手术联合阿托伐他汀治疗慢性硬膜下血肿效果的meta分析

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Abstract Objective To systematically evaluate the clinical effect of operation combined with Atorvastatin in the treatment of chronic subdural hematoma. Methods Wanfang, CNKI, CBM, PubMed, Embase and Web of Science databases were searched by computer and the retrieval period was from biuilding database to May 2019. Randomized controlled trials of operation combined with Atorvastatin in the treatment of chronic subdural hematoma were included. Meta-analysis was conducted on outcome indicators such as efficiency, incidence of complications and recurrence rate with RevMan 5.3 software. Results Finally, 16 literatures were included. The results of meta analysis showed that the effective rate of treatment group was higher than that of control group (OR = 5.74. 95%CI: 3.83, 8.62, P ＜ 0.05), CSS scores in treatment group was lower than that in control group (MD = -4.37, 95%CI: -5.17, -3.57, P ＜ 0.05), the incidence of infection in treatment group was lower than that of control group (OR = 0.22, 95%CI: 0.10, 0.46, P ＜ 0.05), the incidence of intracranial emphysema in treatment group was lower than that in control group (OR = 0.19, 95%CI: 0.08, 0.45, P ＜ 0.05), the incidence of brain injury in treatment group was lower than that in control group (OR = 0.12, 95%CI: 0.04, 0.36, P ＜ 0.05) and the recurrence rate in treatment group was lower than that in control group (OR = 0.06, 95%CI: 0.03, 0.15, P ＜ 0.05). There was no significant difference in the incidence of the increase of hematoma and the incidence of hepatic and renal dysfunction between treatment group and control group (P > 0.05). Conclusion Operation combined with Atorvastatin in the treatment of chronic subdural hematoma has a definite clinical effect. However, it needs to be verified by multi-center randomized clinical trials with high quality and large samples in the future.

Key words： Chronic subdural hematoma Atorvastatin Surgery Meta analysis

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	GAN Yanling1 DENG Yu′er1 ZHANG Zhiqiang2 LI Cong2 ZHAN Wengang2 Tan Qijia2 XIE Caijun2

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GAN Yanling1 DENG Yu′er1 ZHANG Zhiqiang2 LI Cong2 ZHAN Wengang2 Tan Qijia2 XIE Caijun2. Meta-analysis of operation combined with Atorvastatin treatment for chronic subdural hematoma[J]. 中国医药导报, 2020, 17(20): 70-75,92.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I20/70

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