基于网络药理学研究补肾安坤汤治疗早发性卵巢功能不全的作用机制

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Abstract Objective To study the action mechanism of Bushen Ankun Decotion in the treatment of premature ovarian insufficiency (POI ) based on network pharmacology. Methods With the help of traditional Chinese medicine system pharmacology database and analysis platform (TCMSP ), the effective components and related targets were obtained; the standard names of the targets were found according to the Uniprot database; based on Cytoscape software, the network diagram of traditional Chinese medicine component-target was obtained. According to Genecards and OMIM, target genes of disease were obtained. Protein-protein interaction network of core target proteins was obtained by using STRING database and Cytoscape software. DAVID database and Cluego software were used for GO enrichment analysis and KEGG enrichment analysis. PubChem database, Uniprot database, AutoDock Tools software and DS ViewerPro software were used for molecular docking of main components and key targets. Results According to the screening conditions, 150 active components and 1088 targets of Bushen Ankun Decotion were obtained. 2718 POI target genes were retrieved, and 166 common targets of Bushen Ankun Decoction and disease were obtained. The results of molecular docking showed that the main compounds and their corresponding target proteins had good binding activities. GO functional enrichment analysis showed that it was mainly involved in cell surface. KEGG pathway enrichment analysis, a total of 228 pathways were enriched. Conclusion The mechanism of Bushen Ankun Decoction in the treatment of POI reflects the characteristics of multi-component, multi-target and multi-channel of traditional Chinese medicine, and provides a theoretical basis for further study of related diseases and drugs.

Key words： Network pharmacology Molecular docking Bushen Ankun Decotion Premature ovarian insufficiency Action mechanism

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	XIE Xiaohui1 LIU Jinxing2

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XIE Xiaohui1 LIU Jinxing2. Research on the action mechanism of Bushen Ankun Decotion in the treatment premature of ovarian insufficiency based on network pharmacology#br#[J]. 中国医药导报, 2022, 19(9): 31-36.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2022/V19/I9/31

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