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2020 Vol. 17, No. 20
Published: 2020-07-15
 
 
4 Effect of miR-21/PDCD4/AP-1 on proliferation, invasion and migration of esophageal cancer cells
YANG Jingrong1，2 WU Jian2 YE Shixin2 LIAN Duohuang2 ZENG Zhiyong1，2▲
Objective To study the effect of miR-21/PDCD4/AP-1 on the proliferation, invasion and migration of esophageal cancer cells. Methods Transient transfection of esophageal squamous cell carcinoma cells was used as experimental object. The single transfection group: blank control group, miR-21 mimics negative control (miR-21 mimic NC) group, miR-21 mimic group, miR-21 inhibitor NC group, miR-21 inhibitor group, siRNA NC group, PDCD4 siRNA group, c-Jun siRNA group. Cotransfection group: miR-21 inhibitor NC + siRNA NC group, miR-21 inhibitor + siRNA NC group, miR-21 inhibitor + siRNA NC group inhibitor + PDCD4 siRNA group. CCK-8, Transwell migration and invasion were used to detect the effect of miR-21/PDCD4/AP-1 feedback loop on the proliferation, migration and invasion of EC9706 cells. Results From the 2nd day after transfection, the proliferation ability of EC9706 cells in miR-21 mimic group was significantly higher than that in blank control group, miR-21 mimic NC group, miR-21 inhibitor NC group and miR-21 inhibitor group (P < 0.05). The number of cells passing through the chamber in miR-21 mimic group was more than that in blank control group and miR-21 mimic NC group (P < 0.05); the number of cells passing through the chamber in miR-21 inhibitor group was less than that in miR-21 inhibitor NC group (P < 0.05). The number of invasive cells penetrating Matrigel in miR-21 mimic group was more than that in blank control group and miR-21 mimic NC group (P < 0.05); the number of invasive cells penetrating Matrigel in miR-21 inhibitor group was less than that in miR-21 inhibitor NC group (P < 0.05). From the 2nd day after transfection, the proliferation ability of EC9706 cells in PDCD4 siRNA group was higher than that in blank control group and siRNA NC group (P < 0.05). The number of cells passing through the chamber and invading cells passing through Matrigel in PDCD4 siRNA group was higher than that in blank control group and siRNA NC group (P < 0.05). The proliferation ability of EC9706 cells in miR-21 inhibitor + siRNA NC group was lower than that in miR-21 inhibitor + PDCD4 siRNA group and miR-21 inhibitor NC + siRNA NC group (P < 0.05). The number of cells passing through the chamber and the number of cells penetrating Matrigel in miR-21 inhibitor + PDCD4 siRNA group was more than that in miR-21 inhibitor + siRNA NC group (P < 0.05). The proliferation ability of EC9706 cells in c-Jun siRNA group was lower than that in blank control group and siRNA NC group (P < 0.05). The number of cells passing through the chamber and the number of invasive cells passing through Matrigel in c-Jun siRNA group was less than that in siRNA NC group (P < 0.05). Conclusion miR-21/PDCD4/AP-1 feedback loop can regulate the growth and invasion of esophageal cancer cells, which provides a new therapeutic strategy for preventing invasion and metastasis.
2020 Vol. 17 (20): 4-9 [Abstract] ( 104 ) HTML (1 KB)  PDF (1176 KB)  ( 76 )
10 Effect of dietary fiber on inflammatory response after cerebral ischemia in rats
LI Haitao1 QU Bo2 YANG Shida2▲
Objective To investigate the effect of dietary fiber on inflammatory response after cerebral ischemia in rats. Methods Thirty-four adult male rats were divided into sham group (n = 10), ischemic group (n = 12), ischemic+dietary fiber group (n = 12) according to the principle of random distribution. Endothelin was injected into the brain of the ischemia group and ischemic+dietary fiber group to make the cerebral ischemia model, 4 rats died; while sham operation group was injected with isovolume normal saline, all the rats survived. Finally, 10 rats in sham operation group, 10 rats in ischemia group, and 10 rats in ischemia+dietary fiber group. Normal diet was added to the sham group and ischemia group, dietary fiber was added to the ischemia+dietary fiber group. The infarct volume was measured and the number of Iba-1/BrdU and GFAP/BrdU double staining positive cells in the infarct peripheral cortex of each group was observed by immunofluorescence staining. Results There was no significant difference in infarct volume between ischemia group and ischemia+dietary fiber group (P > 0.05). The number of Iba-1/BrdU double staining positive cells, GFAP/BrdU double staining positive cells in ischemia group were more than those in sham operation group, while the number of Iba-1/BrdU double staining positive cells, GFAP/BrdU double staining positive cells in ischemia+dietary fiber group were less than those in ischemia group, and the differences were all highly statistically significant (all P < 0.05). Conclusion Dietary fiber can inhibit the activation of new microglia and astrocytes around the infarct in the recovery period of cerebral infarction, and thus inhibit the inflammatory response after cerebral infarction.
2020 Vol. 17 (20): 10-12 [Abstract] ( 125 ) HTML (1 KB)  PDF (613 KB)  ( 50 )
13 Changes and clinical significance of serum CD40 and ICAM-1 levels in patients with acute cerebral hemorrhage
QUAN Hongjuan XIA Mingwan ZHANG Sheng′an
Objective To study the changes and clinical significance of serum CD40 and intercellular adhesion molecule-1 (ICAM-1) expression in patients with acute cerebral hemorrhage. Methods From January 2017 to January 2019, a total of 153 patients with acute cerebral hemorrhage diagnosed and treated in Chenzhou First People′s Hospital, Hu′nan Province (hereinafter referred to as “our hospital”) were selected as the case group, and 60 healthy physical examinees in our hospital were selected as the control group. According to different prognosis, patients in the case group were divided into 40 cases in death subgroups, 68 cases in good prognosis subgroups and 45 cases in poor prognosis subgroups. CD40 and ICAM-1 expression in serum of two groups were detected by enzyme-linked immunosorbent assay (ELISA). The expression difference between groups and the relationship between the two indexes and clinical characteristics and prognosis were analyzed. Results The expressions of serum CD40 and ICAM-1 in the case group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The expressions of serum CD40 and ICAM-1 in the case group were significantly positively correlated (r = 0.679, P = 0.000). There were significant differences in serum CD40 and ICAM-1 in patients with different cerebral hemorrhage volume and severity of nerve defect (P ＜ 0.05). The expressions of CD40 and ICAM-1 in the death subgroup were significantly higher than those in the good and poor prognosis subgroups, the expressions of serum CD40 and ICAM-1 in the poor prognosis subgroup were significantly higher than those in the good prognosis subgroup, and the differences were statistically significant (P ＜ 0.05). Conclusion The expressions of CD40 and ICAM-1 in the serum of patients with acute cerebral hemorrhage are elevated, they are closely related to the neurological function and prognosis of patients. Monitoring the two indexes is helpful to judge the condition and prognosis of patients with acute cerebral hemorrhage.
2020 Vol. 17 (20): 13-16,20 [Abstract] ( 102 ) HTML (1 KB)  PDF (607 KB)  ( 140 )
17 Study on anti-drug resistant bacteria and antitumor activity of different parts of Tibetan medicine Artemisia vestita in vitro
LI Lei1,2* CUI Herong1* WANG Penglong1* CHEN Jing3* MI Ma3 LEI Haimin1 WANG Chengxiang2
Objective To study on anti-drug resistant bacteria and antitumor activity of different parts from different parts of Tibetan medicine Artemisia vestita in vitro. Methods Stem and leaf of Artemisia vestita were extracted with absolute ethanol and ethyl acetate respectively. The antibacterial activity of different extracts on Methicillin-resistant Staphylococcus aureus (MRSA) was evaluated by K-B paper method, turbidimetric method and flat line marking method. The MTT method was used to detect the inhibition rate of different extracts on human hepatoma cell line HepG2 cells and human cervical cancer cell line HeLa cells. Results After incubation at 37°C for 18 h, the Artemisia vestita leaf absolute ethanol extract (100.00 mg/mL) had the strongest inhibitory effect (5.00 mm) on MRSA (1×107 cfu/mL), and the lowest inhibitory concentration (MIC) was 1.25 mg/mL, the minimum germicidal concentration (MBC) was 5 mg/mL. Highconcentration (500.00 μg/mL) Artemisia vestita leaf ethyl acetate extract showed the best inhibitory activity against human hepatoma cell line HepG2 cells and human cervical cancer cell line HeLa cells. Conclusion Artemisia vestita leaf ethanol extract has better anti-drug resistance to MRSA in vitro, while Artemisia vestita leaf ethyl acetate extract has better antitumor activity.
2020 Vol. 17 (20): 17-20 [Abstract] ( 80 ) HTML (1 KB)  PDF (649 KB)  ( 90 )
21 Diagnostic value of plasma miR-21 and miR-155 levels in pancreatic cancer
LI Xin1 FENG Jin1 GUAN Xing1 DU Meijuan2 MENG Ning3 ZHANG Yubin3
Objective To study the expression and clinical significance of microRNA (miR)-21 and miR-155 in plasma of patients with pancreatic cancer. Methods A total of 88 patients with pancreatic cancer treated in Shijiazhuang First Hospital from April 2017 to May 2019 were selected as the the pancreatic cancer group, 40 cases of chronic pancreatitis were treated as chronic pancreatitis group, and 40 healthy subjects were treated as healthy control group. Fluorescence quantitative PCR (qRT-PCR) was used to detect the expressions of miR-21 and miR-155 in plasma samples of the three groups, and the relationship between the expressions of miR-21 and miR-155 in plasma and clinicopathological features was analyzed in patients with pancreatic cancer. The subject operating characteristic curve was used to analyze the diagnostic value of plasma miR-21, miR-155 and the combined detection for pancreatic cancer. Results The expressions of serum miR-21 and miR-155 in the pancreatic cancer group were significantly higher than those in the chronic pancreatitis group and the healthy control group (all P ＜ 0.05). The expressions of miR-21 and miR-155 in the serum of patients with different tumor differentiation and TNM stage pancreatic cancer were statistically significant (all P ＜ 0.05). There were no statistically significant differences in the expressions of miR-21 and miR-155 in the serum of pancreatic cancer patients with different gender, age, tumor diameter, tumor location, pathological type or whether accompanied by lymph node metastasis (all P ＞ 0.05). The diagnostic value of combined detection of miR-21 and miR-155 was higher than that of any single indicator (all P ＜ 0.05). Conclusion The expressions of miR-21 and miR-155 are increased in patients with pancreatic cancer, and their expression is related to tumor pathological stage and pathological grade. Combined detection of plasma miR-21 and miR-155 has a high diagnostic value in pancreatic cancer.
2020 Vol. 17 (20): 21-24 [Abstract] ( 125 ) HTML (1 KB)  PDF (652 KB)  ( 146 )
25 Clinical effect of radio frequency ablation combined with trans catheter arterial chemoembolization in the treatment of primary liver cancer with portal vein tumor thrombus
RUAN Jianqiu1 CHEN Xin1 ZHANG Honghuan1 YANG Jinzhao2 LI Ronggang3
Objective To investigate the clinical effect of radio frequency ablation (RFA) combined with trans catheter arterial chemoembolization (TACE) in the treatment of primary liver cancer (PHC) with portal vein tumor thrombus (PVTT). Methods A total of 80 PHC patients with PVTT in Jiangmen Central Hospital, Guangdong Province were retrospectively selected from January 2013 to May 2016. According to different treatment methods, they were divided into the study group and the control group, with 40 patients in each group. The control group was treated with TACE and the study group was treated combined with RFA on the basis of the control group. The curative effect, liver function and adverse reactions of the two groups were compared, and the survival of the two groups during the follow-up period was recorded. Results The total clinical response rate of the study group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, glutamate aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBil), alpha fetoprotein (AFP) in the two groups were all decreased compared with those before treatment, while the study group was lower than the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups during treatment (P ＞ 0.05). K-M survival curve analysis found that the survival rate of the study group was significantly higher than that of the control group, with statistically significant difference (P ＜ 0.05). Conclusion PHC patients with PVTT after RFA combined with TACE treatment, the curative effect is accurate, safety is good, the survival rate and survival time of the patients can be improved, and the liver function of the patients can be improved.
2020 Vol. 17 (20): 25-28,33 [Abstract] ( 102 ) HTML (1 KB)  PDF (946 KB)  ( 27 )
29 Research progress of curcumin pharmacological effect and mechanism
SONG Liping1 WANG Yu2
Curcumin is a plant polyphenol extracted from turmeric of traditional Chinese medicine, and it is also the most important active component of turmeric to play a pharmacological role. Modern pharmacological studies have shown that curcumin has anti-tumor, anti-inflammatory, anti-oxidation, anti-fibrosis and myocardial protection and other pharmacological effects. This paper synthesizes the literature of recent years to elaborate the anti-tumor mechanism of curcumin (including inhibiting tumor cell angiogenesis, inhibiting tumor cell proliferation, repressing cell cycle, inducing apoptosis, inhibiting tumor cell migration and invasion, etc.) and the treatment of various tumor, non-tumor diseases by curcumin by exerting its anti-inflammatory, anti-oxidation, anti-fibrotic, myocardial protection, etc., in order to provide reference for the development and utilization of curcumin.
2020 Vol. 17 (20): 29-33 [Abstract] ( 114 ) HTML (1 KB)  PDF (501 KB)  ( 28 )
34 Role of immunoglobulin E in atopic dermatitis
TAN Hanxu1,2 WANG Wenge1
Immunoglobulin E (IgE) plays an important role in the pathogenesis of many autoallergic diseases such as eczema. The study found that the IgE play a role mainly through its high affinity receptor FcεRⅠand low affinity receptors epsilon FcεRⅡ (CD23) in mast cells and basophilic cells, In addition, mast cells and basophilic cells can be activated by the galactosin-3 signaling pathway, eventually lead to the occurrence of autoimmune diseases. This paper reviews the recent literature and analyzes the role and possible pathogenesis of IgE in autoimmune diseases such as eczema, in order to provide guidance for future drug development and clinical work.
2020 Vol. 17 (20): 34-37 [Abstract] ( 108 ) HTML (1 KB)  PDF (479 KB)  ( 131 )
38 Research status of five elements people of traditional Chinese medicine and research progress of related constitution identification methods
ZHANG Weijie1 WANG Jianying2 YIN Xiangyi1 HE Yongmao1 TANG Yunqing1
The theory of five elements people originated from the Spiritual Pivot:Twenty-five Types of People Divided According to Yin and Yang. The book gives a basic exposition of the constitution identification and disease predisposition of five elements people, which is the most complete and important traditional Chinese medicine constitution classification system in the Inner Canon of Yellow Emperor. Based on the analysis of the discussion of five elements people in the original text of the Inner Canon of Yellow Emperor and the progress of modern systematic research, this paper suggests that the existing techniques of traditional Chinese medicine constitution identification can be referred to and combined with modern biological research to jointly lay the foundation for the construction of the five elements people constitution identification technology, so as to provide reference for the health maintenance and clinical diagnosis and treatment of traditional Chinese medicine.
2020 Vol. 17 (20): 38-41 [Abstract] ( 140 ) HTML (1 KB)  PDF (502 KB)  ( 146 )
42 Analysis of physical examination information of 22 560 employees in a large iron and steel group in Tangshan
LI Yunfeng1 HAO Jianchun2 MA Qingkun3 KONG Bin4 ZHANG Lianhua5▲
Objective To understand the physical health of employees of a large iron and steel group in Tangshan, and to provide a basis for health education and prevention. Methods A total of 22 560 employees from a large iron and steel group in Tangshan, from February to December 2017, were selected as survey subjects. The positive detection rate of overweight or obesity, hyperlipidemia, fatty liver, hyperglycemia, hypertension, and liver function abnormality, kidney stones, liver cysts, gallbladder polyps, gallstones, kidney cysts, cholecystitis, thyroid nodules among employees of different ages and genders were compared. Results In this study, the physical examination personnel≥1 physical examination result abnormality was 20 250 people, the abnormal detection rate was as high as 89.76%. Compared with the positive detection rates of different ages, and the differences were highly statistically significant (P ＜ 0.01). Except for the population≥60 years old, the positive detection rate of males in other ages were higher than those of females, and the differences were highly statistically significant (P ＜ 0.01). The positive detection rates of overweight and obesity, hyperlipidemia, hyperglycemia, fatty liver, hypertension, liver dysfunction, kidney stones, and renal cysts among the physical examination personnel of different genders were highly statistically significant (P ＜ 0.01). Conclusion The enterprise is dominated by male employees and has a poorer health status than female employees. Enterprises should pay attention to the potential influencing factors of abnormal physical examination indicators for male employees, strengthening education and learning about healthy life, and formulating health promotion programs, which are of great significance to improving the health of employees.
2020 Vol. 17 (20): 42-45 [Abstract] ( 199 ) HTML (1 KB)  PDF (485 KB)  ( 26 )
46 Research on self-management status quo and influencing factors of patients with non-alcoholic fatty liver disease
LIANG Haili1,2 WANG Hui1,2 WANG Ting1,2 TAO Junxiu1,2 ZHOU Qiong1,2 ZHANG Chuhua1,2
Objective To investigate the self-management situation and influencing factors of patients with nonalcoholic fatty liver disease (NAFLD). Methods Using the convenient sampling method, a total of 217 patients with NAFLD were recruited from the hepatology research clinic of a top three hospital in Wuhan from March to August 2017. The self-management scale, the chronic illness resources survey (CIRS) and general self-efficacy scale (GSES) were used to investigated the patients. Results In self-management of NAFLD patients, the scores of daily life management were (32.36±4.72) points. There were statistically significant differences in the self-management scores of patients with NAFLD in different genders, education degrees and annual income (P ＜ 0.05). The self-management level of patients with NAFLD was positively correlated with various dimensions of chronic disease resource utilization and general self-efficacy (r ＞ 0, P ＜ 0.05). Annual income, gender, workplace, organizational structure, health care team and media policies, and general self-efficacy were the main factors affecting NAFLD self-management (P ＜ 0.05). Conclusion The self-management level of patients with NAFLD is affected by many factors. Nursing staff should implement targeted interventions against controllable factors to promote patient enhancing the level of self-management.
2020 Vol. 17 (20): 46-49,53 [Abstract] ( 214 ) HTML (1 KB)  PDF (535 KB)  ( 76 )
50 Status quo of intercultural communication ability and teaching inspiration of college students in Chinese medicine colleges
HU Liping ZHANG Cunyu
Objective To monitor and evaluate the intercultural communication competence of college students of Chinese medicine colleges and universities, and to provide references and reference for teaching in Chinese medicine colleges and universities. Methods The self-measurement table of the intercultural communication competence of college students of traditional Chinese medicine universities were compiled. From April to September 2019, questionnaire surveys and interviews with students of Beijing University of Chinese Medicine were conducted. The data results were quantitatively and qualitatively analyzed and the differences of the different communication frequencies, educational backgrounds, cultivate in cross-cultural communication abilities of students in categories were compared. Results A total of 234 questionnaires were distributed, and 209 valid questionnaires were recovered, with an effective recovery rate of 89.32%. Intercultural communication ability was positively correlated with language ability, cultural ability, communicative ability and professional ability (r = 0.501, 0.697, 0.587, 0.567, P ＜ 0.05). The language ability, cultural ability, communicative ability and total ability of students with ability were higher than students with low communication frequency, and professional ability was lower than students with low communication frequency, and the differences were statistically significant (P ＜ 0.05). The language ability of postgraduates was lower than that of undergraduates, while the professional ability was higher than that of undergraduates, and the differences were statistically significant (P ＜ 0.05). The differences in language ability and professional ability between students of different training methods were statistically significant (P ＜ 0.05). English comprehensive ability was positively correlated with language ability and overall cross-cultural communication ability (r = 0.653, 0.208, P ＜ 0.05). Conclusion Traditional Chinese medicine universities should cultivate language comprehensive ability, traditional Chinese medicine professional ability of students and promote the practice of intercultural communication for their intercultural communication competence improvement.
2020 Vol. 17 (20): 50-53 [Abstract] ( 125 ) HTML (1 KB)  PDF (484 KB)  ( 38 )
54 The relationship between the platelet to lymphocyte ratio and the stability of coronary plaque in patients with coronary heart disease
SONG Bofan1,2 Nuremanguli·Abudukeremu2 GAO Yanlin1 CHENG Wei1
Objective To study the relationship between platelet (PLT) to lymphocyte (LYM) ratio (PLR) and coronary plaque stability in patients with coronary heart disease (CHD). Methods Two hundred and ninety-two patients with CHD admitted to the Second People′s Hospital of Anhui Province (“our hospital” for short) from January 2016 to January 2019 were selected as CHD group. According to the characteristics of plaque, they were divided into vulnerable plaque group (155 cases) and stable plaque group (137 cases). One hundred and fifty volunteers who took physical examination in our hospital during the same period were selected as control group. Blood cell analysis, blood pressure, blood glucose, blood lipid, liver and kidney function between groups were measured. The risk factors of vulnerable plaque in CHD patients were analyzed by logistic regression, and the diagnostic value of each index was evaluated by ROC curve analysis. Results The body mass index (BMI), the percentage of hypertension and diabetes, C-reactive protein (CRP), serum creatinine (Scr), urea nitrogen (BUN), PLT and PLR in stable plaque group were higher than those in control group, and LYM was lower than that in control group, with statistically significant differences (P < 0.05). BMI, percentage of hypertension and diabetes, CRP, Scr, BUN, FIB and PLR in vulnerable plaque group were higher than those in stable plaque group and control group, triglycerides, LDL cholesterol, total cholesterol, alanine aminotransferase, leukocytes and PLT in vulnerable plaque group were higher than those in control group, LYM of vulnerable plaque group was lower than that of control group, with statistically significant differences (P < 0.05). Multivariate logistic regression analysis showed that PLR (OR = 3.320, 95%CI: 1.622-6.795, P = 0.001), CRP (OR = 2.380, 95%CI: 1.292-4.384, P = 0.005), FIB (OR = 1.862, 95%CI: 1.117-3.105, P = 0.017) were independent risk factors for CHD plaque instability. The sensitivity and specificity of three methods in the diagnosis of CHD was 0.916 and 0.891 respectively. Conclusion PLR is significantly increased in CHD patients, which is an independent risk factor for the stability of coronary plaque. Attention to PLR can guide clinical diagnosis and treatment.
2020 Vol. 17 (20): 54-57,84 [Abstract] ( 105 ) HTML (1 KB)  PDF (1117 KB)  ( 91 )
59 Effect of Trimetazidine combined with Recombinant Human Brain Natriuretic Peptide for Injection in the treatment of chronic ischemic heart failure
WANG Chunlei ZHANG Dan WANG Guidong
Objective To explore the effect of Trimetazidine combined with Recombinant Human Brain Natriuretic Peptide for Injection in the treatment of chronic ischemic heart failure. Methods Eighty patients with chronic ischemic heart failure hospitalized in the First Hospital of Dandong City from October 2016 to October 2019 were selected as research objects, and they were divided into control group (Trimetazidine treatment, 40 cases) and observation group (Trimetazidine combined with Recombinant Human Brain Natriuretic Peptide for Injection treatment, 40 cases) according to the method of random number table. Both groups were treated for 7 days, and the efficacy and adverse reactions of two groups were compared. Left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), stroke volume (SV), cardiac output (CO), left ventricular ejection fraction (LVEF), serum superoxide dismutase (SOD), malondialdehyde (MDA) levels before and after treatment were compared between two groups. Results Total effective rate of observation group was significantly higher than that of control group (P < 0.05). After treatment, LVEDD and LVESD of two groups were shorter than those before treatment, SV and CO were more than those before treatment, LVEF was higher than that before treatment (P < 0.05), and LVEDD and LVESD of observation group were shorter than those of control group, SV and CO were more than those of control group, LVEF was higher than that of control group (P < 0.05). After treatment, serum SOD level of two groups was higher than that before treatment, MDA level was lower than that before treatment (P < 0.05), and serum SOD level of observation group was higher than that of control group, while MDA level was lower than that of control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Trimetazidine combined with Recombinant Human Brain Natriuretic Peptide for Injection has a significant effect on chronic ischemic heart failure, which can significantly improve the cardiac function and oxidative stress state of patients, and have a good safety.
2020 Vol. 17 (20): 59-61 [Abstract] ( 114 ) HTML (1 KB)  PDF (513 KB)  ( 63 )
62 Analysis of changes in plasma renin-angiotensin Ⅱ-aldosterone and heart rate variability in hypertension combined with depression patients
WEI Yuhua1 XIE Chengqin1 GE Beihai2 LIN Guohua3 WEI Yanshi1 LUO Ya1 PAN Runde4
Objective To investigate the changes of renin-angiotensin Ⅱ-aldosterone and heart rate variability in hypertension combined with depression patients. Methods A total of 51 patients with hypertension in the Guangxi Zhuang Autonomous Region Brain Hospital (hereinafter referred to as “our hospital”) from May 2018 to June 2019 were selected. According to the presence or absence of depression, they were divided into hypertension combined with depression group (21 cases) and simple hypertension group (30 cases), while a total of 30 healthy people in the same period in our hospital were selected as the control group. Plasma renin, angiotensin Ⅱ, aldosterone concentration and heart rate variability indicators [standard deviation of normal adjacent RR interval (SDNN), square root of the difference between adjacent RR intervals (RMSSD), the percentage of adjacent RR intervals >50 ms (PNN50)] in three groups were detected and analyzed. Results The levels of renin, angiotensin Ⅱ and aldosterone in hypertension combined with depression group and simple hypertension group were higher than those in the control group, while the levels of renin, aldosterone in hypertension combined with depression group were higher than those in simple hypertension group, and the differences were statistically significant (P ＜ 0.05). The SDNN, RMSSD, and PNN50 of the hypertension combined with depression group and the simple hypertension group were higher than those in the control group, while the hypertension combined with depression group was lower than the simple hypertension group, and the differences were statistically significant (P ＜ 0.05). Conclusion The levels of renin, angiotensin Ⅱ and aldosterone in patients of hypertension combined with depression and simple hypertension are significantly increased, while the level of heart rate variability decreased, and the changes in hypertension combined with depression patients are greater. The joint action of renin-angiotensin system and autonomic dysfunction may be the pathophysiological mechanism of hypertension combined with depression.
2020 Vol. 17 (20): 62-64 [Abstract] ( 102 ) HTML (1 KB)  PDF (562 KB)  ( 120 )
66 Relationship between the levels of serum LP-PLA2, NEFA and severity of coronary artery disease
ZHU Guodong XU Lin LI Zheng
Objective To explore the relationship between the levels of serum lipoprotein phospholipase A2 (Lp-PLA2), non-esterified fatty acid (NEFA) and severity of coronary artery disease. Methods A total of 100 patients with coronary heart disease diagnosed and treated in Yankuang New Journey General Hospital (“our hospital” for short) from July 2016 to December 2018 were selected as the observation group, and a total of 50 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group. The levels of serum LP-PLA2 and NEFA were recorded anong the two groups, patients with different disease counts and patients with different Gensini scores, and the correlation was analyzed. Results The levels of serum LP-PLA2 and NEFA in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The levels of serum LP-PLA2 and NEFA in patients with three-vessel disease were significantly higher than those with double-vessel and single-vessel disease, while patients with double-vessel disease were significantly higher than patients with single-vessel disease, and the differences were statistically significant (P ＜ 0.05). The levels of serum LP-PLA2 and NEFA of patients with Gensini score＞39 points were significantly higher than those other scores, while patients with Gensini scores of 20 to 39 were significantly higher than those with Gensini scores of＜20 points, and the differences were statistically significant (P ＜ 0.05). The levels of serum LP-PLA2, NEFA were positively correlated with the number of lesions (r = 0.592, 0.450, P ＜ 0.05) and Gensini score (r = 0.598, 0.468, P ＜ 0.05). Conclusion The levels of serum LP-PLA2 and NEFA in patients with coronary heart disease are elevated, while the levels of serum LP-PLA2 and NEFA are closely related to the severity of coronary artery disease, and have certain clinical value in the diagnosis and treatment of coronary artery disease.
2020 Vol. 17 (20): 66-69 [Abstract] ( 136 ) HTML (1 KB)  PDF (514 KB)  ( 137 )
70 Meta-analysis of operation combined with Atorvastatin treatment for chronic subdural hematoma
GAN Yanling1 DENG Yu′er1 ZHANG Zhiqiang2 LI Cong2 ZHAN Wengang2 Tan Qijia2 XIE Caijun2
Objective To systematically evaluate the clinical effect of operation combined with Atorvastatin in the treatment of chronic subdural hematoma. Methods Wanfang, CNKI, CBM, PubMed, Embase and Web of Science databases were searched by computer and the retrieval period was from biuilding database to May 2019. Randomized controlled trials of operation combined with Atorvastatin in the treatment of chronic subdural hematoma were included. Meta-analysis was conducted on outcome indicators such as efficiency, incidence of complications and recurrence rate with RevMan 5.3 software. Results Finally, 16 literatures were included. The results of meta analysis showed that the effective rate of treatment group was higher than that of control group (OR = 5.74. 95%CI: 3.83, 8.62, P ＜ 0.05), CSS scores in treatment group was lower than that in control group (MD = -4.37, 95%CI: -5.17, -3.57, P ＜ 0.05), the incidence of infection in treatment group was lower than that of control group (OR = 0.22, 95%CI: 0.10, 0.46, P ＜ 0.05), the incidence of intracranial emphysema in treatment group was lower than that in control group (OR = 0.19, 95%CI: 0.08, 0.45, P ＜ 0.05), the incidence of brain injury in treatment group was lower than that in control group (OR = 0.12, 95%CI: 0.04, 0.36, P ＜ 0.05) and the recurrence rate in treatment group was lower than that in control group (OR = 0.06, 95%CI: 0.03, 0.15, P ＜ 0.05). There was no significant difference in the incidence of the increase of hematoma and the incidence of hepatic and renal dysfunction between treatment group and control group (P > 0.05). Conclusion Operation combined with Atorvastatin in the treatment of chronic subdural hematoma has a definite clinical effect. However, it needs to be verified by multi-center randomized clinical trials with high quality and large samples in the future.
2020 Vol. 17 (20): 70-75,92 [Abstract] ( 108 ) HTML (1 KB)  PDF (1961 KB)  ( 108 )
76 Effect of Topiramate on symptom control and electroencephalogram in children with epilepsy
ZHANG Yuan LIU Xiaoming SANG Yan ZHANG Dongli ZHAO Jiaqiang
Objective To evaluate the effect of Topiramate on symptom control and electroencephalogram in children with epilepsy. Methods From February 2017 to October 2018, 100 epileptic children who admitted to Xuzhou Children′s Hospital of Jiangsu Province were selected as objects. They were divided into the control group and the study group according to the random number table method, with 50 cases in each group. The control group was treated with Oxcarbazepine, and the study group was treated with Topiramate. The clinical efficacy of the two groups was observed. Epilepsy score before and 6 months after treatment, electroencephalogram and quality of life improvement, serum neuropeptide Y (NPY), brain-derived neurotrophic factor (BD-NF) levels and adverse reactions were observed. Results The total effective rate in the study group was higher than that in the control group, and the difference was statistically significant (P < 0.05). The epilepsy scores of the two groups were compared before treatment, and the difference was not statistically significant (P > 0.05); 6 months after treatment, the epilepsy scores of the two groups were lower than those before treatment, the study group was lower than the control group, and the differences were statistically significant (all P < 0.05). Electroencephalogram improvement rate in the study group was higher than that in the control group, and the difference was statistically significant (P < 0.05). Electroencephalogram background activity of the two groups was mainly α wave activity, but there was no significant difference in the activity rates of α, θ, δ waves between the two groups (P > 0.05). There were no significant differences in NPY, BD-NF levels and QOLIE-31 scores between the two groups before treatment (P > 0.05). Six months after treatment, NPY and BD-NF levels in the two groups were lower than those before treatment, and the QOLIE-31 scores were higher than those before treatment, and the differences were statistically significant (all P < 0.05). In addition, NPY and BD-NF levels in the study group were lower than those in the control group, and QOLIE-31 scores were higher than those in the control group, with statistically significant differences (all P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Topiramate therapy in children with epilepsy can effectively improve the clinical treatment effectiveness and the effect of electroencephalogram, so as to effectively improve the quality of life of children.
2020 Vol. 17 (20): 76-79,106 [Abstract] ( 124 ) HTML (1 KB)  PDF (1003 KB)  ( 69 )
80 Effect of head acupuncture combined with swallowing function therapy instrument on patients with ischemic stroke
HUANG Jianfu LIU Jianhao▲ TAN Chunfeng WANG Tianlei XU Qiong
Objective To investigate the effect of head acupuncture combined with swallowing function therapy instrument on patients with ischemic stroke. Methods Ninety patients with ischemic stroke from January 2017 to February 2019 in Sanya Hospital of Traditional Chinese Medicine were divided into control group (45 cases) and observation group (45 cases) according to the random number table method. Both groups were given ischemic conventional treatment of stroke, the control group was given acupuncture treatment, and the observation group was given acupuncture combined with swallowing function treatment instrument. The water swallowing test (WST) grading, standard swallowing assessment (SSA) score, swallowing quality of life questionnaire (SWAL-QOL) score, ultrasound index , treatment effects and adverse reactions and complications of the two groups were compared. Results After 4 weeks of treatment, the overall WST grading level of the two groups was better than that before treatment, and the observation group was better than the control group (P ＜ 0.05). After 4 weeks of treatment, SSA score in both groups decreased, SWAL-QOL score increased, SSA score in the observation group was lower than that in the control group, and SWAL-QOL score was higher than that in the control group, the differences were statistically significant (P ＜ 0.05). After 4 weeks of treatment, the motion amplitude and duration of the two groups were increased, and the motion amplitude of the observation group was significantly higher than that of the control group, while the duration was shorter than that of the control group (P ＜ 0.05). The effective rate of the observation group was significantly higher than that of the control group (P ＜ 0.05). The complication rate of the observation group was significantly lower than that of the control group (P ＜ 0.05). Conclusion The head acupuncture combined with swallowing function treatment is effective in the treatment of swallowing dysfunction in ischemic stroke, and there is no obvious adverse reaction, which can reduce the incidence of complications.
2020 Vol. 17 (20): 80-84 [Abstract] ( 129 ) HTML (1 KB)  PDF (632 KB)  ( 68 )
85 Predictive value of neutrophil/lymphocyte ratio and immediate blood glucose level on short-term prognosis in patients with acute cerebral hemorrhage
LIU Jun
Objective To explore the predictive value of neutrophillymphocyte (NLR) and admission blood glucose (ABG) in the short-term poor prognosis of patients with acute cerebral hemorrhage. Methods A total of 193 patients with acute cerebral hemorrhage admitted to Panjin Liaohe Oilfield Gem Flower Hospital, Liaonig Province from January 2017 to December 2018 were divided into two groups: the poor prevention group (87 cases) and the good prognosis group (106 cases) according to the 90 day modified Rankin scale. The clinical characteristics, biochemical test results and imaging data of the two groups were compared. The influencing factors of short-term prognosis of acute cerebral hemorrhage was analyzed by logistic regression. ROC curve was used to analyze the predictive value of NLR and ABG for short-term poor prognosis of patients with acute cerebral hemorrhage. Results There were significant differences in age, drinking history, diabetes history, the national institutes of health stroke scale score between the two groups (P < 0.05). The proportion of neutrophil count, white blood cell count, ABG, NLR, hematoma volume and the proportion of haemorrhage into ventricle in the poor prognosis group were higher than those in the good prognosis group, and the lymphocyte count was lower than that in the good prognosis group (P < 0.05). Logistic analysis showed that ABG (OR = 2.569, 95%CI [1.569, 5.574], P = 0.002) and NLR (OR = 1.549, 95%CI [1.103, 3.265], P = 0.005) were the high risk factors of poor prognosis in patients with acute cerebral hemorrhage. The area under the curve of ABG in the diagnosis of short-term poor prognosis of acute cerebral hemorrhage was 0.867, 95%CI (0.819, 0.915), the cutoff value was 5.95 mol/L, the sensitivity and specificity were 0.805 and 0.725. The area under the curve under ROC curve of NLR in the diagnosis of short-term poor prognosis of acute cerebral hemorrhage was 0.824, 95%CI (0.655, 0.794), the cutoff value was 2.76, the sensitivity and specificity were 0.897 and 0.453. Conclusion The rising ABG and NLR levels are the risk factors of poor short-term prognosis in patients with acute cerebral hemorrhage. The short-term prognosis of patients can be predicted by detecting the two indexes.
2020 Vol. 17 (20): 85-88 [Abstract] ( 179 ) HTML (1 KB)  PDF (670 KB)  ( 115 )
89 Analysis of the changes of nocturnal blood pressure and the risk factors of stroke in bypertensive patients
CHEN Minglei LIN Kang
Objective To explore the changes of nocturnal blood pressure and the risk factors of stroke in hypertensive patients. Methods A total of 125 hypertensive patients admitted to Sanya Central Hospital from January 2017 to June 2019 due to stroke were selected as the observation group, another 45 patients with simple hypertension and no complications were selected as the control group. 24-hour ambulatory blood pressure monitoring (ABPM) was performed in all patients, and the 24 h systolic blood pressure (24hSBP), 24 h diastolic blood pressure (24hDBP), day systolic blood pressure (dSBP), day diastolic blood pressure (dDBP), nocturnal systolic blood pressure (nSBP), nocturnal diastolic blood pressure (nDBP) were recorded. Whether patients had nocturnal hypertension and the type of circadian rhythm of blood pressure of patients were analyzed, and the risk factors of blood pressure changes was analyzed by logistic regression analysis. Results The nSBP, nDBP and the prevalence of nocturnal hypertension in the observation group were significantly higher than those in the control group (all P ＜ 0.05), the difference of circadian rhythm types between the two groups was statistically significant (P ＜ 0.05). The logistic regression analysis showed that nSBP (OR = 1.446, P = 0.021, 95%CI: 1.058, 1.973), nDBP (OR = 3.064, P = 0.008, 95%CI: 1.507, 6.229), nocturnal hypertension(OR = 14.516, P = 0.014, 95%CI: 1.978，56.058) and circadian rhythm of blood pressure (non-dipper) (OR = 9.347, P = 0.000, 95%CI: 3.716, 17.609) were independent risk factors for stroke. Conclusion The incidence of nocturnal hypertension increased, the circadian rhythm decreased in patients with stroke, nocturnal elevated blood pressure and non-dipper blood pressure are independent risk factors for stroke.
2020 Vol. 17 (20): 89-92 [Abstract] ( 103 ) HTML (1 KB)  PDF (621 KB)  ( 58 )
93 Clinical effect of adjustable lumboperitoneal shunt in the treatment of idiopathic intracranial hypertension
DONG Hao LI Yong XU Yong ZHAO Jingwu SONG Guidong KANG Jun▲
Objective To investigate the clinical effect of adjustable lumboperitoneal shunt in the treatment of idiopathic intracranial hypertension (IIH). Methods The clinical data of 37 patients with visual impairment caused by IIH admitted to the Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University from January 2010 to January 2016 were retrospectively analyzed. All patients underwent adjustable lumboperitoneal shunt. Intracranial pressure, improvement of clinical symptoms before and after operation and postoperative complications were observed. Results In 37 patients, intracranial pressure decreased to below 250 mmH2O after operation. In a total of 71 sides of affected eye, the visual acuity improved on 41 eyes, including 23 eyes in the group with visual acuity ≥0.1 and 18 eyes in the group visual acuity ＜0.1. Among the 30 patients with papilledema, 24 had improved after operation. There was a significant improvement in 19 cases of the 22 patients with headache. Among the 37 patients, 2 cases had shunt obstruction and no infection occurred in all patients. Conclusion It is safe, effective and has a good short-term effect for adjustable lumboperitoneal shunt in the treatment of IIH-induced headache and papilledema, as well as the improvement of visual acuity loss and/or visual field defects. For patients with significant visual acuity loss, active treatment should be performed as soon as possible when visual loss is ≥0.1.
2020 Vol. 17 (20): 93-96,110 [Abstract] ( 85 ) HTML (1 KB)  PDF (1036 KB)  ( 72 )
97 Clinical effect of Xiaoyao Powder addition and subtraction combined with Escitalopram Oxalate in the treatment of elderly patients with post-stroke depression and liver-depression type of fire
ZHAO Shichu1 LU Yanli1 TIAN Zhijun1 SONG Qingyang2
Objective To investigate the clinical effect of Xiaoyao Powder addition and subtraction combined with Escitalopram Oxalate on depressive psychology and daily life ability in the elderly patients with post-stroke depression. Methods A total of 138 elderly patients with post-stroke depression in Beijing Longfu Hospital from February 2018 to November 2019 were selected and divided into the observation group and the control group according to the random number table method, with 69 patients in each group. The control group was treated with Escitalopram Oxalate only, while the observation group was treated with the combination of traditional Chinese and Western medicine treatment with Xiaoyao Powder addition and subtraction combined with Escitalopram Oxalate. After two courses (8 weeks) of treatment, the improvement of depression status, cognitive ability, life ability and social function of patients in the two groups were compared. Results After treatment, the Hamilton depression scale score in the observation group was lower than that of the control group, and the difference was statistically significant (P ＜ 0.05). The score of mini-mental state examination and the Barthel index of activity daily living in the observation group were higher than those in the control group, and the differences were statistically significant (all P ＜ 0.05). The comparison of functional activities questionnaire between the two groups showed no statistically significant difference (P ＞ 0.05). Conclusion The combination of traditional Chinese and Western medicine treatment with Xiaoyao Powder addition and subtraction combined with Escitalopram Oxalate in the elderly stroke patients is more effective in alleviating patients′ depression, improving their mental state and enhancing their activity daily living than the single use of Escitalopram Oxalate.
2020 Vol. 17 (20): 97-100 [Abstract] ( 165 ) HTML (1 KB)  PDF (653 KB)  ( 125 )
101 Expression of serum 25-hydroxyvitamin D, vitamin A and vitamin E in twin premature infants
LIU Kang1 LI Na2 LIU Xian3 PAN Zhaojun1 WU Rong1▲
Objective To observe the expression characteristics of serum 25-hydroxyvitamin D, vitamin A and vitamin E in twin premature infants. Methods Seventy-four twin premature infants who hospitalized in the Neonatal Medical Center of Huai′an Maternal and Child Healthcare Hospital Affiliated to Yangzhou University Medical College in Jiangsu Province from January 2015 to June 2016 were selected as the observation group. In a 1∶1 ratio, 74 single preterm infants with similar diseases and similar gestational age were randomly selected as the control group. The clinical data of the selected premature infants were collected. According to birth weight, the observation group was divided into light fetus group (37 cases) and heavy fetus group (37 cases). According to gestational age, the observation group was divided into small gestational age group (gestational age <32 weeks, 24 cases) and large gestational age group (gestational age ≥32 weeks, 50 cases). According to 25-hydroxyvitamin D, vitamin A and vitamin E deficiency, the observation group was divided into 25-hydroxyvitamin D deficiency group (41 cases) and 25-hydroxyvitamin D non-deficiency group (33 cases); vitamin A deficiency group (24 cases) and vitamin A non-deficiency group (50 cases); Vitamin E deficiency (59 cases) and vitamin E non-deficiency group (15 cases). The serum levels of 25-hydroxyvitamin D, vitamin A and vitamin E within 1 d after birth and the incidence of complications were detected. Results The birth weight of the observation group was lower than that of the control group, and the incidence of maternal gestational hypertension was higher than that of the control group (all P < 0.05). The serum levels of 25-hydroxyvitamin D, vitamin A and vitamin E in the observation group were all lower than those in the control group (all P < 0.05). There was no significant difference in serum levels of 25-hydroxyvitamin D, vitamin A and vitamin E between light fetus group and heavy fetus group (P > 0.05). The serum levels of 25-hydroxyvitamin D, vitamin A and vitamin E in small gestational age group were all lower than those in large gestational age group (all P < 0.05). The incidence of hypoglycemia, necrotizing enterocolitis (NEC) and extrauterine growth retardation (EUGR) in the observation group were higher than those in the control group (all P < 0.05). The incidence of NEC, EUGR and feeding intolerance in light fetus group were all higher than those in heavy fetus group (all P < 0.05). The incidence of respiratory distress syndrome (RDS) and fetal growth restriction (FGR) in 25-hydroxyvitamin D deficiency group were all higher than those in 25-hydroxyvitamin D non-deficiency group (all P < 0.05). The incidence of RDS, bronchopulmonary dysplasia (BPD) and FGR in vitamin A deficiency group were all higher than those in vitamin A non-deficiency group (all P < 0.05). There was no significant difference in the incidence of complications between vitamin E deficiency group and vitamin E non-deficiency group (P > 0.05). Conclusion 25-vitamin D, vitamin A and vitamin E levels of twin premature infants are lower than those of single premature infants with the same gestational age. The levels of 25-hydroxyvitamin D, vitamin A and vitamin E are lower in twin premature infants with small gestational age. Twin premature infants with 25-hydroxyvitamin D deficiency are more likely to have RDS and FGR. Twin premature infants with vitamin A deficiency are more likely to develop RDS, BPD and FGR.
2020 Vol. 17 (20): 101-106 [Abstract] ( 137 ) HTML (1 KB)  PDF (612 KB)  ( 129 )
107 Clinical analysis of 71 children of tuberous sclerosis complex with  epilepsy
ZHAO Qingqing1 HAN Yunli2▲ RUAN Yiyan1 FENG Juntan1 CHEN Yin1 CHEN Yuyi1 WANG Jinqiu1 HUANG Xuelin1
Objective To analyze the clinical data of 71 cases of tuberous sclerosis complex (TSC) with epilepsy, to summarize the clinical characteristics, and to improve the awareness of the disease. Methods Form June 2012 to December 2018, 71 cases of TSC with epilepsy who admitted to the First Affiliated Hospital of Guangxi Medical University and the Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region were selected. Clinical feature, auxiliary examination, treatment outcome were retrospectively analyzed． Results The age of epilepsy onset was ranged from 1 d after birth to 13 years old. The onset forms of epilepsy: focal seizure was 26 cases (36.62%), generalized tonic-clonic seizure was 15 cases (21.13%), generalized convulsions seizure was 11 cases (15.49%), convulsive seizure was 18 cases (25.35%), and absence seizure was 1 case (1.41%). Sixty-six cases (92.96%) were complicated with skin lesions, 43 cases (60.56%) had low intelligence, 71 cases (100%) had abnormal head imaging examination, and 66 cases (92.96%) had abnormal electroencephalogram examination. Nineteen cases gene detetion were positive, 1 case was negative. All the 71 cases were treated with antiepileptic drugs (AEDs), and the total effective rate was 85.91%. Conclusion TSC with epilepsy is more common in children under 1 year old. They often associate with skin lesions and mental retardation, and involve multiple systems. Most epileptic seizures are difficult to control, need a variety of AEDs combined treatment.
2020 Vol. 17 (20): 107-110 [Abstract] ( 126 ) HTML (1 KB)  PDF (551 KB)  ( 131 )
111 Serum SHBG expression and diagnostic value for Uygur gestational diabetes mellitus
SHEN Juanjuan CAI Juejin HA Liya
Objective To investigate serum sex hormone binding globulin (SHBG) expression in gestational diabetes mellitus (GDM) of Uygur women in Xinjiang and its diagnostic value for GDM. Methods From August 2018 to August 2019, 100 cases with Uygur GDM patients in the Second Affiliated Hospital of Xinjiang Medical University were selected as the observation group, 100 Uygur pregnant women in the same period of health examination as the control group. The serum SHBG, fasting blood glucose, fasting insulin, glycosylated hemoglobin (HbA1c) and fasting C peptide level were compared between the two groups of pregnant women in early, middle and late pregnancy. The HOMA-IR was calculated, and the correlation between SHBG level in early pregnancy and other indicators were recorded. The receiver operating characteristic (ROC) was used to analyze the diagnostic value of SHBG level in early pregnancy for GDM. Results The serum SHBG levels in the observation group were lower than those in the control group in early middle and late pregnancy, and the differences were  statistically significant (P < 0.05). HbA1c, fasting C peptide level, fasting blood glucose, fasting insulin and HOMA-IR in the observation group were higher than those in the control group in early middle and late pregnancy, and the differences were statistically significant (all P < 0.05). Serum SHBG level of early pregnancy was negatively correlated with HOMA-IR values (r = -0.869, P < 0.01). The area under the curve of SHBG level in the early pregnancy for diagnosis of GDM was 0.877. Conclusion In different pregnancy stages, serum SHBG level of Uygur GDM pregnant women in Xinjiang is lower and negatively correlated with IR degree. Serum SHBG level in early pregnancy can be an important biochemical indicator for early diagnosis of GDM.
2020 Vol. 17 (20): 111-114 [Abstract] ( 99 ) HTML (1 KB)  PDF (573 KB)  ( 28 )
115 Introduction of professor Wang Xiaoying′s experience in the treatment of menopausal syndrome
ZHAO Mingyu1.2 LYU Bo3
This paper summarizes professor Wang Xiaoying′s academic thoughts on the treatment of menopausal syndrome by sorting out professor Wang Xiaoying′s relevant works, manuscripts, clinical medical cases and clinical teaching notes. Professor Wang Xiaoying thinks that the deficiency of liver and kidney is the basis of the disease, and the imbalance of Yin-Yang is the key to the disease; she also thinks that the hot sweating is not only the first symptom of the disease, but also the main symptom, and that menopausal syndrome should belong to the category of women′s Xue-Lao. Therefore, the treatment mainly includes nourishing liver and kidney, harmonizing Yin-Yang, nourishing blood and calming nerves, and combining disease differentiation with syndrome differentiation. Professor Wang Xiaoying is good at using Wujiadan prescription based on the ancient decoction of  Youjiansan to treat the menopause syndrome.
2020 Vol. 17 (20): 115-117,122 [Abstract] ( 109 ) HTML (1 KB)  PDF (861 KB)  ( 152 )
118 Effect of Recombinant Human Interleukin-11 combined with Docetaxel and Carboplatin in the treatment of advanced non-small cell lung cancer
GAO Eryun CUI Fangbo LI Min
Objective To explore the clinical effect of Recombinant Human Interleukin-11 combined with Docetaxel and Carboplatin in the treatment of advanced non-small cell lung cancer (NSCLC). Methods A total of 80 patients with advanced NSCLC admitted to Maanshan People′s Hospital, Anhui Province from December 2015 to June 2019 were selected and divided into the control group and the treatment group according to the random number table method, with 40 cases in each group. The control group were treated with Docetaxel and Carboplatin, while the treatment group were treated with Recombinant Human Interleukin-11 combined with Docetaxel and Carboplatin for 21 days as one chemotherapy cycle, and both groups were treated for 3 consecutive chemotherapy cycles. The clinical effect of two groups after treatment was evaluated and compared. Eastern cooperative oncology group (ECOG) scores, cytokeratin-19-fragment (CYFRA21-1), insulin-like growth factors-1 (IGF-1), squamous cell carcinoma antigen (SCC-Ag) and peripheral blood CD3+, CD4+, and CD8+ levels were compared between the two groups before and after treatment. The occurrence of toxic side effects during treatment was compared between the two groups. Results The total remission rate in the treatment group was significantly higher than that in the control group, with statistically significant difference (P ＜ 0.05). After treatment, ECOG scores of both groups were lower than those before treatment, and the treatment group was lower than the control group, with statistically significant differences (all P ＜ 0.05). After treatment, serum CYFRA21-1, IGF-1 and SCC-Ag levels in the two groups were all lower than those before treatment, and the treatment group was lower than the control group, with statistically significant differences (all P ＜ 0.05). After treatment, the levels of CD3+ and CD4+ in the control group were lower than those before treatment, and the levels of CD8+ were higher than those before treatment. The levels of CD3+ and CD4+ in the treatment group were higher than those before treatment, and the levels of CD8+ were lower than those before treatment. The levels of CD3+ and CD4+ in the treatment group were higher than those in the control group, and the levels of CD8+ were lower than those in the control group, with statistically significant differences (all P ＜ 0.05). During the treatment, the incidence of toxic side effects in the treatment group was lower than that in the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion Recombinant Human Interleukin-11 combined with Docetaxel and Carboplatin has a significant clinical effect in the treatment of advanced NSCLC, which can improve the physical strength and quality of life of patients, down-regulate the serum CYFRA21-1, IGF-1 and SCC-Ag levels, and improve the immune function of the body.
2020 Vol. 17 (20): 118-122 [Abstract] ( 105 ) HTML (1 KB)  PDF (580 KB)  ( 81 )
123 Effects of Berberine combined with Lapatinib on proliferation and apoptosis of triple negative breast cancer cells
ZHU Jiyang1 CHEN Hua1 XU Yanfang1 SHAO Jinhui2
Objective To investigate the effects of Berberine combined with Lapatinib on proliferation and apoptosis of MDA-MB-231 triple negative breast cancer cells. Methods MTT assay was used to detect the proliferation inhibition of single application for Berberine, Lapatinib and drug combination at different concentrations in MDA-MB-231 triple negative breast cancer cells. CompuSyn software was used to analyze the combined index CI of different dose groups and determine the best combined scheme. The cells were randomly divided into 4 groups: the blank control group, the Berberine group, the Lapatinib group and the drug combination group, and the optimal combination dose selected was used for drug intervention respectively. Flow cytometry was used to detect apoptosis in each group. Results Compared with the single drug, the combination of Berberine and Lapatinib inhibited the proliferation of MDA-MB-231 cells more significantly, and the difference was statistically significant (P ＜ 0.05). CompuSyn software analysis results showed that the CI value of each combined dose was ＜ 1, indicating that the two drugs had synergistic inhibitory effect. The dose group with the lowest CI value was selected for subsequent experiments. Compared with the the blank control group, the total apoptosis rate of the Berberine group and the Lapatinib group increased, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Compared with the Berberine group and the Lapatinib group, the total apoptosis rate of the combined treatment group was increased, and the differences were statistically significant (P ＜ 0.05). Conclusion Berberine combined with Lapatinib can enhance the ability of the proliferation inhibition and induce apoptosis of MDA-MB-231 triple negative breast cancer cells.
2020 Vol. 17 (20): 123-126 [Abstract] ( 180 ) HTML (1 KB)  PDF (787 KB)  ( 106 )
127 Changes of serum GP73 level in patients with primary hepatocellular carcinoma before and after TACE and its clinical value
ZHANG Li XIAO Wei CHEN Kuangrong ZHANG Huiling LI Hui DENG Licong ZHANG Hongwei
Objective To investigate the clinical significance of changes of serum Golgi protein 73 (GP73) level in patients with primary hepatocellular carcinoma (PHC) undergoing transcatheter arterial chemoembolization (TACE) before and after operation, so as to understand whether GP73 can be used as an evaluation index of TACE efficacy. Methods A total of 88 patients with PHC concurrent TACE in the First People′s Hospital of Ziyang, Sichuan Province from September 2016 to October 2018 were enrolled and divided into the improvement group (39 cases) and the deterioration group (49 cases) according to the treatment effect of TACE. The changes of GP73, alpha-fetal protein (AFP) and liver function before and after TACE were recorded. Results The serum GP73 level in the improvement group decreased 1 week after operation compared with that before operation, with statistically significant difference (P ＜ 0.05). Compared with those before and 1 week after the operation, serum GP73 level in the improvement group decreased 1 month after operation, with statistically significant difference (P ＜ 0.05). Compared with that before operation, serum GP73 level in the deterioration group increased 1 week and 1 month after operation, and 1 month after operation was higher than 1 week after operation, with statistically significant differences (all P ＜ 0.05). Serum GP73 level in the improvement group was lower than that in the deterioration group 1 week and 1 month after operation, and the differences were statistically significant (all P ＜ 0.05). One week before TACE, serum GP73 level was not correlated with AFP (rs = 0.056, 0.192, P = 0.613,0.077). Serum GP73 was positively correlated with total bilirubin (rs = 0.295, P = 0.006), and positively correlated with alanine transaminase (rs = 0.301, P = 0.005). Conclusion GP73 may be an effective indicator for evaluating the efficacy of TACE in PHC patients before and after operation, and can reflect the liver function of PHC patients. Effectiveness of GP73 in efficacy monitoring in patients with AFP negative needs to be further expanded to draw conclusions.
2020 Vol. 17 (20): 127-130,139 [Abstract] ( 112 ) HTML (1 KB)  PDF (965 KB)  ( 41 )
131 Guiding role of MiniPDX model in the treatment of advanced lung cancer patients with malignant pleural effusion
JIA Lin CHEN Yiwen JIANG Haosheng HUA Hongwei DING Gang▲
Objective To explore the role of MiniPDX model in guiding the treatment of advanced lung cancer patients with malignant pleural effusion. Methods A total of 30 hospitalized patients with definite diagnosis of advanced lung cancer with malignant pleural effusion were selected from Shanghai International Medical Center from June 2017 to May 2019. They were randomly divided into the MiniPDX group and the control group at 1∶1, with 15 cases in each group. Both groups had received at least first-line treatment in the past and were complicated with malignant pleural effusion after relapse or disease progression. The pleural fluid of patients in the MiniPDX group was extracted to establish a MiniPDX model, and the sensitivity of the relevant treatment drugs was detected. The results of the study were used to guide the treatment of the patients in the group. The control group received only empirical treatment. The objective remission rate (ORR), disease control rate (DCR), progression free survival (PFS), and overall survival (OS) of the two groups were compared. Results Compared with the control group, ORR and DCR in MiniPDX group were improved, OS and PFS were prolonged, and the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01). Conclusion MiniPDX model has certain value in guiding the treatment of advanced lung cancer patients with malignant pleural effusion, and can improve the prognosis of patients.
2020 Vol. 17 (20): 131-134 [Abstract] ( 96 ) HTML (1 KB)  PDF (622 KB)  ( 81 )
135 Effect of Kangfuxin Liquid ultrasonic mist therapy combined with Sanshi Shengxin Cream external application on wound healing after mixed hemorrhoids operation
GAO Xiang1 HONG Likai1 SHEN Wei1 GONG Zhuyun2 LI Ming3
Objective To observe the effect of Kangfuxin Liquid ultrasonic mist therapy combined with Sanshi Shengxin Cream external application on the patients after external stripping and internal ligation of mixed hemorrhoids. Methods A total of 80 patients with mixed hemorrhoids treated in the Second Affiliated Hospital of Anhui University of Traditional Chinese Medicine from January 2015 to December 2019 were selected. The patients were divided into control group (Kangfuxin Liquid ultrasonic mist therapy) and observation group (Kangfuxin Liquid ultrasonic mist therapy combined with Sanshi Shengxin Cream external application) by the random number table method, with 40 cases in each group. Postoperative treatment lasted 9 days, the curative effects of the two groups were compared. The edema resolution time and wound healing time were observed in the two groups. The complications and the changes of anal function index before and after treatment were recorded and compared between the two groups. The quality of life before and after treatment was compared between the two groups. Results The total effective rate of the observation group was higher than that of the control group (P ＜ 0.05). The edema resolution time and wound healing time in the observation group were significantly shorter than those in the control group (all P ＜ 0.05). The degree of fever, pain, perianal edema, bleeding and exudation in the observation group were significantly lighter than those in the control group (P ＜ 0.05). Compared with before treatment, after treatment the anal canal resting pressure, anal canal diastolic blood pressure, anal canal maximum systolic blood pressure in the two groups were significantly increased, anal canal high pressure zone length was significantly shortened (P ＜ 0.05), and the anal canal resting pressure, anal canal diastolic blood pressure, anal canal maximum systolic blood pressure in the observation group was higher those in the control group, anal canal high pressure zone length was shorter than that in the control group (P ＜ 0.05). After treatment, the quality of life scores of the two groups were higher than before treatment, and the observation group was higher than the control group (P ＜ 0.05). Conclusion Kangfuxin Liquid ultrasonic mist therapy combined with Sanshi Shengxin Cream external application has a significant effect in the treatment of patients with mixed hemorrhoids after external stripping and internal ligation. It can accelerate wound healing, reduce and alleviate the occurrence of complications, and improve the quality of life of patients.
2020 Vol. 17 (20): 135-139 [Abstract] ( 149 ) HTML (1 KB)  PDF (472 KB)  ( 68 )
140 Comparison of therapeutic effect of three different treatments for cerebrospinal fluid leakage induced by spinal surgery 
CHU Zhaoming CHEN Ming LYU You QIN Rujie LIU Yi
Objective To compare the effects of three methods of wound compression bandaging, subarachnoid tube drainage and prolonged incision drainage on cerebrospinal fluid leakage after spinal surgery. Methods From March 2008 to March 2017, 183 patients from the Department of Spine Surgery, the First People′s Hospital of Lianyungang, Jiangsu Province, with cerebrospinal fluid leakage after spinal surgery were retrospectively analyzed. They were divided into three groups: wound compression bandaging method with 61 cases (group A), subarachnoid tube drainage methods with 25 cases (group B), prolonged incision drainage method with 97 cases (group C) according to the postoperative treatment method. The cerebrospinal fluid leakage time, incision healing time, dressing change times, success rate of initial treatment and incidence of complications were compared among the three groups, as well as the incidence of postoperative fever, headache, increased inflammatory indicators, abnormal incision pain and muscle dyspepsia. Results The cerebrospinal fluid leakage time, incision healing time in group C, group B was shorter than those in the group A, the frequency of dressing change was less than that in group A, the cerebrospinal fluid leakage time, incision healing time in group C were shorter than that in the group B, the dressing change times was less than that in group B. The success rate of initial treatment in group C was higher than that in group A and B, and the incidence of complications in group C and group B was lower than that in group A, with statistically significant differences (P ＜ 0.05). However, there was no statistically significant difference in the success rate of initial treatment between group A and group B or the incidence of complications between group C and group B (P ＞ 0.05). Postoperative fever, increased inflammatory indicators, headache, abnormal incision pain, muscle strength hypoesthesia, and total occurrence in group B and group C were all less than those in group A, with statistically significant differences (P ＜ 0.05). There was no significant difference between group B and group C (P ＞ 0.05). Conclusions Prolonged incision drainage is a simple and efficient treatment for cerebrospinal fluid leakage after spinal surgery.
2020 Vol. 17 (20): 140-143 [Abstract] ( 108 ) HTML (1 KB)  PDF (464 KB)  ( 69 )
144 Discussion on the idea of professor Cui Shusheng′s massage treatment for internal diseases from “eight methods of abdomen”
SUN Bo1 CUI Shusheng2 JIANG Mengjia2 ZHANG Li′na3 GENG Junlong4
“Eight methods of abdomen” is a commonly used combination of clinical techniques of professor Cui Shusheng, including eight methods of “scraping rib arch”, “kai si men”, “dian san wan”, “tonifying Shénquē”, “penetrating Tiānshū”, “activating Qìhǎi”, “lifting and shaking the abdomen” and “gently rubbing the abdomen”. This paper sums up the specific operation steps of the combination of this technique, and sums up the “zhi zhen dian xue, yi xin tong shou” of professor Cui Shusheng′s operation techniques. In clinical treatment, “the method follows the syndrome, and the technique follows the method”. In the diagnosis and treatment process, “the whole syndrome differentiation and treatment should be based on the principle of conformity”. And then sums up the academic thought of “holistic differentiation and treatment” of Cui Shusheng′s massage diagnosis and treatment for internal diseases. Through the manipulation of massage, all parts of the human body can move smoothly and achieve dynamic balance between material and function, part and whole, acupoints and meridians.
2020 Vol. 17 (20): 144-147 [Abstract] ( 97 ) HTML (1 KB)  PDF (632 KB)  ( 169 )
148 Liu Jianqiu′s treatment experience on chronic bronchitis alleviation of syndrome of intermingling of phlegm and static blood with point-application of Fuxue Huatan Quyu Ointment
WANG Xuehui1 GAO Shen2 ZHANG Yingying3
This article introduces professor Liu Jianqiu′s clinical experience on chronic bronchitis alleviation of  syndrome of intermingling of phlegm and static blood with point-application of Fuxue Huatan Quyu Ointment. Professor Liu holds that the pathogenesis of the disease are yang deficiency, lung-liver disharmony and phlegm and blood stasis. It is suggested that the disease can be eliminated by warming yang at the first time, and relieving the stagnation of liver, promoting blood circulation and removing blood stasis. Although chronic bronchitis alleviation often manifest as “excessive syndrome”, the disease actually caused by deficiency in origin and excess in superficiality. The syndrome of intermingling of phlegm and static blood is infected by yang deficiency and lung-liver disharmony. Therefore, in terms of treatment, we should give consideration to both the specimen and the internal and external treatment. Fuxue Huatan Quyu Ointment is professor Liu′s application of traditional Chinese medicine, combined with many years of clinical experience and the main points of treatment of the disease. After many years of clinical application and treatment, it has achieved good results, so it is worth further discussion and research.
2020 Vol. 17 (20): 148-150,155 [Abstract] ( 71 ) HTML (1 KB)  PDF (642 KB)  ( 81 )
151 Clinical effect of Jiawei Fuling Sini Decoction in the treatment of chronic heart failure
YIN Junyan1 GONG Ying2 GU Wanli1
Objective To investigate clinical effect of Jiawei Fuling Sini Decoction in the treatment of chronic heart failure. Methods One hundred and seventy-eight patients with chronic heart failure of yang deficiency and blood stasis type admitted to Department of Cardiology of Liaocheng People′s Hospital from March 2018 to October 2019 were divided into control group (89 cases) and observation group (89 cases) according to the random number table method. Control group was treated with conventional Western medicine, and observation group was treated with modified formula granules of Fuling Sini Decoction on the basis of control group. Lee heart failure score, 6-min walking distance, traditional Chinese medicine syndrome score and N-terminal pro B-type brain natriuretic peptide (NT-proBNP) level were compared between two groups before and after treatment. Therapeutic effect of New York Heart Association (NYHA) heart function grading, the therapeutic effect of traditional Chinese medicine syndrome and the adverse reactions during treatment between two groups were compared. Results Total effective rate of NYHA in observation group was higher than that in control group (P < 0.05). After treatment, Lee heart failure scores in two groups were lower than those before treatment (P < 0.05), and that in observation group was lower than that in control group (P < 0.05). The walking distance of 6 minutes after treatment in two groups was longer than that before treatment (P < 0.05), and observation group was longer than that in control group (P < 0.05). After treatment, traditional Chinese medicine syndrome scores of two groups were lower than those before treatment (P < 0.05), and observation group was lower than control group (P < 0.05). Total effective rate of traditional Chinese medicine syndrome in observation group was higher than that in control group (P < 0.05). The levels of NT-proBNP in two groups after treatment were lower than those before treatment (P < 0.05), and that in observation group was lower than that in control group (P < 0.05). There were no adverse reactions in two groups. Conclusion Jiawei Fuling Sini Decoction can improve the therapeutic effect of chronic heart failure of yang deficiency and blood stasis type, improve the symptoms of heart failure and heart function of patients, and it is safe to use.
2020 Vol. 17 (20): 151-155 [Abstract] ( 142 ) HTML (1 KB)  PDF (642 KB)  ( 172 )
156 Zhu Shengliang′s experience in the treatment of non-steroidal anti-inflammatory drug-related gastric diseases
ZHENG Xinchun1 ZHU Shengliang2
Non-steroidal anti-inflammatory drug-related gastric diseases are due to the damage of gastric mucosa caused by the use of non-steroidal anti-inflammatory drugs. The incidence rate is higher and higher, and Western medicine lacks good treatment methods at present. Through long-term clinical practice, professor Zhu Shengliang has accumulated rich experience in treating stomach diseases related to non-steroidal anti-inflammatory drugs. Professor Zhu believes that the use of non-steroidal anti-inflammatory drugs is the cause of this disease. The pathogenesis of the diseases are based on weakness of spleen and stomach. Dampness and heat, qi stagnation and blood stasis are important conditions. The syndrome is asthenia in origin and sthenia in superficiality. The treatment is to strengthen the spleen and nourish the stomach, clear the dampness and heat, promote blood circulation and remove blood stasis, regulate the activity of qi, coordinate the rise and fall of qi. Follow this guideline to choose the right Chinese medicine. The advantages of traditional Chinese medicine have been brought into full play and a good clinical effect has been achieved. This paper will introduce professor Zhu Shengliang′s clinical experience in the treatment of non-steroidal anti-inflammatory drug related gastric diseases, also introduce a case.
2020 Vol. 17 (20): 156-159 [Abstract] ( 143 ) HTML (1 KB)  PDF (650 KB)  ( 54 )
160 Clinical effect of abdominal acupuncture combined with Chaihu Shugan Powder in the treatment of perimenopausal insomnia with qi stagnation type
YU Mei WANG Yingchao LI Ling YANG Min
Objective To observe clinical effect of Chaihu Shugan Powder combined with abdominal acupuncture in the treatment of perimenopausal insomnia with qi stagnation type. Methods Ninety-two patients with qi stagnation were selected in Menopause Clinic of Beijing Aerospace General Hospital from January 2018 to September 2019. They were divided into control group and observation group according to the random number table method, with 46 cases in each group. Control group was treated with Chaihu Shugan Powder, observation group was treated with abdominal acupuncture on the basis of control group, both groups were treated for 4 weeks. Clinical efficacy, Pittsburgh sleep quality index (PSQI) score and modified Kupperman index score of two groups were compared. Results After treatment, the sleep quality, sleep latency, length of sleep, sleep disorder, sleep efficiency, daytime function scores and PSQI total score of two groups were lower than those before treatment (P < 0.05), and observation group was lower than control group (P < 0.05). After treatment, modified Kupperman index scores of two groups were lower than those before treatment (P < 0.05), and observation group was lower than control group (P < 0.05). Total effective rate of observation group was significantly higher than that of control group (P < 0.05). Conclusion Chaihu Shugan Powder combined with abdominal acupuncture can improve the clinical effect of perimenopausal insomnia with qi stagnation, better improve the symptoms of patients and enhance sleep quality, it is worthy of clinical promotion.
2020 Vol. 17 (20): 160-163 [Abstract] ( 106 ) HTML (1 KB)  PDF (670 KB)  ( 92 )
164 Analysis of medical advice of potential metabolic drug interactions in psychiatric inpatients
WANG Jing LIU Yan WANG Jianxin
Objective To understand the situation of combined drug use in the medical advice of psychiatric inpatients, analyze the potential drug interaction, and provide reference for clinical drug use. Methods A total of 1658 operational medical records were selected from psychiatric inpatients in the First Hospital of Hebei Medical University (hereinafter referred to as “our hospital”) from July to December 2018 were selected, the medical orders of two or more drugs were screened and counted, and the potential drug interactions were analyzed from the perspective of cytochrome P450 enzyme (CYP450). Results The subtypes of CYP enzymes involved mainly include CYP3A4, CYP2D6, CYP2C9 and CYP2C19, among which CYP2D6 has the most cases, mainly CYP2D6 substrate combined with inhibitors; CYP3A4 was involved in the most medical orders, mainly CYP3A4 substrate combined with substrate. A total of 156 times of 3 or more drugs acting by the same metabolic enzyme, a total of 80 times of 2 or more drugs undergoing 2 metabolic actions. Conclusion There are many potential metabolic drug interactions among psychiatric inpatients in our hospital. The combination of multiple drugs increases the risk of medical treatment, and it is necessary to strengthen the monitoring of therapeutic drugs in clinical application, so as to improve the safety and efficacy of drugs.
2020 Vol. 17 (20): 164-167 [Abstract] ( 97 ) HTML (1 KB)  PDF (317 KB)  ( 70 )
168 Effect of standardized pain assessment on pain and sleep quality of patients in clinical liver surgery
ZHANG Xiaolei SHAN Shihan▲ XIA Xuefeng FU Qiaomei
Objective To explore the influence of standardized pain assessment on pain and sleep quality of patients in clinical liver surgery. Methods From February 2016 to March 2018, 126 patients with liver cancer undergoing liver surgery in Gulou Hospital affiliated to Nanjing University School of Medicine (hereinafter referred to as “our hospital”) were selected as study subjects, from February 2016 to February 2017, 63 patients admitted to our hospital were taken as the control group, from March 2017 to March 2018, 63 patients admitted to our hospital were treated as the observation group. The control group adopted traditional health education and pain assessment measures, and the observation group received standardized pain assessment, physical analgesia and drug analgesia on the basis of the control group. The pain degree, sleep quality and satisfaction were compared between the two groups. Results The pain degree of the observation group was lower than that of the control group at 3 h, 12 h, 1 d, 2 d and 3 d after surgery, and the difference was statistically significant (all P ＜ 0.05). The sleep time, amouto sleep, hypnotic drugs, sleep disorders, sleep efficiency, dysfunction, sleep quality scores and total scores of the observation group were all lower than those of the control group 3 d after surgery, and the differences were statistically significant (all P ＜ 0.05). The satisfaction of the observation group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The application of standardized pain assessment in clinical liver surgery can effectively relieve patients′ pain, improve their sleep quality and satisfaction, which is worthy of clinical promotion.
2020 Vol. 17 (20): 168-171 [Abstract] ( 189 ) HTML (1 KB)  PDF (567 KB)  ( 95 )
172 Application of intraoperative position management based on patients′ role experience in operating room nursing and observation of continuous improvement quality
WANG Wenlong1* XU Xiaoqing2* HUANG Xiantao3
Objective To explore the application of intraoperative position management based on patient role experience in operating room nursing and continuous improvement of quality. Methods From January 2018 to October 2019, the operating room of the First Affiliated Hospital of Hebei North University takes nursing groups as units, thirty operating room nurses were included as study subjects, provide training on common position placement for operating room nurses, and intraoperative postural management intervention based on patient′s role experience was carried out for nurses. The patient′s role experience was carried out and the body position simulation training was carried out, and the training period was 1 month, the whole course video training content is made into teaching video. The satisfaction degree of 520 patients was investigated before and after the training, the position placement score and the method of position placement were compared before and after the training, and incidence of complications of improper position placement in the operating room were compared. Results After the training, the exposed area of operative field, respiration cyle, non-compression of blood vessels and nerves, protect for patient privacy, warmth of skin, selection of postural objects, anti-pressure ulcer measures, functional position of limbs were all higher than those before the training, with statistically significant differences (P ＜ 0.05). Patients′ satisfaction after training was higher than that before training, and the difference was statistically significant (P ＜ 0.05). After the training, the nurses′ overall mastery rate of the operative position placement method was higher than that before the training, with statistically significant difference (P ＜ 0.05). Conclusion The application of intraoperative position management based on the patients′ role experience in operating room nursing can improve nurses′ mastery of surgical position placement scores and methods, and improve patient satisfaction.
2020 Vol. 17 (20): 172-175 [Abstract] ( 169 ) HTML (1 KB)  PDF (530 KB)  ( 40 )
176 Effect of Traditional Chinese medicine rehabilitation nursing on self-nursing ability and quality of life of patients with acute myocardial infarction after percutaneous coronary intervention
CHEN Fangjie WANG Fengrong
Objective To explore the effect of traditional Chinese medicine rehabilitation nursing on self-nursing ability and quality of life of patients with acute myocardial infarction after percutaneous coronary intervention (PCI). Methods From January 2017 to June 2019, 112 patients with acute myocardial infarction after PCI were enrolled in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, according to the random number table method, they were divided into two groups, with 56 cases in each group. The control group adopted comprehensive nursing mode, the observation group adopted the rehabilitation nursing mode of traditional Chinese medicine. Before and after the intervention, the exercise of self-care agency, self rating anxiety scale (SAS), self rating depression scale (SDS) scores and health promoting lifestyle profileⅡ(HPLP-Ⅱ) score were evaluated, the nursing effect of the two groups was compared. Results After intervention, scores of self-concept, self-responsibility, self-nursing skills and health knowledge of patients in both groups were higher than those before intervention, and scores of self-concept, self-responsibility, self-nursing skills and health knowledge in the observation group were higher than those in the control group, with statistically significant differences (all P ＜ 0.05). After intervention, SAS, SDS scores of two groups were lower than those before intervention, HPLP-Ⅱ score was higher than that before intervention, and SAS, SDS scores of the observation group after the intervention were lower than those the control group, HPLP-Ⅱ score was higher than that the control group, the differences were statistical significance (all P ＜ 0.05). The nursing efficiency of the control group was lower than that of the observation group, the difference was statistically significant (P ＜ 0.05). Conclusion Traditional Chinese medicine rehabilitation nursing can improve the self-nursing ability, quality of life and bad mood of patients with acute myocardial infarction after PCI.
2020 Vol. 17 (20): 176-179 [Abstract] ( 168 ) HTML (1 KB)  PDF (565 KB)  ( 85 )
180 Effect of holistic nursing on primigravida′s labor stage
QU Xinhua SONG Linlin LI Ning LIU Shaohua
Objective To investigate the effect of holistic nursing on primigravida′s labor stage. Methods Retrospective case-control study was used, the study was conducted on the 200 primigravidas who underwent vaginal delivery before and after holistic nursing in Yantai Affiliated Hospital of Binzhou Medical University. From April to June 2014, 100 primigravida were selected as the control group, from April to June 2019, 100 primigravida were enrolled in the study group. The primigravida in the control group received health education from nurses in wards and nursing measures from midwives in delivery rooms, the primigravida in the study group received health education from nurses in wards and holistic nursing measures from midwives in delivery rooms. The duration of total labor, the first, second and third stage of labor were analyzed and compared between the two groups. Results The duration of total and the first stage of labor in the study group were shorter than those in the control group, and the differences were statistically significant between the two groups(P ＜ 0.05). There were no significant differences in the duration of the second and third stages of labor (P ＞ 0.05). Conclusion The implementation of holistic nursing model in the delivery room conforms to the current bio-psycho-social model and can effectively shorten the total and the first stage of labor. The application of this measure in the delivery room should be vigorously promoted.
2020 Vol. 17 (20): 180-183 [Abstract] ( 97 ) HTML (1 KB)  PDF (566 KB)  ( 165 )
184 Review and thinking on compiling process of expert consensus for clinical application of Chinese patent medicine
YAN Dengying1 LI Xiaodong1，2，3 LI Hengfei2，3 XIAO Mingzhong2，3 SHENG Guoguang2，3 ZHANG Jia1 ZHU Hui1
Chinese patent medicine plays an important role in the inheritance and development of traditional Chinese medicine in China. However, its clinical application and development is facing a huge dilemma. This paper is aimed at the compiling process of expert consensus for clinical application of Chinese patent medicine developed by Standardization Department of China Association of Chinese Medicine, simultaneously combined with global and practical experience, reviewes and summarizes the experience and precautions in the preliminary preparation and development process, in order to provide skills and references to the development work relevant personnel, and provide inspiration for continuous optimization of the development process and direction for future research work.
2020 Vol. 17 (20): 184-189 [Abstract] ( 138 ) HTML (1 KB)  PDF (596 KB)  ( 134 )
190 Strategy exploration on propaganda and public opinion system of a regional medical center in dealing with emergent events of public health
YAN Jianjun1 GAO Xinyue2 YAO Haihong3 WU Ruilian4 CHEN Yiwen4 CAO Lijing4
In the omnimedia era, how to effectively carry out public opinion management has become a crucial task for a hospital. Especially when faced with emergent events of public health, the sensitivity, response, communication, guidance as well as credibility shown by the propaganda and public opinion system of a hospital will play a decisive role. In recent years, when it comes to emergent events of public health, as a regional medical center, Shanghai Pudong New Area Gongli Hospital has fully integrated all administrative departments including information, publicity, outpatient service, etc. with some clinical departments. Thanks to the internet plus, it has innovated a set of effective responding methods in propaganda and public opinion issues and has achieved good results by properly guiding the public opinion, promoting positive energy, establishing network platform and exploring the embryonic form of internet hospital with all-appointment outpatient service, which has also offered a valuable reference for the propaganda and public opinion system of healthcare industry in using internet to deal with emergent events of public health.
2020 Vol. 17 (20): 190-193 [Abstract] ( 180 ) HTML (1 KB)  PDF (567 KB)  ( 301 )
194 Characteristics and inspiration of foreign health care systems
ZHOU Yisi
Health care system reform is a significant livelihood project. It is a reference for China to deepen the reform of the health system and create a national health system through drawing on the foreign experiences rationally. Based on the analysis of the characters and practices of health care systems in Turkey, Netherlands and Finland, this paper presents some suggestions of health service system construction, health supervision, talent team construction, medical insurance operation mechanism, which can be used for reference in our country.
2020 Vol. 17 (20): 194-封三 [Abstract] ( 123 ) HTML (1 KB)  PDF (774 KB)  ( 54 )
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