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| Research progress on immune regulation mechanism of external therapy of traditional Chinese medicine on inflammatory bowel disease |
| JIAO Yi1 ZHANG Yingqi1 LU Mengqian1 YU Tianyuan1 LIU Zhifeng1 LIU Di2 |
1.School of Acupuncture and Moxibustion and Massage, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Acupuncture and Moxibustion, Oriental Hospital of Beijing University of Chinese Medicine, Beijing 100078, China |
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Abstract Inflammatory bowel disease (IBD) is an autoimmune disease with lesions located in the mucosa of colon and rectum. At present, IBD is believed to be mostly related to diet, mood, infection and immunity, among which immunity is the most studied. Four traditional Chinese medicine external treatment methods are mostly selected clinically, including acupuncture, moxa-wool moxibustion, massage and traditional Chinese medicine enema therapy. In this paper, from the point of inflammation and immunity of IBD, the immune regulation mechanism of external treatment of Chinese medicine on IBD is discussed. The external treatment of traditional Chinese medicine can regulate the inflammatory immune response of the body through multiple targets and channels, so as to achieve the state that the vital qi is stored inside and the pathogen cannot be dried. The four kinds of external therapy intervention methods involved in this paper are different, and the mechanisms involved are also different. Acupuncture provides mechanical stimulation, moxa-wool moxibustion provides warm stimulation, and massage provides both mechanical stimulation and warm stimulation, and traditional Chinese medicine enema therapy provides drug stimulation. Acupuncture and moxa-wool moxibustion are both involved in balancing immune microenvironment and anti-inflammatory mechanism. Acupuncture is also involved in anti-oxidative stress response, anti-endoplasmic reticulum stress response and the alleviation of visceral sensitivity. Massage mainly provides sufficient morphological basis, and traditional Chinese medicine enema therapy regulates immune disorders through direct contact with the lesion site.
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