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2020 Vol. 17, No. 30 Published: 2020-10-25

	4	Mechanism research of Qianyang Decoction inhibits the proliferation of cardiac fibroblasts
		CHEN Jie RUAN Xiaofen WANG Xiaolong
		Objective To discussed the mechanism of Qianyang Decoction inhibits the abnormal proliferation of cardiac fibroblasts (RCF) cells induced by angiotensin Ⅱ (Ang Ⅱ). Methods The RCF cells were divided into blank cell group, Ang Ⅱ group and Ang Ⅱ+Qianyang Decoction group. In the Ang Ⅱ group, a cell model with abnormal proliferation of cardiac fibroblasts induced by Ang Ⅱ for 24 h was selected, and the Ang Ⅱ+Qianyang Decoction group was a cell model that was induced by Ang Ⅱ and intervened with Qianyang Decoction. Western blot was used to analyze and compare the transforming growth factor-β1 (TGF-β1), Collagen Ⅰ type (Collagen Ⅰ), Collagen Ⅲ protein expression among three groups, and quantitative polymerase chain reaction was used to detect and compare the TGF-β1 and Collagen Ⅰ, Collagen Ⅲ genetic expression among three groups. Results The protein expression levels of TGF-β1, Collagen Ⅰ and Collagen Ⅲ in Ang Ⅱ group were higher than those in the blank cell group (all P ＜ 0.01). The protein expression levels of TGF-β1 and Collagen Ⅰ, Collagen Ⅲ in Ang Ⅱ+Qianyang Decoction group were lower than those in the Ang Ⅱ group (P ＜ 0.05 or P ＜ 0.01). The gene expressions levels of TGF-β1, Collagen Ⅰ and Collagen Ⅲ in Ang Ⅱ group were higher than those in the blank cell group (all P ＜ 0.01). The gene expression levels of TGF-β1, Collagen Ⅰ and Collagen Ⅲ in Ang Ⅱ+Qianyang Decoction group were lower than those in Ang Ⅱ group (P ＜ 0.05 or P ＜ 0.01). Conclusion Qianyang Decoction can inhibits the abnormal proliferation of RCF cells by reducing the gene and protein expression level of TGF-β1, Collagen Ⅰ and Collagen Ⅲ, hence alleviate heart muscle fibrosis.
		2020 Vol. 17 (30): 4-7,11 [Abstract] ( 83 ) HTML (1 KB) PDF (705 KB) ( 73 )

	8	Effects of Shencao Tongmai Granules on the mechanism of anti-ventricular remodeling in rats with chronic heart failure
		LIU Xiaolei1 ZHANG Yan2 LI Hai1 WANG Yi1 ZHOU Xue1 CHEN Fei1
		Objective To analyze the mechanism of Shencao Tongmai Granules on anti-ventricular remodeling in rats with chronic heart failure (CHF). Methods A total of 60 SPF rats were selected and ten rats were randomly taken as normal group. The other 50 rats were used to prepare the CHF rat model. In the process of modeling, nine rats failed to survive and the remaining 41 rats were divided into the model group (13 rats), the Shencao Tongmai Granules group (14 rats) and the Lisinopril group (14 rats) randomly. Rats in normal group and the model group were fed normally without drugs and rats in Lisinopril group and Shencao Tongmai Granules group were given drugs consecutively for 42 d. Reverse transcription PCR (RT-PCR) and Western blot (WB) were adopted to determine the mRNA and protein expression of matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1). Results Compared with the model group, the mRNA and protein expressions of MMP-1 in the Shencao Tongmai Granules group and Lisinopril group were reduced, and the differences were highly statistically significant (all P ＜ 0.01). Compared with the Lisinopril group, the MMP-1 mRNA expression of the Shencao Tongmai Granules group was decreased (P ＜ 0.05), while MMP-1 protein expression was increased (P ＜ 0.05). Compared with the model group, the mRNA and protein expressions of TIMP-1 in the Shencao Tongmai Granules group and Lisinopril group both increased, and the differences were highly statistically significant (all P ＜ 0.01). Compared with the Lisinopril group, the mRNA and protein expressions of TIMP-1 in the Shencao Tongmai Granules group were increased (P ＜ 0.05). Conclusion Shencao Tongmai Granules have a significant therapeutic effect on treating rats with CHF and can promote the mechanism of anti-ventricular remodeling.
		2020 Vol. 17 (30): 8-11 [Abstract] ( 180 ) HTML (1 KB) PDF (607 KB) ( 36 )

	12	Difference exploration of mind-keeping effects based on auditory event-related potential MMN
		GUO Jiamei1* WANG Ying1* HU Qingchuan1,2 LYU Jiaxuan1 GUO Yu1 WEI Zeren1 ZHANG Jialei2 WEI Yulong1
		Objective To explore the effect difference of mind-keeping on event-related potential mismatch negative wave (MMN). Methods In March 2019, 72 college students from Dongfang College of Beijing University of Chinese Medicine were recruited and divided into experience group (group A, n = 36) and non-experience group (group B, n = 36) according to whether they had experience or not. EEG was monitored by using event-related potential technology. The latency and peak value of MMN among different states were compared between two groups. Results In group A, the MMN latencies of MK in frontotemporal junction, anterior temporal region, frontal central junction, central region and parietal region were shorter than those of N1 (P < 0.05). In group A, the MMN latencies of N2 in frontal polar region, middle temporal region, frontal central junction area and central region were shorter than those of N1 (P < 0.05). In group B, the MMN latency of MK was shorter than that of N1 in frontotemporal junction (P < 0.05). There was no significant difference in MMN latency among different states between two groups (P > 0.05). In group A, the MMN peak value of MK in frontal region, anterior temporal area, frontal central junction area and central region was decreased compared with N1 (P < 0.05). In group A, the MMN peak of N2 in anterior temporal region was lower than that of N1 (P < 0.05). There was no significant difference in the peak value of MMN among different states in group B (P > 0.05). There was no significant difference in the peak value of MMN among different states between two groups (P > 0.05). Conclusion Mind-keeping can shorten the time for processing external information and improve the efficiency of the brain′s automatic processing.
		2020 Vol. 17 (30): 12-15 [Abstract] ( 150 ) HTML (1 KB) PDF (647 KB) ( 66 )

	16	Correlation analysis of heart function and serum TNF-α, IL-1β levels in children with sepsis
		LUO Lan ZENG Fanglin LONG Caixia CHEN Yanying ZHOU Haiyin
		Objective To explore the correlation between heart function and serum tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) levels in children with sepsis. Methods From October 2016 to October 2019, a total of 126 children with sepsis admitted to the Second Department of Emergency of Hu′nan Children′s Hospital (hereinafter referred to as “our hospital”) were divided into non-myocardial injury group (group A, 49 cases) and myocardial injury group (group B, 77 cases). According to the left ventricular ejection fraction (LVEF), the group B was divided into mild (group B1, 23 cases), medium (group B2, 34 cases), and severe (group B3, 20 cases) myocardial injury group. In the same period, a total of 50 children in our hospital were selected as the control group. The differences in the cardiac function indexes and serum TNF-α and IL-1β levels of each group were compared. Results Acute physiology and chronic health scoring system Ⅱ (APACHE Ⅱ) score, serum cardiac troponin I (cTnI), creatine kinase isoenzyme (CK-MB), N-terminal B-type natriuretic peptide pre Body (NT-proBNP), TNF-α, IL-1β were higher than those in the control group, while LVEF, early mitral valve filling peak velocity E peak / atrial systolic maximum flow velocity A peak (E/A) were lower than those in the control group, and the differences were statistically significant (P < 0.05); moreover, the differences between the above-mentioned index groups between group A and group B were statistically significant (P < 0.05). Comparison of APACHE Ⅱ, LVEF, E/A and cTnI, CK-MB, NT-proBNP, TNF-α, IL-1β in children with different levels of myocardial injury, and the differences were highly statistically significant (P < 0.01); APACHEⅡ, cTnI, CK-MB, NT-proBNP, TNF-α and IL-1β in group B2 and group B3 were all higher than those in group B1, and the differences were statistically significant (P < 0.05); in addition, the differences between the index in B2 group and B3 group were statistically significant (P < 0.05). Serum TNF-α and IL-1β in children with septic myocardial injury were negatively correlated with LVEF and E/A (P < 0.01), while there were positively correlated with serum cTnI, CK-MB, and NT-proBNP (P < 0.01). When the best cut-off values of TNF-α and IL-1β were 80.26 pg/mL and 8.83 pg/mL, respectively, the sensitivity and specificity were 87.6% and 93.5%, 90.5% and 93.5%, respectively; when the four were combined, the sensitivity and specificity were 97.6% and 94.1%. Conclusion Serum TNF-α and IL-1β levels can reflect myocardial damage in children with sepsis, and can be used as reliable markers for the early diagnosis of myocardial damage in children with sepsis. Combined detection with cardiac function indicators can improve accuracy.
		2020 Vol. 17 (30): 16-19,23 [Abstract] ( 79 ) HTML (1 KB) PDF (673 KB) ( 35 )

	20	Study on guinea pig model of acute infection with Mycobacterium tuberculosis H37Rv strain
		KANG Jian1 XU Chengming1 ZHANG Wei2 BAI Yinlan1 HAN Wendong3 SUN Zhiping3 XU Zhikai1 WANG Limei1▲
		Objective To establish a guinea pig model of acute infection with Mycobacterium tuberculosis (Mtb) H37Rv strain. Methods Eighteen guinea pigs were divided into six groups: blank-dose group, subcutaneous high-dose group, subcutaneous low-dose group, intranasal high-dose group, intranasal middle-dose group and intranasal low-dose group according to random number table method. There were three guinea pigs in each group. Subcutaneous high-dose group and subcutaneous low-dose group was infected with Mtb H37Rv PBS suspension of 2×106 CFU/200 μL and 1×106 CFU/200 μL respectively. Intranasal high-dose group, intranasal middle-dose group and intranasal low-dose group was infected with Mtb H37Rv PBS suspension of 5×105, 5×104 CFU/50 μL and 5×103 CFU/50 μL respectively. After four weeks of infection, the number of bacteria and histopathological changes of lung and spleen in each group were detected. Results After four weeks of infection, the number of Mtb in lung and spleen of subcutaneous high-dose group was higher than that of subcutaneous low-dose group (P < 0.05). After four weeks of infection, the number of Mtb in lung of subcutaneous high-dose group was higher than that of intranasal high-dose group (P < 0.05). After four weeks of infection, the lung tissues of guinea pigs in subcutaneous high-dose group, subcutaneous low-dose group and intranasal high-dose group were obviously congested and the alveolar wall were thickened; the lung tissue of guinea pigs in intranasal middle-dose group and intranasal low-dose group had only slight hyperemia. After four weeks of infection, the pathological changes of spleen tissue in each group were not obvious. Conclusion The guinea pig model of acute infection with Mtb H37Rv is established successfully, which provides the research foundation for novel tuberculosis vaccines and new drugs.
		2020 Vol. 17 (30): 20-23 [Abstract] ( 135 ) HTML (1 KB) PDF (1072 KB) ( 95 )

	24	The role and relationship between the expression level of TRAIL of fetal membranes and the level of blood-related inflammatory markers in the occurrence of premature rupture of membranes
		WU Zhaoqing1 YANG Yujiao2 LI Xiaoqiong2 ZHOU Wenli2 ZHANG Shuxuan3
		Objective To explore the role and relationship between the expression level of tumor necrosis factor-related apoptotic ligand (TRAIL) of membranes and serum inflammatory markers level in the pathogenesis of premature rupture of membranes. Methods From January to December 2019, 80 cases of premature rupture of membranes pregnant women admitted to Huai′an Maternal and Child Health Care Hospital of Jiangsu Province were selected as the research objects. They were divided into full-term premature rupture of membranes group (gestational age≥ 37 weeks, 46 cases) and preterm premature rupture of membranes group (gestational age 28-36+6 weeks, 34 cases). 80 pregnant women of full-term fetal membranes were selected as control group in the same period. TRAIL in membranes tissue and blood related inflammatory markers (neutrophil lymphocyte ratio [NLR], platelet lymphocyte ratio [PLR] and lymphocyte monocyte ratio [LMR]) were measured and the correlation between TRAIL and inflammatory markers in membranes tissue was analyzed. Results The TRAIL positive rate, TRAIL mRNA expression level and serum NLR, PLR, LMR levels in preterm premature rupture of membranes group were higher than those of full-term premature rupture of membranes group and control group(all P ＜ 0.05), and the TRAIL positive rate, TRAIL mRNA expression level and serum NLR, PLR, LMR levels in full-term premature rupture of membranes group were higher than those of control group (all P ＜ 0.05). TRAIL expression level in fetal membranes was positively correlated with serum NLR, PLR and LMR levels (r = 0.543, 0.574, 0.651, all P < 0.05). Conclusion TRAIL and serum-related inflammatory markers are highly expressed in the membranes of women with premature rupture of foetal membranes, and there is a positive correlation between them.
		2020 Vol. 17 (30): 24-27 [Abstract] ( 144 ) HTML (1 KB) PDF (658 KB) ( 51 )

	28	Research progress of nonpharmacologic treatment for children with attention deficit hyperactivity disorder
		ZHU Yike1 WANG Xin1 WANG Lin2 YANG Jian1
		Attention deficit hyperactivity disorder (ADHD) is one of the most common chronic neurodevelopment disorder in children. From 4.2% to 6.5% of children and adolescents in China suffer from cognitive dysfunction due to ADHD, which may affects their quality of life seriously. At present, medication is the main treatment for ADHD. Non-pharmacological treatment, as a supplement to medical treatment and an alternative treatment when there are drug contraindications, is simple, feasible and has a good long-term effect, which is receiving more and more attention. Non-pharmacological treatment for ADHD including that psychosocial treatment, neurofeedback, cognitive training, noninvasive brain stimulation technique, sensory integration, traditional Chinese medicine, dietary intervention, etc.
		2020 Vol. 17 (30): 28-32,40 [Abstract] ( 77 ) HTML (1 KB) PDF (671 KB) ( 608 )

	33	Research progress of HER2-positive gastric cancer
		SUN Keran LYU Huifang WANG Saiqi CHEN Xiaobing
		At present, gastric cancer is still the fifth largest malignant tumor in the world and the second largest cause of cancer-related death in the world. Previous studies have found that epidermal growth factor receptor 2 (HER2) positive gastric cancer is a special type of gastric cancer with worse prognosis. This kind of gastric cancer has a high expression of HER2 in the early stage of intraepithelial neoplasia, and the overexpression of HER2 increases significantly with the increase of the degree of dedifferentiation of precancerous lesions. With the emergence of targeted drugs such as Herceptin, the treatment of HER2 positive gastric cancer has taken a turn for the better. But Herceptin alone is not enough. The examination and treatment of HER2 positive gastric cancer are still in the primary level. In recent years, liquid biopsy techniques and a variety of therapeutic drugs are unveiling the mystery of HER2 positive gastric cancer step by step. Among them, the liquid biopsy technique is not only much more efficient than the traditional immunohistochemical technique, but also can monitor the curative effect of Trastuzumab dynamically in real time. This paper reviews the recent research progress of HER2 positive gastric cancer, including the treatment of HER2 positive gastric cancer, drug resistance and the relationship with immune status, so as to provide some reference for clinical practice.
		2020 Vol. 17 (30): 33-36,58 [Abstract] ( 114 ) HTML (1 KB) PDF (698 KB) ( 148 )

	37	Research progress of traditional Chinese medicine intervention on signaling pathway transduction associated with chronic obstructive pulmonary disease
		FENG Jihong1 ZHANG Shanshan2 BI Mingda2
		The signaling pathway is a series of enzymatic reaction pathway, which can transmit extracellular hormone, growth factor, neurotransmitter and other molecular signals through the cell membrane to the intracellular effect. As a disease with high morbidity and disability rate, chronic obstructive pulmonary disease has complex causes, and various signaling pathways play an important role in its development. Traditional Chinese medicine can improve the condition of chronic obstructive pulmonary disease patients by intervening in a variety of signaling pathways. In this paper, the related literature in recent years is systematically sorted out, and seven signaling pathways including JAK/STAT, PPARs, MAPK, TGF-β1/Smads, PI3K/AKT, TLR4/NF-κB and Keap1-Nrf2-ARE are sorted out. It is hoped to provide some reference for the research of traditional Chinese medicine in the treatment of chronic obstructive pulmonary disease.
		2020 Vol. 17 (30): 37-40 [Abstract] ( 90 ) HTML (1 KB) PDF (637 KB) ( 203 )

	41	Progress on the relationship between gastroesophageal reflux disease and chronic cholecystitis
		XIAO Yun LI Yufang QIAO Dawei BU Ping
		Gastroesophageal reflux disease and chronic cholecystitis are high incidence diseases in China. Patients with gastroesophageal reflux disease combined with chronic cholecystitis are very common clinically, which is the difficulty in diagnosis and treatment. At present, there are few studies on the correlation between gastroesophageal reflux disease and chronic cholecystitis at home and abroad. According to the literature review, the combined prevalence of gastroesophageal reflux disease and chronic cholecystitis is high, and there are common risk factors. Surgery, abnormal vagus nerve, abnormal interstitial cells of Cajal, and bile reflux are involved in the occurrence and development of gastroesophageal reflux disease and chronic cholecystitis. The clinical symptoms of gastroesophageal reflux disease and chronic cholecystitis are similar, and both diseases have the same therapeutic drugs. Gastroesophageal reflux disease is closely related to chronic cholecystitis. This article reviews the correlation between gastroesophageal reflux disease and chronic cholecystitis, in order to provide a basis for further research on gastroesophageal reflux disease combined with chronic cholecystitis, and provide a reference for clinical diagnosis and treatment.
		2020 Vol. 17 (30): 41-44 [Abstract] ( 158 ) HTML (1 KB) PDF (634 KB) ( 92 )

	45	Mechanism of Retinoic acid combined with arsenic in the treatment of acute promyelocytic leukemia
		LIU Feng DONG Min XIAO Dinghua
		Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia. The first-line treatment for APL patients is retinoic acid (RA) combined with arsenic at present. There has been some new research achievement about the mechanism of RA and arsenic in the treatment of APL appeared in molecular biology and cytogenetics in the past five years. This article mainly describes the changes of additional genes, non-genetic molecular mechanisms, mechanisms of combined drug, adjuvants and carriers, so as to provide a reference for future basic research.
		2020 Vol. 17 (30): 45-48 [Abstract] ( 110 ) HTML (1 KB) PDF (635 KB) ( 37 )

	49	Progress of gastrointestinal motility effects on prevention and treatment in obesity with insulin resistance
		WANG Wenyan1,2 LIANG Fengxia2
		Abnormal gastrointestinal motility is an important pathological factor of obesity with insulin resistance. Abnormal gastrointestinal motility not only make the body excessive intake of energy, but also can produce the intestinal inflammation, affect information exchanges of brain-gut axis, then reduce insulin sensitivity, and reduce energy consumption relatively, which eventually lead to imbalances in the body′s energy metabolism. Therefore, it may be a new approach to prevent and treat insulin-resistant obesity to set about gastrointestinal motility and develop treatment for various factors affecting gastrointestinal motility, such as inflammation, intestinal flora and enteric nervous system.
		2020 Vol. 17 (30): 49-52 [Abstract] ( 161 ) HTML (1 KB) PDF (663 KB) ( 177 )

	53	Research advances of Anlotinib in the treatment of advanced none-small cell lung cancer
		XIA Bo CHENG Zhixiang
		Angiogenesis is an important segment in the process of multiplication, invasion, and metastasis of malignant tumor cells. Anti-angiogenic drug plays an important role in the treatment of cancer. Anlotinib is a new small molecule multi-target anti-angiogenesis drug tyrosine kinase inhibitor developed independently in China. It can effectively inhibit such as vascular endothelial growth factor receptor, platelet-derived growth factor receptor, fibroblast growth factor receptor, c-kitproto-oncogeneprotein and so on to completely block tumor angiogenesis and inhibit tumor growth with low toxic and side effects. Several clinical trials confirm that Anlotinib has promising efficacy and safety in advanced non-small cell lung cancer. This paper summarizes the current knowledge of Anlotinib in anti-tumor mechanism, clinical efficacy and safety studies, efficacy predictive factors, and drug resistance mechanism in recent years.
		2020 Vol. 17 (30): 53-55，63 [Abstract] ( 113 ) HTML (1 KB) PDF (1001 KB) ( 88 )

	56	Research progress of functional magnetic resonance imaging in acupuncture treatment of insomnia disorder
		HU Junxia YUAN Fang ZHANG Fan WANG Guiling GUO Jing
		Acupuncture is one of the effective ways to treat insomnia, and its effective mechanism remains to be explored in depth. This article reviews the brain functional magnetic resonance imaging studies of acupuncture in the treatment of insomnia in recent years. It is pointed out that acupuncture can regulate the emotions of patients with insomnia, cognitive-related brain areas and functional activities of the brain function network, and further reveal that acupuncture can stabilize mood and improve sleep. The central mechanism is expected to provide an objective basis for broadening the clinical treatment of insomnia.
		2020 Vol. 17 (30): 56-58 [Abstract] ( 163 ) HTML (1 KB) PDF (613 KB) ( 80 )

	59	Comparative analysis of the disease spectrum of elderly emergency patients in a hospital from 2018 to 2020 compared with the same period ten years ago
		LIU Jun1 SUN Ying1 YANG Xue1 MI Weidong2
		Objective To analyze the change trend of the disease spectrum of emergency elderly patients in the Second Medical Center of the People′s Liberation Army General Hospital (“our hospital” for short) from 2018 to 2020 and the disease spectrum ten years ago, and to provide references for improving first-aid work and to improve first-aid level. Methods A total of 5256 patients over 60 years old admitted to Department of Emergency in our hospital from January 2018 to March 2020 were selected as the observation group. Patients aged 60 to less than 80 years old were ordinary elderly patients, and older patients aged ≥80 years old. According to the diagnosis results of the disease, elderly patients admitted to the Department of Emergency in our hospital at present (observation group) and ten years ago (control group, 4062 cases) were classified and described, and the trend of disease spectrum of emergency elderly patients were compared retrospectively. Results The composition of circulatory diseases in the observation group was higher than that in the control group, while the composition of diseases in the respiratory and digestive systems was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). The composition of urinary tract infection and atrial fibrillation were higher than those of the control group, while the composition of upper respiratory tract infection and acute gastroenteritis were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). Except for the included diseases, the other diseases of observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The urinary and other system diseases in the observation group were higher than those in the control group, while the respiratory and digestive system diseases were lower than in the control group, and the differences were statistically significant (P ＜ 0.05). The composition of circulatory diseases in the observation group was higher than that in the control group, while the composition of digestive and other system diseases were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). The composition of coronary heart disease in the observation group ranked first and was higher than that of the control group. The composition of transient ischemic attack, upper respiratory tract infection, and acute gastroenteritis were lower than those of the control group, and the differences were statistically significant (P ＜ 0.05). The composition of urinary tract infection and atrial fibrillation in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Compared with ten years ago, chronic diseases of elderly patients in emergency department are on the rise, and circulatory system diseases have become the most common diseases. According to the characteristics of the disease spectrum, emergency department workers optimize the treatment process, strengthen the training of circulatory, respiratory, urinary, trauma and other specialized emergency diseases, and provide health education and targeted preventive measures for elderly patients.
		2020 Vol. 17 (30): 59-63 [Abstract] ( 169 ) HTML (1 KB) PDF (569 KB) ( 252 )

	64	Analysis on the prevalence of “three high” diseases in HBIS Group Tangsteel Company workers from 2015 to 2017
		LI Yunfeng1 LI Xinghua2 HAO Jianchun3 MA Qingkun4 KONG Bin5 ZHANG Lianhua6▲
		Objective To analyze the detection of hypertension, diabetes, and hyperlipemia in steel workers of HBIS Group Tangsteel Company from 2015 to 2017, and to discuss the current health status of steel workers and countermeasures. Methods The health examination data of steel workers in Department of Long Products, HBIS Group Tangsteel Company from January 2015 to December 2017 were analyzed, while the groups were divided according to year and gender, and the prevalence of hypertension, diabetes, hyperlipidemia were compared and performed statistics analysis. Results From 2015 to 2017, the differences in the detection rate of hypertension among steel workers were highly statistically significant (P ＜ 0.01); among them, the differences in the detection rate of hypertension among men in each year were highly statistically significant (P ＜ 0.01); there were no statistically significant differences in the annual detection rate of hypertension among women (P ＞ 0.05). The detection rate of hypertension in men were higher than those in women in 2015 and 2016 (P ＜ 0.01), but there was no statistically significant difference between different genders in 2017 (P ＞ 0.05). The differences in the detection rate of diabetes in steel workers from 2015 to 2017 were highly statistically significant (P ＜ 0.01). Among them, the differences in the detection rate of diabetes in men in each year were highly statistically significant (P ＜ 0.01); compared with the detection rate in women with diabetes in each year, the differences were not statistically significant (P ＞ 0.05). The detection rate of diabetes in men were higher than those in women from 2015 to 2017 (P ＜ 0.01). There were no statistically significant difference in the detection rate of hyperlipidemia among steel workers from 2015 to 2017 (P ＞ 0.05). Among them, the differences in the detection rate of male hyperlipidemia in each year were statistically significant (P ＜ 0.05); the differences in the detection rate of female hyperlipidemia in each year were not statistically significant (P ＞ 0.05). The detection rate of hyperlipidemia in men from 2015 to 2017 were higher than those in women, and the differences were highly statistically significant (P ＜ 0.01). Conclusion The company is dominated by male steel workers, and their health status are relatively poor compared with that of female. Special attention should be paid to the “three high” disease prevalence of male steel workers. At the same time, the 2015 to 2017 diabetes detection rate is increasing year by year, and special attention should be paid to the formulation of intervention measures for the prevention of diabetes, which has a positive significance in reducing the prevalence of the “three high” diseases of steel workers.
		2020 Vol. 17 (30): 64-67 [Abstract] ( 120 ) HTML (1 KB) PDF (558 KB) ( 82 )

	68	Construction of the clinical practice model for master of nursing specialist based on the cultivation of core competence
		SUN Xihui1 YANG Li1 ZHAO Ping1 HUANG Debin2
		Objective To construct a clinical practice model for master of nursing specialist (MNS) based on core competence training. Methods Based on literature research and expert interviews, a letter questionnaire was formed. From May to September 2019, a total of 28 nursing experts in 15 prefecture-level cities across the country were asked to conduct two rounds of letter inquiries through the Delphi method. Results At the end of the two rounds of letter inquiries, the expert opinions tended to be the same. The expert authority coefficients were 0.839 and 0.847, while the Kendall harmony coefficients were 0.251 and 0.328 (P ＜ 0.01). Preliminarily established the clinical practice model and its extended 14 first-level indicators and 73 second-level indicators covering core capabilities and training points, clinical practice arrangements, and assessment systems. Conclusion MNS clinical practice training program should focus on the core competence shaping to meet the needs of professional, applied, and high-level talent training goals. The results of expert letter inquiries show that this practice model can provide a reference for colleges and universities to improve the training of MNS clinical practice.
		2020 Vol. 17 (30): 68-71 [Abstract] ( 103 ) HTML (1 KB) PDF (554 KB) ( 110 )

	72	Qualitative study on the influencing factors of compliance with self-intermittent cleansing catheterization in patients with neurogenic bladder
		ZHOU Liqiong1,2,3 WANG Ruixiang3 FAN Chunhua4 JIANG Yuting3 CHEN Ling1 CAI Wenzhi1
		Objective To deeply understand the influencing factors affecting the compliance of patients with neurogenic bladder during self-intermittent cleansing and catheterization. Methods The behavioral event interview method was adopted to select 13 patients with neurogenic bladder discharged from Shenzhen Longcheng Hospital from June to September 2019 for in-depth interviews, and the Colaizzi seven-step analysis method was used to analyze and organize the data. Results A total of five themes were refined: lack of cognition related to intermittent catheterization; multiple negative emotional experiences; physical disorders; special physiological anatomy; economic status. Conclusion The compliance of patients with neurogenic bladder for self-intermittent cleansing and catheterization is affected by many factors. Managers should formulate targeted intervention measures to improve their compliance and improve the quality of life.
		2020 Vol. 17 (30): 72-75 [Abstract] ( 170 ) HTML (1 KB) PDF (582 KB) ( 229 )

	76	Clinical efficacy of moxibustion combined Valsartan in the treatment of early diabetic nephropathy
		HUANG Hai1,2 GUO Yi2,3 CHEN Li4 JIN Jingsong2,5
		Objective To observe the clinical efficacy of moxibustion combined Valsartan in the treatment of early diabetic nephropathy (DN). Methods From August 2018 to October 2019, 48 patients with early DN who diagnosed and treated in Department of Nephrology, Hubei Provincial Hospital of Traditional Chinese Medicine were selected as the study subjects. They were divided into the control group and the observation group according to the random table number method，with 24 cases in each group. The control group was given Valsartan on the basis of basic treatment, and the observation group was treated with moxibustion on the basis of the control group. Four weeks for treatment. The urine volume during 24 hours (24 h-UV), urine protein during 24 hours (24 h-UP), microalbuminuria (MAU), urinary transferrin (TRF), urinary α1 microglobulin (α1-MG), urinary retinol-binding protein (RBP), blood urea nitrogen (BUN), serum creatinine (Scr) levels were compared before and after treatment between two groups. Results After treatment, 24 h-UV, 24 h-UP, MAU, TRF, α1-MG, RBP, BUN and Scr levels in two groups were lower than those before treatment (all P < 0.05). 24 h-UV, 24 h-UP, MAU, α1-MG and RBP levels in the observation group were lower than those in the control group（all P < 0.05）; but there were no statistically significant differences in BUN, Scr and TRF levels (P > 0.05). Conclusion Moxibustion combined Valsartan can effectively reduce the excretion of urinary microprotein during early DN and alleviate renal kidney damage，so it is worthy of clinical application and research.
		2020 Vol. 17 (30): 76-78 [Abstract] ( 69 ) HTML (1 KB) PDF (489 KB) ( 45 )

	80	Correlation study between serum FT4 and TT4 levels and intervention effect of microwave ablation on benign thyroid nodules
		MU Zhengqing1 ZHOU Fan1 REN Yi2 LU Jun1▲
		Objective To study the correlation between the levels of serum free thyroxine (FT4) and total thyroxine (TT4) and the intervention effect of microwave ablation on benign thyroid nodules. Methods Retrospective analysis was performed on 80 patients with benign thyroid nodules who underwent microwave ablation intervention in the Affiliated Huai′an No.1 People′s Hospital of Nanjing Medical University from October 2015 to October 2018. All patients were followed up for one year after treatment, and they were divided into observation group (nodule reduction rate ≥50%, 63 cases) and control group (nodule reduction rate < 50%, 17 cases) according to the nodule reduction rate. The influencing factors of microwave ablation for benign thyroid nodules were analyzed. Results Thyroid stimulating hormone (TSH), FT4 and TT4 were independent influencing factors for the intervention effect of microwave ablation on benign thyroid nodules (P < 0.05). Conclusion Serum TSH, FT4 and TT4 are independent factors of the therapeutic effect of microwave ablation for benign thyroid nodules.
		2020 Vol. 17 (30): 80-82,87 [Abstract] ( 118 ) HTML (1 KB) PDF (505 KB) ( 114 )

	83	Clinical effect of Puhua Decoction in treatment of diabetic foot
		XIAO Yang1 KE Ting1 LI Ting2 QI Haiyan1 WANG Gaolei1 HANG Cheng1 HUANG Qian1 XU Jianqin1▲
		Objective To investigate the clinical effect of external application of Puhua Decoction in treatment of diabetic foot. Methods From September 2017 to December 2018, 60 patients in the Second Department of Endocrinology, Mie′s Internal Medicine, Shaanxi Traditional Chinese Medicine Hospital were selected as study subjects. They were divided into the treatment group and the control group according to the random number table method, with 30 cases in each group. The control group was treated with conventional Western medicine, and surgical debridement and dressing change. While, in the treatment group, Puhua Decoction was applied externally for debridement and dressing change on the basis of traditional Western medicine dressing. The course of treatment was eight weeks. The condition of foot wound, traditional Chinese medicine symptom score, clinical effect, ankle-brachial index (ABI) and toe-to-brachial index (TBI) of both lower limbs, white blood cell count, neutrophil ratio, hypersensitive C-reactive protein, fasting blood glucose, 2 h postprandial blood glucose, glycosylated hemoglobin and serum advanced glycation end products(AGEs) level were compared between two groups. Results After treatment, the scores of foot wound in both groups were lower than those before treatment (all P < 0.01). However, there was no statistically significant difference in the scores of foot wound between the two groups (P > 0.05). After treatment, the traditional Chinese medicine symptom scores in both groups were lower than those before treatment, and the treatment group were lower than the control group (all P < 0.05). There was no statistically significant difference in clinical efficacy between the two groups (P > 0.05). After treatment, there was no statistically significant difference in ABI, TBI between the two groups (P > 0.05). After treatment, the white blood cells, neutrophils ratio, hypersensitive C-reactive protein, fasting blood glucose, 2 h postprandial blood glucose and glycosylated hemoglobin in the two groups were all lower than those before treatment (all P < 0.01), and the white blood cells and fasting blood glucose in the treatment group were lower than those in the control group (all P < 0.05). After treatment, serum AGEs levels of both groups were lower than those before treatment (all P < 0.01), but there was no statistically significant difference in serum AGEs levels between the two groups (P > 0.05). Conclusion External application of Puhua Decoction can improve diabetic foot wound and the clinical traditional Chinese medicine symptom of “heat and blood stasis” to a certain extent, significantly reduce white blood cells and fasting blood glucose levels, and can also reduce serum AGEs levels to a certain extent, protect vascular endothelium, and reduce sugar foot amputation and the risk of infection. So as to provide guidance value for clinical treatment of diabetic foot topical medication. However, due to the limited number of patients actually included in this article, the sample size is too small, and the sample size still needs to be further expanded to continue relevant clinical trial observations.
		2020 Vol. 17 (30): 83-87 [Abstract] ( 95 ) HTML (1 KB) PDF (541 KB) ( 94 )

	88	Correlation analysis between serum type Ⅰ collagen amino terminal prolongation peptide and β-type Ⅰ collagen carboxy terminal peptide and type 2 diabetes mellitus with osteoporotic fracture
		XU Xu CAO Li ZHAO Xiong WANG Qian
		Objective To analyze the correlation between serum type Ⅰ collagen amino terminal prolongation peptide (P1NP) and β-type Ⅰ collagen carboxy terminal peptide (β-CTX) and type 2 diabetes mellitus (T2DM) with osteoporosis fracture. Methods A total of 120 T2DM patients with osteoporosis fracture at the First Affiliated Hospital of Air Force Medical University of the People′s Liberation Army from June 2016 to January 2019 were selected and divided into T2DM osteoporosis with fracture group (54 cases) and T2DM osteoporosis without fracture group (66 cases). Plasma P1NP, β-CTX were measured by chemiluminescence method, and bone density, fasting blood glucose (FBG), body mass index (BMI), glycated hemoglobin (GHb), serum 25 hydroxyvitamin D [25 (OH)D] were measured, and the Pearson product correlation coefficient r was used to express the linear relationship. Results The levels of P1NP and β-CTX in T2DM osteoporosis with fracture group were lower than those in T2DM osteoporosis without fracture group (all P ＜ 0.05). P1NP and β-CTX were not significantly correlated with age, FBG, GHb, body mass index, BMI and 25 (OH)D in the two groups (P ＞ 0.05), but P1NP was positively correlated with β-CTX in the two groups (r = 0.744, 0.495, all P ＜ 0.05). Conclusion The levels of P1NP and β-CTX may be related to osteoporotic fracture in T2DM.
		2020 Vol. 17 (30): 88-90,98 [Abstract] ( 117 ) HTML (1 KB) PDF (560 KB) ( 92 )

	91	Effect contrast of Multiloc intramedullary nail and proximal humeral locking plate in the treatment of Neer Ⅱ type elderly humeral surgical neck fracture
		LIU Bing ZHANG Qiang ZHANG Ming
		Objective To compare the effect of Multiloc intramedullary nail and proximal humeral locking plate in the treatment of Neer Ⅱ type elderly humeral surgical neck fracture. Methods The clinical data of 200 cases of Neer Ⅱ type elderly humeral surgical neck fracture who were admitted to Benxi Central Hospital from June 2016 to June 2018 were retrospectively selected. Among them, 99 patients treated with Multiloc intramedullary nail were included in group A， and 101 patients treated with proximal humeral locking plate were included in group B. The patients were followed up by outpatient reexamination or telephone. The clinical effects, clinical related indicators, shoulder joint function and pain of the last follow-up were compared between the two groups, and the complications after operation were compared between the two groups. Results There was no significant difference in the excellent and good rate at the last follow-up between the two groups (P ＞ 0.05). There were no significant differences in incision length, operation time, intraoperative bleeding volume and fracture healing time after operation between the two groups (P ＞ 0.05). The neck shaft angle of group A was bigger than that of group B on the one day after operation (P ＜ 0.05). There were no significant differences in shoulder range of motion, Constant-Murley score and visual analogue scale score between the two groups at the last follow-up (P ＞ 0.05). There was no significant difference in the incidence rate of complications after operation between the two groups (P ＞ 0.05). Conclusion Multiloc intramedullary nail and proximal humeral locking plate are effective for Neer Ⅱ type elderly humeral surgical neck fracture, but Multiloc intramedullary nail with “nail in nail” internal fixation method at the same time on the effective control the rotation of humerus fracture end has better recovery of neck shaft angle one day after operation. According to the actual situation of the patients, the appropriate surgical treatment can be selected in clinic.
		2020 Vol. 17 (30): 91-94 [Abstract] ( 145 ) HTML (1 KB) PDF (518 KB) ( 68 )

	95	Influence of different operation timing on perioperative safety of patients with multiple rib fractures
		HU Wenfeng HONG Wei▲
		Objective To explore the influence of different operation timing on perioperative safety of patients with multiple rib fractures. Methods A total of 54 patients with multiple rib fractures from August 2015 to August 2019 in Huangshan City People′s Hospital, Anhui Province were selected as the study subjects. According to the time from injury to intraoperative fixation, the patients were divided into the early group (≤72 h, 26 cases) and the late group (> 72 h, 28 cases). The operation conditions (length of hospital stay, incision length, chest tube indwelling time and fracture healing time) of the two groups were compared and the laboratory indicators (C-reactive protein [CRP], procalcitonin [PCT]) before and after operation and the total incidence of complications were compared between the two groups. Results There were no significant differences in length of hospital stay, incision length and chest tube indwelling time between the two groups (P ＞ 0.05). Fracture healing time in the early group was shorter than that in the late group, and the difference was statistically significant (P ＜ 0.05). Comparison of CRP and PCT before operation between the two groups showed no significant difference (P ＞ 0.05). CRP and PCT after operation in the early group were lower than those before operation and after operation in the late group, with statistically significant differences (all P ＜ 0.05). The total incidence of complications in the early group was lower than that in the late group, with statistically significant difference (P ＜ 0.05). Conclusion Early surgical treatment of patients with multiple rib fractures can improve the efficacy, reduce the level of inflammation in the body, and have high safety, which is worthy of clinical promotion.
		2020 Vol. 17 (30): 95-98 [Abstract] ( 90 ) HTML (1 KB) PDF (512 KB) ( 121 )

	99	Clinical effect of PFNA and InterTan internal fixation in the treatment of elderly intertrochanteric fracture
		WANG Wei YANG Shen TAO Yong ZHANG Yifei▲
		Objective To investigate the clinical effect of proximal femoral nail antirotation (PFNA) and InterTan internal fixation in the treatment of elderly intertrochanteric fracture and provide reference for clinical treatment. Methods The clinical data of 94 elderly patients with intertrochanteric fractures admitted to the First People′s Hospital of Hefei City, Anhui Province from January 2016 to April 2019 were retrospectively analyzed. The patients were divided into PFNA group and InterTan group by different intraoperative fixation methods, with 47 patients in each group. Perioperative conditions, Harris score and complications during follow-up were compared between the two groups. Results There were no statistically significant differences between the two groups in incision length, hospital stay, early load-bearing time and fracture healing time (P ＞ 0.05). The operation time of PFNA group was shorter than that of InterTan group, intraoperative blood loss was less than that of InterTan group and drainage volume 24 h after operation was more than that of InterTan group, and the differences were statistically significant (all P ＜ 0.05). Overall analysis: there were statistically significant differences between the two groups at different time points (P ＜ 0.05), while there were no statistically significant differences between the two groups in comparison and interaction (P ＞ 0.05). Further pairwise comparison showed that Harris scores were higher in both groups six and twelve months after surgery than before surgery, and that twelve months after surgery was higher than six months after surgery in both groups, with statistically significant differences (all P ＜ 0.05). During follow-up, the total incidence of complications in the PFNA group was higher than that in the InterTan group, and the difference was statistically significant (P ＜ 0.05). Conclusion The effects of PFNA and InterTan internal fixation in elderly patients with intertrochanteric fractures are similar. PFNA internal fixation can be used to reduce injuries in patients with poor systemic condition, while InterTan internal fixation can be used to reduce long-term complications in patients with good systemic condition.
		2020 Vol. 17 (30): 99-102 [Abstract] ( 168 ) HTML (1 KB) PDF (546 KB) ( 31 )

	103	Effect of microwave ablation combined with absolute ethanol on endocrine status and reproductive outcomes in patients with uterine fibroids
		ZHAO Junda1 LIANG Lingyun1 YIN Yan2 MA Junqi1
		Objective To investigate the effect of microwave ablation combined with absolute ethanol on endocrine status and reproductive outcomes in patients with uterine fibroids. Methods One hundred and two patients with uterine fibroids treated in the First Affiliated Hospital of Xinjiang Medical University from January 2014 to March 2017 were divided into control group (51 cases) and observation group (51 cases) according to random number table method. Control group was treated with conventional microwave ablation, while observation group was treated with absolute ethanol on the basis of microwave ablation. The clinical effects, estradiol (E2), progesterone (P), luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels before and after treatment were compared between two groups. At the same time, the birth outcomes and adverse reactions of two groups were observed. Results The complete ablation rate of myoma in observation group was higher than that in control group after treatment of 24 hours and three months, and the differences were statistically significant (P < 0.05). There were no significant differences in E2, P, LH and FSH levels between groups and within groups in two groups three days before treatment and three months after treatment (P > 0.05). The natural delivery rate, neonatal Apgar score and neonatal quality of observation group were higher than those of control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Microwave ablation combined with absolute alcohol in the treatment of uterine fibroids can improve clinical efficacy, and can improve the patients′ reproductive outcome and endocrine status, which is an effective method for the treatment of uterine fibroids, it is worth widely used in clinical.
		2020 Vol. 17 (30): 103-106 [Abstract] ( 91 ) HTML (1 KB) PDF (652 KB) ( 69 )

	107	Meta-analysis of clinical efficacy and safety of Chinese medicine in the treatment of adenoidal hypertrophy
		XU Xin1 CEN Jingtu1 LIU Zheng2 RUAN Yan2
		Objective To systematically evaluate the efficacy and safety of traditional Chinese medicine in the treatment of adenoidal hypertrophy. Methods Eight databases including Wanfang, VIP, CNKI, CBM, PubMed, EMbase, Web of Science and Cochrane Library were searched by computer. The retrieval time was from the establishment of the database to December 2019. Chinese key words were adenoid hypertrophy, traditional Chinese medicine. English key words were adenoidal hypertrophy, adenoids, Chinese Medicine, Chinese herb. According to the natriuretic criteria, all the randomized controlled trials of traditional Chinese medicine in the treatment of adenoid hypertrophy in children were screened out. Treatment group was treated with oral Chinese medicine, supplemented by external treatment of traditional Chinese medicine; control group was treated with conventional Western medicine. The observation indexes included total effective rate of clinical treatment, integral of main clinical symptoms of traditional Chinese medicine, ratio of nasopharynx cavity (A/N ratio) in nasopharyngeal lateral film and adenoid volume change under nasal endoscope. The quality of the literature was evaluated according to the risk bias assessment tool in Cochrane evaluation manual, and the meta-analysis was conducted by Stata 14.0. Results A total of 4824 articles were retrieved, and 17 Chinese literatures were included. A total of 1339 patients were included, including 672 patients in the treatment group and 667 patients in the control group. Compared with control group, treatment group could significantly improve total effective rate (RR = 1.33, 95%CI: 1.25 to 1.41, P = 0.00), effectively improve nasal obstruction symptoms (WMD = -0.61, 95%CI: -0.82 to -0.39, P = 0.00), snoring symptoms (WMD = -0.82, 95%CI: -1.14 to -0.50, P = 0.00), mouth opening breathing symptoms (WMD = -0.54, 95%CI: -0.72 to -0.36, P = 0.00), effectively reduce A/N ratio (WMD = -0.11, 95%CI: -0.16 to -0.05, P = 0.00), effectively reduce adenoid volume under nasal endoscopy (WMD = -0.63, 95%CI: -0.78 to -0.48, P = 0.00). Conclusion The curative effect of traditional Chinese medicine in improving the main clinical symptoms of adenoid hypertrophy in children, reducing A/N ratio, reducing adenoid volume is significant. No serious adverse reactions are found. It is worthy of widely clinical application.
		2020 Vol. 17 (30): 107-111,117 [Abstract] ( 140 ) HTML (1 KB) PDF (1409 KB) ( 21 )

	112	Systematical evaluation and meta analysis of adjuvant probiotic treatment in childhood asthma based on the theory of “interior-exterior relationship between lung and large intestine”
		YANG Fushuang1 CAO Fang1 GUO Lei1 GUO Tingting1 WANG Zhongtian1 SUN Liping2
		Objective To systematically evaluate the efficacy and safety of probiotics in the adjuvant treatment of childhood asthma, so as to provide evidence-based medical evidence for probiotics in the treatment of childhood asthma. Methods Randomized controlled trials of probiotics combined with conventional anti-inflammatory and antiasthmatic drugs as intervention measures in the treatment of childhood asthma were collected in PubMed, EMbase, Cochrane Library, CNKI, Wanfang, VIP and CBM databases with the keywords “asthma, probiotics, children, random”. The searching time range was from the establishment of the database to April 2019. Meta analysis was performed with software RevMan 5.3 after independently screening the literature, evaluating the risk of literature bias, and extracting the clinical total effective rate, recurrence rate, FEV1, IFN-γ, IgE and adverse reaction indicators by the two investigators. Results A total of ten RCTs involving 992 asthma patients were included. Meta analysis results showed that: compared with control group, clinical total effective rate of experimental group improved (OR = 3.57, 95%CI: 2.41-5.30, P ＜ 0.000 01), FEV1 increased (MD = 0.29, 95%CI: 0.13-0.45, P = 0.0003), IFN-γ level increased (MD = 30.28, 95%CI: 26.80-33.77, P ＜ 0.000 01), IgE level decreased (MD = -24.03, 95%CI: -31.15 to -16.90, P ＜ 0.00001), recurrence rate decreased (OR = 0.37, 95%CI: 0.19-0.72, P = 0.003). There was no significant difference in the incidence of adverse reaction between two groups (OR = 1.08, 95%CI: 0.49-2.39, P = 0.85). Conclusion Based on the current clinical evidence, probiotics adjuvant treatment of childhood asthma can effectively improve the clinical efficacy and quality of life of patients, and reduce the recurrence rate. Due to the low quality and small sample size of the included studies, more high-quality, large sample size, multi center clinical studies are needed to verify the exact conclusion.
		2020 Vol. 17 (30): 112-117 [Abstract] ( 126 ) HTML (1 KB) PDF (1606 KB) ( 32 )

	118	Relationship between high risk human papillomavirus infection and vaginal microecology and cervical local cellular immunity
		HUANG Minmin1 YIN Zhifa2 QIN Xinlei1
		Objective To explore the relationship between high risk human papillomavirus (HR-HPV) infection and vaginal microecology and cervical local cellular immunity. Methods One hundred and sixty patients with human papillomavirus (HPV) infection treated in the Second People′s Hospital of Lianyungang (“our hospital” for short) from February 2017 to August 2019 were divided into non HR-HPV group (85 cases) and HR-HPV group (75 cases) according to whether the patients were accompanied with HR-HPV infection. At the same time, 80 healthy women who had physical examination in our hospital at the same time were selected as control group. The vaginal microecology was detected by enzyme chemical reaction method, HPV-DNA was detected by fluorescence probe hybridization capture technology, and the proportion of positive cells of leukocyte differentiation antigen 3+ (CD3+), leukocyte differentiation antigen 4+ (CD4+) and leukocyte differentiation antigen 8+ (CD8+) were detected by flow cytometry. The incidence of vaginal microecology, the distribution of vaginal flora and the distribution of T lymphocyte subsets among groups were compared. Results HR-HPV patients were mainly single type of HPV infection, and HPV16, 18 and HPV33 were the main types. The incidence of vaginal microecological disorder in HR-HPV group was higher than that in non HR-HPV group and control group, while that in non HR-HPV group was higher than that in control group (P < 0.05). The positive rates of Lactobacillus abnormality, bacterial vaginitis, Chlamydia, Ureaplasma urealyticum and trichomonas in HR-HPV group and non HR-HPV group were significantly higher than those in control group (P < 0.05). The positive rates of Lactobacillus and Chlamydia in HR-HPV group were significantly higher than those in non HR-HPV group (P < 0.05). CD3+, CD4+ and CD4+/CD8+ in HR-HPV group were lower than those in non HR-HPV group and control group, while CD3+, CD4+ and CD4+/CD8+ in non HR-HPV group were lower than those in control group (P < 0.05). CD8+ in HR-HPV group was higher than that in non HR-HPV group and control group, while CD8+ in non HR-HPV group was higher than that in control group (P < 0.05). Conclusion HR-HPV infection can cause serious imbalance of vaginal microecology, increase the distribution of vaginal flora and further reduce the number of T-lymphocyte subsets, resulting in the deterioration of patients′ condition.
		2020 Vol. 17 (30): 118-121,125 [Abstract] ( 152 ) HTML (1 KB) PDF (683 KB) ( 83 )

	122	Logistic regression analysis of the risk factors of postpartum hemorrhage in the elderly women with second cesarean section
		GU Shuang QU Sirao XU Yang
		Objective To explore the risk factors of postpartum hemorrhage in elderly women with second cesarean section. Methods The clinical data of 480 elderly women who underwent second cesarean section in the Fourth People′s Hospital of Shenyang from January 2017 to April 2019 were analyzed retrospectively. According to whether there was postpartum hemorrhage, they were divided into hemorrhage group (60 cases) and non-hemorrhage group (420 cases). The general situation, medical history and pregnancy process of the two groups were compared, and the high risk factors of postpartum hemorrhage of the elderly women in the second cesarean section were analyzed by logistic regression analysis. Results There were significant differences in abortion, fetal position, macrosomia, placenta previa, placental implantation and placental attachment between two groups (P ＜ 0.05). There were no significant differences between two groups in parturient times, induced labor, gestational hypertension and gestational diabetes (P ＞ 0.05). Multiple logistic regression analysis showed that the placental attachment position [OR = 3.611, 95%CI (1.471-8.864), P = 0.005], placenta previa [OR = 5.214, 95%CI(2.456-11.069), P ＜ 0.001] and placental implantation [OR = 15.213, 95%CI(7.245-31.941), P = 0.001] were the high risk factors of postpartum hemorrhage in elderly women with second cesarean section. Conclusion The postpartum hemorrhage of the elderly women in the second cesarean section should not be ignored. The elderly women in the second cesarean section with placenta previa, placenta implantation and placental attachment position are more likely to have postpartum hemorrhage. Therefore, the positive preventive measures should be taken in clinical practice.
		2020 Vol. 17 (30): 122-125 [Abstract] ( 137 ) HTML (1 KB) PDF (611 KB) ( 72 )

	126	Predictive value of lipid accumulation index for metabolic syndrome in patients with polycystic ovary syndrome
		HAO Songli HOU Lihui XU Fang SUN Miao ZHANG Chunlan MENG Xiaoyu
		Objective To explore the predictive value of lipid accumulation index (LAP) for the occurrence of metabolic syndrome (MS) in patients with polycystic ovary syndrome (PCOS). Methods From June 2015 to December 2019, 507 patients with PCOS were selected from the Gynecological Outpatient Department of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine. According to MS diagnostic criteria, they were divided into PCOS with MS group (200 cases) and PCOS non MS group (307 cases). The general clinical data, clinical biochemical indexes and LAP value were collected. Results Systolic blood pressure, diastolic blood pressure, body weight, body mass index, waist circumference, hip circumference, waist to hip ratio, luteinizing hormone, luteinizing hormone/follicle stimulating hormone, androstenedione, sex hormone binding globulin, free androgen index, fasting blood glucose, postprandial 2 h blood glucose, fasting insulin, postprandial 2 hours insulin, insulin resistance index of steady-state model, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, apolipoprotein A, apolipoprotein B, apolipoprotein B/apolipoprotein A, LAP levels and the incidence rate of obesity, central obesity, black acanthosis, acne and insulin resistance between two groups were compared, the differences were statistically significant (P < 0.05). Spearman correlation analysis showed that: LAP was positively correlated with body weight, body mass index, waist circumference, hip circumference, waist hip ratio, fasting insulin, homeostasis model insulin resistance index, triacylglycerol, total cholesterol, apolipoprotein B, apolipoprotein B/apolipoprotein A (r = 0.398, 0.452, 0.469, 0.345, 0.349, 0.308, 0.269, 0.800, 0.143, 0.214, 0.172, all P < 0.05). LAP was negatively correlated with luteinizing hormone, luteinizing hormone/follicle stimulating hormone, sex hormone binding globulin and high density lipoprotein (r = -0.179, -0.142, -0.143, -0.327, all P < 0.05). ROC curve showed that the area under LAP curve was 0.90, the optimal tangent point was 47.51, the sensitivity was 86.50%, and the specificity was 81.40%. Conclusion LAP has a high predictive value for the occurrence of MS in PCOS patients, and can be a reliable marker for screening MS in PCOS.
		2020 Vol. 17 (30): 126-129 [Abstract] ( 146 ) HTML (1 KB) PDF (667 KB) ( 77 )

	130	Analysis of clinical effects of initial periodontal treatment and Triamcinolone Acetonide oral ointment on gingival lichen planus
		WANG Xiang1 ZHANG Peng2 ZHENG Lichun3 WANG Wenmei1 DUAN Ning1 CHU Zhijuan1
		Objective To analyze the clinical effect of periodontal therapy combined with Triamcinolone Acetonide for treatment of lichen planus gingiva. Methods From January to September in 2019, 40 patients affected with gingival lichen planus and chronic periodontitis diagnosed in the clinics of Nanjing Stomatological Hospital Medical School of Nanjing University, according to the random number table method, the patients were randomly divided into the treatment group and the control group, with 20 patients in each group. The treatment group was treated with periodontal therapy combined with topical triamcinolone acetonide oral ointment, while the control group was treated with topical triamcinolone acetonide oral ointment. Both groups were given the drug for three months, the pain degree, lesion area and total effective rate before and after treatment were observed. Results The pain degree of patients in different time and groups was different, and there was interaction between time and groups, and the differences were statistically significant (P ＜ 0.05). Further pair comparison and intra-group comparison: the pain degree of the two groups at one week, two weeks, one month and six months after treatment were lower than those before treatment, and the difference were statistically significant (P ＜ 0.05). Comparison between groups: one week and two weeks after treatment, the pain degree of the treatment group was lower than that of the control group, with statistically significant differences (P ＜ 0.05). The lesion area was different at different times, and the difference was statistically significants (P ＜ 0.05); there was interaction between time and groups, and the difference was statistically significant (P ＜ 0.05). Further pairwise comparison and intra-group comparison: the lesion area at one week, two weeks, one month and six months after treatment were smaller than that before treatment, and the differences were statistically significant (P ＜ 0.05). Two weeks, one month and six months after treatment, the lesion area of the treatment group were smaller than that of the control group, with statistically significant differences (P ＜ 0.05). The total effective rate of the treatment group at one, two weeks, one month and six months after treatment were higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion Periodontal basic treatment combined with Triamcinolone Oral Ointment for lichen planus gingival has quick short-term effect, good maintenance effect and good long-term effect.
		2020 Vol. 17 (30): 130-133 [Abstract] ( 192 ) HTML (1 KB) PDF (476 KB) ( 17 )

	134	Imaging anatomy of the ethmoid maxillary sinus pneumatae and its correlation with the vesicular middle turbinate
		ZHOU Fangwei LYU Hao XU Yu▲
		Objective To analyze the imaging anatomy of ethmoidal maxillary sinus (EMS) air chamber and to explore its correlation with ipsilateral vesicular middle turbinate. Methods The CT scan results of 580 patients in Renmin Hospital of Wuhan University from January to December 2019 were retrospectively analyzed. The incidence of EMS gas chamber was observed, and the maximum diameter of EMS gas chamber in the coronal position was measured, type by maximum diameter. The correlation between EMS gas chamber and ipsilateral vesicular middle turbinate were explored. Results The incidence of EMS gas chamber was 10.2%. Among them, unilateral account for 3.8%, bilateral account for 6.4%. The incidence of alveolar middle turbinate on the affected side of EMS gas chamber was significantly higher than that on the affected side of non-EMS gas chamber (P ＜ 0.05). The maximum diameter of EMS gas chamber on the coronal plane was 3.48-26.18 mm, with an average diameter of (11.27±5.02) mm. The difference between the three types of EMS bubble middle turbinate gasification index was highly statistically significant (P ＜ 0.05). Compared with type Ⅰ, type Ⅱ was significantly increased (P ＜ 0.05). Type Ⅲ was significantly higher than type Ⅱ (P ＜ 0.05). Conclusion EMS gas chamber is a common anatomic variation associated with ipsilateral vesicular middle turbinate. The greater the degree of EMS gasification, the greater the degree of ipsilateral vesicular middle turbinate gasification.
		2020 Vol. 17 (30): 134-137 [Abstract] ( 113 ) HTML (1 KB) PDF (532 KB) ( 98 )

	138	Microbial limit test and influence factor analysis of Qingshen Pills
		YI Wei LI Si WU Jingjing SU Hua GONG Guangming
		Objective To establish the microbial limit test method for Qingshen Pills, and analyze the results of the microbiological tests, and provide reference for actual production. Methods With reference to the method in the 2015 edition of the Chinese Pharmacopoeia, a method for microbial counting of 8 kinds of traditional Chinese medicine in Qingshen Pills and Qingshen Pills was established. The microbial limit tests of 30 batches of Qingshen Pills were tested to investigate the correlation between the content of aerobic bacteria and the moisture of the pill, and the correlation between the microbial content and the baking time. And the microbiological contents of 8 kinds of traditional Chinese medicine in Qingshen Pills were analyzed. Results The microbial contamination of Qingshen Pills is mainly aerobic bacteria. The higher the water content of Qingshen Pills was, the higher the microbial contamination level was. The longer the baking time, the less the moisture of the pills and the less the total number of aerobic bacteria. Dandelion had the most serious microbial contamination in 8 kinds of traditional Chinese medicine. Conclusion The water content and baking time of Qingshen Pills should be strictly controlled, and microbial limit standards for traditional Chinese medicine should be established to guide actual production and gradually improve the quality of Qingshen Pills.
		2020 Vol. 17 (30): 138-141 [Abstract] ( 174 ) HTML (1 KB) PDF (493 KB) ( 110 )

	142	Effects of Ticagrelor on EMPs and sICAM-1 in patients with acute coronary syndrome and its prognosis
		TAN Wenpeng LI Wenjie HE Xiaoqing
		Objective To observe the changes of serum endothelial microparticles (EMPs) and soluble intercellular adhesion molecule-1 (sICAM-1) levels and prognosis of Ticagrelor in treatment of patients with Non-ST-Elevation acute coronary syndrome (NSTE-ACS). Methods A total of 146 patients with NSTE-ACS admitted to the Third Affiliated Hospital of Guangzhou Medical University from January to June 2019, according to the random number table method, patients were divided into two groups, with 73 patients in each group. Clopidogrel group was treated with Clopidogrel, Ticagrelor group was treated with Ticagrelor. The levels of EMPs and sICAM-1 in the two groups were observed before percutaneous coronary intervention (PCI) as well as 24 h, 7 d and 30 d after PCI. The major adverse cardiac events (MACE) and adverse reactions were compared between the two groups within six months after PCI. Results The levels of EMPs and sICAM-1 of the two groups increased significantly at 24 h after PCI, decreased significantly at seven days after PCI compared with 24 h after PCI, and decreased significantly at 30 d after PCI compared with seven days after PCI, the differences were statistically significant (P ＜ 0.05). The levels of EMPs and sICAM-1 in Ticagrelor group were lower than those in Clopidogrel group seven days after PCI, and were lower than those in Clopidogrel group 30 d after PCI， and the differences were statistically significant (P ＜ 0.05). The total MACE events in Ticagrelor group were lower than that in Clopidogrel group, the differences were statistically significant (P ＜ 0.05), and there was no statistical difference in the incidence of bleeding events between the two groups (P ＞ 0.05). Conclusion Ticagrelor can improve endothelial function and reduce inflammatory reaction more rapidly in the treatment of NSTE-ACS patients, andstabilize atherosclerotic plaques, protect myocardium and does not increase bleeding risk.
		2020 Vol. 17 (30): 142-145 [Abstract] ( 68 ) HTML (1 KB) PDF (400 KB) ( 25 )

	146	Effect of Low Molecular Weight Heparin combined with Xingxiong Sodium Chloride in stroke patients complicated with deep vein thrombosis
		XING Liang1 TENG Zhipeng1 LUO Chao1 PENG Xing1 HE Yi′na2
		Objective To observe the effect of Low Molecular Weight Heparin combined with Xingxiong Sodium Chloride Injection in stroke patients complicated with deep vein thrombosis. Methods From December 2015 to December 2018, 38 stroke patients complicated with deep vein thrombosis in Chongqing Traditional Chinese Medicine Hospital were selected as study subjects. According to the treatment method, they were divided into the control group (21 cases) and the observation group (17 cases). The control group was treated with Low Molecular Weight Heparin Calcium Injection, and the observation group was treated with Xingxiong Sodium Chloride Injection on the basis of the control group. The cure rate of deep vein thrombosis and clinical efficacy were compared between the two groups. Results The cure rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). The total effective rate of the observation group was higher than that of the control group, and the difference was statistically significant (P < 0.05). Conclusion Xingxiong Sodium Chloride Injection combined with Low Molecular Weight Heparin can promote the cure rate of deep vein thrombosis and relieve the symptoms more effectively.
		2020 Vol. 17 (30): 146-148,156 [Abstract] ( 77 ) HTML (1 KB) PDF (873 KB) ( 81 )

	149	Viewing the difference of medical thought between ancient and modern from lily disease
		HUANG Tianyu ZHANG Qicheng
		Historically, there are few comments on the lily disease in the Synopsis of the Golden Chamber, and few related discussions. After the founding of the People′s Republic of China, there have been few mentions of this article. This paper sorted out the main knowledge of ancient and modern physicians about the nature, location and legislative formulation of lily disease, pointed out the inappropriate analysis of lily disease by medical thought of later generations of physicians in their own era, and put forward the viewpoint that the pathogenesis of lily disease is pulse deficiency and invading fever from the perspective of early medicine before Jin and Yuan Dynasty medical reform, explained the reasons for the complex changes of symptoms of lily disease, and borrowed relevant contents of the early Chinese herbal books analyzed the rule of law and prescription principles of lily disease, and tried to explore the effective ways to study the ancient prescriptions of Han and Tang Dynasty.
		2020 Vol. 17 (30): 149-152,160 [Abstract] ( 82 ) HTML (1 KB) PDF (722 KB) ( 106 )

	153	Clinical analysis of acupuncture treatment of premature ovarian failure
		XU Donghan1 FANG Gang2 WEI Yan3 LUO Yehao2 WU Jiamin3 ZENG Mengjie1 YAN Peiyu1
		Objective To review the current status of acupuncture treatment of premature ovarian failure (POF) in the past six years. Methods The China National Knowledge Infrastructure (CNKI) Database, Wanfang Data, CQVIP, PubMed, Embase, Web of Science were retrieved from the time of January 2015 to April 2020. A randomized controlled trial of acupuncture as the main intervention for the treatment of POF was included. The retrieved documents were screened, data information extraction and database establishment were performed. The data information mainly included diagnostic criteria, intervention means, traditional Chinese medicine (TCM) syndrome, meridian selection, acupoint frequency, random allocation scheme, treatment course. Results The use of diagnostic criteria on randomized controlled trials of acupuncture for POF lacks uniformity and standardization. The most common treatment method was acupuncture therapy combined with drug therapy. The main TCM syndrome types were kidney deficiency, liver depression and kidney deficiency. The acupoints belonged to the bladder meridian of Zutaiyang, the kidney meridian of Zushaoyin and the conception channel were the most used. The treatment course varied greatly. Conclusion At present, acupuncture treatment has significant effect on POF. However, many aspects of clinical design are still defective, which affects the credibility of clinical conclusions. All of these need to be improved in future clinical research.
		2020 Vol. 17 (30): 153-156 [Abstract] ( 109 ) HTML (1 KB) PDF (728 KB) ( 137 )

	157	Professor Wang Jiehong′s experience in the treatment of precancerous lesion of gastric cancer
		WANG Li1 WANG Jiehong2 ZHAO Weihan2 CHEN Shimin1
		Introduce the clinical experience and medication characteristics of Professor Wang Jiehong, a well-known traditional Chinese medicine doctor in Shaanxi Province, in the treatment of precancerous lesion of gastric cancer by supplementing Yiwei Huayu Decoction. Professor Wang Jiehong believes that precancerous lesion of gastric cancer is mostly based on deficiency of the root and excess of the manifestation, that is, deficiency of stomach yin and deficiency of spleen qi are the roots, qi stagnation, blood stasis, damp-heat, phlegm-turbidity and toxin are the manifestations, emphasizing that the key pathogenesis of the disease is obstruction of toxin and blood stasis. In the treatment, emphasis is placed on strengthening the spleen and stomach, detoxifying and removing blood stasis, together with the elimination of tangible evils. Self-made Yiwei Huayu Decoction is the basic prescription, which is modified to the symptoms, and each obtains good effects. This paper discusses and summarizes Professor Wang Jiehong′s experience of clinical syndrome from the aspects of etiology, pathogenesis, rules of treatment and examples of case examination.
		2020 Vol. 17 (30): 157-160 [Abstract] ( 144 ) HTML (1 KB) PDF (699 KB) ( 120 )

	161	Effect of Bushen Huoxue Decoction in the treatment of patients with benign prostatic hyperplasia after electrocision and its effect on sex hormone levels
		DAI Chaobo ZHANG Longhui LAN Jinyao
		Objective To investigate the effect of Bushen Huoxue Decoction in the treatment of patients with benign prostatic hyperplasia (BPH) after electrocision and its effect on sex hormone levels. Methods A total of 92 patients admitted to Lishui Hospital of Traditional Chinese Medicine, Zhejiang Province for BPH electrocision from February 2018 to June 2019 were selected and divided into control group and study group according to the random number table method, with 46 cases in each group. The control group was given routine intervention + Tamsulosin Hydrochloride Sustained Release Tablets, the study group was treated with Bushen Huoxue Decoction on the basis of the control group, and the total clinical effective rate, sex hormones (testosterone [T], estradiol [E2], luteinizing hormone [LH], prolactin [PRL]), urine volume (RU), maximum flow rate (Qmax), international prostate symptom score (I-PSS), quality of life score (QOL) and adverse reactions were compared between the two groups. Results After three months of treatment, the total clinical effective rate of the study group was higher than that of the control group (P ＜ 0.05). After three months of treatment, PRL and T levels in both groups were higher than those before treatment, and the study group was higher than the control group (P ＜ 0.05). E2 and LH levels were both lower than those before treatment, and the study group was lower than the control group (P ＜ 0.05). After three months of treatment, Qmax in both groups was higher than that before treatment, and the study group was higher than the control group (P ＜ 0.05), while, the RU, I-PSS and QOL were all lower than those before treatment, and the study group was lower than those of the control group (P ＜ 0.05). The incidence rate of adverse reactions in the study group was lower than that of the control group (P ＜ 0.05). Conclusion BPH patients after BPH electrocision combined with Bushen Huoxue Decoction on the basis of routine intervention can effectively promote the balance of sex hormones, improve the symptoms and quality of life of patients, at the same time, the incidence rate of adverse reactions is low, and the curative effect is significant.
		2020 Vol. 17 (30): 161-164 [Abstract] ( 107 ) HTML (1 KB) PDF (701 KB) ( 16 )

	165	Exploration the medication rules of premature ovarian failure based on the proven records of famous doctors
		LI Lan ZHONG Dayuan YANG Kaifeng XIAO Xiaoqin
		Objective To collect cases of premature ovarian failure (POF) treated by famous traditional Chinese medicine doctors, and to analyze the rules of formulating prescriptions, to provide reference for the selection of prescriptions and ideas for clinical treatment. Methods A computer search of proven records of famous doctors in treating POF included in the China National Knowledge Infrastructure (CNKI) database, with the subject term “premature ovarian failure” searched for documents collected from the establishment of the database until February 2020. Statistical analysis based on the frequency of drug use, nature and flavour, channel tropism of the drugs and the results of Apriori association rules as observation indicators. Results A total of 103 papers and 112 prescriptions were included, and 165 herbs were involved. The herbs listed in usage frequency from high to low were Radix Rehmanniae Preparata, Semen Cuscutae, Radix Angelicae Sinensis, Herba Epimendii, Fructus Lycii. Four nature of drugs listed from high to low were warm, clam, cold, cool, hot. The proportion of five flavors from high to low were sweet, bitter, pungent, sour, astringent, salty, tasteless. The frequency of drug used in descending order were liver, kidney, spleen, lung, heart. Apriori association rules showed that the highest rule support were Radix Rehmanniae Preparata combined with Radix Angelicae Sinensis, Radix Rehmanniae Preparata combined with Radix Angelicae Sinensis and Semen Cuscutae. Conclusion The mainly etiology of POF are deficiency of kidney and sometimes with stagnation of liver and blood stasis. The disease is intermingled deficiency and excess, mainly deficiency. The treatment principles are strengthening and nourishing marrow and essence, and combined with benefiting qi and nourishing blood, and dispersing stagnated liver qi.
		2020 Vol. 17 (30): 165-168 [Abstract] ( 82 ) HTML (1 KB) PDF (791 KB) ( 72 )

	169	Verification cases analysis of scleroderma treated by professer Xuan Guowei with treat from kidney and the theory sources
		GUAN Yingyu1 LI Hongyi2 DU Zemin1 SU Xiang1 WU Meida1 LIAO Liehui2
		This study reviews the statement between the kidney and “skin and hair” in the classics， combines with the pathogenesis and clinical manifestations of scleroderma, reflects on the relationship between “kidney” of Traditional Chinese medicine and scleroderma, states the theory sources on the treatment of scleroderma from kidney, summarizes the experiences and clinical cases of professor Xuan Guowei who treats scleroderma with kidney-nourishing method based on kidney theory. The kidney contains the inborn-yin and inborn-yang, being the root of the yin and yang of the human body. The treatment of scleroderma based on kidney theory is the manifestation of the concept of “treating disease from the root”. Scleroderma is a stubborn skin disease. Grasping the core of the treatment, starting from the “kidney”, and applying the kidney-nourishing method properly, the severe and lingering illness will be cured. This study attempts to provide the idea for clinical treatment of scleroderma with kidney-nourishing method based on kidney theory.
		2020 Vol. 17 (30): 169-172 [Abstract] ( 148 ) HTML (1 KB) PDF (703 KB) ( 46 )

	173	Clinical effect of treating chronic refractory cough with intradermal needle regulating liver and lung
		LIU Zhiguo1,2 LI Haixia3 WANG Lei1 BIAN Yongjun1 LI Guangxi1 LI Guoqin1 RONG Yi1 KANG Xiuhong4▲
		Objective To study the clinical effect of treating chronic refractory cough with intradermal needle regulating liver and lung. Methods According to Excel, a random number table was generated, and the 24 patients diagnosed as liver fire invading lung type chronic refractory cough in the outpatient clinic of Guang′anmen Hospital, China Academy of Chinese Medical Sciences from June 2015 to March 2016 were divided into treatment group and control group by random, controlled and single blind method, with 12 cases in each group. Both groups were given basic treatment, on this basis, the treatment group was given intradermal needle treatment, and the control group was given true acupoint comfort needle treatment. Treatment was performed for four weeks, and one follow-up was performed after four weeks of treatment. Cough symptom score, Leicester cough questionnaire (LCQ) and cough visual analogue scale (VAS) scores were used as the main evaluation indicators. Results During the study, three cases of abscission, two cases of loss of follow-up, one case of business trip and the remaining nine cases were in the control group. Cough symptom scores: there were statistically significant differences in the time points and the interaction of daytime cough between the two groups (all P ＜ 0.05), but no statistically significant differences between the two groups (P ＞ 0.05). The differences of night cough score at time points were statistically significant (all P ＜ 0.05), while the differences between the two groups and interaction were not statistically significant (all P ＞ 0.05). Intra-group comparison: after four weeks of treatment and four weeks after the end of the treatment course, the scores of daytime cough and night cough in the treatment group were all lower than those before treatment, and the scores of night cough in the control group were lower than those before treatment (all P ＜ 0.05). VAS score: there were statistically significant differences in the scores of cough degree and cough frequency between groups and at time points (all P ＜ 0.05), but no statistically significant difference in the interaction (P ＞ 0.05). The differences of night cough score at time point were statistically significant (all P ＜ 0.05), while the differences between the two groups and interaction were not statistically significant (all P ＞ 0.05). Intra-group comparison: after four weeks of treatment and four weeks after the end of treatment course, cough degree, cough frequency and night cough score of the two groups were all lower than those before treatment (all P ＜ 0.05). Comparison between groups: after four weeks of treatment and four weeks after the end of treatment course, the scores of cough degree and cough frequency in the treatment group were lower than those in the control group (all P ＜ 0.05). LCQ scores: there were statistically significant differences in the time points of the physiological, psychological and social part scores (P ＜ 0.05), while the differences between the two groups and interaction were not statistically significant (all P ＞ 0.05). There were no statistically significant differences between the two groups, time points and interaction in the total score (all P ＞ 0.05). Intra-group comparison: after four weeks of treatment and four weeks after the end of treatment course, the treatment group physical parts, psychological part, social part scores were higher than those before treatment, the differences were statistically significant (all P ＜ 0.05), four weeks after the end of treatment course, the control group psychological part, social part scores were higher than those before treatment, the differences were statistically significant (all P ＜ 0.05). Conclusion Intradermal needle is safe and effective in treating chronic refractory cough. The therapeutic effect is mainly reflected in reducing the severity and frequency of cough.
		2020 Vol. 17 (30): 173-177 [Abstract] ( 151 ) HTML (1 KB) PDF (746 KB) ( 120 )

	178	Application experience and literature analysis of vacuum sealing drainage in incision infection in patients with cholangiocarcinoma
		CHEN Jinmei1 HUANG Zhonghai2 YU Yuan2 WU Huashuai1 GAN Yirong1 LI Chengji1
		Student Academy of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530022, China; 2.Department of Hepatobiliary Surgery, the First Affiliated Hospital of Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530023, China [Abstract] In recent years, with the development of medical and health services, vacuum sealing drainage has been widely used in surgical wound healing as a new method to promote wound repair, and has played a unique advantage. In March 2019, the First Affiliated Hospital of Guangxi University of Chinese Medicine underwent a percutaneous transhepatic biliary angiography + internal and external drainage of the biliary tract for “severe jaundice”, followed by radical cholangiocarcinoma. Postoperative anastomosis caused an incision infection of elderly male patients, after applying the vacuum sealing drainage to continuously drain the incision, the incision gradually improved, healed, and the effect was good. This article reports the clinical data of this patient, and expounds the application experience and literature analysis of using vacuum sealing drainage in abdominal postoperative incision infection in order to provide clinical guidance.
		2020 Vol. 17 (30): 178-181 [Abstract] ( 81 ) HTML (1 KB) PDF (488 KB) ( 73 )

	182	Discuss time of retinal artery occlusion based on vascular diseases
		XU Jing HAO Xiaofeng LUO Jie YUAN Hang XIE Like
		Retinal artery occlusion is an ophthalmic blinding emergency, which has a rapid onset and a high blinding rate. The time window of treatment is the key factor to determine the degree of vision recovery of patients. Many clinical patients miss the best time for diagnosis and treatment and delay the disease. The pathogenesis of retinal artery occlusion is complex. At present, the most common cause are atherosclerosis and vasospasm, which can lead to a variety of vascular diseases. And these two risk factors can lead to a variety of systemic vascular diseases. In this paper, through the common systemic vascular diseases of the two categoriesthe time of occurrence of hypertension and coronary heart disease were analyzed, the relationship between these two diseases and retinal artery occlusion was analyzed and discussed from modern medical research and traditional Chinese medicine theory. Discover its good hair time were mainly in the morning (6∶00-8∶00) and afternoon (16∶00-18∶00). Good season to winter for more, according to these laws targeted to find countermeasures, effective timing care, take more targeted treatment, improve the curative effect, better prevention and treatment of retinal artery occlusion.
		2020 Vol. 17 (30): 182-185 [Abstract] ( 82 ) HTML (1 KB) PDF (444 KB) ( 73 )

	186	Effect of pharmaceutical care on the treatment effect and self-management behavior of patients with type 2 diabetes
		LI Sijia1 LI Sainan1 PAN Ying1 CHEN Jia1 YANG Na2
		Objective To explore the effect of pharmaceutical care on the treatment effect and self-management behavior of patients with type 2 diabetes. Methods One hundred and thirty-two patients with type 2 diabetes admitted to the Third Hospital of Hebei Medical University from June 2018 to June 2019 were selected, they were divided into control group (n = 66, routine monitoring) and monitoring group (n = 66, pharmaceutical monitoring + routine monitoring) by random number table method, all patients were monitored for six months. Clinical indexes, drug compliance, incidence of irrational drug use, self-management, satisfaction with pharmaceutical care and incidence of hypoglycemia were compared between two groups. Results After intervention, the levels of 2-hour postprandial blood glucose, fasting plasma glucose, body mass index, glycosylated hemoglobin, systemic blood pressure, diastolic blood pressure in two groups were lower than those before intervention, and those in monitoring group were lower than those in control group (P < 0.05). Total compliance rate of monitoring group after intervention was higher than that of control group (P < 0.05). The incidence of irrational drug use in monitoring group after intervention was lower than that in control group (P < 0.05). The proportion of daily blood glucose monitoring, reasonable diet, medication compliance and adequate sleep in monitoring group after intervention was higher than that in control group (P < 0.05). There was no significant difference in the proportion of exercise rule between two groups after intervention (P > 0.05). After intervention, the total satisfaction of monitoring group was higher than that of control group (P < 0.05), and the incidence of hypoglycemia of monitoring group was lower than that of control group (P < 0.05). Conclusion The pharmaceutical care model developed in this study for type 2 diabetic patients is helpful to control blood glucose, promote rational drug use, significantly improve the self-management behavior of patients.
		2020 Vol. 17 (30): 186-189 [Abstract] ( 133 ) HTML (1 KB) PDF (445 KB) ( 88 )

	190	Practice of building a smart health management platform based on the “Internet +” model
		GAO Hongwei1 WANG Shixin2
		The “Internet medical + health management” health service model relies on smart technologies such as the internet, big data, the internet of things, cloud computing, and smart wearables, and poses new challenges to the health management model. The current intelligent medical internet health management of modern information technology is becoming a hot direction in the advancement of the big health field, and it is an extension and development of the traditional medical service system. Through the construction and practice of the “Internet medical + health management” smart health management platform, this article comprehensively analyzes the necessity of integration of internet medical models and smart health management from the aspects of health management business requirements, health management system functional design, and health management platform development and application prospects. The “Internet medical + health management” model integrates internet technology with health examinations, disease diagnosis and treatment, and optimizes multiple steps such as health monitoring, health risk assessment and analysis, health guidance, and health risk factor intervention, breaking the original restrictions on the spatial and temporal limitations of health information collection.
		2020 Vol. 17 (30): 190-192，封三 [Abstract] ( 154 ) HTML (1 KB) PDF (622 KB) ( 464 )

	193	Research on the development and competitiveness of Yunnan traditional Chinese medicine industry innovation cluster
		ZHANG Difan1 CHANG Haojuan1 YU Bo1 ZHANG Qianru1 MENG Qinghong2
		In order to enhance the competitiveness of Yunnan′s traditional Chinese medicine industry, Yunnan′s traditional Chinese medicine urgently needs the innovative development of industrial clusters. The advantages of Yunnan′s medicinal resources, ethnic medicine and geographic characteristics are the foundation for the development of innovation cluster. The policy emphasis on the development of traditional Chinese medicine, strong market demand, and extensive cooperation at home and abroad provide good opportunities for innovation cluster. The innovation cluster structure of the traditional Chinese medicine industry in Yunnan has been formed basically, but is not perfect in operational system and mechanism, with no obvious synergistic effect and weak internal and external effects as well. The innovation cluster of the traditional medicine industry in Yunnan needs to further improve its operational system, enlarge its financial investment and talent introduction, and promote the effective play of the cluster effect with the help of domestic and foreign cooperation platforms.
		2020 Vol. 17 (30): 193-封三 [Abstract] ( 120 ) HTML (1 KB) PDF (767 KB) ( 133 )

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