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| Expression of serum 25-hydroxyvitamin D, vitamin A and vitamin E in twin premature infants |
| LIU Kang1 LI Na2 LIU Xian3 PAN Zhaojun1 WU Rong1▲ |
1.Neonatal Medical Center, Huai′an Maternity and Child Healthcare Hospital Affiliated to Yangzhou University Medical College, Jiangsu Province, Huai′an 223002, China;
2.Department of Pediatrics, Heze Municipal Hospital, Shandong Province, Heze 274000, China;
3.Department of Pediatrics, People′s Hospital of Guannan, Jiangsu Province, Lianyungang 222500, China |
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Abstract Objective To observe the expression characteristics of serum 25-hydroxyvitamin D, vitamin A and vitamin E in twin premature infants. Methods Seventy-four twin premature infants who hospitalized in the Neonatal Medical Center of Huai′an Maternal and Child Healthcare Hospital Affiliated to Yangzhou University Medical College in Jiangsu Province from January 2015 to June 2016 were selected as the observation group. In a 1∶1 ratio, 74 single preterm infants with similar diseases and similar gestational age were randomly selected as the control group. The clinical data of the selected premature infants were collected. According to birth weight, the observation group was divided into light fetus group (37 cases) and heavy fetus group (37 cases). According to gestational age, the observation group was divided into small gestational age group (gestational age <32 weeks, 24 cases) and large gestational age group (gestational age ≥32 weeks, 50 cases). According to 25-hydroxyvitamin D, vitamin A and vitamin E deficiency, the observation group was divided into 25-hydroxyvitamin D deficiency group (41 cases) and 25-hydroxyvitamin D non-deficiency group (33 cases); vitamin A deficiency group (24 cases) and vitamin A non-deficiency group (50 cases); Vitamin E deficiency (59 cases) and vitamin E non-deficiency group (15 cases). The serum levels of 25-hydroxyvitamin D, vitamin A and vitamin E within 1 d after birth and the incidence of complications were detected. Results The birth weight of the observation group was lower than that of the control group, and the incidence of maternal gestational hypertension was higher than that of the control group (all P < 0.05). The serum levels of 25-hydroxyvitamin D, vitamin A and vitamin E in the observation group were all lower than those in the control group (all P < 0.05). There was no significant difference in serum levels of 25-hydroxyvitamin D, vitamin A and vitamin E between light fetus group and heavy fetus group (P > 0.05). The serum levels of 25-hydroxyvitamin D, vitamin A and vitamin E in small gestational age group were all lower than those in large gestational age group (all P < 0.05). The incidence of hypoglycemia, necrotizing enterocolitis (NEC) and extrauterine growth retardation (EUGR) in the observation group were higher than those in the control group (all P < 0.05). The incidence of NEC, EUGR and feeding intolerance in light fetus group were all higher than those in heavy fetus group (all P < 0.05). The incidence of respiratory distress syndrome (RDS) and fetal growth restriction (FGR) in 25-hydroxyvitamin D deficiency group were all higher than those in 25-hydroxyvitamin D non-deficiency group (all P < 0.05). The incidence of RDS, bronchopulmonary dysplasia (BPD) and FGR in vitamin A deficiency group were all higher than those in vitamin A non-deficiency group (all P < 0.05). There was no significant difference in the incidence of complications between vitamin E deficiency group and vitamin E non-deficiency group (P > 0.05). Conclusion 25-vitamin D, vitamin A and vitamin E levels of twin premature infants are lower than those of single premature infants with the same gestational age. The levels of 25-hydroxyvitamin D, vitamin A and vitamin E are lower in twin premature infants with small gestational age. Twin premature infants with 25-hydroxyvitamin D deficiency are more likely to have RDS and FGR. Twin premature infants with vitamin A deficiency are more likely to develop RDS, BPD and FGR.
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