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2021 Vol. 18, No. 21 Published: 2021-07-25

	4	Effects of Jianpi Yiqi Formula on gastric tissue of rats with chronic atrophic gastritis with syndrome of spleen deficiency
		XU Yuxuan1 YAN Zhanpeng2 XU Tingting2 WANG Pei1 ZHENG Xue1 ZHU Fangshi1,2
		Objective To observe the effect of Jianpi Yiqi Formula on gastric tissue of rats with chronic atrophic gastritis (CAG) with syndrome of spleen deficiency. Methods Fifty-five healthy SD rats were selected to make the model of rat with CAG with syndrome of spleen deficiency by MNNG + Ranitidine method. After 24 weeks of intervention, five of them were selected to observe the morphology of their gastric mucosa to confirm the success of modeling. The last rats were divided into Jianpi Yiqi Formula low (13.1 g/ [kg·d]), medium (26.2 g/ [kg·d]) and high dose group (52.4 g/ [kg·d]), and model group (normal saline), positive drug group (folic acid 2.7 mg/ [kg·d] + Teprenone 13.5 mg/ [kg·d]) by random number table method, with ten rats in each group, another ten healthy SD rats were selected as blank group (normal saline). The status and body weight of the six groups were recorded by gavage for eight weeks. The pathological changes of the gastric tissues were observed by HE method. The changes of serum gastrin and somatostatin (SST) levels were determined by enzyme linked immunosorbent assay, and the protein expressions of Ki67, Notch1, Notch2 and Hes1 were determined by immunohistochemical stain. Results Blank group fur was white and shiny, active. The fur of the model group was yellow and easy to fall off, and the activity was reduced. The positive drug group and the low-dose, medium-dose and high-dose groups of invigorating spleen and replenishing qi formula had bright fur and high activity. The body weight of the model group was lower than that of the blank group, and the body weight of the Jianpi Yiqi Formula medium-dose and high-dose groups were higher than that of the model group, with statistical significance (P ＜ 0.05 or P ＜ 0.01). The results of HE staining showed that the gastric mucosa epithelial layer was clear and the glands were normal in the blank group. Gastric mucosal epithelium in model group was thinned, glands were reduced, arranged loosely and disorderly, and goblet cells could be seen. In the other four groups, the gastric mucosal epithelium was thickened, the glands were increased, the arrangement tended to be orderly, and the infiltration of inflammatory cells was decreased. Serum gastrin and SST levels in model group were lower than those in blank group, while the levels of serum gastrin in Jianpi Yiqi Formula high-dose group was higher than that in model group, and the levels of SST in Jianpi Yiqi Formula low-dose, medium-dose and high-dose groups were higher than that in model group, with statistical significance (P ＜ 0.05 or P ＜ 0.01). The protein expressions of Ki67, Notch1, Notch2 and Hes1 in model group were lower than those in blank group, the protein expression level of Ki67 in Jianpi Yiqi Formula low-dose group was higher than that in the model group, the protein expression levels of Notch1 and Notch2 in Jianpi Yiqi Formula low-dose, medium-dose and high-dose groups were higher than that in the model group, and the protein expression level of Hes1 in Jianpi Yiqi Formula high-dose group was higher than that in the model group, with statistical significance (P ＜ 0.05 or P ＜ 0.01). Conclusion Jianpi Yiqi Formula can improve the pathological state of gastric mucosa atrophy in CAG rats with syndrome of spleen deficiency, and the mechanism is related to the up-regulation of the expression of proteins related to Notch and other signaling pathways.
		2021 Vol. 18 (21): 4-7,32 [Abstract] ( 363 ) HTML (1 KB) PDF (833 KB) ( 105 )

	8	Expression and clinical significance of Tim-3, Gal-9 and IFN-γ in oral lichen planus lesions
		WANG Xun1 WANG Dongping2 CAI Yang1
		Objective To investigate the expression of T cell immunoglobulin domain and mucin domain protein-3 (Tim-3), galectin-9 (Gal-9) and interferon-γ (IFN-γ) in oral lichen planusand (OLP) tissues and the role of Tim-3/ Gal-9 pathway in the formation of OLP and its significance. Methods From October 2016 to October 2019, 41 cases of OLP patients treated in the Department of Periodontal Mucosa, Stomatological Hospital of Guizhou Medical University (“our hospital” for short) were selected as the OLP group, and 10 normal oral mucosal people treated in our hospital during the same period were selected as the normal group. The expression of Tim-3, Gal-9, and IFN-γ in the two groups and their correlation were detected by immunohistochemical SABC method, at the same time, the correlation between the pathological characteristics of OLP patients and Tim-3, Gal-9 and IFN-γ were analyzed. Results The positive expression rates of Tim-3 and IFN-γ in the OLP group were higher than those in the normal group, and the positive expression rates of Gal-9 was lower than that in the normal group, with statistical significance (P < 0.05). In OLP tissue, the expression of Tim-3 was positively correlated with the epithelium and lamina propria (r > 0, P < 0.05); the expression of Tim-3 and Gal-9 was negatively correlated in the epidermis (r < 0, P < 0.05); and the expression of Tim-3 and IFN-γ was positively correlated in lamina propria (r > 0, P < 0.05). The score of lymphocyte infiltration was positively correlated with the positive expression of Tim-3 in the epithelium and lamina propria (r > 0, P < 0.05), and negatively correlated with Gal-9 (r < 0, P < 0.05); the score of liquefaction infiltration of basal cells was positively correlated with the positive expression of Tim-3 and IFN-γ in the epidermis (r > 0, P < 0.05). Conclusion The high expression of Tim-3 and low expression of Gal-9 in the lesions of OLP patients may be due to the abnormal Tim-3/Gal-9 pathway, which enhances T helper cell 1 effector cells and promotes the secretion of IFN-γ, and is involved in the process of pathological injury in the lesion area of OLP.
		2021 Vol. 18 (21): 8-11 [Abstract] ( 173 ) HTML (1 KB) PDF (807 KB) ( 47 )

	12	Discussion on the mechanism of Ligustri Lucidi Fructus in the treatment of liver cancer based on network pharmacology
		ZHANG Fei1 LIU Jiemin2 ZHAO Qi3
		Objective To investigate the mechanism of Ligustri Lucidi Fructus in the treatment of liver cancer based on network pharmacology. Methods The compounds of Ligustri Lucidi Fructus were screened by traditional Chinese medicine systems pharmacology database and analysis platform, CNKI, Wanfang Medical Oline and PubMed. Target prediction was carried out in SwissTargetPrediction database, and “compound-target” network was constructed by Cytoscape software. The liver cancer targets were collected and intersected in Genecards, online Mendelian inheritance in man database to obtain the effective targets of Ligustri Lucidi Fructus in the treatment of liver cancer. Proteinprotein interaction (PPI) networks of effective targets of Ligustri Lucidi Fructus in the treatment of liver cancer were generated from the String database, and GO analysis and KEGG pathway enrichment analysis were performed in the Metascape database. Results There were ten kinds of effective chemical components and 134 targets of Ligustri Lucidi Fructus, 1033 targets of liver cancer were collected, and 47 targets of Ligustri Lucidi Fructus in the treatment of liver cancer were collected. The results of PPI network diagram showed that AKT1, ESR1 and EGFR were well associated with other proteins. GO analysis in Metascape database obtained 20 items most associated with disease, and KEGG pathway enrichment analysis obtained 14 pathways most associated with disease. Conclusion The mechanism of Ligustri Lucidi Fructus in the treatment of liver cancer is mainly through multi-target, multi-pathway and multi-pathway.
		2021 Vol. 18 (21): 12-17,49 [Abstract] ( 477 ) HTML (1 KB) PDF (2618 KB) ( 434 )

	18	Investigation and analysis on the health literacy of middle-aged and elderly Kazakhs in Yili, Xinjiang Uygur Autonomous Region
		CHEN Tianqi1 WANG Yushan1 CHE Yajie2 YAO Hua3 LIU Bo1
		Objective To study the current health literacy status and influencing factors of Kazakh middle-aged and elderly people in Yili, Xinjiang Uygur Autonomous Region, and to provide scientific basis for the later formulation of relevant intervention measures. Methods From April to November 2019, the stratified cluster sampling method was used to select middle-aged and elderly Kazakhs aged 45 to 75 in Yili of Xinjiang Uygur Autonomous Region as the research subjects, and the survey was conducted through the residents’ health literacy questionnaire. Results There were 1923 subjects in this study, with a health literacy score (43.56±16.85) points, and the health literacy possession rate was 4.84%. The differences in health literacy scores of middle-aged and elderly people with different education levels, occupations, average monthly income, household registration, chronic disease status, and self-rated health status were statistically significant (P ＜ 0.05). The results of multiple linear stepwise regression analysis showed that average monthly income, education level, household registration type, chronic disease status, and self-rated health status were the influencing factors of the health literacy of the Kazakh middle-aged and elderly people in Yili, Xinjiang Uygur Autonomous Region (P ＜ 0.05). The mediating effect analysis showed that health knowledge and ideas could indirectly affect healthy lifestyles and behaviors through health skills (P ＜ 0.01), and health skills played a part of the mediating role (95%CI: 0.0930-0.1306). Conclusion The health literacy level of Kazakh middle-aged and elderly people in Yili of Xinjiang Uygur Autonomous Region is relatively low. The government and relevant health departments should strengthen health education and publicity in response to the current health status of middle-aged and elderly people, and further improve the health literacy status of middle-aged and elderly people in the region.
		2021 Vol. 18 (21): 18-22 [Abstract] ( 156 ) HTML (1 KB) PDF (739 KB) ( 109 )

	23	Bioinformatics analysis of Parkinson disease and prediction of potential treatment of traditional Chinese medicine
		ZHAO Jiajia MUNIRE Aihaiti ZHANG Yujie YANG Junling YE Hongxia XU Zhong
		Objective To perform bioinformatics analysis of genes differentially expressed in Parkinson disease (PD) and to predict potential traditional Chinese medicines for the treatment of PD, so as to provide new research directions and ideas for the prevention and treatment of PD. Methods GEO2R was used to analyze PD data sets (GSE22491) and (GSE54536) to obtain differential genes. String was used to construct protein-protein interaction network, and GO and KEGG analysis were performed. Target-signal pathway network was constructed, and the key genes and potential pathological mechanisms in the development of PD was screened, traditional Chinese medicine systems pharmacology database and analysis platform and Coremine Medical platform were used to screen potential therapeutic traditional Chinese medicine, and molecular docking was conducted. Results 576 genes with significant difference were screened out, among which 428 genes were up-regulated and 148 genes were down-regulated. Significant genes were SRC, MAPK14, HSP90AA1, TNF, CXCR4 and GRIN1, which were mainly enriched in PI3K-Akt, Tight junction, and Neuroactive ligand-receptor interaction signaling pathway, etc. Potential therapeutic traditional Chinese medicines included Polygonum cuspidatum, Tripterygium fordii and Hippophylla rhamnoides, etc. Conclusion The 576 PD key genes have antibacterial and anti-inflammatory effects, improve blood circulation, enhance immunity, and reduce the metabolic disorders of brain neuromediators, etc., so as to achieve therapeutic effects and provide reference for the clinical treatment of PD.
		2021 Vol. 18 (21): 23-27 [Abstract] ( 149 ) HTML (1 KB) PDF (2288 KB) ( 167 )

	28	Study on the quality standard of Panax notoginseng ultra-low temperature broken wall powder
		HUANG Dongfang1 WEI Jinyu1 LIANG Jie1,2,3 CHEN Huihua1 QI Jinli1 HU Jue1 LIU Min4 ZHAO Lichun1,2,3
		Objective To establish the quality standard of Panax notoginseng ultra-low temperature broken wall powder. Methods According to the detection method of Pharmacy of the People’s Republic of China (2020 edition), 10 batches of Panax notoginseng ultra-low temperature wall powder were tested for its properties, microscopic characteristics, thin-layer chromatography, moisture, ash and extract; and the content of ginsenoside Rb1, ginsenoside Rg1, notoginsenoside R1 were determined by high performance liquid chromatography with Syncronis C18(250 mm×4.6 mm, 5 μm) and water-acetonitrile was used as the mobile phase gradient elution, the 30℃ was used as the column temperature, the 0.8 ml/min was used as the flow rate, the 203 nm was used as the detection wavelength. Results The spots in thin-layer chromatography identification were clear and the separation was good. The content of the moisture, total ash, acid-insoluble ash, extract were 8.85%-10.45%, 3.23%-3.49%, 1.69%-2.32%, 18.71%-20.08%. Ginsenoside Rg1, ginsenoside Rb1 and notoginsenoside R1 in the range of 0.0503-2.0133 mg/ml (r = 0.9995), 0.0567-2.2667 mg/ml (r = 0.9995), 0.0196-0.7833 mg/ml (r = 0.9995) showed good linear relationship with the peak area. The average recovery rate of the ginsenoside Rg1, ginsenoside Rb1 and notoginsenoside R1 were 97.2%(RSD = 1.48%), 96.0%(RSD = 1.45%), 102.8% (RSD = 1.59%). Conclusion The method is reliable with good stability and good repeatability, and can be used for the quality control of Panax notoginseng ultra-low temperature broken wall powder.
		2021 Vol. 18 (21): 28-32 [Abstract] ( 136 ) HTML (1 KB) PDF (857 KB) ( 86 )

	33	Application of ctDNA in the diagnosis and treatment of colorectal cancer
		LIU Li JIANG Ping▲ GE Wei
		Colorectal cancer is the fifth leading cause of death among malignancies in China. Screening methods for colorectal cancer are of great significance for early diagnosis, selection of targeted drugs and immunotherapy and prognosis. With the continuous development of high-throughput sequencing technology and tumor genomics, circulating tumor DNA (ctDNA) detection technology has been widely used and studied in clinic due to its non-invasive and high specificity. The methylation level, mutation and copy number variation of colorectal cancer related genes detected by ctDNA can achieve early screening effect. ctDNA detection of RAS, HER2 and other target genes plays an important guiding role in individualized medication and prognosis monitoring of patients. In this review, the recent advances in the application of ctDNA in the early screening, treatment and prognosis of colorectal cancer are reviewed.
		2021 Vol. 18 (21): 33-37 [Abstract] ( 155 ) HTML (1 KB) PDF (557 KB) ( 90 )

	38	Research progress on immune regulation mechanism of external therapy of traditional Chinese medicine on inflammatory bowel disease
		JIAO Yi1 ZHANG Yingqi1 LU Mengqian1 YU Tianyuan1 LIU Zhifeng1 LIU Di2
		Inflammatory bowel disease (IBD) is an autoimmune disease with lesions located in the mucosa of colon and rectum. At present, IBD is believed to be mostly related to diet, mood, infection and immunity, among which immunity is the most studied. Four traditional Chinese medicine external treatment methods are mostly selected clinically, including acupuncture, moxa-wool moxibustion, massage and traditional Chinese medicine enema therapy. In this paper, from the point of inflammation and immunity of IBD, the immune regulation mechanism of external treatment of Chinese medicine on IBD is discussed. The external treatment of traditional Chinese medicine can regulate the inflammatory immune response of the body through multiple targets and channels, so as to achieve the state that the vital qi is stored inside and the pathogen cannot be dried. The four kinds of external therapy intervention methods involved in this paper are different, and the mechanisms involved are also different. Acupuncture provides mechanical stimulation, moxa-wool moxibustion provides warm stimulation, and massage provides both mechanical stimulation and warm stimulation, and traditional Chinese medicine enema therapy provides drug stimulation. Acupuncture and moxa-wool moxibustion are both involved in balancing immune microenvironment and anti-inflammatory mechanism. Acupuncture is also involved in anti-oxidative stress response, anti-endoplasmic reticulum stress response and the alleviation of visceral sensitivity. Massage mainly provides sufficient morphological basis, and traditional Chinese medicine enema therapy regulates immune disorders through direct contact with the lesion site.
		2021 Vol. 18 (21): 38-41 [Abstract] ( 207 ) HTML (1 KB) PDF (546 KB) ( 172 )

	42	Research progress on the influencing factors of radiation lung injury
		XIONG Zhongkui1,2 LANG Juan3 WANG Siben1
		Radioactive lung injury is a possible adverse event in patients with thoracic cancer receiving radiotherapy, and it is also one of the dose-limiting toxicity to maximize the radiotherapy benefit in patients with thoracic cancer under the premise of ensuring radiotherapy safety. The influencing factors of radiation lung injury include radiological factors, tumor factors and patient factors. To elucidate the influencing factors of radiation lung injury will provide a theoretical basis for reducing the incidence of radiation lung injury in tumor patients receiving chest radiotherapy.
		2021 Vol. 18 (21): 42-45 [Abstract] ( 101 ) HTML (1 KB) PDF (586 KB) ( 141 )

	46	Research progress of Xianfang Huoming Decoction in the treatment of ulcerative colitis
		HAN Yunyu1 SUN Jiangyong1 CHAI Zhongqiu2 PANG Xiaochen3 ZHOU Bing2▲
		The pathogenesis of ulcerative colitis is not yet clear. It is an inflammatory disease mainly involving the rectum and the colonic mucosa. The disease is repeated and difficult to cure. In recent years, the internal administration of traditional Chinese medicine has been recognized by the majority of doctors and patients in terms of the short-term and long-term clinical effects in the treatment of ulcerative colitis and the improvement of patients’ quality of life. Many clinical studies have shown that Xianfang Huoming Decoction in compound has a clear clinical effect on the treatment of ulcerative colitis. This article discusses the theoretical basis for the treatment of ulcerative colitis by comparing the prescription efficacy, formulation analysis and pharmacological action of the drugs contained with the pathogenesis and therapeutic mechanism of ulcerative colitis, and provides ideas for its better application in the treatment of ulcerative colitis.
		2021 Vol. 18 (21): 46-49 [Abstract] ( 187 ) HTML (1 KB) PDF (546 KB) ( 310 )

	50	Analysis of risk factors related to colorectal polyps
		ZHANG Qian1 REN Junyao1 XING Jie1 SUN Xiujing1 YUE Bing2 ZHU Shengtao1 LI Peng1 ZHANG Shutian1
		Objective To explore the risk factors of colorectal polyps found in colonoscopy. Methods A retrospective analysis of 662 patients who underwent colonoscopy at the Digestive Endoscopy Center of Beijing Friendship Hospital, Capital Medical University from March 2013 to November 2014. According to the results of endoscopic and pathological diagnosis, a total of 255 patients with colorectal polyps were included in the polyp group, and 407 subjects with normal results or inflammatory lesions were included in the control group. The age, gender, personal history, past history and other factors of patients were collected, and the related risk factors that affect the occurrence of colorectal polyps were analyzed. Results Age, body mass index (BMI), proportion of males, proportion of light physical labor, smoking rate, alcohol consumption, prevalence of hypertension and previous prevalence of polyps of the polyp group were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Multivariate logistic regression model analysis showed that age (OR = 1.050), BMI (OR = 1.059), smoking (OR = 2.359), alcohol (OR = 1.644) and history of previous polyps (OR = 1.758) were independent risk factors for colorectal polyps (P ＜ 0.05); age (OR = 1.049), male (OR = 0.381), smoking (OR = 1.784), and history of polyps (OR = 2.301) were independent risk factors for multiple colorectal polyps (P ＜ 0.05). Conclusion Age, gender, BMI, smoking, drinking, and history of polyps may be independent risk factors for the occurrence or occurrence of colorectal polyps. Therefore, when performing colonoscopy, attention should be paid to comprehensively considering the relevant risk factors of patients, and focusing on screening and follow-up of high-risk groups to improve the detection rate of adenomas.
		2021 Vol. 18 (21): 50-53,66 [Abstract] ( 114 ) HTML (1 KB) PDF (936 KB) ( 185 )

	54	Investigation on the cognition of party workers with different working years to the standardized construction of basic-level party organizations
		REN Jing1 JIANG Hui2 LI Chunxia3
		Objective To understand the attitudes and influencing factors of party workers with different working years in Beijing-affiliated hospitals towards the standardized construction of basic-level party organizations, and to provide references for the standardized construction of basic-level party organizations. Methods Using in-depth interviews and questionnaire survey methods, a survey was conducted on 11 directors of the party committee office and 157 grassroots party workers in Beijing hospitals from October to November 2018. Among them, 81 people were engaged in party building work for less than 5 years, 30 people were more than 5-10 years, 28 people were more than 10-15 years, and 18 people were more than 15 years. The content of the questionnaire survey was included background information and the status quo, views, opinions and suggestions of the unit’s party building work standardization construction of the survey respondents, and the differences in various indicators of party workers with different working years were analyzed. Results There were statistically significant differences in the attitude proportions of party workers with different working years regarding the “Do you have standards and procedures for party building work that you are responsible for and engaged in?” “Do you think that setting norms and procedures for every party building work is of great help to the work?” and “How do you evaluate the party building work of the unit?” (P ＜ 0.05). It also showed that the higher the working years, the more people agreeed with the importance of experience to the party building work, and the lower the working years, the more people believed that the lack of unified norms and procedures was the main reason for the difficulty of party building work. Conclusion The lower the working years of party affairs workers, the higher the recognition of the standardized construction of basic-level party organizations.
		2021 Vol. 18 (21): 54-58 [Abstract] ( 99 ) HTML (1 KB) PDF (480 KB) ( 88 )

	59	Analysis of psychological distress and influencing factors in elderly patients with diabetic nephropathy
		FENG Lanying1 XIANG Yanjun1 ZHU Chuanmei1 TAN Mingying1 ZHOU Xun2
		Objective To understand the psychological distress of elderly patients with diabetic nephropathy (DN), and to analyze the possible influencing factors. Methods The medical records of 130 elderly patients with DN who were admitted to the West China Hospital of Sichuan University from January 2017 to December 2019 who were evaluated by the Kessler psychological distress scale (K10) at the time of admission were reviewed through retrospective research. The K10 scores of elderly DN patients with different data characteristics were compared, and the related factors that affect the psychological distress of elderly DN patients were analyzed. Results All 130 elderly patients with DN had different degrees of psychological distress, and the median K10 score was 26.00 (24.00, 29.00) points. The K10 scores of elderly DN patients with different diabetes course, social support, and negative emotions were compared, and the differences were statistically significant (P ＜ 0.05). The results of multiple linear regression analysis showed that course of diabetes (X1), social support (X2), and negative emotions (X3) might be the influencing factors of the psychological distress of elderly patients with DN (P ＜ 0.05). The linear regression equation was obtained: Y=23.345+5.395X1+2.870X2+2.655X3. Conclusion Elderly patients with DN have a certain degree of psychological distress, which may be related to the diabetes course, level of social support, negative emotions of patients. The clinic should focus on the above factors and give corresponding interventions.
		2021 Vol. 18 (21): 59-62 [Abstract] ( 200 ) HTML (1 KB) PDF (510 KB) ( 32 )

	63	Correlation between serum uric acid and renal function in patients with diabetes mellitus type 2
		XU Jiwei1 XUAN Xiaoming1 ZHANG Juanjuan2 SU Gang1▲
		Objective To analyze the correlation between serum uric acid and renal function in patients with diabetes mellitus type 2. Methods A total of 80 patients with diabetes mellitus type 2 admitted to Wuhu First People’s Hospital, Anhui Province from January 2016 to August 2020 were selected. The patients were divided into hyperuricemia (HUA) group (male＞420 μmol/L, female＞360 μmol/L, 37 cases) and normal uric acid (NUA) group (male≤420 μmol/L, female≤360 μmol/L, 43 cases) according to their serum uric acid levels. The general clinical data and renal function indexes of the two groups were collected and compared. Pearson correlation coefficient was used to analyze the correlation between serum uric acid level and renal function indexes in the two groups. Results The levels of serum uric acid, urea nitrogen, serum creatinine, the incidence of renal insufficiency and urinary microalbumin creatinine ratio in HUA group were higher than those in NUA group, and the estimated glomerular filtration rate (eGFR) level was lower than that in NUA group, with statistical significance (P < 0.05). Pearson correlation analysis showed that serum uric acid was positively correlated with urea nitrogen (r = 0.462), serum creatinine (r = 0.527), and urinary microalbumin creatinine ratio (r = 0.431), and negatively correlated with eGFR (r = -0.475, P ＜ 0.05). Conclusion Serum uric acid is significantly correlated with renal function in patients with diabetes mellitus type 2, and more attention should be paid to the control of serum uric acid level in early phase.
		2021 Vol. 18 (21): 63-66 [Abstract] ( 141 ) HTML (1 KB) PDF (465 KB) ( 104 )

	67	Clinical effect of intensive hypoglycemic regimens in the treatment of patients with diabetes mellitus type 2 complicated with ischemic stroke
		Nadila WEI Wei LU Xueling
		Objective To observe the effect of intensive hypoglycemic regimens in the treatment of patients with diabetes mellitus type 2 complicated with ischemic stroke. Methods A total of 100 patients with diabetes mellitus type 2 complicated with ischemic stroke admitted to the Seventh Affiliated Hospital of Xinjiang Medical University from May 2019 to January 2020 were selected and divided into the enhanced group (glycosylated hemoglobin > 9.0%, 50 cases) and the control group (glycosylated hemoglobin ≤9.0%, 50 cases) according to the glycosylated hemoglobin condition. Continuous subcutaneous insulin infusion was given to the intensive group, which was adjusted to multiple subcutaneous insulin injections after discharge. After three months of oral hypoglycemic drug treatment in the control group, if glycosylated hemoglobin ≥7.0%, the treatment plan was adjusted until glycosylated hemoglobin ＜7.0%. The treatment time of both groups was six months. Biochemical indexes were compared between the two groups at admission and after six months of treatment, and neurological function was compared between the two groups after six months of treatment. Results After six months of treatment, the levels of fasting blood glucose, two hours postprandial blood glucose, glycated hemoglobin, and homocysteine in the enhanced group were lower than those at admission, while the levels of two hours postprandial blood glucose and homocysteine in the control group were lower than those at admission, with statistical significance (P ＜ 0.05). The levels of two hours postprandial blood glucose and glycosylated hemoglobin in the enhanced group were higher than those in the control group at admission, with statistical significance (P ＜ 0.05). After six months of treatment, fasting blood glucose and two hours postprandial blood glucose in the enhanced group were higher than those in the control group, and creatinine was lower than those in the control group, the differences were statistically significant (P ＜ 0.05). After six months of treatment, the neurological function was compared between two groups, and the difference was statistically significant (P ＜ 0.05). Conclusion Intensive hypoglycemic regimens can improve the recovery of neurological function in patients with diabetes after stroke.
		2021 Vol. 18 (21): 67-70 [Abstract] ( 169 ) HTML (1 KB) PDF (462 KB) ( 102 )

	71	Comparison of the effects of two different surgical methods in the treatment of papillary carcinoma of thyroid
		YU Ming1 NA Zhaoyang1 YAN Changhong1 YU Xin2 YAN Jiangtao1 WU Xi1 LI Changbai1 BIAN Hui3
		Objective To compare and analyze the effect of two different surgical methods in the treatment of papillary carcinoma of thyroid. Methods A total of 84 patients with papillary thyroid carcinoma who underwent surgical treatment in Qinhuangdao Orthopedic Hospital, Hebei Province from January 2012 to December 2018 were selected as the research subjects. According to the random number table method, they were divided into control group and experimental group, with 42 cases in each group. The control group was treated with traditional multi-functional lateral neck preserving lymphadenectomy, and the experimental group was treated with multi-functional lateral neck preserving lymphadenectomy assisted by endoscopy. The surgical indexes (surgical time, blood loss, length of hospital stay), body stress-related serum indexes (C reactive protein, superoxide dismutase, malondialdehyde), incidence of complications, Vancouver scar scale (VSS), self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores were compared between the two groups. Results The surgical time of the experimental group was longer than that of the control group, the amount of blood loss, the total incidence of complications, VSS, SAS and SDS scores were lower than those of the control group, and the length of hospital stay of the experimental group was shorter than that of the control group, the differences were statistically significant (P ＜ 0.05). The levels of C reactive protein and malondialdehyde after surgery were higher than those before surgery, and the level of superoxide dismutase was lower than those before surgery, while the levels of C reactive protein and malondialdehyde in the experimental group were lower than those in the control group, and the level of superoxide dismutase in the experimental group was higher than those in the control group, with statistical significance (all P ＜ 0.05). Conclusion The effect of multi-functional lateral neck preserving lymph adenectomy assisted by endoscopy in the treatment of papillary carcinoma of thyroid is ideal, with the advantages of less blood loss, short hospital stay, low incidence of complications, beautiful incision, and can reduce the body stress reaction, anxiety and depression of patients, which is worthy of clinical application.
		2021 Vol. 18 (21): 71-74 [Abstract] ( 130 ) HTML (1 KB) PDF (460 KB) ( 51 )

	75	Clinical effect of internal and external administration of Huli Powder in the treatment of knee osteoarthritis with coldness and dampness blocking collaterals
		ZHANG Jiawen1 YUAN Yundong1 WANG Yanjun2 QI Liqing1
		Objective To investigate the effect of internal and external administration of Huli Powder in the treatment of knee osteoarthritis with coldness and dampness blocking collaterals. Methods A total of 120 patients with knee osteoarthritis in the Third Department of Orthopedics, the First Affiliated Hospital of Hebei University of Chinese Medicine from September 2018 to January 2020 were selected and they were divided into treatment group (internal and external administration of Huli Powder) and control group (internal and external administration of Diclofenac Sodium) by random number table method, with 60 cases in each group. Both groups were treated for four weeks. Visual analog scale (VAS) score, Western Ontario and McMaster University (WOMAC) osteoarthritis index score, interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) levels were recorded in both groups before and after treatment, respectively. Patients’ knee pain and improvement of knee symptoms were evaluated. Results After treatment, VAS and WOMAC osteoarthritis index scores of the two groups were lower than before treatment, and the treatment group was lower than the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the levels of IL-1 and TNF-α in the two groups were lower than before treatment, and the differences were statistically significant (P ＜ 0.05). After treatment, there were no significant differences in IL-1 and TNF-α between the two groups (P ＞ 0.05). After treatment, the total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The clinical effect of internal and external administration of Huli Powder in the treatment of knee osteoarthritis with coldness and dampness blocking collaterals is definite, and can reduce the levels of serum IL-1 and TNF-α, which is better than that of internal and external administration of Diclofenac Sodium in alleviating symptoms.
		2021 Vol. 18 (21): 75-78,91 [Abstract] ( 185 ) HTML (1 KB) PDF (622 KB) ( 78 )

	79	Comparison of effects of manual reduction combined with percutaneous curved vertebroplasty and pure percutaneous kyphoplasty in the treatment of osteoporotic vertebral compression fractures
		ZHANG Ning1 CAI Fei2 LI Changhong3 WANG Fei3
		Objective To compare the clinical effects of manual reduction combined with percutaneous curved vertebroplasty (PCVP) and pure percutaneous kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fractures (OVCF). Methods A total of 97 fresh single-segment OVCF patients admitted in the Department of Spinal Surgery, the First Hospital Yulin from January 2019 to January 2020 were selected. According to different treatment methods, they were divided into observation group and control group, 47 cases in observation group were treated with manual reduction combined with PCVP, and 50 cases in control group were treated with PKP alone. The operative time, intraoperative C-arm fluoroscopy times, treatment related costs, amount of bone cement, bone cement leakage rate, and distribution of bone cement in the vertebral body were recorded between the two groups. Preoperative and postoperative anterior edge height (AVH), cabbose Cobb angle, visual analog scale (VAS) score, and Oswestry dysfunction index (ODI) score were compared. Results The operation time, the number of C-arm fluoroscopy and the cost of treatment of the observation group were less than that of the control group, and the differences were statistically significant (P ＜ 0.05). The amount of bone cement in the observation group was greater than that in the control group, and the distribution of bone cement was better than that in the control group, the differences were statistically significant (P ＜ 0.05). There was no significant difference in the leakage rate of bone cement between the two groups (P ＞ 0.05). Compared before surgery, there were statistically significant differences in AVH, Cobb angle, VAS score and ODI score between the two groups after surgery (P ＜ 0.05); there were no significant differences in AVH, Cobb angle, VAS score and ODI score between the two groups before and after surgery (P ＞ 0.05). Conclusion Manipulation reduction combined with PCVP and PKP alone in the treatment of OVCF can reduce the injured vertebrae and improve the kyphosis, but compared with PKP, it can save the operation time, reduce the number of intraoperative C-arm fluoroscopy, and save the treatment cost.
		2021 Vol. 18 (21): 79-83 [Abstract] ( 130 ) HTML (1 KB) PDF (562 KB) ( 140 )

	84	Comparison of the effect of threaded headless compression cannulated screw and anatomical plate in the treatment of triplane fracture of distal tibia in juvenile
		MA Zhilin1 QIAO Guoyong1▲ FENG Wenfang2 DUAN Xiaowei3 CHEN Xinzhi1 ZHANG Yongtao1 NIU Jing4 LIU Zhichun5
		Objective To evaluate the effect of threaded headless compression cannulated screw and anatomical plate in the treatment of triplane fracture of distal tibia in juvenile. Methods A total of 48 juvenile patients with triplane fracture of distal tibia treated in the Department of Orthopedics, Affiliated Hospital of Hebei Engineering University from January 2017 to June 2020 were selected. According to patients’ wishes, 24 patients treated with threaded headless compression cannulated screw were selected as the study group, and 24 patients treated with anatomic plate fixation were selected as the control group. The incision length, operation time, the amount of intraoperative blood loss and postoperative blood loss were compared between the two groups. The healing time, postoperative time to ground, visual analogue scale (VAS) score and the necrosis rate of skin flap were compared between the two groups. The incidence of adverse reactions was compared between the two groups, and the improvement of joint function was compared between the two groups. Results The incision length and operation time in the study group were shorter than those in the control group, and the amount of intraoperative blood loss and postoperative blood loss in the study group were less than those in the control group, with statistical significance (P ＜ 0.05). The healing time and postoperative time to ground of the study group were shorter than those of the control group, with statistical significance (P ＜ 0.05). There was no significant difference in VAS score and necrosis rate of skin flap between the two groups (P ＞ 0.05). Both groups had slight limb swelling after operation, and no serious adverse reactions occurred in both groups. The improvement rate of joint function in the study group was higher than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion In the treatment of distal tibial fracture, threaded headless compression cannulated screw has less trauma, less bleeding, better protection of periosteum, faster fracture healing, and more conducive to the recovery of joint function. Although both schemes have better anatomical stabilization, threaded headless compression cannulated screw has more advantages and is worthy of promotion.
		2021 Vol. 18 (21): 84-87 [Abstract] ( 132 ) HTML (1 KB) PDF (686 KB) ( 75 )

	88	Effect of Compound Shangtong Capsules combined with radiofrequency ablation in the treatment of lumbar disc herniation
		HUANG Jinyi DENG Jun▲ WEI Ke WEN Zhiqian LAN Jian
		Objective To observe the effect of Compound Shangtong Capsules combined with radiofrequency ablation in the treatment of lumbar disc herniation (LDH). Methods A total of 124 LDH patients admitted to Youjiang Medical University for Nationalities from September 2018 to April 2019 were selected and they were divided into control group and observation group according to random number table method, with 62 cases in each group. The control group received oral Diclofenac Sodium Sustained-release Tablets after radiofrequency ablation, and the observation group received oral Compound Shangtong Capsules after radiofrequency ablation. The treatment course was ten days. Numerical rating scale (NRS) score, lumbar Oswestry disability index (ODI) score and clinical efficacy were compared between the two groups. The inflammatory factors (interleukin [IL]-1β, IL-6, IL-8, tumor necrosis factor-α [TNF-α]) in serum were determined by enzyme linked immunosorbent assay, and the incidence of adverse reactions was recorded. Results After treatment, NRS score, ODI score, IL-1β, IL-6, IL-8, TNF-α levels in two groups were decreased compared with before treatment, with statistical significance (P ＜ 0.05). There was no significant difference in NRS score, ODI score, IL-1β, IL-6, IL-8 and TNF-α levels between the two groups (P ＞ 0.05). There was no statistical significance in the excellent and good rates between the two groups (P ＞ 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Compound Shangtong Capsules are safe and effective in the treatment of LDH, which were worthy of clinical promotion.
		2021 Vol. 18 (21): 88-91 [Abstract] ( 154 ) HTML (1 KB) PDF (555 KB) ( 94 )

	92	Bibliometric analysis of the application of health education in gestational diabetes mellitus in China
		YANG Ya ZHAO Mei ZHU Xinyi QING Qiting
		Objective To understand the application status of health education in gestational diabetes mellitus in China, and to provide reference for future research. Methods The relevant literatures published by CNKI, Wanfang and VIP from January 2012 to June 2020 were searched by computer, with “gestational diabetes mellitus”“gestational diabetes”“health education”“health mission” as the subject terms, the year, journal, institution, author, fundation, research content and high-frequency keywords were analyzed statistically by excel and medical literature wang 5.0 software. Results After retrieval and screening, 677 literatures were included, and the annual number of published papers showed an increasing trend. Journal distribution was scattered and the core journal was few. Although there were many researchers, the core research group and collaboration trend had not been formed yet. Most of the research places were located in the eastern coastal areas, and the research places were mainly general hospitals and maternal and child health care hospital. Twenty papers were supported by foundation; and the research type was mainly experimental research. The top three keywords were gestational diabetes mellitus, health education, and pregnancy outcome. Social network analysis shows that gestational diabetes mellitus, health education, pregnancy outcome, nursing intervention and so on belong to the mainstream of current research. Conclusion The application of health education in gestational diabetes mellitus in China has made some progress, but the literature quality needs to be improved. In future research, we will strengthen investment and cooperation in the application of health education in gestational diabetes mellitus, so as to better play the role of health education in this field.
		2021 Vol. 18 (21): 92-95 [Abstract] ( 146 ) HTML (1 KB) PDF (618 KB) ( 84 )

	96	Meta analysis of the changes of endocrine and fertility function after fertility-sparing treatment for malignant ovarian germ cell tumors
		HU Mingmiao1 CHEN Mengjie2 LIANG Yuejuan2 WANG He2
		Objective To systematically evaluate the changes of endocrine and fertility function after fertility-sparing treatment for malignant ovarian germ cell tumors. Methods Literatures related to menstruation and fertility changes after fertility-sparing treatment for malignant ovarian germ cell tumors were searched in PubMed, EMbase, CNKI, Wanfang and other databases by computer. The search time was from the establishment of the database to January 2021. The method of combining subject words and key words was used to search. R3.6.1 software was used for data analysis. Results Finally, 13 articles involving 727 patients were included. Meta analysis results showed that, the complication rate of pregnancy was 88% (95%CI: 84%-92%) and the complication rate of normal menstruation was 90% (95%CI: 85%-95%) after fertility-sparing treatment for malignant ovarian germ cell tumor. Conclusion Fertility-sparing treatment for malignant ovarian germ cell tumors has little effect on ovarian function, and no lasting effect on menstruation and fertility function has been found at present.
		2021 Vol. 18 (21): 96-100 [Abstract] ( 142 ) HTML (1 KB) PDF (685 KB) ( 92 )

	101	Visualization analysis of research hotspot and frontier of endometriosis
		SUN Wenjie1 CHANG Weiqian2 ZHANG Yongjia1 ZHAO Ruihua1
		Objective To explore the hotspot and frontier of endometriosis (EMT) research published in Web of Science by visualization analysis in the past 20 years. Methods From January 2001 to December 2020, related studies on EMT published in the Web of Science core collection database were retrieved. CiteSpace was used to visually analyze and map the keywords, countries, authors, institutions, journals and so on in the literatures. Results A total of 12 051 literatures were included. The number of papers published in the relevant literatures showed an overall increasing trend. The number of papers published in the United States took the first place. The authors and institutions with high yields were all from China, and Fertility and Sterility were the influential journals in this field. Research focuses and hotspots were focused on etiology (persistent organic pollutants and microorganisms group), pathogenesis (eutopic endometrium and epithelial mesenchymal transition), diagnosis (laparoscopy and transvaginal ultrasound), treatment (embryo transfer and segmental resection), and long-term management, diseases such as cancer and uterine adenomyosis correlation studies. Conclusion Using CiteSpace to conduct visual analysis of EMT related research can directly reflect the research status, hot spots and evolution trend of EMT field, and provide some reference for researchers.
		2021 Vol. 18 (21): 101-104,109 [Abstract] ( 185 ) HTML (1 KB) PDF (1414 KB) ( 66 )

	105	Clinical effect of anterior chamber puncture combined with two different methods in the treatment of primary acute angle closure glaucoma with cataract
		LI Chao DU Shaolin CHEN Hongjia MA Huihui
		Objective To observe the clinical effect of anterior chamber puncture combined with two different methods in the treatment of primary acute angle closure glaucoma with cataract. Methods A total of 68 patients with primary acute angle closure glaucoma with cataract in Dongguan Tungwah Hospital, Guangdong Province from June 2018 to June 2020 were selected as the research subjects. According to random number table method, they were divided into group A and group B, with 34 cases in each group. After anterior chamber puncture, group A was treated with phacoemulsification + intraocular lens implantation + goniosynechialysis, group B was treated with trabeculectomy. Visual acuity (converted from international standard visual acuity to LogMAR visual acuity), intraocular pressure, corneal endothelium count, retinal nerve fiber layer (RNFL) thickness, atrial angle open range and central anterior chamber depth (ACD) were recorded and compared between two groups before and three months after surgery. The incidence of complications in two groups was observed. Results Before surgery, there were no significant differences in visual acuity (LogMAR), ACD, atrial angle open range between two groups (P > 0.05). At three months after surgery, the visual acuity (LogMAR), ACD, atrial angle open range of group A were higher those that before surgery, and group A was higher than group B, and the differences were statistically significant (P < 0.05); while the visual acuity (LogMAR), ACD, atrial angle open range of group B were not significantly differences from those before surgery (P > 0.05). Before and three months after surgery, there was no significant difference in intraocular pressure between two groups (P > 0.05). Three months after surgery, intraocular pressure of two groups were lower than those before surgery, and the differences were statistically significant (P < 0.05). There were no significant differences in RNFL thickness between two groups before and three months after surgery (P > 0.05). Before surgery, there was no significant difference in corneal endothelium count between two groups (P ＞ 0.05). Three months after surgery, corneal endothelium count in group A was lower than that before surgery, and group A was lower than group B, and the differences were statistically significant (P < 0.05); while corneal endothelium count of group B was not significantly difference from that before surgery (P > 0.05). There was no significant difference in the incidence of complications between two groups (P > 0.05). Conclusion Anterior chamber puncture combined with two different methods can reduce intraocular pressure and protect visual function, but combined with phacoemulsification + intraocular lens implantation + goniosynechialysis can effectively increase anterior chamber depth and improve visual acuity, which is worthy of further clinical application.
		2021 Vol. 18 (21): 105-109 [Abstract] ( 98 ) HTML (1 KB) PDF (491 KB) ( 72 )

	110	Changes of serum interleukin-8, interleukin-22 and tumor necrosis factor-α levels in patients with allergic rhinitis and their relationship with the severity of disease
		TIAN Shuangshuang1 LI Qin2
		Objective To investigate the changes of serum interleukin -8 (IL-8), IL-22 and tumor necrosis factor-α (TNF-α) levels in patients with allergic rhinitis and their relationship with the severity of disease. Methods Eighty patients with allergic rhinitis who diagnosed and treated in Clinical Medicine School, Qingdao University (“our hospital”for short) from January 2018 to December 2019 were selected as the case group. According to the degree of allergic rhinitis, they were divided into mild rhinitis group (31 cases) and moderate-severe rhinitis group (49 cases). All patients received Budesonide Aerosolized Suspension and Montelukast Sodium Tablets, and the treatment lasted for 12 weeks. Another 80 healthy volunteers in our hospital during the same period were selected as the control group. Serum IL-8, IL-22, and TNF-α levels between the case group and the control group were compared before treatment and 12 weeks after treatment. Serum IL-8, IL-22, TNF-α levels, and score for allergic rhinitis (SFAR) in patients with different degree of allergic rhinitis were compared and the correlation between serum IL-8, IL-22, TNF-α levels, and SFAR score were analyzed. Results Before treatment, IL-8, IL-22, and TNF-α levels in the case group were higher than those in the control group, and the differences were statistically significant (P < 0.05). After 12 weeks of treatment, serum IL-8, IL-22, and TNF-α levels in the case group were lower than those before treatment, and the differences were statistically significant (P < 0.05); there was no significant difference in serum IL-8, IL-22, and TNF-α levels between the case group and the control group (P > 0.05). Serum IL-8, IL-22, and TNF-α levels in moderate-severe rhinitis group were higher than those in mild rhinitis group, and the differences were statistically significant (P < 0.05). SFAR score in moderate-severe rhinitis group was higher than that in mild rhinitis group, and the difference was statistically significant (P < 0.05). Serum IL-8, IL-22 and TNF-α levels were positively correlated with SFAR score (r = 0.825, 0.737, 0.792, P < 0.05). Conclusion Serum IL-8, IL-22 and TNF-α levels in patients with allergic rhinitis are generally elevated, which can be used in the auxiliary diagnosis and disease assessment of allergic rhinitis in clinical practice.
		2021 Vol. 18 (21): 110-113 [Abstract] ( 107 ) HTML (1 KB) PDF (445 KB) ( 102 )

	114	Reflection on improving the curative effect of pain by blending Western medicine into Chinese medicine
		NIU Qun1 WANG Huan2 WU Ruixin3 ZHANG Shaoyou4 DONG Changsheng1,5
		As a complex subjective experience, pain can occur in many parts of the patient’s body and is often the main reason for them to seek medical attention. Traditional Chinese medicine has a history of thousands of years in the treatment of pain, as early as in Huangdi Neijing has systematically elaborated the cause of pain, pathogenesis, syndrome, prognosis and so on. It has formed its unique treatment system under the continuous supplement and improvement of many doctors in the later generations. But up to now, there are many disadvantages in pain treatment of traditional Chinese medicine, such as the great influence of subjective factors, difficulty in standardization and high difficulty in clinical promotion, which are not conducive to the development of pain theory of traditional Chinese medicine. Therefore, this paper applies traditional Chinese medicine thinking to integrate modern medical theories and methods into traditional Chinese medicine pain treatment and research, and probes into the molecular biological connotation of traditional Chinese medicine pathogenesis based on pain signal transmission, which may play a positive role in the study of traditional Chinese medicine pain, in order to improve the treatment effect of pain.
		2021 Vol. 18 (21): 114-117 [Abstract] ( 101 ) HTML (1 KB) PDF (375 KB) ( 40 )

	118	Treatment of stroke from the replenishing liver and kidney based on Huang Yuanyu’s theory of “one qi circulation”
		LIU Zehua1 YAN Yongmei1 LI Tao1 WANG Dou2
		Most physicians in the past dynasties believe that the cause of stroke is closely related to insufficient qi and blood and deficiency of liver and kidney. Huang Yuanyu’s theory of “one qi circulation” has been innovative on the basis of inheriting the classic theory. He believes that the deficiency of middle qi runs through the whole course of stroke. Based on the holistic view of “one qi circulation and soil drives four emblems”, he concludes that the pathogenesis of stroke is deficiency of primordial qi, deficiency of middle qi, cold water and soil dampness, and stagnation of wood that lead to liver wind symptoms, liver wood inability to grow and stretch, leading to stroke. The author uses the theory of “one qi circulation” to analyze the internal mechanism of stroke “yin-yang disharmony, qi and blood reverse disorder”, and concludes that the primary cause of stroke is deficiency of qi and soil dampness, and the fundamental cure is to replenish liver and kidney. The treatment should focus on regulating the rise of the left path of the kidney, spleen and liver in the “one qi circulation”. To replenish the liver and kidney focuses on “making cold water warm” instead of “making depleted water abundant”. By warming the kidney and water to warm yuanyang, drying the spleen and soil to consolidate the middleqi, benefiting the qi of liver to make the pivot flexible, to achieve a good prognosis of mild soil and water, flourishing liver and wood, and quiet wood and wind. The theory of “one qi circulation” has important clinical guiding significance in differentiating and treating stroke, which is worthy of further study.
		2021 Vol. 18 (21): 118-121 [Abstract] ( 159 ) HTML (1 KB) PDF (750 KB) ( 163 )

	122	Analysis on the medication rule of Yi Bu Quan Lu for treatment of diarrhea based on data mining
		WANG Zhaochu1 SHI Rong2 WANG Jing2
		Objective To analyze the rules of prescription medication in treating diarrhea in Yi Bu Quan Lu. Methods The data mining and analysis of prescription drugs for diarrhea in Yi Bu Quan Lu was carried out by traditional Chinese medicine inheritance assist platform V2.5. Results A total of 156 prescriptions for the treatment of diarrhea were screened, involving 132 kinds of traditional Chinese medicine, including 30 kinds of traditional Chinese medicine with frequency ≥10. The four nature of drugs were mainly warm and calm, the five flavours were mainly pungent and sweet, and the channel tropism of spleen and stomach were mainly. According to association rule analysis, 32 high-frequency drug combinations and eight core drug combinations were counted. Conclusion The medication rule in Yi Bu Quan Lu for the treatment of diarrhea have obvious tendency, which can provide reference for clinical treatment and research.
		2021 Vol. 18 (21): 122-125 [Abstract] ( 157 ) HTML (1 KB) PDF (824 KB) ( 57 )

	126	Analysis on medication rules of external hairdressing prescriptions in ancient Chinese medicine classics based on data mining
		QU Baoquan1 LIU Dun1 HOU Wenbin1 JIANG Yuqi1 GU Miao1 YANG Dingquan2
		Objective To analyze and summarize the medication rules of external hairdressing prescriptions in ancient Chinese medicine classics. Methods The external prescriptions for promoting hair growth, hair dyeing, antidandruff and antipruritic were collected and sorted out by using the database of Chinese medical canon. The frequency, four natures, five tastes, meridian tropism, association rules and complex network were analyzed by using the ancient and modern medical cases cloud platform. Results A total of 221 prescriptions were included. The external prescriptions for promoting hair growth were mainly composed of herbs that dispel wind and relieve exterior syndrome, promote blood and qi circulation, clear heat and cool blood, most of the drugs used were pungent, warm, liver, stomach, spleen, and lung meridians. The external prescriptions for hair dyeing were mainly composed of natural plants and minerals with hair dyeing function. The external prescriptions for antidandruff and antipruritic were mainly used herbs of dispelling wind and relieving exterior pain, most of which were pungent, warm, and lung meridian. Conclusion This paper preliminarily explores the medication characteristics of external hairdressing prescriptions in ancient Chinese medicine classics through data mining, which has a certain reference value for the clinical treatment of scalp hair diseases.
		2021 Vol. 18 (21): 126-129,149 [Abstract] ( 147 ) HTML (1 KB) PDF (997 KB) ( 453 )

	130	Experience of Professor Huang Chunlin in the treatment of chronic erosive gastritis with five methods of invigorating spleen
		GU Yewen1 WANG Zhike1 LI Hucai2 WANG Lixin2
		Chronic erosive gastritis is a kind of nonspecific inflammation of gastric mucosa caused by a variety of reasons, which is characterized by gastric mucosal erosion, hyperemia, edema and bleeding. It is a common clinical disease, with the characteristics of protracted, easy to repeat, reduce the life quality of patients. Professor Huang Chunlin is a famous expert of traditional Chinese medicine in China and a director of the national clinical research base of traditional Chinese medicine. He has rich clinical experience in the treatment of spleen and stomach disease. He thinks that the basic pathogenesis of the disease is spleen dyskinesia, and puts forward the theory of five methods of strengthening spleen to guide clinical practice. Professor Huang Chunlin often uses these five methods in clinical treatment, and the curative effect is good. By following Professor Huang Chunlin’s study, the author summarizes the commonly used drugs of “invigorating qi and strengthening spleen”“invigorating stomach and strengthening spleen”“clearing heat/warming cold and strengthening spleen”“regulating qi and strengthening spleen”“appetizing stomach and strengthening spleen”, so as to improve the clinical efficacy.
		2021 Vol. 18 (21): 130-133 [Abstract] ( 161 ) HTML (1 KB) PDF (751 KB) ( 127 )

	134	Professor Zheng Shaozhou’s experience in treating multiple sclerosis from “endotoxin”
		GUO Yanyan1 GONG Hongtao2 ZHAO Duo2
		This paper sorts out Professor Zheng Shaozhou’s experience in treating multiple sclerosis from the theory of endotoxin, and the primary responsibility for the pathogenesis of multiple sclerosis lies in the kidney. It is closely related to the liver and spleen. Deficiency of viscera leads to endotoxin, endogenous turbid toxin is a key factor in the pathogenesis and recurrence of multiple sclerosis. The collaterals are the transmission pathways of toxins, so the treatment of detoxification and collaterals runs through the treatment of the disease, differentiation and treatment of the internal organs, detoxify, cutting off the conversion chain of endotoxin, and treatment by stages. In the acute attack stage, it is mainly evil and excess, the main focus is to detoxify and dredge collaterals, as well as tonifying the kidney; in the chronic progression stage, deficiency is the mainstay or a mixture of deficiency and excess, aiming to balance yin and yang, replenish viscera, and dispel evil; in remission stage, deficiency of healthy qi, loss of blood yin and yang, internal poisonous evil, mixed deficiency and excess, yin and yang interlaced, treatment must focus on strengthening the body, taking into account the elimination of pathogens, adjusting the balance of yin and yang in the viscera, and fundamentally removing the internal factors of the occurrence and development of the disease. The dependent nature of toxins, treatment rules, and prescriptions have their own emphasis. The prescription is selected according to the evidence, and the case is analyzed to grasp the main line. The effect is quite good.
		2021 Vol. 18 (21): 134-137 [Abstract] ( 120 ) HTML (1 KB) PDF (785 KB) ( 137 )

	138	Study on the knowledge map of Chinese medicine syndrome differentiation and treatment of coronary heart disease based on Neo4j
		CHEN Shanda1,2 XIA Shuaishuai1,2 DENG Wenxiang1,2 LI Liang1,2 YAN Junfeng1,3
		Objective To explore the methods and common steps to express the rules of treatment by syndrome differentiation of coronary heart disease by using Neo4j. Methods A total of 329 clinical cases of coronary heart disease from January 2010 to February 2020 including syndrome, syndrome element of the nature of disease and medicine were collected from CNKI, VIP and Wangfang data. Frequency analysis, weight calculation and association analysis were carried out with Excel table and Python and the results were loaded into Neo4j to generate the graphic database. Results Chest tightness, chest pain, shortness of breath, white fur, and fatigue were the symptoms with occurrence frequency more than 50%. Blood stasis, phlegm, qi deficiency, qi stagnation, yang deficiency, yin deficiency, dampness and fire (heat) were the syndrome elements with occurrence frequency more than 10%. Salviae Miltiorrhizae Radix et Rhizoma and Glycyrrhizae Radix et Rhizoma were the medication with use frequency more than 50%. The results of weight calculation showed that the relationship of “central syndrome-element disease syndrome-syndrome-medication” had the highest correlation: blood stasis-qi deficiency-petechia (ecchymotic) tongue-Persicae Semen, phlegm-fire (heat)-slippery pulse-Trichosanthis Pericarpium, qi deficiency-yin deficiency-fatigue-Schisandrae Chinensis Fructus. Related Chinese medicines of occurrence frequency more than 10% and confidence more than 75% were Santali Albi Lignum→Salviae Miltiorrhizae Radix et Rhizoma, Persicae Semen and Angelicae Sinensis Radix→Chuanxiong Rhizoma and Carthami Flos, Amomi Fructus→Salviae Miltiorrhizae Radix et Rhizoma. Conclusion It will be more convenient and concise to express the knowledge of diagnosis and treatment by using Neo4j to explore the rules of clinical cases. Graph database including Neo4j will be a powerful tool to express the knowledge in the field of Chinese medicine.
		2021 Vol. 18 (21): 138-141 [Abstract] ( 129 ) HTML (1 KB) PDF (1097 KB) ( 97 )

	142	Clinical effect of Yiqi Yangxue Huayu Decoction in treating acute attack stage of chronic hepatitis B
		LI Jianmin1 ZHANG Weiping2▲ LIANG Dong3 DU Daping1
		Objective To observe clinical effect of Yiqi Yangxue Huayu Decoction in the treatment of acute attack stage of chronic hepatitis B. Methods Eighty patients with acute attack stage of chronic hepatitis B admitted to Bozhou Hospital of Traditional Chinese Medicine from January 2016 to January 2020 were selected and divided into two groups according to random number table method, with 40 cases in each group. Control group was treated with antiviral, liver protection and immune regulation, while observation group was treated with Yiqi Yangxue Huayu Decoction on the basis of control group. The course of treatment was eight weeks. Total effective rate, before and after treatment of alanine aminotransferase (ALT), total bilirubin (TBil), interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) levels were compared between two groups. Results Total effective rate of observation group was higher than that of control group, the difference was statistically significant (P < 0.05). After treatment, the levels of ALT and TBil in two groups were lower than those before treatment, and observation group was lower than control group, the differences were statistically significant (P < 0.05). After treatment, the levels of IFN-γ and TNF-α in two groups were lower than those before treatment, and observation group was lower than control group, the differences were statistically significant (P < 0.05). Conclusion Yiqi Yangxue Huayu Decoction is effective in treating acute attack stage of chronic hepatitis B.
		2021 Vol. 18 (21): 142-145 [Abstract] ( 154 ) HTML (1 KB) PDF (749 KB) ( 133 )

	146	Professor Zhou Yabin’s experience in treating perimenopausal insomnia
		ZHAO Chenyu1 YANG Jianfei1，2 ZHOU Yabin1，2 FAN Zengguang1
		The pathogenesis of insomnia is mainly the disharmony of yin and yang. Due to the influence of the special physiological state of perimenopausal women, the deficiency of chong and ren and the disharmony of yin and yang are more obvious. Perimenopausal women are more likely to have insomnia than other age groups, which is a high-risk group of insomnia, and the pathogenesis is complex and changeable, the disease is lingering and difficult to heal, which seriously affects the quality of life of patients. Professor Zhou Yabin has been working for more than 30 years. He has accumulated some experience in the treatment of perimenopausal insomnia and has good clinical effect. The author has the honor to follow Professor Zhou Yabin to learn from his experience and summarizes his experience in diagnosis and treatment in order to be helpful for colleagues.
		2021 Vol. 18 (21): 146-149 [Abstract] ( 180 ) HTML (1 KB) PDF (786 KB) ( 125 )

	150	Effect of acupuncture plus moxibustion in treating chronic fatigue syndrome with yang deficiency of spleen and kidney and its influence on immune function
		SUN Yuan
		Objective To investigate the effect of acupuncture plus moxibustion in treating chronic fatigue syndrome (CFS) with yang deficiency of spleen and kidney and its influence on immune function. Methods Eighty patients with CFS with yang deficiency of spleen and kidney admitted to Outpatient Department of Preventive Treatment in Ma’anshan Hospital of Traditional Chinese Medicine from February 2017 to July 2020 were selected as the research subjects. All patients were divided into control group and observation group according to random number table method, with 40 cases in each group. Control group was treated with ordinary acupuncture, and observation group was treated with moxibustion on the basis of control group, once every other day, five times for a course of treatment, six courses of treatment. The curative effect, symptom score, immunoglobulin G (IgG), immunoglobulin A (IgA) and immunoglobulin M (IgM) levels before and after treatment were compared between two groups, and the adverse reaction was observed. Results Total effective rate of observation group was higher than that of control group, the difference was statistically significant (P < 0.05). After treatment, the scores of memory loss, anxiety, insomnia and depression in two groups were lower than those before treatment, and observation group was lower than control group, the differences were statistically significant (P < 0.05). After treatment, the levels of IgG, IgA and IgM in two groups were higher than those before treatment, and observation group was higher than control group, the differences were statistically significant (P < 0.05). There was no obvious adverse reaction in two groups. Conclusion Acupuncture plus moxibustion is an effective and safe in treating CFS with yang deficiency of spleen and kidney, which can effectively improve clinical symptoms and immune function.
		2021 Vol. 18 (21): 150-152,172 [Abstract] ( 180 ) HTML (1 KB) PDF (1180 KB) ( 114 )

	153	Meta-integration of psychological experience in patients undergoing hematopoietic stem cell transplantation during protective isolation period
		WANG Yingying HUANG Lu WU Yun
		Objective To systematically evaluate the psychological experience of patients undergoing hematopoietic stem cell transplantation during the protective isolation period, and to provide reference for medical staff to provide supportive care. Methods PubMed, the Cochrane Library, Psyc INFO, Web of Science, EMbase, CINAHL, CNKI, CBM, Wang Fang, VIP and other databases were searched by computer. Qualitative research on the psychological experience of protective isolation in patients with hematopoietic stem cell transplantation were retrieved from the establishment of the database until May 25, 2020. The results were integrated using the evaluation literature of evidence-based Health Care Australia’s Quality Evaluation Criteria for Qualitative Research (2017) and the meta integration method. Results A total of 11 articles, two in Chinese and nine in English, were included, a total of 85 results were extracted and grouped into nine new categories, which were integrated into three results: general feelings before transplantation, negative effects of protective isolation, and positive coping factors. Conclusion Clinical medical staff should pay attention to the overall feeling of patients with hematopoietic stem cell transplantation during the protective isolation period, understand the real experience and needs of patients, and provide timely and targeted help to patients.
		2021 Vol. 18 (21): 153-156 [Abstract] ( 87 ) HTML (1 KB) PDF (791 KB) ( 112 )

	157	Effect of health education based on the law of forgetting curve on health beliefs and health behaviors of elderly patients with osteoporosis
		LI Shufen LIN Jing ZHENG Haihua ZHENG Chunmei
		Objective To explore the effect of health education based on the law of forgetting curve in elderly patients with osteoporosis. Methods A total of 100 elderly patients with osteoporosis who were admitted to the Cadre Sanatorium of Hainan & Geriatric Hospital of Hainan from January 2018 to June 2019 were selected, they were divided into 50 cases in the treatment group and 50 cases in the control group by random number table method, abscission cases were excluded, 48 cases were included in the treatment group and 43 cases in the control group. The control group was given regular health education, and the treatment group adopted health education based on the law of forgetting curve. Follow-up for six months, the two group’s health beliefs, health behaviors, bone density were compared. Results After six months of follow-up, the health belief scores of the two groups were higher than those before education, the scores of susceptibility, severity, dyskinesia, calcium intake, health motivation, and health belief total socre in the treatment group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05); the compliance with medical drugs, calcium supplementation, vitamin D supplementation, and moderate exercise of two groups increased significantly compared with those before education in the same group, the compliance with moderate exercise of treatment group was significantly higher than that of the control group, the differences were statistically significant (P ＜ 0.05); the bone density of the two groups increased significantly compared with before education (P ＜ 0.05), the bone density of the lumbar spine, femoral neck, greater trochanter and Wang’s triangle in the treatment group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Health education based on the law of forgetting curve can help improve the health belief level of elderly patients with osteoporosis, promote the development of healthy behaviors, improve bone density.
		2021 Vol. 18 (21): 157-160 [Abstract] ( 155 ) HTML (1 KB) PDF (656 KB) ( 33 )

	161	Impact of health education based on the strong concept on self-management efficacy and treatment compliance behaviors of patients with chronic obstructive pulmonary disease complicated with tuberculosis
		MAO Xuejuan WANG Hong▲
		Objective To explore the impact of health education based on the strong concept on self-management and treatment compliance behaviors of patients with chronic obstructive pulmonary disease (COPD) complicated with tuberculosis. Methods A total of 120 COPD patients with pulmonary disease tuberculosis admitted to the Fourth People’s Hospital of Huai’an from January 2018 to February 2020 were selected and divided into intervention group 60 cases and control group 60 cases by random number table method. The control group was given regular health education, and the intervention group jointly applied health education based on the strength concept. Follow up for six months the self-management efficacy and treatment compliance behavior of the two groups were compared. Results After six months of follow-up, the intervention group actually completed the follow-up of 58 cases, and the control group actually completed the follow-up of 56 cases. The scores of self-management efficacy in both groups were higher than those before education (all P ＜ 0.05). The scores of dyspnea management, emotional fluctuations, physical activity, environment and temperature, and self-management efficacy total scores in the intervention group were higher than those of the control group (P ＜ 0.05). The treatment compliance behavior scores of the two groups were higher than those before education (P ＜ 0.05). The scores of the intervention group’s compliance with medication, self-monitoring, regular follow-ups, behavior changes, and treatment compliance total score were higher than those of the control group (P ＜ 0.05). Conclusion Health education based on the strong concept will help to promote the self-management efficacy of patients with COPD complicated with tuberculosis and improve treatment compliance behavior.
		2021 Vol. 18 (21): 161-164 [Abstract] ( 167 ) HTML (1 KB) PDF (705 KB) ( 78 )

	165	Application of health management based on eCASH concept in ICU elderly mechanical ventilation patients
		XU Yaping1 ZHU Ling2
		Objective To explore the effect of health management based on eCASH concept in patients with intensive care unit (ICU) elderly mechanical ventilation. Methods A total of 88 elderly ICU patients with mechanical ventilation admitted to the 904th Hospital of Joint Logistic Support Force of the People’s Liberation Army from January to December 2019 were selected, according to random number table method, 44 cases were divided into observation group and 44 cases in control group (42 cases were actually included). The control group was given routine nursing intervention, health management based on eCASH concept was given in the observation group. The mechanical ventilation treatment related indicators, delirium and ICU acquired debilitating, and intensive care experience were compared between two groups. Results The time of mechanical ventilation, ICU hospitalization and total hospitalization in observation group were significantly shorter than those in control group (P ＜ 0.05); the incidence of delirium and ICU acquired debilitating was significantly lower than that in the control group (P ＜ 0.05), delirium duration was significantly shorter than control group (P ＜ 0.01), the score of MRC muscle strength was significantly higher than that in the control group (P ＜ 0.05); environmental perception, cognitive and sensory changes, interpersonal support needs, treatment and disease information, the total score of intensive care experience were significantly lower than those in the control group (P ＜ 0.05). Conclusion Health management based on eCASH concept can shorten mechanical ventilation and hospital stay, reduce the incidence of delirium and ICU acquired debilitating, alleviate the painful experience of intensive care.
		2021 Vol. 18 (21): 165-168 [Abstract] ( 121 ) HTML (1 KB) PDF (657 KB) ( 38 )

	169	Effect of detailed nursing based on humanistic care on the medical experience and satisfaction of outpatients
		WEI Meiai HUANG Xiaoli LI Huihan HAN Linling LUO Zhongsan CHEN Ying
		Objective To explore the effect of detailed nursing based on humanistic care on the medical experience and satisfaction of outpatients. Methods A total of 1147 outpatient patients were selected from Baise People’s Hospital of Guangxi Zhuang Autonomous Region from January 2018 to December 2019, according to the time of visit, they were divided into control group (January to December 2018) 565 cases and observation group (January to December 2019) 582 cases. The control group received routine outpatient nursing intervention, and the observation group received detailed nursing based on humanistic care. Medical experience and satisfaction were compared between the two groups. Results The scores of physical environment and convenience, doctor-patient communication, medical information and medical service in the observation group were significantly higher than those in the control group (P ＜ 0.05); the satisfaction of observation group was significantly higher than that of control group (P ＜ 0.05). Conclusion Detail nursing intervention based on humanistic care is helpful to enhance the outpatient experience of happiness, improve patient satisfaction.
		2021 Vol. 18 (21): 169-172 [Abstract] ( 97 ) HTML (1 KB) PDF (700 KB) ( 205 )

	173	Application of electrical stimulation biofeedback intervention combined with rehabilitation nursing in children with fecal incontinence after operation of hirschsprung’s disease
		SUN Ying YIN Qiang▲ TANG Qian LIU Qin WAN Sihong PENG Xia
		Objective To explore the application of electrical stimulation biofeedback intervention combined with rehabilitation nursing in children with fecal incontinence (FI) after operation of hirschsprung’s disease (HD). Methods Atotal of 85 childrens with HD treated in a Three Grade A Class Children’s Hospital from December 2017 to December 2019 were selected as the research subjects, divided them by random number table method into control group 43 cases and observation group 42 cases. Both groups were given routine intervention, on this basis, the control group was received electrical stimulation biofeedback intervention, the observation group was given rehabilitation nursing on the basis of the control group, the intervention effect was evaluated after continuous intervention for five weeks, including monitoring rectal sensory threshold, anorectal dynamics. Results The initial sensory capacity, defecation sensory capacity and the strongest defecation capacity were compared of children in both groups before intervention, there were no statistical significant differences (P ＞ 0.05); after five weeks of intervention, the initial sensory capacity, defecation sensory capacity and the strongest defecation capacity of children in both groups were higher than those before intervention, and the observation group was higher than the control group, and there were statistical significant differences (P ＜ 0.05); the maximum systolic pressure, the longest systolic time and the resting pressure of anal canal were compared of children in two groups before intervention, there were no statistical significant differences (P ＞ 0.05); after five weeks of intervention, the maximum systolic pressure, the longest systolic time and the resting pressure of anal canal of children in groups were higher than those before intervention, and the observation group was higher than the control group, and there were statistical significant differences (P ＜ 0.05). Conclusion Children with FI after operation of HD receiving electrical stimulation biofeedback intervention combined with rehabilitation nursing have ideal benefits, the rectal sensory threshold and anorectal dynamics are improved.
		2021 Vol. 18 (21): 173-176 [Abstract] ( 107 ) HTML (1 KB) PDF (699 KB) ( 104 )

	177	Influencing factors of self-care ability after discharge of patients with acute myocardial infarction after PCI
		FENG Sili1 CHEN Yaqin1 SUN Hairong1 GUO Chunling2 LIU Mei2▲
		Objective To observe the self-care ability after discharge of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI), and to analyze the influencing factors of self-care ability after discharge of patients. Methods A total of 200 patients who met the treatment criteria for PCI and received PCI were selected from Xuzhou Cancer Hospital, Jiangsu Province from June 2018 to June 2020. After discharge, the patients were followed up for three months. At the end of follow-up, the patients were divided into low level group (≤57 points, 81 cases) and medium high level group (≥58 points, 119 cases) according to their exercise of self-care agency scale scores. A general data questionnaire was used to record the baseline data of patients and were compared. The general self-efficacy scale (GSES) was used to evaluate their self-efficacy. Multivariate analysis was used to analyze the factors affecting the self-care ability of patients with AMI treated by PCI after discharge. Results Among the 200 patients, 81 cases (40.50%) had low self-care ability, 65 cases (32.50%) had moderate self-care ability, and 54 cases (27.00%) had high self-care ability. The proportion of negative emotions and one to two kinds of medication in the low level group were higher than those in the middle and high level group, and the difference was statistically significant (P ＜ 0.05). There were statistically significant differences in educational level and GSES scores between the two groups (P ＜ 0.05). Multivariate analysis showed that low education level, negative emotion and one or two kinds of medication were independent risk factors for low self-care ability of AMI patients treated with PCI (all OR ＞ 1, P ＜ 0.05), and high GSES score was the protective factor (OR ＜ 1, P ＜ 0.05). Conclusion The level of self-care ability of AMI patients with the treatment of PCI is low after discharge, which may be affected by the factors such as low educational level, negative emotion, less types of medication and low self-efficacy, clinical should focus on the above factors to give targeted intervention measures.
		2021 Vol. 18 (21): 177-180,184 [Abstract] ( 192 ) HTML (1 KB) PDF (723 KB) ( 150 )

	181	Application effect of dignity nursing combined with resistance breathing training in lung cancer patients with chemotherapy
		JIANG Haitao1 QU Lili2 SONG Guifang3▲
		Objective To observe the effect of dignity nursing combined with resistance breathing training in lung cancer (LC) patients with chemotherapy. Methods A total of 85 LC patients who received chemotherapy in Qingdao Municipal Hospital from January 2018 to March 2020 were prospectively selected, according to the add or even number of outpatient, divided them into group A 43 cases and group B 42 cases, both groups were received resistance breathing training, on this basis, group A was combined with routine nursing, group B was combined with with dignity nursing on the basis of group A; before and four weeks of intervention, the respiratory function (forced vital capacity [FVC], forced expiratory volume in one second [FEV1]), mental state (Hospital Anxiety and Depression Scale [HAD]) were compared between the two groups; the incidence of adverse events in the two groups was recorded. Results After four weeks of intervention, the levels of FVC and FEV1 in both groups were increased than those before intervention (P ＜ 0.05), but compared FVC and FEV1 levels of both groups, there were no statistical significant difference (P ＞ 0.05); after four weeks of intervention, the HAD scores of both groups were decreased than those before intervention, and group B was lower than group A (P ＜ 0.05); the incidence of adverse events of both groups were compared, there was no statistical significant difference (P ＞ 0.05). Conclusion Dignity nursing combined with resistance breathing training in LC chemotherapy patients is more conducive to alleviate anxiety, depression and other adverse emotions, improve their respiratory function, and has high application value.
		2021 Vol. 18 (21): 181-184 [Abstract] ( 288 ) HTML (1 KB) PDF (708 KB) ( 48 )

	185	A case of multiple system atrophy with inappropriate antidiuretic hormone secretion syndrome combined with central fever treated with integrated traditional Chinese and Western medicine
		ZHANG Chen1 HAO Conglin2 SHANG Juju1 ZHOU Xusheng1 ZHAI Junpeng1 LI Jing1
		Multiple system atrophy (MSA) is a rare and relatively rapid neurodegenerative disease involving the three major systems of autonomic nervous system, extrapyramidal system and cerebellum. Syndrome of inappropriate antidiuretic hormone secretion (SIADHS) is a clinical syndrome in which excessive secretion of antidiuretic hormone (ADH) leads to body water retention, dilutional hyponatremia, and elevated urine sodium and urine osmotic pressure. Case reports of MSA combined with SIADHS are rare. Combined with central fever, the prognosis is worse. Western medicine treatment is not effective. Clinically, it has been shown that combined traditional Chinese and Western medicine is more effective than Western medicine alone. This article reports the diagnosis and treatment process of a case of MSA with inappropriate antidiuretic hormone secretion syndrome combined with central fever treated with mtegrated traditional Chinese and Western medicine, showing that Qinghao Biejia Decoction has a good effect on the treatment of this disease. At the same time, a literature review is carried out in order to strengthen the understanding of the disease and to explore the advantages of traditional Chinese medicine in the treatment of the disease.
		2021 Vol. 18 (21): 185-188 [Abstract] ( 494 ) HTML (1 KB) PDF (391 KB) ( 450 )

	189	Enlightenment and reference from the standardized training model of American urology residents
		TANG Min1 LI Pu1 LIU Bianjiang1 MENG Xiaoxin1 WANG Donghua2▲
		Standardized training of residents is a necessary way for medical students to grow into a qualified clinician after graduation. The United States has formed a mature standardized training system for residents in urology, and the standardized training of urology residents in my country is still in its infancy. This article compares in detail the differences in education systems, training methods, and assessments of the Chinese and American urology training models, and puts forward suggestions for improvement of the urology training work in China, including strengthening the regular assessment and evaluation of training bases, building a unified and standardized residential training evaluation system, highlighting the step-wise training of resident doctors’ clinical ability, and cultivating their self-expanding learning ability.
		2021 Vol. 18 (21): 189-192 [Abstract] ( 110 ) HTML (1 KB) PDF (485 KB) ( 213 )

	193	Enlightenment of “Invisible Narrative” in traditional Chinese medicine to narrative medicine
		WANG Jinglin1 FU Xinjun1 LI Yajun1,21.College of Humanities and management, Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China; 2.Research Center of Traditional Chi
		In the face of the increasingly prominent ideological value-related issues in the global public health field, narrative medicine has emerged as the times require. Exploring the characteristics of traditional Chinese medicine in that the humanistic spirit runs through the diagnosis and treatment of diseases, so the “narrative” nature of traditional Chinese medicine is inherent. In diagnosis and treatment, traditional Chinese medicine practitioners record parallel medical records with the patient as the protagonist through the “four diagnoses combined with reference” and “seeing the micro-knowledge”, and combine pathogenesis, syndrome differentiation, and prescription elements to form an “invisible narrative” logic. Finally, both doctors and patients can truly understand and trust on the spiritual level. This fully embodies the three elements of narrative medicine: attention, reproduction and belonging. Based on this, the concept of “invisible narrative” in Chinese medicine is explored under the current medical situation in China, in order to provide a reference for narrative medicine to achieve the ultimate goal of doctor-patient empathy.
		2021 Vol. 18 (21): 193-196 [Abstract] ( 163 ) HTML (1 KB) PDF (490 KB) ( 87 )

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