中药治疗小儿腺样体肥大临床效果和安全性的meta分析

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Abstract Objective To systematically evaluate the efficacy and safety of traditional Chinese medicine in the treatment of adenoidal hypertrophy. Methods Eight databases including Wanfang, VIP, CNKI, CBM, PubMed, EMbase, Web of Science and Cochrane Library were searched by computer. The retrieval time was from the establishment of the database to December 2019. Chinese key words were adenoid hypertrophy, traditional Chinese medicine. English key words were adenoidal hypertrophy, adenoids, Chinese Medicine, Chinese herb. According to the natriuretic criteria, all the randomized controlled trials of traditional Chinese medicine in the treatment of adenoid hypertrophy in children were screened out. Treatment group was treated with oral Chinese medicine, supplemented by external treatment of traditional Chinese medicine; control group was treated with conventional Western medicine. The observation indexes included total effective rate of clinical treatment, integral of main clinical symptoms of traditional Chinese medicine, ratio of nasopharynx cavity (A/N ratio) in nasopharyngeal lateral film and adenoid volume change under nasal endoscope. The quality of the literature was evaluated according to the risk bias assessment tool in Cochrane evaluation manual, and the meta-analysis was conducted by Stata 14.0. Results A total of 4824 articles were retrieved, and 17 Chinese literatures were included. A total of 1339 patients were included, including 672 patients in the treatment group and 667 patients in the control group. Compared with control group, treatment group could significantly improve total effective rate (RR = 1.33, 95%CI: 1.25 to 1.41, P = 0.00), effectively improve nasal obstruction symptoms (WMD = -0.61, 95%CI: -0.82 to -0.39, P = 0.00), snoring symptoms (WMD = -0.82, 95%CI: -1.14 to -0.50, P = 0.00), mouth opening breathing symptoms (WMD = -0.54, 95%CI: -0.72 to -0.36, P = 0.00), effectively reduce A/N ratio (WMD = -0.11, 95%CI: -0.16 to -0.05, P = 0.00), effectively reduce adenoid volume under nasal endoscopy (WMD = -0.63, 95%CI: -0.78 to -0.48, P = 0.00). Conclusion The curative effect of traditional Chinese medicine in improving the main clinical symptoms of adenoid hypertrophy in children, reducing A/N ratio, reducing adenoid volume is significant. No serious adverse reactions are found. It is worthy of widely clinical application.

Key words： Traditional Chinese medicine Adenoidal hypertrophy Clinical efficacy Safety Meta-analysis

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	XU Xin1 CEN Jingtu1 LIU Zheng2 RUAN Yan2

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XU Xin1 CEN Jingtu1 LIU Zheng2 RUAN Yan2. Meta-analysis of clinical efficacy and safety of Chinese medicine in the treatment of adenoidal hypertrophy[J]. 中国医药导报, 2020, 17(30): 107-111,117.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I30/107

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