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| Effect of Topiramate on symptom control and electroencephalogram in children with epilepsy |
| ZHANG Yuan LIU Xiaoming SANG Yan ZHANG Dongli ZHAO Jiaqiang |
| Department of Neurology, Xuzhou Children′s Hospital, Jiangsu Province, Xuzhou 221000, China |
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Abstract Objective To evaluate the effect of Topiramate on symptom control and electroencephalogram in children with epilepsy. Methods From February 2017 to October 2018, 100 epileptic children who admitted to Xuzhou Children′s Hospital of Jiangsu Province were selected as objects. They were divided into the control group and the study group according to the random number table method, with 50 cases in each group. The control group was treated with Oxcarbazepine, and the study group was treated with Topiramate. The clinical efficacy of the two groups was observed. Epilepsy score before and 6 months after treatment, electroencephalogram and quality of life improvement, serum neuropeptide Y (NPY), brain-derived neurotrophic factor (BD-NF) levels and adverse reactions were observed. Results The total effective rate in the study group was higher than that in the control group, and the difference was statistically significant (P < 0.05). The epilepsy scores of the two groups were compared before treatment, and the difference was not statistically significant (P > 0.05); 6 months after treatment, the epilepsy scores of the two groups were lower than those before treatment, the study group was lower than the control group, and the differences were statistically significant (all P < 0.05). Electroencephalogram improvement rate in the study group was higher than that in the control group, and the difference was statistically significant (P < 0.05). Electroencephalogram background activity of the two groups was mainly α wave activity, but there was no significant difference in the activity rates of α, θ, δ waves between the two groups (P > 0.05). There were no significant differences in NPY, BD-NF levels and QOLIE-31 scores between the two groups before treatment (P > 0.05). Six months after treatment, NPY and BD-NF levels in the two groups were lower than those before treatment, and the QOLIE-31 scores were higher than those before treatment, and the differences were statistically significant (all P < 0.05). In addition, NPY and BD-NF levels in the study group were lower than those in the control group, and QOLIE-31 scores were higher than those in the control group, with statistically significant differences (all P < 0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P > 0.05). Conclusion Topiramate therapy in children with epilepsy can effectively improve the clinical treatment effectiveness and the effect of electroencephalogram, so as to effectively improve the quality of life of children.
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[1] 贾颐，代晓杰.托吡酯对癫痫患者血清中NPY和BD-NF表达的影响[J].西南国防医药，2015，25（10）：1078-1080.
[2] 贾蕾，王娟娟，高学军，等.托吡酯用于癫痫患者治疗中的价值及对血糖等的影响[J].检验医学与临床，2017，14（2）：201-203.
[3] Proposal for revised clinical and electroencephalographicclassification of epileptic seizures. From the commission on classification and terminology ofthe internationallergue agaition epilepsy [J]. Epilepsia，1981，22（4）：489-501.
[4] 张承军，陈小艳，罗松，等.托吡酯对癫痫患者血清NPY、BD-NF表达及临床效果分析[J].脑与神经疾病杂志，2018， 26（4）：243-246.
[5] 王艳，张晓鑫，杨清成.丙戊酸钠和苯妥英钠联合治疗对难治性癫痫患者痫样放电及认知功能的影响[J].新乡医学院学报，2018，35（2）：114-117.
[6] Liu C，Song M，Wang J. Nightly oral administration of topiramate forbenign childhood epilepsy with centrotemporal spikes [J]. Childs Nerv Syst，2016，32（5）：839-843.
[7] 李志毅.托吡酯和左乙拉西坦对学龄期癫痫患儿骨代谢的影响[J].河北医学，2018，24（3）：408-411.
[8] 周艳辉，周峰，余丹，等.托吡酯治疗脑梗死后继发癫痫临床效果及认知功能分析[J].解放军医药杂志，2018，30（2）：94-97.
[9] Yüksel A，Sarslan O，Devrano■lu K，et al. Effect of valproate and carbamazepine on visual evoked potentials in epileptic children [J]. Acta Paediatr Jpn，1995，37（3）：358-361.
[10] 杨圣海，王珺，王立文，等.癫痫儿童抗癫痫药使用情况及超说明书用药的调查分析[J].中国医药导报，2018， 15（11）：45-48.
[11] 李香丹，尹明姬，杨洋，等.托吡酯腹腔注射后癫痫大鼠海马组织损伤变化及其机制探讨[J].山东医药，2017， 57（27）：14-18.
[12] 文迪，陈超阳，冯梅梅，等.重症肺炎合并癫痫患儿的药学监护[J].中国临床药理学杂志，2019，35（15）：1669-1671.
[13] 邹琴，陈永敏，刘惠，等.不同抗癫痫药物对部分性癫痫患者认知功能和生活质量的影响[J].华西药学杂志，2018，33（4）：460-462.
[14] 李军强，刘鹏鹏，令调文，等.癫痫住院患者抗癫痫药物和病因及发作形式的回顾性研究[J].中国神经精神疾病杂志，2018，44（5）：266-271.
[15] 杨志刚，李巷，刘人凯，等.托吡酯、卡马西平与丙戊酸钠治疗脑炎继发癫痫效果分析[J].西北药学杂志，2015， 11（3）：295-297.
[16] 秦娜，张彦，王圆圆，等.托吡酯对纠正癫痫神经递质异常的可行性研究[J].国际神经病学神经外科学杂志，2016， 43（6）：502-506.
[17] Lima PA，de Brito Sampaio LP，Damasceno NR. Ketogenic diet in epileptic children：impact on lipoproteins and oxidative stress [J]. Nutr Neurosci，2015，18（8）：337-344.
[18] 张静，魏红艳，左艳芳，等.抗癫痫药和脑电图放电指数对癫痫患儿认知功能的影响[J].临床和实验医学杂志，2019，18（15）：1625-1628.
[19] 叶静萍.托吡酯与丙戊酸钠对癫痫患儿体质量、糖代谢影响的临床观察[J].中国药房，2015，7（6）：740-742.
[20] 罗国君，季业，刘振.丙戊酸钠联合托吡酯治疗引起丙戊酸钠相关性高血氨脑病1例[J].神经损伤与功能重建，2018，13（5）：269-270.
[21] 许倍铭，陈冰.新型抗癫痫药物的治疗药物监测研究进展[J].中国药房，2017，28（35）：5036-5040.
[22] 王薇，李鑫，王丽辉，等.不同剂量托吡酯联合卡马西平对改善小儿癫痫症状效果分析[J].脑与神经疾病杂志，2018，26（1）：29-32. |
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