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| Changes and clinical significance of serum CD40 and ICAM-1 levels in patients with acute cerebral hemorrhage |
| QUAN Hongjuan XIA Mingwan ZHANG Sheng′an |
| Department of Critical Care Medicine, Chenzhou First People′s Hospital, Hu′nan Province, Chenzhou 423000, China |
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Abstract Objective To study the changes and clinical significance of serum CD40 and intercellular adhesion molecule-1 (ICAM-1) expression in patients with acute cerebral hemorrhage. Methods From January 2017 to January 2019, a total of 153 patients with acute cerebral hemorrhage diagnosed and treated in Chenzhou First People′s Hospital, Hu′nan Province (hereinafter referred to as “our hospital”) were selected as the case group, and 60 healthy physical examinees in our hospital were selected as the control group. According to different prognosis, patients in the case group were divided into 40 cases in death subgroups, 68 cases in good prognosis subgroups and 45 cases in poor prognosis subgroups. CD40 and ICAM-1 expression in serum of two groups were detected by enzyme-linked immunosorbent assay (ELISA). The expression difference between groups and the relationship between the two indexes and clinical characteristics and prognosis were analyzed. Results The expressions of serum CD40 and ICAM-1 in the case group were higher than those in the control group, and the differences were statistically significant (P ＜ 0.05). The expressions of serum CD40 and ICAM-1 in the case group were significantly positively correlated (r = 0.679, P = 0.000). There were significant differences in serum CD40 and ICAM-1 in patients with different cerebral hemorrhage volume and severity of nerve defect (P ＜ 0.05). The expressions of CD40 and ICAM-1 in the death subgroup were significantly higher than those in the good and poor prognosis subgroups, the expressions of serum CD40 and ICAM-1 in the poor prognosis subgroup were significantly higher than those in the good prognosis subgroup, and the differences were statistically significant (P ＜ 0.05). Conclusion The expressions of CD40 and ICAM-1 in the serum of patients with acute cerebral hemorrhage are elevated, they are closely related to the neurological function and prognosis of patients. Monitoring the two indexes is helpful to judge the condition and prognosis of patients with acute cerebral hemorrhage.
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