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| Relationship between the levels of serum LP-PLA2, NEFA and severity of coronary artery disease |
| ZHU Guodong XU Lin LI Zheng |
| Department of Cardiovascular, Yankuang New Journey General Hospital, Shandong Province, Zoucheng 273500, China |
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Abstract Objective To explore the relationship between the levels of serum lipoprotein phospholipase A2 (Lp-PLA2), non-esterified fatty acid (NEFA) and severity of coronary artery disease. Methods A total of 100 patients with coronary heart disease diagnosed and treated in Yankuang New Journey General Hospital (“our hospital” for short) from July 2016 to December 2018 were selected as the observation group, and a total of 50 healthy patients who underwent physical examination in our hospital during the same period were selected as the control group. The levels of serum LP-PLA2 and NEFA were recorded anong the two groups, patients with different disease counts and patients with different Gensini scores, and the correlation was analyzed. Results The levels of serum LP-PLA2 and NEFA in the observation group were significantly higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The levels of serum LP-PLA2 and NEFA in patients with three-vessel disease were significantly higher than those with double-vessel and single-vessel disease, while patients with double-vessel disease were significantly higher than patients with single-vessel disease, and the differences were statistically significant (P ＜ 0.05). The levels of serum LP-PLA2 and NEFA of patients with Gensini score＞39 points were significantly higher than those other scores, while patients with Gensini scores of 20 to 39 were significantly higher than those with Gensini scores of＜20 points, and the differences were statistically significant (P ＜ 0.05). The levels of serum LP-PLA2, NEFA were positively correlated with the number of lesions (r = 0.592, 0.450, P ＜ 0.05) and Gensini score (r = 0.598, 0.468, P ＜ 0.05). Conclusion The levels of serum LP-PLA2 and NEFA in patients with coronary heart disease are elevated, while the levels of serum LP-PLA2 and NEFA are closely related to the severity of coronary artery disease, and have certain clinical value in the diagnosis and treatment of coronary artery disease.
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