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2021 Vol. 18, No. 25
Published: 2021-09-05
 
 
4 Discussion of the characteristics of Professor Gu Shizhe treating depression by acupuncture and moxibustion based on R language
ZHAO Peihan1 LUO Changyong2 WANG Zhaoyang1 CHEN Dan1 CAO Feng1 LI Siting1 GU Shizhe1 YU He2
Objective To disscuss Professor Gu Shizhe’ s acupoint selection and compatibility experience in treating depression by acupuncture and moxibustion based on R language. Methods The medical data of patients with depression admitted to Professor Gu Shizhe’s Outpatient Department of Guoyitang of Beijing University of Chinese Medicine from January 2015 to November 2020, the monograph Knowledge of Needles and Knowledge of Medicine which summarized Professor Gu Shizhe’s experience, and related medical records in Professor Gu Shizhe’s papers published on CNKI were selected. Microsoft Office Excel 2019 was used to construct data database of acupuncture prescription of Professor Gu Shzhe, and R software was used to conduct descriptive analysis, Apriori association rule analysis and hierarchical cluster analysis. Results Professor Gu Shizhe used 86 acupoints for the treatment of depression, with a total of 1601 times. The top seven acupoints in the list of times of use were dànzhōng, sìshéncōng, bǎihuì, nèiguān, shénmén, yìntáng, and tiānshū. The meridians with the highest frequency of use were conception channel, and the selected points were mostly in the four roots and three knots of the meridians. When compatibility pay attention to root knot phase, manifestation and root cause corresponding. The differentiation of zang-fu viscera mainly focused on clearing the heart and calming the mind, and attaches importance to the regulation of liver, gallbladder, spleen and stomach. Association analysis showed that the common acupoint combinations were nèiguān-tiānshū-dànzhōng, xíngjiān-xiáxī-dànzhōng, jiànlǐ-zhōngwǎn-tiānshū, and jiànlǐ-dànzhōng-zhōngwǎn. The results of cluster analysis showed that Professor Gu Shizhe’s thinking on the treatment of depression based on syndrome differentiation was benefiting qi and nourishing yin, invigorating the spleen and calming the heart, clearing the mind and calming the mind, and dispersing stagnated liver qi for promoting bile flow. Conclusion Professor Gu Shizhe use dànzhōng as the main acupuncture point in the treatment of depression. According to syndrome differentiation, the main ideas are benefiting qi and nourishing yin, invigorating the spleen and calming the heart, clearing the mind and calming the mind, and dispersing stagnated liver qi for promoting bile flow.
2021 Vol. 18 (25): 4-8 [Abstract] ( 80 ) HTML (1 KB)  PDF (933 KB)  ( 46 )
9 Identification of key genes and pathways for autophagy in osteoarthritis based on bioinformatics methods
YUAN Changshen1 RONG Weiming2 LI Zhe2 GUAN Yanbing2 MEI Qijie1 DUAN Kan1
Objective To explore the potential role of autophagy related genes in osteoarthritis (OA) by bioinformatics methods. Methods Using the GEO DataSets retrieval window of the GEO database with the keyword “Osteoarthritis”, the data disclosure date was limited to January 1st, 2010 to January 1st, 2020. The gene microarray dataset (GSE55457) was screened, and the differentially expressed genes (DEGs) were obtained from GSE55457 after correction. Then, the autophagy related genes obtained from GeneCards were used to intersection with DEGs, and the intersection genes were performed by GO and KEGG enrichment analysis and the proteinprotein interaction network was mapped. Finally, the key modules were obtained and the key genes of Hub were screened by KEGG enrichment analysis. Results A total of 203 DEGs and 5786 autophagy genes were obtained, and 65 genes were obtained from the intersection of the two, which were enriched in 279 GO entries and 44 KEGG entries. The genes of important modules were mainly involved in MAPK, JAK-STAT, and PI3K-Akt signaling pathways, and the key genes were VEGFA, JUN, CTNNB1, MYC, NR4A1, MAP2K7, and DUSP1. Conclusion The genes VEGFA, JUN, and CTNNB1 regulate the autophagy response through the main pathways of MAPK, JAK-STAT, and PI3K-Akt, and affect the occurrence and development of OA.
2021 Vol. 18 (25): 9-13 [Abstract] ( 134 ) HTML (1 KB)  PDF (1191 KB)  ( 227 )
14 Discussion on the mechanism of action of Shenyuan Granules in treating diabetic nephropathy based on network pharmacology
WAN Yaqin1 WANG Xiaoqin2
Objective To explore the mechanism of action of Shenyuan Granules in treating diabetic nephropathy based on network pharmacology. Methods Through the traditional Chinese medicine systems pharmacology database and analysis platform, the pharmaceutical components and action targets of Shenyuan Granules were collected. Target genes of diabetic nephropathy were collected from GeneCards, OMIM, PharmGKB, TTD, and DrugBank databases, and the intersection of drug and disease targets was taken to obtain the intersection target of the prescription for treating diabetic nephropathy. Cytoscape 3.7.2 software was used to construct the Shenyuan Granules composition-intersection target-disease network. The STRING database was used to analyze the intersection targets and construct the protein interaction network. The CytoNCA topological properties were used to construct the topological map of key target proteins, and the intersection gene targets and compounds were ranked according to the nodal degree and intermediate centrality. GO biological processes and KEGG metabolic pathways of key targets were analyzed by R language. Results Thirty-five compounds were selected and 292 predicted targets of Shenyuan Granules were obtained. The number of intersection targets between drugs and diabetic nephropathy was 67. The intersection proteins were uploaded to the STRING database and 55 intersection proteins were obtained. The topology of key targets showed that the first three compounds were quercetin, 7-O-methylisopeugenol and kaempferol. Key targets were protein kinase B, vascular endothelial growth factor A and epidermal growth factor receptor. GO enrichment analysis showed that it mainly involved biological processes such as G-protein-coupled receptors, cellular components such as presynaptic membrane and postsynaptic membrane, and molecular functions such as G protein-coupled amine receptor activity. The enrichment analysis of KEGG metabolism pathway showed that it was mainly involved in stimulating neural tissue action pathway and so on. Conclusion The rationality of the prescription of Shenyuan Granules and the scientificity of the treatment of diabetic nephropathy are preliminarily verified, and the theoretical foundation is laid for the in-depth study of the mechanism of treating diabetic nephropathy with Shenyuan Granules.
2021 Vol. 18 (25): 14-18 [Abstract] ( 85 ) HTML (1 KB)  PDF (1652 KB)  ( 101 )
19 Regulating effect of Erzhi Pills and Guizhi Decoction on Cisplatin resistance in triple negative breast cancer cell lines
YANG Huifen1 MAO Juanjuan2
Objective To study the effect of Erzhi Pills and Guizhi Decoction on Cisplatin (CDDP) resistance of triple negative breast cancer (TNBC) cell lines. Methods TNBC cell line MDA-MB-231 was selected and treated with 0.01, 0.1, 0.5, 1, 5, 10 μmol/L CDDP to prepare CDDP resistant cell line (MDA-MB-231/CDDP). The cell activities of MDA-MB-231 and MDA-MB-231/CDDP were detected by CCK-8 at different concentrations (0.01, 0.1, 0.5, 1, 5, 10 μmol/L) of CDDP. At the same time, the sample wells without CDDP were used as control group. The mRNA and protein expressions of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-lα (HIF-1α) were detected by quantitative reverse transcriptase-mediated PCR(qRT-PCR) and Western blot to verify the prepared MDA-MB-231/CDDP. MDA-MB-231/CDDP cell lines were divided into blank group (without any treatment), Erzhi Pills and Guizhi Decoction group (200 μg/ml Erzhi Pills and Guizhi Decoction), CDDP group (10 μmol/L CDDP), and combined group (200 μg/ml Erzhi Pills and Guizhi Decoction +10 μmol/L CDDP). CCK-8 and flow cytometry were used to detect cell viability and apoptosis. The mRNA and protein expressions of VEGF and HIF-1α were determined by qRT-PCR and Western blot. Results The IC50 values of MDA-MB-231 and MDA-MB-231/CDDP cells to CDDP were 1.6001 μmol/L and 36.4320 μmol/L, respectively. The mRNA expression levels of VEGF and HIF-1α in MDA-MB-231 and MDA-MB-231/CDDP cells with CDDP concentration of 10 μmol/L were lower than those in the control group, the mRNA expression level of VEGF in MDA-MB-231/CDDP cells with CDDP concentration of 10 μmol/L was higher than that in MDA-MB-231 cells, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The protein expression levels of HIF-1α and VEGF in MDA-MB-231 cells with CDDP concentration of 10 μmol/L were lower than those in the control group, and the protein expression levels of HIF-1α in MDA-MB-231/CDDP cells were lower than those in the control group, with statistical significance (P ＜ 0.05 or P ＜ 0.01). The protein expression levels of HIF-1α and VEGF in MDA-MB-231/CDDP cells with CDDP concentration of 10 μmol/L were higher than those in MDA-MB-231 cells, and the differences were statistically significant (P < 0.05). The survival rates of CDDP group and combined group 24 h after treatment were lower than those of blank group, and the cell survival rate of combined group was lower than that of CDDP group and Erzhi Pills and Guizhi Decoction group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). the cell survival rate of Erzhi Pills and Guizhi Decoction group, CDDP group and combined group 48 h after treatment was lower than that of blank group, and the cell survival rate of combined group was lower than that of CDDP group and Erzhi Pills and Guizhi Decoction group, the differences were highly statistically significant (P ＜ 0.01). The apoptosis rate of Erzhi Pills and Guizhi Decoction group, CDDP group and combined group was higher than that of blank group, and the differences were highly statistically significant (P ＜ 0.01). The apoptosis rate of combined group was higher than that of Erzhi Pills and Guizhi Decoction group and CDDP group, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). The mRNA and protein expression levels of HIF-1α and VEGF in MDA-MB-231/CDDP cells in CDDP group and combined group were lower than those in blank group, and those in combined group were lower than those in Erzhi Pills and Guizhi Decoction group, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion Erzhi Pills and Guizhi Decoction can reverse CDDP resistance of TNBC cell line by regulating HIF-1α signaling pathway and down-regulating the VEGF expression.
2021 Vol. 18 (25): 19-25 [Abstract] ( 113 ) HTML (1 KB)  PDF (1377 KB)  ( 62 )
26 Experimental study on antitumor effect and the effect of tumor immune microenvironment of Yanghe Decoction on Lewis lung cancer mice
WU Lin1 ZHANG Weibo2 XING Yanli1 LI Yan1 ZHAO Meifeng1 YAO Huan1
Objective To investigate the antitumor effect and the effect of tumor immune microenvironment of Yanghe Decoction on Lewis lung cancer mice. Methods A total of 50 male C57BL/6 mice were subcutaneously inoculated with 0.2 ml Lewis lung cancer cell suspension at the concentration of 2×107/ml in the right anterior axilla to establish Lewis lung cancer mouse model. After the model was made, according to random number table method, these mice were divided into tumor-bearing model group, Cyclophosphamide group, Yanghe Decoction high concentration group, Yanghe Decoction medium concentration group， and low concentration group, with 10 mice in each group. Normal saline, 25 mg/kg Cyclophosphamide, 27.5, 18.3, and 9.2 g/kg Yanghe Decoction were given by intragastric administration for 10 days, respectively, one time per day. The body weight and tumor weight of mice in each group were observed. The expressions of interleukin (IL)-2, transforming growth factor (TGF)-β, and cytotoxic lymphocyte (CTL) and regulatory T cell (Treg) markers CD3+CD8+ CD4+Foxp3+ in tumor tissues were detected by immunohistochemistry and immunofluorescence, respectively. Results Compared with tumor-bearing model group, the body weight of mice in Yanghe Decoction high, medium concentration groups were increased (P < 0.05 or P < 0.01); compared with Cyclophosphamide group, the body weight of mice in Yanghe decoction high, medium, and low concentration groups were increased (P < 0.01); and compared with Yanghe Decoction high concentration group, the body weight of mice in Yanghe Decoction low concentration group was decreased (P < 0.05). Compared with tumor-bearing model group, tumor weight of mice in Yanghe Decoction high concentration group was decreased (P < 0.05); and compared with Cyclophosphamide group, tumor weight of mice in Yanghe Decoction medium, low concentration groups were increased (P < 0.05). The tumor inhibition rate from high to low was Cyclophosphamide group, Yanghe Decoction high concentration group, Yanghe Decoction medium concentration group and Yanghe Decoction low concentration group. Compared with tumor-bearing model group, the expression of IL-2 in Lewis lung cancer tissues of mice in Yanghe Decoction high, medium, and low concentration groups were increased (P < 0.05 or P < 0.01); compared with Cyclophosphamide group, the expression of IL-2 in Lewis lung cancer tissues of mice in Yanghe Decoction high, medium, and low concentration groups were increased (P < 0.01); and compared with Yanghe Decoction high concentration group, the expression of IL-2 in Lewis lung cancer tissues of mice in Yanghe Decoction medium, low concentration were decreased (P < 0.01). Compared with tumor-bearing model group, the expression of TGF-β in Lewis lung cancer tissue of mice in Yanghe Decoction high, medium concentration groups were decreased (P < 0.01); compared with Cyclophosphamide group, the expression of TGF-β in Lewis lung cancer tissues of mice in Yanghe Decoction medium, low concentration groups were increased (P < 0.05). Compared with tumor-bearing model group, the expression of CD3+CD8+ in Lewis lung cancer tissues of mice in Yanghe Decoction high, medium, and low concentration groups were increased (P < 0.05 or P < 0.01); compared with Cyclophosphamide group, the expression of CD3+CD8+ in Lewis lung cancer tissues of mice in Yanghe Decoction high, medium, and low concentration groups were increased (P < 0.01); and compared with Yanghe Decoction high concentration group, the expression of CD3+CD8+ in Lewis lung cancer tissues of mice in Yanghe Decoction medium, low concentration were decreased (P < 0.01). Compared with tumor-bearing model group, the expression of CD4+Foxp3+ in Lewis lung cancer tissues of mice in Yanghe Decoction high, medium concentration groups were decreased (P < 0.05 or P < 0.01). Conclusion Yanghe Decoction has a good anti-tumor effect on Lewis lung cancer mice without affecting their body weight, can increase the expression of IL-2 and CTL content in tumor immune microenvironment, and reduce the expression of TGF-β and the content of Treg in tumor immune microenvironment.
2021 Vol. 18 (25): 26-30 [Abstract] ( 56 ) HTML (1 KB)  PDF (975 KB)  ( 34 )
31 Preparation and characterization of ambrisentan β-cyclodextrin inclusion complex
ZHONG Wenjun1 SHI Lei1 LIU Yongli1 LIN Xiaoyan1 ZHANG Haihong2
Objective To prepare ambrisentan β-cyclodextrin inclusion complex and to study its physicochemical property. Methods The inclusion complex of ambrisentan β -cyclodextrin was prepared by saturated aqueous solution method using a high speed homogenizer. The drug content in the inclusion complex was determined by high performance liquid chromatography. The inclusion complex was characterized by scanning electron microscopy, differential scanning calorimetry, X-ray diffraction, inclusion rate, solubility and dissolution in vitro. Results The linear range of ambrisentan concentration was 2.04-163.20 μg/ml. The precision of the instrument and the recovery rate was good. The average inclusion rate was 68.0%. The solubility of ambrisentan in water was 46.35 μg/ml and the solubility of the drug in inclusion complex was 592.17 μg/ml, in vitro accumulative dissolution rate of the inclusion complex capsules reached 83.17% in 60 min. The lifferential scanning calorometry and X-ray diffraction results showed that the new phase was formed. Conclusion The preparation method is simple and reliable, the inclusion rate is high, and the aqueous solubility of the drug and in vitro dissolution rate are improved greatly. This study provides a method for the development of the ambrisentan preparation.
2021 Vol. 18 (25): 31-34 [Abstract] ( 78 ) HTML (1 KB)  PDF (996 KB)  ( 76 )
35 Effect of CagA on CDX1 expression and epithelial mesenchymal transition in human normal gastric epithelial HFE145 cells
ZHANG Shanshan1 MIAO Feng1 LIU Lu1 LYU Wenyao2 ZHANG Shen1 ZHAO Zhifeng1
Objective To investigate the effect of Helicobacter pylori virulence factor cytotoxin related gene A (CagA) on cadual type homeobox transcription factor 1 (CDX1) expression and epithelial mesenchymal transition in human normal gastric epithelial HFE145 cells. Methods Human normal gastric epithelial HFE145 cells were divided into control group, negative group, CagA group and combined group. Lipofectamine 2000 was used to transfect blank reagent, pcDNA3.1, WT CagA, and WT CagA combined with SC-35731-V, respectively. The expression levels of CDX1, CagA, E-cadherin, Vimentin, and N-cadherin in transfected cells were detected by Western blot; invasion and migration ability of transfected cells were detected by Transwell chamber method; the potential binding sites of CagA related factors were determined by fluorescein. Results The expression level of CDX1 in CagA group was higher than that in control group and negative group (P < 0.05), while the expression level of CDX1 in combination group was lower than that in CagA group (P < 0.05). Invasion and migration ability of HFE145 cells in CagA group were higher than those in control group and negative group (P < 0.05), while invasion and migration ability of HFE145 cells in combination group were lower than that in CagA group (P < 0.05). The expression level of E-cadherin in CagA group was lower than that in control group and negative group (P < 0.05), while the expression level of E-cadherin in combination group was higher than that in CagA group (P < 0.05). The expression levels of Vimenti and N-cadherin in CagA group were higher than those in control group and negative group (P < 0.05), while the expression levels of Vimenti and N-cadherin in combination group were lower than those in CagA group (P < 0.05). Deletion of 501-1000 bp upstream of CDX1 exon did not inhibit luciferase activity, while deletion of 1-500 bp inhibited luciferase activity. Conclusion Helicobacter pylori virulence factor CagA induced the abnormal expression of CDX1, and the effect of targeted inhibition of CDX1 on the occurrence and development of gastric cancer has the value of further study.
2021 Vol. 18 (25): 35-39,43 [Abstract] ( 143 ) HTML (1 KB)  PDF (1004 KB)  ( 167 )
40 Expression and clinicopathological significance of Her-2 and Ki-67 in invasive ductal carcinoma of the breast
ZHU Ting SUN Xiaochong LYU Yanguan
Objective To explore the expression of human epidermal growth factor receptor 2 (Her-2) and cell proliferation index Ki-67 in invasive ductal carcinoma of breast and its clinicopathological significance. Methods From January 2017 to January 2020, 91 cases of embedded paraffin pieces of invasive ductal carcinoma of the breast in Department of Pathology, Huai’an Maternal & Child Health Hospital, Affiliated to Yangzhou University were selected as the experimental group, and 30 cases of normal breast tissue with a distance of more than 5 cm were randomly selected as the control group. The expression levels of HER-2 and Ki-67 in the two groups were detected by immunohistochemistry, and the relationship between the two levels and patients’ age, lymph node metastasis, tumor diameter and TNM stage was analyzed. Results The positive expression rates of HER-2 and Ki-67 in the experimental group were higher than those in the control group, with statistically significance (P ＜ 0.05). The expression of HER-2 and Ki-67 in patients with infiltrating ductal carcinoma of breast was correlated with TNM stage (P ＜ 0.05), but had no correlation with age, lymph node metastasis or tumor size (P ＞ 0.05). Spearman correlation analysis showed that there was a positive correlation between the expression of HER-2 and Ki-67 in invasive ductal carcinoma of breast (r = 0.275, P ＜ 0.05). Conclusion The expressions of HER-2 and Ki-67 in invasive ductal carcinoma of the breast are increased and positively correlated, suggesting that they may be related to the malignant degree and stage of breast cancer, and may be an important indicator for the prognosis of breast cancer.
2021 Vol. 18 (25): 40-43 [Abstract] ( 58 ) HTML (1 KB)  PDF (571 KB)  ( 59 )
44 Research progress of iron death in cardiovascular disease
LIU Liheng WANG Yanying JIAO Lei ZHANG Ying
Iron death is a new type of iron dependent programmed cell death, which is caused by the increase of fatty acid lipid peroxidation and the accumulation of reactive oxygen species induced by cell iron overload. Iron death is closely related to the occurrence and development of many major diseases such as tumor, neurodegenerative disease, metabolic disease and aging disease. Iron death is involved in many disease processes such as cardiomyopathy, myocardial infarction, heart failure, coronary atherosclerosis, myocardial ischemia-reperfusion injury, and diabetic cardiomyopathy. In this paper, the possible mechanisms of iron death in various pathological processes of cardiovascular disease are reviewed, which will help to improve understanding of iron death in cardiovascular disease.
2021 Vol. 18 (25): 44-46,79 [Abstract] ( 61 ) HTML (1 KB)  PDF (899 KB)  ( 85 )
47 Research progress of integration of traditional and Western medicine in the treatment of female uncomplicated recurrent urinary tract infection
YANG Xiaoqin1 GAO Zhan2 SHAO Kuiqing2 SHEN Jianwu2 DING Jiasen3 ZHANG Zejia3 XIE Jiaqi3 CHEN Haote1
The female uncomplicated recurrent urinary tract infection seriously affects the quality of life of patients. Based on literatures review, this paper finds that traditional Chinese medicine theories have formed a complete system of etiology and pathogenesis theories and treatment methods of “stranguria”, which are differentiated by stages and treated by type. The treatment method combined with traditional Chinese medicine decoction, acupuncture and moxibustion, fumigation and washing therapy have their own characteristics. Many clinical trials have proved that the combination of antibiotics and traditional Chinese medicine therapy can alleviate the clinical symptoms of patients more quickly than the simple treatment of antibiotics. In the acute phase of the disease, enough and course of antibiotics are used to eliminate pathogenic microorganisms, and the combination of traditional Chinese medicine therapy can alleviate the clinical symptoms of patients. The remission period is mainly based on traditional Chinese medicine therapy, combined with low-dose antibiotic treatment, aiming to improve the body’s immunity and reduce the recurrence rate. It shows the advantages and characteristics of integrated Chinese and Western medicine in treating women with uncomplicated urinary tract infection.
2021 Vol. 18 (25): 47-50 [Abstract] ( 131 ) HTML (1 KB)  PDF (475 KB)  ( 32 )
51 Construction of online and offline mixed examination system for Tuina Gongfa
QIN Yuan ZHAO Jizhong AN Guanghui JIN Daopeng YAO Fei
The establishment of the skill assessment model of Tuina Gongfa should reflect the importance of students’ process learning, and the hybrid assessment system needs to use the online platform of the internet to combine the advantages of the modern assessment mode with the offline traditional assessment mode. The mixed assessment system is divided into two parts: regular assessment and final exam results, the assessment accounts for 30%, and the final score accounts for 70%. Each part has online assessment mode and offline assessment mode. The usual assessment includes attendance, quizzes and assignments, students are required to pay full attention to process learning in practice. The instability and randomness of the final exam are avoided. Using online and offline visual measurement, physical measurement and mechanical measurement to evaluate the Tuina Gongfa of the mixed assessment system, it reflects the objectivity, diversity and fairness of the Tuina Gongfa assessment, and can improve students’ interest in learning and exam results. It deepens the students’ understanding of the meaning of massage and expand the clinical application of massage.
2021 Vol. 18 (25): 51-54 [Abstract] ( 46 ) HTML (1 KB)  PDF (704 KB)  ( 118 )
55 Development path and system construction of biomedical engineering discipline in traditional Chinese medicine colleges and universities
WEI Guohui MIN Weiwei
The construction of first-class disciplines of biomedical engineering with traditional Chinese Medicine characteristics is not only the need for the training of innovative interdisciplinary talents of traditional Chinese medicine, but also the inevitable choice for the construction of disciplines of biomedical engineering in traditional Chinese medicine cdleges and universities. Based on the analysis of the development status of biomedical engineering, six main approaches for the construction of biomedicine engineering with traditional Chinese Medicine characteristics are put forward: traditional Chinese medicine speciaity Research areas, personnel training, characteristics of Chinese medicne curriculum system development, faculty development, selection of academic leaders, and research and innovation teams conseruction. The disciplinary development path proposed in this paper can play a positive role in cultivating innovative interdisciplinary talents of traditional Chinese medicine and provide useful reference for the development of biomedical engineering in traditional Chinese medicine colleges and universities.
2021 Vol. 18 (25): 55-58 [Abstract] ( 63 ) HTML (1 KB)  PDF (664 KB)  ( 281 )
59 Application effect of CBL and bilingual Seminar teaching mode based on ZOOM platform in residency training of general practice
XIE Tuxiu1 LYU Jingjun2 ZHANG Xinqi1 WANG Jing2
Objective To explore the application effect of case-based learning (CBL) and bilingual Seminar teaching mode based on the ZOOM platform in residency training of general practice. Methods A total of 180 subjects trained in the Department of General Practice of Renmin Hospital of Wuhan University from September 2019 to November 2020 were selected. They were divided into the control group and the experimental group according to the random number table method, with 90 cases in each group. The control group was given lecture-based learning (LBL), and the experimental group was given CBL and bilingual Seminar teaching mode based on the ZOOM platform. The theoretical scores health problem recording system, soap case analysis scores and self-administered questionnaire in the two groups, were analyzed after three months of learning. Results Compared with the control group, the scores of theory and soap case analysis in experimental group were significantly improved (P ＜ 0.05); the scores of self-cultivation of interest, self-learning ability, self-expression ability, English vocabulary level, English listening level, self-theoretical level, doctor-patient communication ability, clinical thinking ability, innovation ability, and teamwork ability in the experimental group were higher compared with control group (P ＜ 0.05); the satisfaction of teaching presentation form, mobilization of students’ enthusiasm, active learning atmosphere and teaching effect in experimental group were significantly higher compared with control group (P ＜ 0.05), but there were no statistically significant differences between the two groups in the scores of the teaching attitude, teacher professionalism, pre-teaching preparation, teaching content, expression ability, and teaching arrangement scores (P ＞ 0.05). Conclusion The CBL and bilingual Seminar teaching mode based on the ZOOM platform is better than LBL for general practice residents.
2021 Vol. 18 (25): 59-62 [Abstract] ( 51 ) HTML (1 KB)  PDF (710 KB)  ( 112 )
63 Analysis of intercultural communication competence cultivation of traditional Chinese medicine university students from the perspective of “a community of common health for mankind”
LI Fang
The concept of “human health community” is a vivid practice of a community of human destiny in the field of hygiene and health, which has important guiding significance for the training of talents in Chinese medicine universities. Foreign language education is closely related to the cultivation of cross-cultural competence, but how to improve the cross-cultural competence of traditional Chinese medicine talents through foreign language education? Its research needs to be developed urgently. The questionnaire was used to understand and analyze the current situation of intercultural competence of Chinese medicine university students in the post-epidemic era: the language and cultural knowledge related to traditional Chinese medicine is in urgent need of strengthening, the awareness and confidence of foreign exchange need to be improved, and there is no opportunity to practice intercultural competence. This paper puts forward the strategies of intercultural competence training for traditional Chinese medicine college students, including establishing the training objectives, constructing the training framework, and setting up diversified intercultural practice platforms. Finally, some suggestions for further research are put forward.
2021 Vol. 18 (25): 63-66,83 [Abstract] ( 133 ) HTML (1 KB)  PDF (715 KB)  ( 164 )
67 Systematic evaluation of the application effect of virtual reality technology in basic nursing practice teaching
YANG Min1 JIANG Li2 YIN Haiyan1
Objective To evaluate the application effects of virtual reality technology in the teaching of practical training on basic Nursing. Methods The CNKI full-text database, Chinese Biomedical Literature Database, China Scientific and Technical Journal Database, Wanfang database, Cochrane Library, JBI Library, and PubMed for randomized controlled trials and quasi-experimental studies on basic nursing practice teaching using virtual simulation technology were searched. The retrieval time was from the establishment of the database to March 2020. After the methodological quality evaluation of the included literatures, RevMan 5.3 software was used for data consolidation and analysis. Results A total of 15 papers were included. Among them, three papers were randomized controlled experiments and others were experimental researches. The systematic review showed that VR technology was helpful to improve several practical skills, nasal feeding skill and tracheotomy nursing. But the influence of VR teaching on venipuncture related skills was inconsistent. For the student satisfaction, the results of each study were inconsistent, and there was no unified conclusion. Conclusion The teaching effects of technology are related to the course contents. Thus, more high-quality evidence is still needed to prove its exact effect.
2021 Vol. 18 (25): 67-71 [Abstract] ( 35 ) HTML (1 KB)  PDF (1277 KB)  ( 136 )
72 Exploration of Seminar teaching mode in tradition Chinese medicine classic courses based on the enhancement of graduate students’ innovation ability
WANG Yufang ZHENG Hong SONG Suhua
Innovation ability training is the core element to improve the quality of postgraduate education. At present, in the postgraduate education of traditional Chinese medicine, students’ innovation ability is insufficient due to the single curriculum model, the limited attention to traditional Chinese medicine classic courses, the lack of integration and other factors. Based on this, according to the characteristics of traditional Chinese medicine classic courses and the situation of postgraduate students, this paper explores and practices the application of Seminar teaching mode in traditional Chinese medicine classic courses, trying to improve the closed single traditional Chinese medicine classic teaching mode and truly realize “student-centered”. Traditional Chinese medicine classic teaching integrated effectively with Seminar mode is of great significance and role in improving students’ innovation ability and teaching quality, realizing the sharing and integration of curriculum resources, and deepening teaching reform.
2021 Vol. 18 (25): 72-75 [Abstract] ( 71 ) HTML (1 KB)  PDF (666 KB)  ( 46 )
76 Exploration and practice of the first-class undergraduate course construction of oral anatomy and physiology
ZHENG Xiaodan1 LUO Xiaoan2▲ PAN Xiawei1
The construction of first-class undergraduate courses of both sexes is a continuous and important work in the teaching reform of higher education in China in the new period.Take the course construction of oral anatomy and physiology as an example: based on moral education and personnel training, the teaching objectives in line with the competency of stomatologists were formulated, the teaching modules were integrated and reshaping, the ideological and political elements were explored, and the interdisciplinary integration curriculum system was explored. Exploring and practicing ways to build first-class undergraduate courses from various aspects, building high-quality teaching teams, carrying out student-centered teaching reform, practicing the "Internet +" flipped classroom teaching mode, and creating diversified evaluation methods for the whole course.
2021 Vol. 18 (25): 76-79 [Abstract] ( 39 ) HTML (1 KB)  PDF (886 KB)  ( 224 )
80 Practice and enlightenment of cross-cultural competence cultivation among medical undergraduates
HAN Ye FANG Wei WU Hao
How to provide customized cross-cultural competence instruction according to the characteristics of learning subjects is an important topic in cross-cultural foreign language teaching. This study attempts to explore a college English teaching method based on the cultivation of cross-cultural competence of medical undergraduates. The study first clarifies the concept of cross-cultural competence of medical students, and combined with the learning theme, designs the classroom teaching of cross-cultural knowledge, attitude and competence cultivation for teaching objects. Finally, this paper proposes that the integration of college English teaching and cross-cultural competence training of medical students should take into account characteristics of majors of teaching objects, create an empathetic learning environment, carry out research-based deep learning and cultivate a global caring trend.
2021 Vol. 18 (25): 80-83 [Abstract] ( 108 ) HTML (1 KB)  PDF (819 KB)  ( 129 )
84 Relationship between serum interleukin-35, T cell subset and the severity and prognosis of patients with sepsis
JIN Lei1,2 ZHU Jiajia3 YANG Yadong1
Objective To explore the relationship between serum interleukin-35 (IL-35), T cell subset and the severity and prognosis of patients with sepsis. Methods A total of 240 patients with sepsis admitted to Huainan First People’s Hospital, Anhui Province (hereinafter referred to as “our hospital”) from July 2019 to July 2020 were selected as the case group. According to their severity, they were divided into sepsis group (71 cases), severe sepsis group (126 cases) and septic shock group (43 cases). According to their prognosis 28 days after admission, they were divided into survival group (182 cases) and death group (58 cases). Sixty healthy subjects from our hospital during the same period were selected as control group. Serum IL-35 was detected by enzyme linked immunosorbent assay and T cell subsets were detected by flow cytometry. Acute physiology and chronic health evaluation (APACHEⅡ) scores of sepsis patients with different severity were compared. Sepsis-related organ failure assessment (SOFA) scores were compared between the survival group and the death group. The correlation of serum IL-35 and T cell subsets with APACHEⅡ and SOFA scores in the case group was analyzed. The predictive value of IL-35 and CD4+/CD8+ on the prognosis of sepsis was evaluated by the receiver operating characteristic curve. Results The levels of IL-35 and CD8+ in the case group were higher than those in the control group, and the levels of CD3+, CD4+, and CD4+/CD8+ in the case group were lower than those in the control group, with statistical significance (P ＜ 0.05). The levels of IL-35, CD8+, and APACHEⅡ scores in the severe sepsis group and septic shock group were higher than those in the sepsis group, and those in the septic shock group was higher than the severe sepsis group, the differences were statistically significant (P ＜ 0.05). The levels of CD3+, CD4+, and CD4+/CD8+ in severe sepsis group and septic shock group were lower than those in severe sepsis group, and the levels of septic shock group were lower than those in severe sepsis group, with statistical significance (P ＜ 0.05). The levels of IL-35, CD8+, and SOFA scores in the survival group were lower than those in the death group, and the levels of CD3+, CD4+ and, CD4+/CD8+ were higher than those in the death group, with statistical significance (P ＜ 0.05). IL-35 and CD8+ in the case group were positively correlated with APACHEⅡ and SOFA scores (r ＞ 0, P ＜ 0.05), while CD3+, CD4+, and CD4+/CD8+ were negatively correlated with APACHEⅡ and SOFA scores (r ＜ 0, P ＜ 0.05). The area under the curve of IL-35 combined with CD4+/CD8+ in predicting the death of sepsis patients after 28 days of treatment was 0.923, and the sensitivity and specificity were 91.38% and 95.05%, respectively. Conclusion Abnormal changes of serum IL-35 and T cell subsets are closely related to the severity and prognosis of patients with sepsis. Early combined detection can be used as an important indicator for clinical auxiliary prediction of prognosis.
2021 Vol. 18 (25): 84-88 [Abstract] ( 74 ) HTML (1 KB)  PDF (675 KB)  ( 79 )
89 Randomized controlled study of fluid resuscitation regimen centered on ΔPCO2/ΔCa-vO2 in the treatment of early tissue hypoperfusion in sepsis
ZOU Chunxi1 GU Zenghui2
Objective To investigate the effect of fluid resuscitation based on the ratio of the difference of partial pressure of carbon dioxide in venous-arterial blood and the difference of oxygen content in arterial-venous blood (ΔPCO2/ΔCa-vO2) in the treatment of early tissue hypoperfusion in sepsis. Methods A total of 120 patients with sepsis admitted to the 903th Hospital of the Joint Support Force of the People’s Liberation Army from June 2017 to June 2019 were selected as the research subjects. They were divided into ΔPCO2/ΔCa-vO2 group and oxygen saturation in central venous blood (ScvO2) group by random number table method, with 60 patients in each group. The ΔPCO2/ΔCa-vO2 group was treated with fluid resuscitation regimen centered on ΔPCO2/ΔCa-vO2, and the ScvO2 group was treated with fluid resuscitation regimen centered on ScvO2. The hemodynamic indexes and outcome indexes before and after treatment were observed in the two groups. Results After treatment, heart rate and lactate level in two groups were lower than those before treatment, mean arterial pressure, central venous pressure, and lactate clearance were higher than those before treatment, the cardiac index of ΔPCO2/ΔCa-vO2 group was higher than that before treatment, and the central venous pressure, cardiac index, and lactate clearance in ΔPCO2/ΔCa-vO2 group were higher than those in ScvO2 group, with statistical significance (P ＜ 0.05). The hospitalization time and mechanical ventilation time of ΔPCO2/ΔCa-vO2 group were shorter than those of ScvO2 group, and the fluid consumption to achieve the six hours recovery goal was lower than ScvO2 group, with statistical significance (P ＜ 0.05). There was no significant difference in 28-day mortality between the two groups (P ＞ 0.05). Conclusion The fluid resuscitation regimen with ΔPCO2/ΔCa-vO2 as the center is more effective in treating early sepsis hypoperfusion.
2021 Vol. 18 (25): 89-92,102 [Abstract] ( 63 ) HTML (1 KB)  PDF (651 KB)  ( 61 )
93 Predictive value of C-reactive protein and procalcitonin in the short-term prognosis of pyemia shock
LI Fenghui1 PENG Zhiyun1 TANG Zhongxiang1 XIE Weining2
Objective To investigate the value of C-reactive protein and procalcitonin to predict short-term prognosis in pyemia shock patients. Methods A total of 121 patients with pyemia shock hospitalized in the Department of Critical Care Medicine, Guangdong Hospital of Integrated Traditional Chinese and Western Medicine from January 2015 to January 2020 were selected as the study subjects. According to the prognosis within 28 days, they were divided into survival group (83 cases) and death group (38 cases). Sepsis-related organ failure assessment (SOFA), acute physiology and chronic health evaluationⅡ(APACHEⅡ) scores, and related laboratory indicators were collected and compared between the two groups at admission. Cox regression model was used to analyze the influencing factors of death within 28 days. All subjects were divided into low CRP group (≤89.4 mg/L, 42 cases) and high CRP group (＞89.4 mg/L, 79 cases) according to CRP level, and then divided into low PCT group (≤10.0 ng/ml, 97 cases) and high PCT group (＞10.0 ng/ml, 24 cases) according to PCT level. Receiver operating characteristic (ROC) curve was used to analyze the predictive value of CRT and PCT in the short-term prognosis of pyemia shock within 28 days. Kaplan-Meier method was used to analyze 28 d survival curve of patients with different levels of CRP and PCT pyemia shock. Results SOFA and APACHEⅡscores, CRP, PCT, serum creatinine, total bilirubin, and fasting blood glucose in the survival group were lower than those in the death group, while oxygenation index, platelet count, mean arterial pressure in the survival group were higher than those in the death group, with statistical significance (P ＜ 0.05). High SOFA score, high CRP level, and high PCT level were independent risk factors for death within 28 d in pyemia shock patients (HR ＞ 1, P ＜ 0.05), and high oxygenation index was a protective factor (HR ＜ 1, P ＜ 0.05). The area under ROC curve of CRT combined with PCT in the diagnosis of sepsis shock within 28 days was higher than that of CRT and PCT, and the difference was statistically significant (P ＜ 0.05). The 28-day cumulative survival rate of high CRP group was lower than that of low CRP group, and the 28-day cumulative survival rate of high PCT group was lower than that of low PCT group (P ＜ 0.05). Conclusion CRP and PCT are independent risk factors for death within 28 days in patients with pyemia shock, and the combination of CRP and PCT has certain predictive value for the prognosis within 28 days of pyemia shock.
2021 Vol. 18 (25): 93-97 [Abstract] ( 44 ) HTML (1 KB)  PDF (702 KB)  ( 72 )
98 Relationship between peripheral blood protein phosphatase magnesium-dependent 1A level and airway remodeling in patients with bronchial asthma
XU Lei1 HE Xinhua1 CHEN Ang2 TAN Xian3
Objective To investigate the relationship between peripheral blood protein phosphatase magnesium-dependent 1A (PPM1A) level and airway remodeling in patients with bronchial asthma. Methods A total of 114 patients with bronchial asthma admitted to Boai Hospital of Zhongshan, Guangdong Province (hereinafter referred to as “our hospital”) from August 2017 to January 2020 were selected. The patients were divided into severe group (51 cases) and mild to moderate group (63 cases) according to the asthma grading standards in the Global Asthma Initiative. Another 50 healthy volunteers from our hospital during the same period were selected as the control group. Serum levels of PPM1A, interleukin (IL)-4, IL-17A, IL-13, lung function and airway remodeling were measured. The correlation between serum PPM1A level and airway remodeling, lung function, IL-4, IL-17A, and IL-13 was analyzed. Results Serum PPM1A level, forced expiratory volume in one second (FEV1), ratio of FEV1 to forced vital capacity (FEV1/FVC), and percentage of FEV1 to predicted value (FEV1%pred) in severe and mild to moderate groups were lower than those in the control group, the levels of serum PPM1A, FEV1, FEV1/FVC, and FEV1%pred in severe group were lower than those in mild to moderate group, with statistical significance (P < 0.05). The levels of IL-17A, IL-13, and IL-4, the percentage of airway wall thickness/airway outer diameter and the percentage of airway wall area/total area of the airway in the severe and mild to moderate groups were higher than those in the control group. The levels of IL-17A, IL-13 and IL-4, the percentage of airway wall thickness/airway outer diameter to the percentage of airway wall area/total area of the airway in the severe group were higher than those in the mild to moderate group, and the differences were statistically significant (P < 0.05). The linear regression equation was PPM1A=2.035+0.492 IL-4-0.671 IL-17A -0.503 IL-13+0.586 FEV1+0.416 FEV1/FVC +0.356 FEV1%pred -0.725 percentage of airway wall thickness/airway outer diameter-0.783 percentage of airway wall area/total area of the airway（R2 = 0.786，adjustment R2 = 0.753，F = 39.265，P ＜ 0.001）. The level of PPM1A in asthmatic patients was positively correlated with FEV1, FEV1/FVC and FEV1%pred (P < 0.05), and negatively correlated with the percentage of airway wall thickness/airway outer diameter, the percentage of airway wall area/total area of the airway, IL-4, IL-17A, and IL-13 (P < 0.05). Conclusion The level of PPM1A in peripheral blood of patients with bronchial asthma decreased significantly, and the loss of PPM1A may be involved in the process of airway remodeling in bronchial asthma.
2021 Vol. 18 (25): 98-102 [Abstract] ( 210 ) HTML (1 KB)  PDF (568 KB)  ( 25 )
103 Influencing factors of shivering during recovery period in patients with transurethral enucleation of prostate under general anesthesia
WAN Qin1,2 LUO Lili1,2 YIN Xiaorong1,2▲
Objective To observe the influencing factors of shivering during recovery period in patients with transurethral enucleation of prostate under general anesthesia. Methods The data of 112 patients undergoing transurethral enucleation of prostate under general anesthesia in West China Hospital, Sichuan University from January 2019 to October 2020 were retrospectively analyzed. According to the occurrence of shivering of patients during recovery period, patients were divided into occurrence group (18 cases) and non-occurrence group (94 cases). The general data of the two groups were compared, and the influencing factors of the occurrence of shivering during recovery period were found by single and multiple logistic regression analysis. Results There were statistically significant differences in body mass index, operation time, pain degree, and postoperative body temperature between the two groups (P ＜ 0.05). Single and multiple logistic regression analysis showed that moderate to severe pain, postoperative body temperature < 36℃ and long operation time were independent risk factors for the occurrence of shivering during recovery period in patients with transurethral enucleation of prostate under general anesthesia (OR = 15.439, 10.846, 1.172, P ＜ 0.05). High body mass index was a protective factor for the occurrence of shivering during recovery period in patients with transurethral enucleation of prostate under general anesthesia (OR = 0.749, P ＜ 0.05). Conclusion Body mass index, pain, postoperative temperature, and operation time are the influential factors for the occurrence of shivering during recovery period in patients with transurethral enucleation of prostate under general anesthesia.
2021 Vol. 18 (25): 103-106 [Abstract] ( 63 ) HTML (1 KB)  PDF (584 KB)  ( 58 )
107 Application effect of drinking water test after MRI examination under Sevoflurane inhalation anesthesia in children
LI Yajun1 LI Xia1 DING Sihan1 JIANG Zhongquan1 YANG Yanfei2▲
Objective To analyze the application effect of drinking water test after MRI examination under Sevoflurane inhalation anesthesia in children, so as to provide reference for clinical practice. Methods From May 2018 to May 2020, 232 children with MRI examination under Sevoflurane inhalation anesthesia in Kunming Children’s Hospital were selected and they were divided into group A and group B according to the random number table method, with 116 cases in each group. MRI examination was performed under Sevoflurane inhalation anesthesia in both groups. Group A was given no intervention after MRI examination, while group B was given drinking water test after MRI examination. The anesthesia recovery(anesthesia recovery time, anesthesia recovery room stay time), agitation during recovery (pediatric anesthesia emergence delirium [PAED], agitation rating system during anesthesia recovery [Watchha]), eating (eating time, eating quantity) and complications (dehydration, hypoglycemia, aspiration, cough, hypoxemia, agitation) of two groups were compared. Results The anesthesia recovery time and anesthesia recovery room stay time of group B were shorter than those of group A, and the differences were statistically significant (P < 0.05). The PAED score and Watcha score of group B were higher than those of group A, and the differences were statistically significant (P < 0.05). The eating time of group B was shorter than that of group A, and the difference was statistically significant (P < 0.05); there was no significant difference in eating quantity between two groups (P > 0.05). There was no significant difference in the total incidence of complications between two groups (P > 0.05). Conclusion Drinking water test to evaluate swallowing reflex after MRI examination under Sevoflurane inhalation anesthesia in children is helpful to shorten the anesthesia recovery time, improve the eating condition of children, and has significant significance to improve the quality of anesthesia recovery, which is worthy of clinical promotion.
2021 Vol. 18 (25): 107-110 [Abstract] ( 84 ) HTML (1 KB)  PDF (502 KB)  ( 108 )
111 Effect of Sevoflurane mask inhalation general anesthesia combined with sacral block anesthesia on children undergoing indirect hernia repair
HUANG Guangmei ZHOU Yuhua LIANG Kaiyuan
Objective To investigate the effect of Sevoflurane mask inhalation general anesthesia combined with sacral canal block anesthesia on children undergoing indirect hernia repair. Methods A total of 300 children who underwent laparoscopic indirect hernia repair (single site) in Guigang Peopele’s Hospital，Guangxi Zhuang Autonomous Region from January 2016 to December 2019 were selected as the research objects, they were divided into study group (150 cases, Sevoflurane mask inhalation general anesthesia supplemented with sacral block anesthesia) and control group (150 cases, intravenous general anesthesia alone) by random drawing. Heart rate and mean arterial pressure before anesthesia induction (T1), 5 min after anesthesia induction (T2), at the beginning of operation (T3), 15 min after operation (T4), at the end of operation (T5) and at the time of recovery (T6) were compared, and the fluctuation value was statistically analyzed; the recovery time and pain degree were compared between two groups; the occurrence of anesthesia adverse reactions was observed and recorded. Results Compared with T1, heart rate and mean arterial pressure were increased at T2-T6 in control group and at T2-T5 in study group, and the differences were statistically significant (P < 0.05). Compared with control group, heart rate was decreased, and the mean arterial pressure was slowed down in study group at T2-T6, and the differences were statistically significant (P < 0.05). Compared with control group, the fluctuation values of heart rate and mean arterial pressure in study group were smaller, and the differences were statistically significant (P < 0.05). Compared with control group, the postoperative recovery time was shortened and the pain score was decreased in study group, and the differences were statistically significant (P < 0.05). Compared with control group, the total incidence of anesthetic adverse reactions in study group was decreased, and the differences were statistically significant (P < 0.05). Conclusion Sevoflurane mask inhaled general anesthesia combined with sacral canal block anesthesia has a good effect on the anesthesia of children with indirect hernia repair, and can improve the anesthesia safety.
2021 Vol. 18 (25): 111-114 [Abstract] ( 60 ) HTML (1 KB)  PDF (508 KB)  ( 48 )
115 Analysis of influencing factors of hypoxemia in patients with thoracoscopic surgery under general anesthesia during anesthesia recovery period
HE Jiajing FENG Xiaolan▲
Objective To analyze the influencing factors of hypoxemia in patients with thoracoscopic surgery under general anesthesia during anesthesia recovery period. Methods The clinical data of 150 patients undergoing thoracoscopic surgery under general anesthesia admitted to Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine from October 2019 to October 2020 were analyzed. According to the occurrence of hypoxemia during anesthesia recovery period, they were divided into the occurrence group (42 cases) and the non-occurrence group (108 cases). Through univariate and multivariate analysis, the influencing factors of hypoxemia in patients undergoing thoracoscopic surgery under general anesthesia were found. Results There were statistically significant differences in body mass index (BMI), combined diabetes mellitus, surgical position, interleukin-6 (IL-6), and C-reactive protein (CRP) levels between the two groups (P < 0.05). Overweight (OR = 3.520, 95%CI: 1.770-6.999), combined with diabetes mellitus (OR = 2.367, 95%CI: 1.111-5.043), supine position surgery (OR = 2.348, 95%CI: 1.123-4.908), IL-6 overexpression (OR = 1.628, 95%CI: 1.134-2.335), CRP overexpression (OR = 3.107, 95%CI: 1.381-6.990) were the influencing factors of hypoxemia in patients with thoracoscopic surgery under general anesthesia during anesthesia recovery period (P < 0.05). Conclusion The occurrence of hypoxemia in patients with thoracoscopic surgery under general anesthesia during anesthesia recovery period is related to overweight, combined with diabetes mellitus, supine position surgery and overexpression of IL-6 and CRP.
2021 Vol. 18 (25): 115-118 [Abstract] ( 59 ) HTML (1 KB)  PDF (530 KB)  ( 152 )
119 Exploration on material basis and mechanism of Bushen Huoxue Decoction in treating multiple myeloma based on network pharmacology and molecular docking technology
ZHOU Yanqun LIN Lingyun CHEN Benshu WANG Liqiong LIU Zenghui
Objective To explore the effective components and pharmacological targets, signal pathways of Bushen Huoxue Decoction in treating multiple myeloma based on network pharmacology and molecular docking technology. Methods The chemical components of Bushen Huoxue Decoction were searched in traditional Chinese medicine systems pharmacology database and analysis platform. The whole target genes corresponding with the components of Bushen Huoxue Decoction were predicted by searching Swiss Target Prediction database. The gene microarray data of multiple myeloma patients and healthy persons were retrieved from the GEO database by taking “multiple myeloma” as the keyword and compared to screen the differentially expressed genes by the internet analyzer of GEO2R. DAVID database was used for gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of intersection genes. Further, Cytoscape software was used to analyze the network topology parameters, and the core genes and key components were selected according to the degree value, proximity to centrality and intermediary number. Finally, AutoDock Vina was used to verify the molecular docking between core genes and key genes. Results About 97 active components and 98 potential target genes were collected for Bushen Huoxue Decoction corresponding with multiple myeloma therapy. Active ingredients-target network constructed by intersection genes contained 195 nodes and 756 edges. KEGG pathway mainly involved cancer signaling pathway, MAPK signaling pathway and nuclear factor-κB signal transduction pathway, osteoclast differentiation, TNF signal pathway, etc. Molecular docking showed that the key components of Bushen Huoxue Decoction could spontaneously bind to the key targets of multiple myeloma, and the binding performance of methyl cimicifugin with MAPK14 was the best. Conclusion Bushen Huoxue Decoction can inhibit the proliferation of multiple myeloma cells, enhance the effect of chemotherapy and reduce bone damage through multi-component, multi-target and multi-channel. It has a certain value in the treatment of multiple myeloma.
2021 Vol. 18 (25): 119-123 [Abstract] ( 89 ) HTML (1 KB)  PDF (1319 KB)  ( 83 )
124 Analysis on medication rules of Menstrual Diseases in Zhichan Medical Cases from Menghe famous doctor He Jiheng
CHEN Yutong YU Rong TAN Yan ZHOU Cong WU Yongjun XIANG Qin
Objective To analyze medication rules of Menstrual Diseases in Zhichan Medical Cases based on ancient and modern medical record cloud platform, and provide reference for clinical treatment of menstrual diseases. Methods The effective medical records of Menstrual Diseases in Zhichan Medical Cases were screened and recorded, database was created and imported into ancient and modern medical records cloud platform. The frequency analysis of single drug, correlation analysis, traditional Chinese medicine attribute and cluster analysis were carried out by software to study rules and characteristics of He Jiheng’s menstrual regulation drugs. Results A total of 258 effective prescriptions of menstrual diseases were entered, involving 167 traditional Chinese medicines. Fifteen traditional Chinese medicines were used more than 70 times, of which Angelicae Sinensis Radix (249 times) was the most used traditional Chinese medicine. Drugs were mainly attributed to liver and spleen channels. The main effects were regulating menstruation and relieving pain, moistening intestines and defecating, tonifying blood and activating blood circulation. The drug combination with the highest frequency of drug association analysis was Angelicae Sinensis Radix-Paeoniae Radix Alba. Cluster analysis showed that the three groups of cluster prescriptions were frequently used in clinical practice. Conclusion He Jiheng pays attention to nourishing blood and qi, soothing liver and strengthening spleen in the treatment of menorrhagia, and implements two methods of regulating qi and blood and regulating liver and spleen from beginning to end.
2021 Vol. 18 (25): 124-127,145 [Abstract] ( 66 ) HTML (1 KB)  PDF (904 KB)  ( 61 )
128 Study on the physiological mechanism of spleen governing transportation and transformation based on hyperlipidemia
WU Zaoxia1 ZHANG Qiming2 WANG Yiguo2
Hyperlipidemia is a systemic disease caused by the disorder of lipid metabolism, it belongs to the category of “turbid phlegm” and “blood stasis” in traditional Chinese medicine. In the whole process of its formation, whether the function of spleen governing transportation and transformation is normal or not is the key to its pathogenesis. According to the etiology and pathogenesis of hyperlipidemia, and on the basis of functional connotation, this paper discusses the physiological mechanism of spleen governing transportation and transformation from three aspects: physiological function, anatomical location, and executive structure. Thus it is found that spleen governing transportation and transformation is the hinge of water-damp and fine matter transportation, and the central link of the whole diet metabolism process. The spleen’s function of governing transportation and transformation is performed by the modern anatomical organ liver. Its executive structure is the digestive system with digestion, absorption and excretion functions, and the material exchange system with metabolic function.
2021 Vol. 18 (25): 128-131 [Abstract] ( 81 ) HTML (1 KB)  PDF (712 KB)  ( 47 )
132 Visual analysis of traditional Chinese medicine in the treatment of degenerative lumbar spinal stenosis based on CiteSpace
WANG Peng1 MI Lingyu2▲ ZHAO Ruoqi3 GUO Ran3 LI Yonghui3 ZHANG Su3 LI Teng3 SHI Mengya3▲
Objective To visually analyze the research content and direction of traditional Chinese medicine in the treatment of degenerative lumbar spinal stenosis in the past 20 years by drawing map, and to provide reference for further development of this field. Methods A total of 3426 literatures of Chinese medicine for lumbar stenosis was retrieved from January 2000 to December 2020 by China National Knowledge Infrastructure. CiteSpace 5.7.R5 software was used to make the relevant maps of authors, research institutions and keywords, analyze the distribution and cooperation of main research forces in this field, and explore the frontier and hot spots information in this field. Results The analysis of published papers showed that in the past 20 years, the number of published papers on the treatment of lumbar spinal stenosis with traditional Chinese medicine fluctuated greatly. It was obviously affected by the sudden hot spots around 2018, but the overall trend was on the rise. The author collaboration map analysis showed that three teams with Gao Jinghua, Yang Kexin and Gao Chunyu were formed as the core. The map analysis of research institutions showed that the inter-agency cooperation was not good. The co-occurrence map of key words showed that lumbar disc herniation was the first; lumbar spinal stenosis, massage and disc herniation were important support points for the current research in the field of traditional Chinese medicine treatment for lumbar spinal stenosis; twelve large clusters were formed, reflecting the current research hotspots, involving lumbar disc herniation, degenerative lumbar spinal stenosis, lumbago and leg pain, etc. The time line map indicated that the related studies of disc herniation and spinal stenosis lasted for 10 years or more, which was the research focus and future trend of traditional Chinese medicine treatment for lumbar spinal stenosis. Conclusion The overall research in the field of lumbar spinal stenosis is not perfect; the future research should strengthen the close cooperation between authors and institutions, deeply study the clinical efficacy of traditional Chinese medicine methods on lumbar spinal stenosis, further carry out clinical randomized control trials, strengthen the basic research, and improve the traditional Chinese medicine treatment research system of lumbar spinal stenosis.
2021 Vol. 18 (25): 132-137 [Abstract] ( 102 ) HTML (1 KB)  PDF (1745 KB)  ( 71 )
138 Professor Huang Lijuan’s experience in diagnosis and treatment of coronary heart disease
LIU Meiqi1 ZHAO Fanying1 MENG Yuan1 GUO Xiping1 YANG Lin1 ZHENG Jun1 HUANG Lijuan2 WANG Zhenyu3
Coronary heart disease is one of the most common diseases with high fatality rate. Traditional Chinese medicine mostly thinks that it belongs to “heart pain”. Professor Huang Lijuan is a famous national traditional Chinese medicine master. According to the changes of deficiency and excess of the patient’s condition in different periods, professor Huang Lijuan identifies with the thoughts of treatment aiming at its root causes and treatment according to syndrome differentiation. She points out that the disease pathogenesis is “deficient root and excessive superficial”, the acute attack period is mainly domination of pathogen and “intermingle phlegm and stasis”. In the remittent period, deficient vital qi is the dominant. Most of the causes of recurrent angina pectoris after interventional therapy are “yang deficiency and yin congelation”. During the treatment, we should “run through the holism”, “regulate liver and spleen，keep pace with the times”. In treatment, we should emphasizie “warm yang and benefite qi”, “promote blood circulation for removing obstruction in collaterals”, and “regulate qi-flowing for eliminating phlegm”.
2021 Vol. 18 (25): 138-141 [Abstract] ( 88 ) HTML (1 KB)  PDF (677 KB)  ( 44 )
142 Meta analysis on the rules of acupuncture and moxibustion of vascular dementia
WANG Qiang1 DING Dingming2 LI Sikang2 ZHAO Pengfei2 SHI Qiaoyun3 WANG Zhongju1
Objective To analyze and summarize the rules of acupuncture and moxibustion in the treatment of vascular dementia. Methods The relevant literatures of acupuncture and moxibustion in the treatment of vascular dementia from December 2010 to December 2020 in CNKI database, Wanfang database and VIP database were searched. Chinese key words included acupuncture, acupuncture treatment, acupuncture, acupoints, electroacupuncture, acupoint selection, acupoints, vascular dementia, etc. English search terms included acupunture therapy, moxibustion, and vascular dementia. A total of 36 literatures were screened by computer retrieval, which met the requirements. The data was entered and statistically analyzed by Microsoft Excel 2016 software, and included into the compatibility rules of relevant acupoints in the literature. Results The first three meridians involved in acupuncture and moxibustion in the treatment of vascular dementia were du meridian, stomach meridian, and gallbladder meridian. Bǎihuì, zúsānlǐ, sìshéncōng, fēngchí, sānyīnjiāo were the top five main acupoints. The top five points used as matching points were zhōngwǎn, tàixī, tàichōng, nèiguān, bǎihuì, zúsānlǐ. Conclusion The treatment of vascular dementia with acupuncture and moxibustion is mainly based on the selection of local acupoints on the head combined with the matching of distal acupoints. The principle and feature of acupuncture and moxibustion is the combination of disease differentiation and dialectics.
2021 Vol. 18 (25): 142-145 [Abstract] ( 146 ) HTML (1 KB)  PDF (715 KB)  ( 99 )
146 Data mining analysis on law of acupoint selection by massage in children with functional constipation based on traditional Chinese medicine inheritance auxiliary platform
GAO Xiaoxiao WANG Wenyi SI Mengran JI Qing CAI Junhao
Objective To explore the law of acupoint selection of massage in the treatment of functional constipation in children based on traditional Chinese medicine inheritance auxiliary platform (V3.0). Methods Reverse search method was used, with “constipation”“infantile constipation”“infantile massage”“chiropractic”“infantile ”as the key words, the literatures related to pediatric massage from May 1992 to October 2020 in China HowNet database, Wanfang database and VIP database were searched. The pediatric massage prescription for the treatment of functional constipation was excavated, and the data was imported into traditional Chinese medicine inheritance auxiliary platform. The data mining method was used to analyze the law of the screened prescriptions. Results There were 86 massage prescriptions, involving 75 acupoints, 13 high-frequency acupoints whose frequency was more than 20. By setting the support degree as 10% or 30%, the corresponding network diagram of acupoints could be obtained respectively. By setting the support level to 46% and the confidence level to 0.9, 13 pairs of commonly used acupoint combinations and 9 combination rules were gotten. Conclusion The acupoint selection of infantile massage in the treatment of functional constipation has a certain regularity, which provides a reference for clinicians in the treatment of the disease and is convenient for its application in grass-roots hospitals.
2021 Vol. 18 (25): 146-149 [Abstract] ( 70 ) HTML (1 KB)  PDF (835 KB)  ( 36 )
150 Thoughts on the refined management of key research and development projects in hospitals
XIE Yu1 ZHAO Heling1 DU Jun1▲ TIAN Xiaojia2 LIU Zhihua3
In the context of innovation-driven strategies and scientific and technological system reforms, strengthening the management of scientific research projects by medical institutions is an important support for enhancing scientific and technological innovation capabilities. This article focuses on the positioning, formation mechanism, and organizational management characteristics of Key Research and Development Programs, combined with the top-level design of the National Key Research and Development Program Projects of the Cancer Hospital of the Chinese Academy of Medical Sciences, collaborative innovation network construction, research team training, etc., application planning, management supervision, etc. Practical experience in management, put forward relevant work suggestions from the aspects of data mining and sharing, and promote the transformation of results, and provide reference and reference for medical institutions to improve their innovation capabilities and solve national disease prevention and control needs during the “14th Five-Year Plan” period.
2021 Vol. 18 (25): 150-153 [Abstract] ( 72 ) HTML (1 KB)  PDF (545 KB)  ( 30 )
154 PEST-SWOT analysis on the construction of a regional medical consortium in Tianjin
LI Hongtao1 QIN Shanchun1 YANG Licheng2
In recent years, with the successive promulgation of relevant national policies, the construction of our country’s medical consortium has ushered in new opportunities, which will gradually transition from the stage of exploration and development to the stage of standardized development. This article takes the regional medical consortium construction work carried out by Tianjin Medical University General Hospital Airport Hospital as an example, and uses the PEST -SWOT analysis theory to construct the PEST-SWOT analysis matrix. Through the analysis of advantages, disadvantages, opportunities and threats, development strategies and countermeasures are put forward to provide reference basis for hospital managers to carry out medical consortium work in the new era.
2021 Vol. 18 (25): 154-157 [Abstract] ( 73 ) HTML (1 KB)  PDF (600 KB)  ( 94 )
158 Research on the construction practice and application of logistic management system in modern hospitals
LI Jin NIE Tian▲
With the continuous advancement of the medical reform work, the state has successively introduced guiding policies to put forward corresponding requirements for the construction of hospital management systems, logistics service socialization, operation management informationization, building a one-stop service system, reducing energy consumption expenditures for 10 000 yuan of income, asset management, etc., and advocated relying on contract energy management models to promote the digital transformation of hospitals. This article analyzes the practical effect of the construction of modern hospital logistics management system based on the current situation of the hospital, and follows the national guidance on the establishment of a modern hospital management system. The modern hospital logistics management model and management system of Guang’anmen Hospital China Academy of Chinese Medical Sciences are constructed from four aspects: one-stop portal for hospital logistics, medical care and patients, digital management platform, management team and logistics service social management system. The practice of digital platform and process reengineering from four aspects, including security and stability, asset resources, energy consumption, and operating costs, has shown good economic value.
2021 Vol. 18 (25): 158-161 [Abstract] ( 25 ) HTML (1 KB)  PDF (603 KB)  ( 215 )
162 柳昭羽（1986.9-），女，硕士；研究方向：医院管理。#br#
2021 Vol. 18 (25): 162-165,177 [Abstract] ( 95 ) HTML (1 KB)  PDF (1038 KB)  ( 58 )
166 Application of narrative medicine model in health education for elderly patients undergoing radiofrequency ablation of atrial fibrillation
GENG Yi1 LI Xin1 JU Weizhu2 FENG Jie1 HE Ying1▲
Objective To explore the application effect of health education based on narrative medicine model in elderly patients with atrial fibrillation undergoing radiofrequency ablation. Methods From January to December 2019, Jiangsu Provincial Hospital who underwerrt radiofrequency ablation to treat 112 elderly patients with atrial fibrillation were selected. According to the random number table method, they were divided into experimental group of 57 cases and control group of 55 cases. The control group was given regular health education, and the experimental group was jointly applied with narrative medicine model health education. Follow-up for six months, the level of knowledge and behavior, complications, quality of life of radiofrequency ablation were compared between the two groups. Results Excluding those who fell off during follow-up, 55 cases and 51 cases were included in the experimental group and control group, respectively. Follow-up for six months, the total scores of health-related knowledge, beliefs, behaviors and knowledge, beliefs and behaviors of the two groups were higher than those before education, while the experimental group was higher than the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of complications in the experimental group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). After six months of follow-up, the quality of life score of the experimental group was higher than that before education; the scores of physiological function, physiological function, physical pain, vitality, social function, emotional function, and mental health of the control group were higher than those before education, and the differences were statistically significant (P ＜ 0.05). After six months of follow-up, the scores of physiological function, physiological function, social function, emotional function, and mental health of the experimental group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Health education based on the narrative medicine model can help improve the knowledge, belief, and behavior of elderly patients undergoing radiofrequency ablation of atrial fibrillation, reduce the incidence of complications, and improve the quality of life of patients.
2021 Vol. 18 (25): 166-169 [Abstract] ( 139 ) HTML (1 KB)  PDF (652 KB)  ( 84 )
170 Effect of 3H high-quality nursing concept intervention on the improvement of symptoms, adverse reactions and disease knowledge in children with severe pneumonia
ZHU Xiaoyu ZHOU Min QIAO Hongyu YANG Ni▲
Objective To explore the impact of 3H high-quality nursing concept intervention on the improvement of symptoms, adverse reactions and disease knowledge in children with severe pneumonia. Methods A total of 108 children with severe pneumonia admitted to the First Affiliated Hospital of the Air Force Military Medical University of the Chinese People’s Liberation Army from January 2018 to December 2020 were selected as the research objects. They were divided into control group and observation group by a random number table method, with 54 cases in each group. The control group was adopted routine nursing intervention, and the observation group was adopted 3H high-quality nursing intervention on the basis of the control group. The improvement of symptoms, adverse reactions, knowledge of family members’ diseases, and levels of C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were compared between the two groups. Results The antipyretic time, shortness of breath improvement time, cough relieving time, and hospital stay of observation group were shorter than those of the control group, and the differences were statistically significant (P ＜ 0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). The awareness rate of family members in the observation group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). After the intervention, the levels of CRP, IL-6, and TNF-α in the two groups were higher than before the intervention, and the observation group was lower than the control group, the differences were statistically significant (P ＜ 0.05). Conclusion The application of 3H high-quality nursing concept intervention can promote the improvement of the symptoms of children with severe pneumonia, reduce the occurrence of adverse reactions, improve the knowledge of family members, and inhibit the overreaction of inflammatory factors.
2021 Vol. 18 (25): 170-173 [Abstract] ( 180 ) HTML (1 KB)  PDF (651 KB)  ( 85 )
174 The mediating role of psychological resilience in the work-family conflict and professional training load of clinical female nurses
SHI Xueping XU Zhenzhen DING Xiwei LI Wen
Objective To explore the mediating role of psychological resilience in the work-family conflict of clinical female nurses and professional training load, and to provide references for coping with the training load. Methods From April to May 2020, a total of 204 female nurses were selected as the subjects from Nanjing Gulou Hospital of Jiangsu Province, Subei People’s Hospital, Nanjing Jiangning Traditional Chinese Medicine Hospital, Lishui District People’s Hospital, Anqing Petrochemical Hospital of Anhui Province, and Nanjing University Hospital by the convenience sampling method. The work-family conflict scale, professional training load scale and mental resilience scale were used to conduct online questionnaire surveys, and the mediation effect was analyzed by Amos 24.0 software. Results The mental resilience and training load of nurses were at a medium level, and the perception of family work conflict was at a medium-to-high level. Mental resilience, resilience, and self-strength were negatively correlated with work-family conflict and training load (r ＜ 0, P ＜ 0.05), and optimism was negatively correlated with training load (r ＜ 0, P ＜ 0.05). Psychological resilience had a partial mediating effect between work-family conflict and training load, and the effect accounts for 22.62%. Conclusion Psychological resilience is a mediating variable of female nurses’ work-family conflict and training load.
2021 Vol. 18 (25): 174-177 [Abstract] ( 107 ) HTML (1 KB)  PDF (757 KB)  ( 124 )
178 Application effect of comprehensive relaxation training combined with information support in the perioperative period of endoscopic retrograde cholangiopancreatography
WANG Minghao1 ZHOU Zhengchi2 WANG Zhen3▲
Objective To explore the effect evaluation of comprehensive relaxation training combined with information support applied to perioperative patients with endoscopic retrograde cholangiopancreatography (ERCP). Methods A selection of 92 patients who were admitted to Qingdao Municipal Hospital and planned to undergo ERCP surgery from July 2018 to June 2020 were divided into observation group and control group according to the random number table method, with 46 cases in each group. The control group was received ERCP perioperative routine care, and the observation group was used comprehensive relaxation training combined with information support on the basis of the control group. The anxiety and heart rate, blood pressure fluctuations and related indexes of surgery were observed before and after intervention in the two groups. Results After the intervention, the self-rating anxiety scale (SAS) score of the two groups was lower than that before the intervention, and the SAS score of the observation group was lower than that of the control group, and the differences were statistically significant (P ＜ 0.05); the systolic blood pressure, diastolic blood pressure, and heart rate levels of the two groups were higher than those before the intervention, while systolic blood pressure, diastolic blood pressure, and heart rate levels of the observation group were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The rate of good operation cooperation in the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05); the operation time and the time to get out of bed after surgery were shorter in the observation group than the control group, and the differences were statistically significant (P ＜ 0.05). The incidence of postoperative complications in the observation group was significantly lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Comprehensive relaxation training combined with information support can effectively alleviate the perioperative psychological and physiological stress response of ERCP patients, improve surgical cooperation, promote postoperative recovery, and help reduce postoperative complications.
2021 Vol. 18 (25): 178-181 [Abstract] ( 71 ) HTML (1 KB)  PDF (681 KB)  ( 35 )
182 Application of case management model based on humanistic care in continuous care of patients undergoing total hysterectomy
XU Xiaoqiong1 GUO Ying2 HU Guiqiong3
Objective To explore the application effect of case management model based on humanistic care in continuous care of patients undergoing total hysterectomy. Methods A total of 108 patients with total hysterectomy were selected from Leshan Maternal and Child Health Hospital of Sichuan Province from July 2019 to June 2020. According to the operation time, 57 patients were divided into the observation group (July to December 2019) and 51 patients were divided into the control group (January to Tune 2017). The control group was given routine continuity care, and the observation group was combined with case management based on humanistic care, they were followed up for six months, the negative emotions and coping styles of the two groups were compared. Results After six months of follow-up, the scores of self-rating anxiety scale (SAS) and self-rating depression scale (SDS) in two groups were significantly lower than those in the same group at discharge, and the scores of SAS and SDS in observation group were significantly lower than those in control group (P ＜ 0.05). The scores of solving problems and seeking help were significantly higher than those of the same group at discharge (P ＜ 0.05), and the scores of self-blame and avoidance were significantly lower than those of the same group at discharge (P ＜ 0.05), the scores of problem solving and seeking help in the observation group were significantly higher than those in the control group, and the scores of self-blame and avoidance were significantly lower than those in the control group (P ＜ 0.05). Conclusion The continuous nursing of case management based on humanistic care can help to resolve the anxiety and depression of total hysterectomy patients, avoid negative coping behaviors such as self-blame and avoidance, and promote the development of positive coping methods such as solving problems and seeking help.
2021 Vol. 18 (25): 182-185 [Abstract] ( 81 ) HTML (1 KB)  PDF (648 KB)  ( 59 )
186 Application effect of multi-family synchronous health education in maintenance hemodialysis patients
WU Shan LIU Jinzhi ZHANG Yu
Objective To explore the application effect of multi-family synchronous health education in maintenance hemodialysis patients. Methods A total of 96 patients with maintenance hemodialysis Suzhou Hospital of Anhui Medical University from January 2019 to August 2020 were selected. According to the time of dialysis, 52 patients were divided into the experimental group (November 2019 to August 2020) and 44 patients were divided into the control group (January 2019 to October 2019). Both groups were given maintenance hemodialysis education, at the same time, families in the experimental group were given diversified and synchronous health education. Follow-up for four months, the two groups of dry weight control self-management behaviors, complications and quality of life were compare of twro groups. Results After four months of follow-up, the scores of self-management behavior of dry weight control in both groups were higher than before education, the total scores of liquid and ion restriction behavior, food quantity management behavior, physical and psychosocial activities and self-management behavior of the experimental group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05); the incidence of complications was lower than the control group, the difference was statistically significant (P ＜ 0.05); the quality of life score of the two groups was higher than that before education, the total score of nephropathy and dialysis-related quality of life, general health-related quality of life and quality of life of the experimental group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Diversified family members’ synchronous health education is helpful to promote the development of dry weight control and self-management behavior in maintenance hemodialysis patients, reduce the incidence of hemodialysis complications and improve the quality of life.
2021 Vol. 18 (25): 186-189 [Abstract] ( 104 ) HTML (1 KB)  PDF (650 KB)  ( 38 )
190 Application effect of targeted nursing in reducing the infection rate of patients with esophageal cancer by long-term nasal feeding
QIAN Jinyu ZHU Yuan
Objective To explore the effect of targeted nursing in reducing the infection rate of patients with esophageal cancer by long-term nasal feeding. Methods A total of 60 patients diagnosed with esophageal cancer in Shanghai Chest Hospital from April 2019 to January 2021 who had difficulty in eating and needed long-term enteral nutrition (＞ one month) by placing nasogastric tube were selected, the patients were randomly divided into control group and experimental group with 30 cases in each group. The experimental group received targeted nursing measures of nasal feeding, the intervention group received routine nursing of nasal feeding. The incidence of infection and the prevalence of special strains were compared between the two groups. Results The infection rate of the experimental group was lower than that of the control group, the difference was statistically significant (P ＜ 0.05). The infection rate of special strains in the experimental group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). Conclusion Compared with traditional nursing measures, targeted nursing measures can effectively reduce the infection rate of esophageal cancer patients with long-term nasal feeding, and can effectively reduce the infection rate of special bacteria.
2021 Vol. 18 (25): 190-193,196 [Abstract] ( 70 ) HTML (1 KB)  PDF (693 KB)  ( 58 )
193 Prevention of feeding intolerance in premature infants by breast-milk oral care based on feedforward control
BIAN Guofang YANG Feng
Objective To investigate the prevention of feeding intolerance in preterm infants by breast-milk oral care based on feedforward control. Methods A total of 80 cases of premature infants treated in Xuancheng People’s Hospital of Anhui Province from January 2016 to October 2020 were selected for the study, according to the random number table method, they were divided into observation group and control group, with 40 cases in each group, the control group was given routine care after birth, and the observation group was given breast-milk oral care based on feedforward control, all patients received continuous care until discharge. Clinical treatment, growth and feeding intolerance were compared between the two groups. Results The breastfeeding begins time, sucking function establishment time, total intestine feeding time, and hospital stay in the observation group were shorter than those in the control group, and the differences were statistically significant (P ＜ 0.05); after nursing, the weight, body length and head circumference of the two groups were significantly higher than before nursing, the weight, body length, and head circumference of the observation group were higher than the control group, the differences were statistically significant (P ＜ 0.05); the total incidence of feeding intolerance symptoms such as gastric retention, vomiting, abdominal distension, and diarrhea in patients was lower than that in control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Breast-milk oral care based on feedforward control has a preventive effect on feeding intolerance of premature infants, and is helpful to promote growth and development, so it is worthy of application and promotion.
2021 Vol. 18 (25): 193-196 [Abstract] ( 67 ) HTML (1 KB)  PDF (649 KB)  ( 80 )
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