高血压合并抑郁症患者血浆肾素-血管紧张素Ⅱ-醛固酮及心率变异性水平变化的分析

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Abstract Objective To investigate the changes of renin-angiotensin Ⅱ-aldosterone and heart rate variability in hypertension combined with depression patients. Methods A total of 51 patients with hypertension in the Guangxi Zhuang Autonomous Region Brain Hospital (hereinafter referred to as “our hospital”) from May 2018 to June 2019 were selected. According to the presence or absence of depression, they were divided into hypertension combined with depression group (21 cases) and simple hypertension group (30 cases), while a total of 30 healthy people in the same period in our hospital were selected as the control group. Plasma renin, angiotensin Ⅱ, aldosterone concentration and heart rate variability indicators [standard deviation of normal adjacent RR interval (SDNN), square root of the difference between adjacent RR intervals (RMSSD), the percentage of adjacent RR intervals >50 ms (PNN50)] in three groups were detected and analyzed. Results The levels of renin, angiotensin Ⅱ and aldosterone in hypertension combined with depression group and simple hypertension group were higher than those in the control group, while the levels of renin, aldosterone in hypertension combined with depression group were higher than those in simple hypertension group, and the differences were statistically significant (P ＜ 0.05). The SDNN, RMSSD, and PNN50 of the hypertension combined with depression group and the simple hypertension group were higher than those in the control group, while the hypertension combined with depression group was lower than the simple hypertension group, and the differences were statistically significant (P ＜ 0.05). Conclusion The levels of renin, angiotensin Ⅱ and aldosterone in patients of hypertension combined with depression and simple hypertension are significantly increased, while the level of heart rate variability decreased, and the changes in hypertension combined with depression patients are greater. The joint action of renin-angiotensin system and autonomic dysfunction may be the pathophysiological mechanism of hypertension combined with depression.

Key words： Hypertension Depression Renin-angiotensin Ⅱ-aldosterone Heart rate variability

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	WEI Yuhua1 XIE Chengqin1 GE Beihai2 LIN Guohua3 WEI Yanshi1 LUO Ya1 PAN Runde4

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WEI Yuhua1 XIE Chengqin1 GE Beihai2 LIN Guohua3 WEI Yanshi1 LUO Ya1 PAN Runde4. Analysis of changes in plasma renin-angiotensin Ⅱ-aldosterone and heart rate variability in hypertension combined with depression patients[J]. 中国医药导报, 2020, 17(20): 62-64.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I20/62

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