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| Predictive value of lipid accumulation index for metabolic syndrome in patients with polycystic ovary syndrome |
| HAO Songli HOU Lihui XU Fang SUN Miao ZHANG Chunlan MENG Xiaoyu |
| Department of Gynaecology, the First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Heilongjiang Province, Harbin 150040, China |
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Abstract Objective To explore the predictive value of lipid accumulation index (LAP) for the occurrence of metabolic syndrome (MS) in patients with polycystic ovary syndrome (PCOS). Methods From June 2015 to December 2019, 507 patients with PCOS were selected from the Gynecological Outpatient Department of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine. According to MS diagnostic criteria, they were divided into PCOS with MS group (200 cases) and PCOS non MS group (307 cases). The general clinical data, clinical biochemical indexes and LAP value were collected. Results Systolic blood pressure, diastolic blood pressure, body weight, body mass index, waist circumference, hip circumference, waist to hip ratio, luteinizing hormone, luteinizing hormone/follicle stimulating hormone, androstenedione, sex hormone binding globulin, free androgen index, fasting blood glucose, postprandial 2 h blood glucose, fasting insulin, postprandial 2 hours insulin, insulin resistance index of steady-state model, triglyceride, total cholesterol, high-density lipoprotein, low-density lipoprotein, apolipoprotein A, apolipoprotein B, apolipoprotein B/apolipoprotein A, LAP levels and the incidence rate of obesity, central obesity, black acanthosis, acne and insulin resistance between two groups were compared, the differences were statistically significant (P < 0.05). Spearman correlation analysis showed that: LAP was positively correlated with body weight, body mass index, waist circumference, hip circumference, waist hip ratio, fasting insulin, homeostasis model insulin resistance index, triacylglycerol, total cholesterol, apolipoprotein B, apolipoprotein B/apolipoprotein A (r = 0.398, 0.452, 0.469, 0.345, 0.349, 0.308, 0.269, 0.800, 0.143, 0.214, 0.172, all P < 0.05). LAP was negatively correlated with luteinizing hormone, luteinizing hormone/follicle stimulating hormone, sex hormone binding globulin and high density lipoprotein (r = -0.179, -0.142, -0.143, -0.327, all P < 0.05). ROC curve showed that the area under LAP curve was 0.90, the optimal tangent point was 47.51, the sensitivity was 86.50%, and the specificity was 81.40%. Conclusion LAP has a high predictive value for the occurrence of MS in PCOS patients, and can be a reliable marker for screening MS in PCOS.
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