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| Analysis of the changes of nocturnal blood pressure and the risk factors of stroke in bypertensive patients |
| CHEN Minglei LIN Kang |
| Department of Neurology, Sanya Central Hospital, Hainan Province, Sanya 572000, China |
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Abstract Objective To explore the changes of nocturnal blood pressure and the risk factors of stroke in hypertensive patients. Methods A total of 125 hypertensive patients admitted to Sanya Central Hospital from January 2017 to June 2019 due to stroke were selected as the observation group, another 45 patients with simple hypertension and no complications were selected as the control group. 24-hour ambulatory blood pressure monitoring (ABPM) was performed in all patients, and the 24 h systolic blood pressure (24hSBP), 24 h diastolic blood pressure (24hDBP), day systolic blood pressure (dSBP), day diastolic blood pressure (dDBP), nocturnal systolic blood pressure (nSBP), nocturnal diastolic blood pressure (nDBP) were recorded. Whether patients had nocturnal hypertension and the type of circadian rhythm of blood pressure of patients were analyzed, and the risk factors of blood pressure changes was analyzed by logistic regression analysis. Results The nSBP, nDBP and the prevalence of nocturnal hypertension in the observation group were significantly higher than those in the control group (all P ＜ 0.05), the difference of circadian rhythm types between the two groups was statistically significant (P ＜ 0.05). The logistic regression analysis showed that nSBP (OR = 1.446, P = 0.021, 95%CI: 1.058, 1.973), nDBP (OR = 3.064, P = 0.008, 95%CI: 1.507, 6.229), nocturnal hypertension(OR = 14.516, P = 0.014, 95%CI: 1.978，56.058) and circadian rhythm of blood pressure (non-dipper) (OR = 9.347, P = 0.000, 95%CI: 3.716, 17.609) were independent risk factors for stroke. Conclusion The incidence of nocturnal hypertension increased, the circadian rhythm decreased in patients with stroke, nocturnal elevated blood pressure and non-dipper blood pressure are independent risk factors for stroke.
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