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| Research progress of HER2-positive gastric cancer |
| SUN Keran LYU Huifang WANG Saiqi CHEN Xiaobing |
| Department of Gastroenterology, Affiliated Tumor Hospital of Zhengzhou University, He′nan Province, Zhengzhou 450000, China |
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Abstract At present, gastric cancer is still the fifth largest malignant tumor in the world and the second largest cause of cancer-related death in the world. Previous studies have found that epidermal growth factor receptor 2 (HER2) positive gastric cancer is a special type of gastric cancer with worse prognosis. This kind of gastric cancer has a high expression of HER2 in the early stage of intraepithelial neoplasia, and the overexpression of HER2 increases significantly with the increase of the degree of dedifferentiation of precancerous lesions. With the emergence of targeted drugs such as Herceptin, the treatment of HER2 positive gastric cancer has taken a turn for the better. But Herceptin alone is not enough. The examination and treatment of HER2 positive gastric cancer are still in the primary level. In recent years, liquid biopsy techniques and a variety of therapeutic drugs are unveiling the mystery of HER2 positive gastric cancer step by step. Among them, the liquid biopsy technique is not only much more efficient than the traditional immunohistochemical technique, but also can monitor the curative effect of Trastuzumab dynamically in real time. This paper reviews the recent research progress of HER2 positive gastric cancer, including the treatment of HER2 positive gastric cancer, drug resistance and the relationship with immune status, so as to provide some reference for clinical practice.
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