in cystic fibrosis [J]. J Breath Res，2017，11（2）：026001.
[9] Maniscalco M，Vitale C，Vatrella A，et al. Fractional exhaled nitric oxide-measuring devices：technology update [J]. Med Devices（Auckl），2016，9（1）：151-160.
[10] Horváth I，Barnes PJ，Loukides S，et al. A European Respiratory Society technical standard：exhaled biomarkers in lung disease [J]. Eur Respir J，2017，49（4）：1600965.
[11] Liu C，Zheng M，He F，et al. Role of exhaled nasal nitric oxide in distinguishing between chronic rhinosinusitis with and without nasal polyps [J]. Am J Rhinol Allergy，2017，31（6）：389-394.
[12] Yoshida K，Takabayashi T，Imoto Y，et al. Reduced nasal nitric oxide levels in patients with eosinophilic chronic rhinosinusitis [J]. Allergol Int，2019，68（2）：225-232.
[13] Lee JM，Mcknight CL，Aves T，et al. Nasal nitric oxide as a marker of sinus mucosal health in patients with nasal polyposis [J]. Int Forum Allergy Rhinol，2015，5（10）：894-899.
[14] Hou J，Lou H，Wang Y，et al. Nasal ventilation is an important factor in evaluating the diagnostic value of nasal nitric oxide in allergic rhinitis [J]. Int Forum Allergy Rhinol，2018，8（6）：686-694.
[15] Maniscalco M，Sofia M，Pelaia G. Nitric oxide in upper airways inflammatory diseases [J]. Inflamm Res，2007，56（2）：58-69.
[16] Vlad D，Albu S. Arginase Isoform Expression in Chronic Rhinosinusitis [J]. J Clin Med，2019，8（11）：1809.
[17] Wang B，Wu Z，Wang F，et al. Nasal nitric oxide testing for allergic rhinitis patients：Systematic review and meta-analysis [J]. ImmunInflamm Dis，2021，9（3）：635-648.
[18] Heffler E，Pizzimenti S，Badiu I，et al. Nasal nitric oxide is a marker of poor asthma control [J]. J Breath Res，2013，7（2）：026009.
[19] Wen YS，Lin CY，Yang KD，et al. Nasal nitric oxide is a useful biomarker for acute unilateral maxillary sinusitis in pediatric allergic rhinitis：A prospective observational cohort study [J]. World Allergy Organ J，2019，12（4）：100027.
[20] Marthin JK，Nielsen KG. Hand-Held Tidal Breathing Nasal Nitric Oxide Measurement-A Promising Targeted Case-Finding Tool for the Diagnosis of Primary Ciliary Dyskinesia [J]. PLoS One，2013，8（2）：e57262.
[21] Bachert C，Zhang N，Hellings PW，et al. Endotype-driven care pathways in patients with chronic rhinosinusitis [J]. J Allergy Clin Immunol，2018，141（5）：1543-1551.
[22] Takahara D，Kono T，Takeno S，et al. Nasal nitric oxide in the inferior turbinate surface decreases with intranasal steroids in allergic rhinitis：A prospective study [J]. Auris Nasus Larynx，2019，46（4）：507-512.
[23] Nishida M，Takeno S，Takemoto K，et al. Increased Tissue Expression of Lectin-Like Oxidized LDL Receptor-1（LOX-1）Is Associated with Disease Severity in Chronic Rhinosinusitis with Nasal Polyps [J]. Diagnostics（Basel），2020，10（4）：246.
[24] 刘承耀，王向东，李琴，等.鼻一氧化氮在慢性鼻-鼻窦炎伴或不伴鼻息肉诊断中的应用研究[J].中国耳鼻咽喉头颈外科，2019，26（6）：315-320.
[25] Lee DJ，Yip J，Lee JM. Nasal nitric oxide as a long-term monitoring and prognostic biomarker of mucosal health in chronic rhinosinusitis [J]. Int Forum Allergy Rhinol，2020，10（8）：971-977.
[26] Ragab SM，Lund VJ，Saleh HA，et al. Nasal nitric oxide in objective evaluation of chronic rhinosinusitis therapy [J]. Allergy，2006，61（6）：717-724.
[27] 朱梦迪，高学欢，朱壮，等.鼻呼出气一氧化氮测定在慢性鼻窦炎伴鼻息肉诊断及分型中的应用价值[J].临床耳鼻咽喉头颈外科杂志，2021，35（3）：216-223.
[28] Alexandersson C，Tuomi L，Olin AC. Measurement of Nasal Nitric Oxide in Chronic Rhinosinusitis and Its Relationship to Patient-Reported Outcome：A Longitudinal Pilot Study [J]. Ear Nose Throat J，2021，100（7）：522-529.
[29] Rosenfeld RM，Piccirillo JF，Chandrasekhar SS，et al. Clinical practice guideline（update）：adult sinusitis [J]. Otolaryngol Head Neck Surg，2015，152（S2）：598-609.
[30] 王昶，邓安春.慢性鼻窦炎鼻息肉手术治疗的研究进展[J].医学综述，2021，27（6）：1170-1173，1178.
[31] Fu CH，Huang CC，Chen YW，et al. Nasal nitric oxide in relation to quality-of-life improvements after endoscopic sinus surgery [J]. Am J Rhinol Allergy，2015，29（6）：187-191.
[32] Fu CH，Tseng HJ，Huang CC，et al. Nasal nitric oxide in unilateral sinus disease [J]. PLoS One，2017，12（2）：e0171965.
[33] 母东勤，潘家华.上下气道呼出气一氧化氮与哮喘控制水平的相关性研究[J].中国当代儿科杂志，2019，21（5）：426-430.
[34] 李华斌，曹玉洁.儿童鼻窦炎的临床诊疗进展[J].山东大学耳鼻喉眼学报，2019，33（6）：16-19.
[35] Torretta S，Bossi A，Capaccio P，et al. Nasal nitric oxide in children with adenoidal hypertrophy：a preliminary study [J]. Int J Pediatr Otorhinolaryngol，2010，74（6）：689-693.
[36] Chen QB，Chen L，Zheng XY，et al. The Clinical Significance of Nasal Nitric Oxide Concentrations in Preschool Children with Nasal Inflammatory Disease [J]. Int Arch Allergy Immunol，2019，181（1）：1-5.
[37] Rybnikar T，Senkerik M，Chladek J，et al. Adenoid hypertrophy affects screening for primary ciliary dyskinesia using nasal nitric oxide [J]. Int J Pediatr Otorhinolaryngol，2018，115：6-9.
[38] Struben VM，Wieringa MH，Mantingh CJ，et al. Nasal NO：normal values in children age 6 through to 17 years [J]. Eur Respir J，2005，26（3）：453-457.