支气管哮喘患者外周血蛋白磷酸酶1A水平与气道重塑的关系

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Abstract Objective To investigate the relationship between peripheral blood protein phosphatase magnesium-dependent 1A (PPM1A) level and airway remodeling in patients with bronchial asthma. Methods A total of 114 patients with bronchial asthma admitted to Boai Hospital of Zhongshan, Guangdong Province (hereinafter referred to as “our hospital”) from August 2017 to January 2020 were selected. The patients were divided into severe group (51 cases) and mild to moderate group (63 cases) according to the asthma grading standards in the Global Asthma Initiative. Another 50 healthy volunteers from our hospital during the same period were selected as the control group. Serum levels of PPM1A, interleukin (IL)-4, IL-17A, IL-13, lung function and airway remodeling were measured. The correlation between serum PPM1A level and airway remodeling, lung function, IL-4, IL-17A, and IL-13 was analyzed. Results Serum PPM1A level, forced expiratory volume in one second (FEV1), ratio of FEV1 to forced vital capacity (FEV1/FVC), and percentage of FEV1 to predicted value (FEV1%pred) in severe and mild to moderate groups were lower than those in the control group, the levels of serum PPM1A, FEV1, FEV1/FVC, and FEV1%pred in severe group were lower than those in mild to moderate group, with statistical significance (P < 0.05). The levels of IL-17A, IL-13, and IL-4, the percentage of airway wall thickness/airway outer diameter and the percentage of airway wall area/total area of the airway in the severe and mild to moderate groups were higher than those in the control group. The levels of IL-17A, IL-13 and IL-4, the percentage of airway wall thickness/airway outer diameter to the percentage of airway wall area/total area of the airway in the severe group were higher than those in the mild to moderate group, and the differences were statistically significant (P < 0.05). The linear regression equation was PPM1A=2.035+0.492 IL-4-0.671 IL-17A -0.503 IL-13+0.586 FEV1+0.416 FEV1/FVC +0.356 FEV1%pred -0.725 percentage of airway wall thickness/airway outer diameter-0.783 percentage of airway wall area/total area of the airway（R2 = 0.786，adjustment R2 = 0.753，F = 39.265，P ＜ 0.001）. The level of PPM1A in asthmatic patients was positively correlated with FEV1, FEV1/FVC and FEV1%pred (P < 0.05), and negatively correlated with the percentage of airway wall thickness/airway outer diameter, the percentage of airway wall area/total area of the airway, IL-4, IL-17A, and IL-13 (P < 0.05). Conclusion The level of PPM1A in peripheral blood of patients with bronchial asthma decreased significantly, and the loss of PPM1A may be involved in the process of airway remodeling in bronchial asthma.

Key words： Bronchial asthma Protein phosphatase magnesium-dependent 1A Airway remodeling Transforming growth factor β Lung function

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	XU Lei1 HE Xinhua1 CHEN Ang2 TAN Xian3

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XU Lei1 HE Xinhua1 CHEN Ang2 TAN Xian3. Relationship between peripheral blood protein phosphatase magnesium-dependent 1A level and airway remodeling in patients with bronchial asthma[J]. 中国医药导报, 2021, 18(25): 98-102.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I25/98

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