虎力散内服外用治疗寒湿阻络型膝骨关节炎的临床效果

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Abstract Objective To investigate the effect of internal and external administration of Huli Powder in the treatment of knee osteoarthritis with coldness and dampness blocking collaterals. Methods A total of 120 patients with knee osteoarthritis in the Third Department of Orthopedics, the First Affiliated Hospital of Hebei University of Chinese Medicine from September 2018 to January 2020 were selected and they were divided into treatment group (internal and external administration of Huli Powder) and control group (internal and external administration of Diclofenac Sodium) by random number table method, with 60 cases in each group. Both groups were treated for four weeks. Visual analog scale (VAS) score, Western Ontario and McMaster University (WOMAC) osteoarthritis index score, interleukin-1 (IL-1) and tumor necrosis factor-α (TNF-α) levels were recorded in both groups before and after treatment, respectively. Patients’ knee pain and improvement of knee symptoms were evaluated. Results After treatment, VAS and WOMAC osteoarthritis index scores of the two groups were lower than before treatment, and the treatment group was lower than the control group, the differences were statistically significant (P ＜ 0.05). After treatment, the levels of IL-1 and TNF-α in the two groups were lower than before treatment, and the differences were statistically significant (P ＜ 0.05). After treatment, there were no significant differences in IL-1 and TNF-α between the two groups (P ＞ 0.05). After treatment, the total effective rate of the treatment group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The clinical effect of internal and external administration of Huli Powder in the treatment of knee osteoarthritis with coldness and dampness blocking collaterals is definite, and can reduce the levels of serum IL-1 and TNF-α, which is better than that of internal and external administration of Diclofenac Sodium in alleviating symptoms.

Key words： Knee osteoarthritis Huli Powder Diclofenac Sodium Pain score Inflammatory factors

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	ZHANG Jiawen1 YUAN Yundong1 WANG Yanjun2 QI Liqing1

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ZHANG Jiawen1 YUAN Yundong1 WANG Yanjun2 QI Liqing1. Clinical effect of internal and external administration of Huli Powder in the treatment of knee osteoarthritis with coldness and dampness blocking collaterals[J]. 中国医药导报, 2021, 18(21): 75-78,91.

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https://www.yiyaodaobao.com.cn/EN/ OR https://www.yiyaodaobao.com.cn/EN/Y2021/V18/I21/75

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