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| Research progress of iron death in cardiovascular disease |
| LIU Liheng WANG Yanying JIAO Lei ZHANG Ying |
| Department of Pharmacology, College of Pharmacy, Harbin Medical University, Heilongjiang Province, Harbin 150081, China |
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Abstract Iron death is a new type of iron dependent programmed cell death, which is caused by the increase of fatty acid lipid peroxidation and the accumulation of reactive oxygen species induced by cell iron overload. Iron death is closely related to the occurrence and development of many major diseases such as tumor, neurodegenerative disease, metabolic disease and aging disease. Iron death is involved in many disease processes such as cardiomyopathy, myocardial infarction, heart failure, coronary atherosclerosis, myocardial ischemia-reperfusion injury, and diabetic cardiomyopathy. In this paper, the possible mechanisms of iron death in various pathological processes of cardiovascular disease are reviewed, which will help to improve understanding of iron death in cardiovascular disease.
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