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| Effect of microwave ablation combined with absolute ethanol on endocrine status and reproductive outcomes in patients with uterine fibroids |
| ZHAO Junda1 LIANG Lingyun1 YIN Yan2 MA Junqi1 |
1.Department of Gynecology, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830054, China;
2.Department of Obstetrics, the First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi 830054, China |
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Abstract Objective To investigate the effect of microwave ablation combined with absolute ethanol on endocrine status and reproductive outcomes in patients with uterine fibroids. Methods One hundred and two patients with uterine fibroids treated in the First Affiliated Hospital of Xinjiang Medical University from January 2014 to March 2017 were divided into control group (51 cases) and observation group (51 cases) according to random number table method. Control group was treated with conventional microwave ablation, while observation group was treated with absolute ethanol on the basis of microwave ablation. The clinical effects, estradiol (E2), progesterone (P), luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels before and after treatment were compared between two groups. At the same time, the birth outcomes and adverse reactions of two groups were observed. Results The complete ablation rate of myoma in observation group was higher than that in control group after treatment of 24 hours and three months, and the differences were statistically significant (P < 0.05). There were no significant differences in E2, P, LH and FSH levels between groups and within groups in two groups three days before treatment and three months after treatment (P > 0.05). The natural delivery rate, neonatal Apgar score and neonatal quality of observation group were higher than those of control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Microwave ablation combined with absolute alcohol in the treatment of uterine fibroids can improve clinical efficacy, and can improve the patients′ reproductive outcome and endocrine status, which is an effective method for the treatment of uterine fibroids, it is worth widely used in clinical.
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