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2020 Vol. 17, No. 12 Published: 2020-04-25

	4	A cross-sectional survey of body composition and blood pressure of college freshmen in colleges
		LI Ju1,2 YANG Liting2 LEI Sai1,2 YAO Zijun2,3 YU Kefei1,4 ZHANG Yao2,3 ZHONG Ping5 GUO Huailan2,3
		Objective To explore the body composition and blood pressure levels of freshmen in colleges. Methods Cluster sampling was used to measure the body composition and blood pressure of freshmen in a college in Shiyan City, Hubei Province from September to October 2018. Results A total of 3172 students were included in this survey. Boys′body weight, body mass index, bone mass, protein, muscle, skeletal muscle, lean body mass, total water, basal metabolism and edema coefficient were higher than girls, and body fat rate and fat were lower than girls, the differences were highly statistically significant (P ＜ 0.01). The differences in body fat rate, body mass index and blood pressure detection rate between different genders were highly statistically significant (P ＜ 0.01). Compared with new bone, protein, muscle, skeletal muscle, lean body mass, total water and basal metabolism of freshmen among different blood pressure levels, and the differences were highly statistically significant (P ＜ 0.01). Body mass index, waist-to-hip ratio were positively correlated with blood pressure (r ＞ 0, P ＜ 0.01); bone mass/weight, basal metabolic rate/weight, edema coefficient/weight were negatively correlated with blood pressure (r ＜ 0, P ＜ 0.05 or P ＜ 0.01). In addition, edema coefficient/body weight, muscle/body weight, bone mass/body weight, basal metabolic rate/body weight were influencing factors of systolic blood pressure (P ＜ 0.05). Conclusion A large proportion of freshmen are overweight, obesity, normal high blood pressure, high blood pressure. The college should strengthen health education in order to help students lose weight, fat and blood pressure.
		2020 Vol. 17 (12): 4-8 [Abstract] ( 118 ) HTML (1 KB) PDF (743 KB) ( 181 )

	9	The key genes in esophageal squamous cell carcinoma screened by bioinformatics
		ZHAO Fei1 YUAN Zhiqing2
		Objective To provide new ideas for the study of tumor pathogenesis by screening the key genes of esophageal squamous cell carcinoma (ESCC). Methods The gene expression chips of ESCC were retrieved in GEO database. The differential expression genes were analyzed for obtaining common differential genes. GO and KEGG pathway enrichment analysis were performed in DAVID online database. The 10 key genes with the highest link were obtained by String database and Cytoscape software, and verified in the TCGA database. Results A total of 204 differentially expressed genes were screened. GO analysis showed that the biological process was enriched in 163 items, such as cell division, organelle fission, cell cycle, etc. Cytological components were enriched in 48 entries including extracellular, cytoplasmic and organelle lumen. Molecular function enrichment in 46 entries, such as regulating peptidase activity, binding to extracellular matrix, etc. KEGG pathways were enriched in 12 entries, including local adhesion, p53 signaling pathways, mismatch repair, etc. The 10 highest-linked Hub genes were verified to be highly expressed in ESCC by TCGA databases (P ＜ 0.01). Conclusion CDK1, CCNA2, RFC4, CCNB1, TOP2A, AURKA, CDC6, BUB1, BUB1B and PLK1 are the key genes of ESSC, and may be biomarkers and therapeutic targets in ESCC.
		2020 Vol. 17 (12): 9-13 [Abstract] ( 136 ) HTML (1 KB) PDF (1399 KB) ( 172 )

	14	Quality standard for Kangbingduganmao Granules
		XU Yuan ZHANG Tingting ZHANG Ruitao WU Dan DANG Xueliang LIU Mei ZHANG Yan
		Objective To establish the quality standard of Kangbingduganmao Granules, to better control the product quality and to provide guarantee for clinical safety application. Methods Bupleuri Radix, Lonicerae Japonicae Caulis and Isatidis Radix in Kangweiganmao Granules were identified qualitatively by thin layer chromatography (TLC). The content of loganin, the main effective component of Lonicerae Japonicae Caulis was determined by high performance liquid chromatography. The ODS-3 was used as the column and acetonitrile-water (12∶88) was used as the mobile phase, the detection wavelength was 236 nm. Results TLC spots were clear, the resolution was good, specificity was strong, and negative control had no interference. The loganin in the range of 4.72-236.00 μg/mL showed good linear relationship with the peak area (r = 0.9999). The average recovery rate was 100.57% and RSD was 1.19% (n = 6). The determination results of three batches of samples were 0.4335, 0.3741 and 0.3142 mg/g respectively. Conclusion The established qualitative and quantitative methods are accurate, reliable and reproducible, and can be used as quality control methods for antiviral cold granules.
		2020 Vol. 17 (12): 14-17 [Abstract] ( 274 ) HTML (1 KB) PDF (914 KB) ( 101 )

	18	The malignant phenotype of gefitini-resistant non-small cell lung cancer mediated by miR-501 targeted BLID
		GE Ling1 CHEN Hejian2 XU Hangdi3
		Objective To explore the role of miR-501 in non-small cell lung cancer (NSCLC) with gefitinib resistance and its underlying mechanism. Methods The expression of miR-501 in NSCLC with gefitinib resistance serum and PC9/GR were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR). The effect of miR-501 on the malignant phenotype of PC9/GR was detected by CCK-8, scratch test and Transwell test. The online database was used to predict the potential target of miR-501 and to verify its specific role in PC9/GR. Results Compared with the healthy control people and the normal lung epithelial cell lines, the expression level of miR-501 in gefitini-resistant NSCLC patients serum and PC9/GR were increased, and the differences were highly statistically significant (P ＜ 0.01). Compared with the mimics NC, the proliferation, migration and invasion capacity of PC9/GR in the miR-501 mimics were increased, and the differences were highly statistically significant (P ＜ 0.01). The luciferase reporter assay confirmed that BLID was a direct target for miR-501. Compared with the miR-501 mimics+pcDNA3.1, the proliferation, migration and invasion of PC9/GR in the miR-501 mimics+ pcdna3.1-blid were decreased, and the differences were highly statistically significant (P ＜ 0.01). Conclusion The upregulation of miR-501 promoted the proliferation, migration, and invasion of geffitini-resistant NSCLC by inhibiting BLID. Therefore, miR-501 is a potential target for gefitinib-resistant NSCLC.
		2020 Vol. 17 (12): 18-22,27 [Abstract] ( 141 ) HTML (1 KB) PDF (1121 KB) ( 107 )

	23	Study on the effect and mechanism of Mongolian medicine Sirixi in preventing and treating experimental gastric ulcer
		Aodengqimuge WANG Hairong Wuhanqimuge Tegexibaiyin
		Objective To study the preventive and therapeutic effect of Mongolian medicine Sirixi on gastric ulcer and its possible mechanism. Methods A total of 25 Wistar rats were selected to make rat acute gastric ulcer model induced by indomethacin. Changes of gastric mucosa were observed by hematoxylin-eosin staining. A total of 25 Kunming mice were selected to observe the changes of myeloperoxidase (MPO) activity, glutathione (GSH) level and peripheral blood T lymphocyte level in gastric tissues in the ethanol/HCL-induced acute gastric ulcer model. A total of 20 Wistar rats were selected and the expression levels of inflammatory tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule 1 (ICAM-1) in gastric tissues were determined by enzyme-linked immunosorbent assay in a acetic acid-burning chronic gastric ulcer model. Results Compared with the model group, the gastric mucosal lesions were alleviated in the Sirixi Powder group. Compared with the model group, the gastric tissue MPO activity, the expression levels of TNF-α and ICAM-1 in the gastric mucosa of the Sirixi Powder group were decreased, and the expression levels of GSH were increased, the differences were highly statistically significant (all P ＜ 0.01). Compared with the model group, the thymus, spleen weight index and the expression levels of peripheral blood CD4+ cells were increased in the Sirixi Powder group, with statistically significant differences (P ＜ 0.05 or P ＜ 0.01), while there was no significant difference in the expression levels of CD3+, CD4+/CD8+ and CD8+ between the two groups (P ＞ 0.05). Conclusion The mechanism of action of Sirixi Powder in the prevention and treatment of gastric ulcer may be realized by promoting defense factor, inhibiting damage factor and improving immune ability.
		2020 Vol. 17 (12): 23-27 [Abstract] ( 193 ) HTML (1 KB) PDF (818 KB) ( 124 )

	28	Study on inhibition of influenza A virus by influenza Shuangjie Decoction in vitro experimental
		ZHOU Yaping LI Guochun GUAN Xiaowei
		Objective To analysis inhibition of influenza A virus by influenza Shuangjiefang Decoction in vitro experimental. Methods Twenty-four New Zealand white rabbits were random divided into three groups, eight per group. Influenza Shuangjiefang Decoction, Ribavirin, and normal saline were given by gavage and drug-containing serum was prepared to analyze the effect of drugs on inhibiting influenza A virus. Results The influenza A virus rat lung adaptation strain A/PR8/34 (H1N1) TCID50 was 10-4.575/100 μL. The maximum non-toxic concentration of influenza Shuangjiefang Decoction and Ribavirin-containing serum were 40% and 50%, respectively. The experiments prevent infection, direct inactivation and replication proliferation inhibition showed that the OD value of the virus infection group was lower than that of the cell group (P ＜ 0.05); the OD value of the ribavirin group and the influenza Shuangjiefang Decoction group were higher than that of the virus infection group (P ＜ 0.05). There was no statistically significant difference in virus inhibition rate between the ribavirin group and the influenza Shuangjiefang Decoction group (P ＞ 0.05). Conclusion Influenza Shuangjiefang Decoction has the functions of in vitro prevention, direct killing and inhibition of influenza A virus after infection.
		2020 Vol. 17 (12): 28-31 [Abstract] ( 110 ) HTML (1 KB) PDF (755 KB) ( 106 )

	32	Study on the correlation between the methylation of miR-203 gene promoter region and the level of synovitis in obese patients with knee osteoarthritis
		LI Jianwei1 ZHANG Li′na2 ZHANG Yingmin1 KANG Shaoying1 WEI Meng1
		Objective To study the correlation between abnormal methylation of miR-203 gene promoter region in synovial tissues and the level of joint fluid proinflammatory factors in obese knee osteoarthritis (KOA). Methods Synovial tissue and joint fluid of KOA patients were taken from 36 patients who underwent knee arthroplasty in Handan Central Hospital in Hebei Province from January 2018 to January 2019. Patients with body mass index (BMI)≥28.0 kg/m2 were included in the obesity group (23 cases), and patients with 18.0 kg/m2≤BMI≤23.9 kg/m2 were included in the normal control group (13 cases). Methylation specific PCR (MSP) was used to detect the methylation status of the gene promoter region of miR-203 in synovial tissues. The expression level of miR-203 in synovial tissues was determined by quantitative polymerase chain reaction (qPCR). qPCR was used to detect the expression levels of miR-203 in the obese group and the normal control group. Pearson correlation analysis was used to investigate the correlation between miR-203 and BMI, tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6) in joint fluid. Results In the synovial tissues of the obese group, the promoter region of miR-203 gene was abnormally hypomorphic, while in the normal control group, it was partially hypomorphic. Compared with the normal control group, the expression level of miR-203 in synovial tissues of the obesity group was increased, and the difference was statistically significant (P ＜ 0.05). The relative expressions of IL-1β, IL-6 and TNF-α in the joint fluid of the obese group were higher than those of the normal control group, with statistically significant differences (all P ＜ 0.05). The methylation level in the promoter region of miR-203 gene was negatively correlated with population BMI and the IL-1β, IL-6 and TNF-α in the joint fluid (all P ＜ 0.05). The expression level of miR-203 was positively correlated with population BMI and the IL-1β, IL-6 and TNF-α in the joint fluid (all P ＜ 0.05). Conclusion Hypophalation of miR-203 gene promoter in synovial tissues of KOA patients is closely related to BMI and levels of joint fluid proinflammatory factors in obese KOA patients, and miR-203 can be used as an important regulatory factor for inflammation of obese KOA and a potential target for treatment of KOA.
		2020 Vol. 17 (12): 32-35,60 [Abstract] ( 148 ) HTML (1 KB) PDF (1133 KB) ( 119 )

	36	Overview of animal model study of Alzheimer′s disease and analysis of non-experimental causes of death
		ZHANG Huiye1 CHONG Wenqiang1 LI Ang1 WANG Mengjing1 ZHAO Xian1 XING Wenwen2 LIU Qi1
		This paper briefly introduces the animal model of Alzheimer′s disease (AD) and analyzes the non-experimental death factors in animal experiments. By consulting, sorting out and summarizing a large number of literatures, this paper gives a overview of the common animal models for AD, while investigates the correlation between environmental factors, motor factors and non-experimental causes of death in AD animal models. The animal feeding density and regular exercise in environmental factors affect the survival rate and experimental results of AD model animals. Establish an ideal AD animal model, in order to provide a reference for the scientific selection of AD animal models in experimental research. In addition, the control of animal population density feeding and regular exercise are adopted to evaluate the safety of high-model animals to better ensure the objectivity of the experimental results.
		2020 Vol. 17 (12): 36-40,64 [Abstract] ( 183 ) HTML (1 KB) PDF (758 KB) ( 68 )

	41	Research on the main factors affecting the chemical composition of Eucommia ulmoides Oliv.
		LIU Kun1 PAN YingYi1 WANG Jianying2 CHENG Xiaoyun3 YUAN Ying1
		This article reviews the chemical composition of Eucommia ulmoides Oliv. from different medicinal parts, processing methods, producing area, collection time and serum drug metabolism. It is found that the influence of different medicinal parts of Eucommia ulmoides Oliv. on the chemical composition is mainly reflected in the great difference in the content of effective components and the representative components of each part. The influence of collection time in producing area is mainly manifested in the obvious difference of chemical composition content. The processing methods of Eucommia ulmoides Oliv. mainly changes the structure of its chemical composition and the ratio of its species. The chemical components of Eucommia ulmoides Oliv. are still prototype after drug metabolism, but the pharmacokinetic characteristics of each component are quite different. This article also combines five main influencing factors to elaborate the relevant drug effects. It may provide a reference to explain the material basis of Eucommia ulmoides Oliv. exerting different drug effects to a certain extent, and may also provide a reference for the clinical application and resource development of Eucommia ulmoides Oliv..
		2020 Vol. 17 (12): 41-44 [Abstract] ( 114 ) HTML (1 KB) PDF (665 KB) ( 92 )

	45	Progress in the establishment of atherosclerosis models in rats
		WANG Shuqi1,2 LI Hui1,2 YANG Xiaoqiang3 BAI Yunqi2 LIN Yiyi2 GAO Zhao2 SUN Kehan1 NIE Bo1,2▲
		Atherosclerosis is a common vascular disease that affects the arteries from the intima, and it is the main cause of coronary heart disease, cerebral infarction and peripheral vascular disease. The establishment of an animal model of atherosclerosis is of great significance in understanding the pathogenesis, development, clinical diagnosis and prevention of atherosclerosis. By referring to relevant literatures at home and abroad, this paper summarizes the modeling methods of atherosclerosis in rats, compares the advantages and disadvantages of various modeling methods, and summarizes the current situation and progress of establishing animal models of atherosclerosis. Through the review of related literature at home and abroad, this article induces and summarizes the modeling method of atherosclerosis in rats, and compares the advantages and disadvantages of various modeling methods, an overview of the current situation and progress of establishing animal models of atherosclerosis, and concludes that the simple high-fat feed is difficult to form the atherosclerosis lesions, and high-fat feed combined with vitamin D can cause early pathological changes and the build mode for a long time, but the high fat feedstuff combined with vitamin D at the same time, the mechanical damage to surgery can form and human similar mature lesions of atherosclerosis plaques.
		2020 Vol. 17 (12): 45-48,68 [Abstract] ( 175 ) HTML (1 KB) PDF (693 KB) ( 314 )

	49	Research progress on metabonomics biomarkers of major depressive disorder
		QI Yonghua SUN Hui WANG Xijun
		Major depressive disorder (MDD) is a major mental disorder worldwide, it causes enormous economic and emotional stress on society. The discovery of biomarkers can not only improve the diagnosis of depression and accelerate the development of new drugs, but also be used to predict the likelihood of depression and advance the process of personalized treatment of MDD. In recent years, the rapid development of metabolomics and its extensive application in disease diagnosis have provided the possibility for further screening of MDD related biomarkers. This paper will summarize and discuss the research progress of metabonomics biomarkers in the MDD based on the metabolomics of blood, urine and cerebrospinal fluid, with the purpose of enabling researchers to make new discoveries on the basis of existing studies, and expect the biomarker of MDD to play an important role in clinical practice as soon as possible to improve the quality of life of MDD patients.
		2020 Vol. 17 (12): 49-52 [Abstract] ( 159 ) HTML (1 KB) PDF (664 KB) ( 55 )

	53	Structure, function and innervation of ciliary muscle
		LYU Xiaoli1,2 TAO Jinhua1 MIAO Wanhong1
		The structure and function of ciliary muscle are related to the occurrence and development of many ophthalmic diseases, such as anterior rotation, hypertrophy of ciliary muscle are associated with glaucoma， vitreous body movement driven by ciliary muscle contraction is related to vitreoretinal interface diseases such as idiopathic macular membrane and idiopathic macular hole, the excessive and insufficient function of ciliary muscle can lead to the occurrence of visual fatigue. At the same time, the structure and function of ciliary muscle are also affected by local and systemic factors, such as local eye injury can lead to ciliary body edema, brain injury can lead to ciliary muscle spasm and psychological factors can also affect the function of ciliary muscle. These factors can directly affect the peripheral ciliary muscle to cause structural and functional abnormalities, and can also affect the functional state of the ciliary muscle through the central nerve innervation. Therefore, a deep understanding of the structure and innervation of ciliary muscle is of great significance for the diagnosis and treatment of clinical diseases and research in related fields. This paper aims to summarize ciliary muscle structure and function, focusing on ciliary muscle level, the midbrain Edinger-Westphal nuclear level and the supra nuclear level, describe the general situation of ciliary muscle nerve innervation.
		2020 Vol. 17 (12): 53-56 [Abstract] ( 782 ) HTML (1 KB) PDF (711 KB) ( 2179 )

	57	Overview of tumor nutrition therapy and its application in ovarian cancer
		LI Qiushu1 WANG Zanhong2 REN Songjie1
		Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies, and of the three major causes of mortality, only malnutrition can be corrected with standardized nutritional therapy. Tumor nutrition therapy not only provides nutrients and energy for the body, but also plays an important role in nutrient metabolism and immune regulation. Tumor nutrition therapy has a complete theory system, including nutrition diagnosis (nutrition screening, nutrition evaluation and comprehensive evaluation), nutrition intervention (five steps of nutrition therapy) and efficacy evaluation, which runs through the whole process of tumor treatment. Surgery, chemotherapy, immunotherapy, molecular targeted therapy and end-stage with OC are different in terms of nutritional interventions. In this paper, the nutritional therapy for cancer and the nutritional therapy for OC in different stages are summarized in order to provide references for nutritional therapy for OC.
		2020 Vol. 17 (12): 57-60 [Abstract] ( 130 ) HTML (1 KB) PDF (717 KB) ( 168 )

	61	Mechanism of acupuncture in the treatment of allergic rhinitis
		PENG Yongjun1 JIANG Xingzhuo1 LI Wenqian1 WU Xu1 ZHU Bingmei2
		Allergic rhinitis (AR) is a common non-infectious chronic inflammatory disease of the nasal mucosa mediated by immunoglobulin E (IgE) when body is exposed to allergens. Acupuncture, as a common treatment for AR, has the advantages of safety, effectiveness, and few side effects. This review summarized and discussed the progress of the pathogenesis of AR and the mechanisms of acupuncture treatment by retrieving relevant literatures in recent years. The mechanisms underlying AR are complex, including immunity disorder, nerve dysfunction, and nasal mucosal inflammatory cell infiltration. The studies showed that acupuncture can play a therapeutic role through immunoregulation, neuromodulation, decreasing IgE, and reducing nasal mucosal inflammatory infiltration. Also, the review pointed out some problems and shortcomings in the current research, and provided ideas for further study.
		2020 Vol. 17 (12): 61-64 [Abstract] ( 140 ) HTML (1 KB) PDF (721 KB) ( 40 )

	65	Treatment progress on traditional Chinese and Western medicine of postherpetic neuralgia
		HUANGFU Jiaxin SHEN Dexin
		Postherpetic neuralgia (PHN) is the most common complication of acute herpes zoster. The persistence of pain has a substantial effect on the patients′ quality of life. At present, a variety of methods are used to treat PHN. Anticonvulsants, antidepressants, opioids and topical therapies including Lidocaine and Capsaicin are the most widely used therapies for the treatment of PHN, due to adverse effects, they should be used carefully in the elderly patients or with significant comorbidities. Nerve block, neuromodulation and other measures also play an important role in the treatment of PHN. However, the efficacy, tolerability and safety of these invasive methods should be closely monitored. Chinese medicine therapy have little side effects and significant effect for the treatment of PHN, we should be carried out individualized differentiation of symptoms and signs on the basis of types. For some PHN patients who have intractable pain and poor treatment effect, we can consider integrated traditional Chinese and Western medicine to give full play to their advantages. This paper reviews the traditional Chinese and Western medicine treatment of PHN, so as to provide reference for clinical treatment.
		2020 Vol. 17 (12): 65-68 [Abstract] ( 123 ) HTML (1 KB) PDF (670 KB) ( 114 )

	69	Intervention effect of health education on feeding behavior of children in poverty and ethnic minorities areas
		LIU Xiaoxi1,2 CHEN Yongchao2 DING Xue2 WANG Fang2
		Objective To evaluate the intervention effect of ethnic-sensitive health education on feeding behavior of children in poverty and ethnic minorities areas. Methods A total of 869 and 897 caregivers of preschool children in Nujiang Prefecture, Yunnan Province were sampled respectively by multi-stage random sampling from May to June 2012 and November 2015 to January 2016. The release of ethnic-sensitive health communication materials, publicity activities, and nutrition counseling through routine outpatient were included in the interventions. Chi-square test and logistic regression were adopted for statistical analysis. Results After the intervention, the proportion of preschool children who did not or less than 4 times/month eat milk, beans, meat and eggs were lower than other eating frequencies, and the differences were highly statistically significant (P ＜ 0.01). With the exception of legumes, the frequency of eating other types of food ≥5 times/week were significantly higher than those of other eating frequencies, and the differences were highly statistically significant (P ＜ 0.01). Acceptance of intervention, high family income, and parents not working outside were influencing factors of eating various types of food (OR ＞ 1, P ＜ 0.05). Conclusion Health education is helpful to improve the feeding behavior of children in poverty and ethnic areas. It is suggested to take comprehensive interventions such as health education, raising family income and paying attention to left behind children.
		2020 Vol. 17 (12): 69-71,84 [Abstract] ( 132 ) HTML (1 KB) PDF (666 KB) ( 64 )

	72	Study on the relationship between coping style and mental health of assembly line staff in a pharmaceutical enterprise in Chengdu
		TANG Xu1 LI Yang2 ZHAO Miao3▲
		Objective To investigate the characteristic and relationship between coping style and mental health of assembly pipeline staffs in a pharmaceutical enterprise in Chengdu. Methods A total of 303 workers on the assembly lines of Sichuan Kelun Pharmaceutical Co.Ltd. were selected for the investigation by using symptom checklist（SCL-90）and coping style scale in January 2019. Pearson correlation analysis was used to explore the correlation between SCL-90 score and coping style. Results In survey results of the SCL-90, except for anxiety, hostility, terror and paranoia, the scores of other factors were higher than the national norm, and the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in the scores of somatization, obsessive-compulsive symptoms, depression, anxiety, and terror among employees of different ages (P ＜ 0.05). In terms of coping styles, there were statistically significant differences in the scores of withdrawal, fantasy, self-blame, and help-seeking (P ＜ 0.05). There were statistically significant differences in the scores of somatization, depression, hostility, terror, paranoia, and psychosis among employees of different marital status (P ＜ 0.05). In terms of coping styles, there was statistically significant difference in the scores of withdrawal (P ＜ 0.05). The indicators of withdrawal and fantasy were positively correlated with mental health (r ＞ 0.5, P ＜ 0.05). Conclusion There are certain problems with the mental health of assembly pipeline staffs of this pharmaceutical enterprise. The coping styles of withdrawal and fantasy will have an adverse effect on mental health and should be paid attention to by pharmaceutical enterprise.
		2020 Vol. 17 (12): 72-75 [Abstract] ( 106 ) HTML (1 KB) PDF (441 KB) ( 93 )

	76	Bladder residual urine volume measurement and international prostate symptom score preliminary screening of diabetic neurogenic bladder
		DUAN Lijun1 GUO Hongtao1 SHANG Shuxia1 ZHAO Junkui2 SUN Qiujie3 JIA Hongli4
		Objective To explore the methods and possible influencing factors of primary screening of neurogenic bladder in type 2 diabetes mellitus. Methods From January to December 2018, 209 male patients with type 2 diabetes were selected from the Department of Endocrinology of Jizhong Energy Fengfeng Group Hospital. According to different bladder residual urine volume, 125 cases were divided into group A (bladder residual urine volume ＜ 50 mL) and 84 cases were divided into group B (bladder residual urine volume ≥50 mL). Prostate volume, international prostate symptom score (IPSS), random blood glucose, glycosylated hemoglobin, diastolic blood pressure, systolic blood pressure and diabetes course were compared between the two groups; the effect of the above observation indexes on bladder residual urine volume was analyzed by multiple regression analysis; the probability of increased bladder residual urine volume caused by diabetes course and prostate volume was compared between the two groups. Pearson test was used to analyze the correlation between bladder residual urine volume and diabetes course, glycosylated hemoglobin and random blood glucose at admission. Results Compared with group A, group B had longer diabetes course, enlarged prostate volume and high blood glucose at admission (P ＜ 0.05). The score of urination problem in group B was significantly higher than that in group A, and the difference was statistically significant (P ＜ 0.05); the number of patients with residual urine ≥50 mL was significantly increased in patients with diabetes course greater than 10 years and prostate volume greater than 30 mL (P ＜ 0.05); glycosylated hemoglobin, duration of diabetes, and prostate volume were risk factors for increased bladder residual urine volume (P ＜ 0.05); when the prostate volume was less than 30 mL, the amount of residual bladder urine was closely related to the course of diabetes (r = 0.289, P ＜ 0.05); when prostate volume increased (≥30 mL), bladder residual urine volume was closely correlated with glycosylated hemoglobin and random blood glucose upon admission (r = 0.370, 0.381, P ＜ 0.05). Conclusion Bladder residual urine measurement combined with IPSS can assist in early screening of diabetic neurological bladder. The method is simple and easy to use. For patients with diabetes with a long course and enlarged prostate, early intervention and active prevention and treatment are needed.
		2020 Vol. 17 (12): 76-79 [Abstract] ( 161 ) HTML (1 KB) PDF (351 KB) ( 28 )

	80	Changes and clinical significance of serum human epididymal protein 4 in patients with chronic kidney disease after kidney transplantation
		LUO Boxun1 ZHANG Weiping2 MENG Fanhang3
		Objective To analyze the changes and clinical significance of serum human epididymal protein 4 (HE4) in patients with chronic kidney disease (CKD) after kidney transplantation. Methods A total of 87 patients with CKD after kidney transplantation who were followed up in Huizhou Central People′s Hospital and Guangdong Hospital of Traditional Chinese Medicine from January 2014 to June 2019 were selected as the study subjects (CKD group), another 50 healthy subjects who underwent physical examination in Huizhou Central People′s Hospital were selected as the control group. The estimated glomerular filtration rate (eGFR) and serum levels of HE4, creatinine (SCr), urea nitrogen (BUN) and urinary β2-microglobulin (β2-MG) were compared between the two groups. The correlation between HE4 and various nephropathy-related indicators was analyzed, the risk factors for CKD were analyzed, and the predictive value of HE4, SCr, BUN, and β2-MG on CKD was plotted by ROC. Results The levels of HE4, SCr, BUN and β2-MG in patients in the CKD group were significantly higher than those in the control group, while the levels of eGFR were lower than those in the control group (P ＜ 0.05). The HE4 level of patients with CKD1 stage was higher than that of the control group, and the difference of HE4 level in different CKD stages was statistically significant (all P ＜ 0.05). The levels of SCr, BUN and 2-MG of CKD stage2 patients were higher than those of the control group, and the differences between SCr, BUN and 2-MG in different CKD stages were statistically significant (all P ＜ 0.05). eGFR in patients with stage2 of CKD was lower than that in the control group, and the differences in eGFR in different stages of CKD were statistically significant (all P ＜ 0.05). There was an obvious positive correlation between HE4 and SCr, BUN and β2-MG in CKD group (r = 0.611, 0.555, 0.539, P ＜ 0.05), while negatively correlated with eGFR(r = -0.762, P ＜ 0.05). Logistic multivariate regression analysis showed that elevated HE4, SCr, BUN and β2-MG levels were all independent risk predictors of CKD (all P ＜ 0.05). HE4 predicted that the ROC area of CKD was 0.877 higher than SCr (0.785), BUN (0.752) and β2-MG (0.778), and the area under ROC of CKD was the highest, up to 0.965. Conclusion After kidney transplantation, serum HE4 level of CKD patients is significantly increased, has a high predictive value for the occurrence of CKD in patients, which could assist in the early diagnosis of CKD in clinical practice.
		2020 Vol. 17 (12): 80-84 [Abstract] ( 177 ) HTML (1 KB) PDF (546 KB) ( 85 )

	85	Clinical comparative study of suprapatellar approach and transpatellar ligament approach with intramedullary nail in the treatment of middle and lower tibial fractures
		LI Dengjun1 LI Hailiang2 LIU Chenggong2 LIU Guangquan1
		Objective To compare the clinical effects of suprapatellar approach and transpatellar ligament approach with intramedullary nail in the treatment of middle and lower tibial fractures. Methods A total of 100 cases of middle and lower tibial fractures admitted to Dongying People′s Hospital in Shandong Province from March 2015 to March 2018 were selected as the research object. According to the different treatment plans, the patients were divided into group A and group B, with 50 cases in each group. The group A was fixed with suprapatellar approach with intramedullary nail fixation, and the group B was fixed with transpatellar ligament approach with intramedullary nail fixation. The postoperative clinical effect, clinical related indicators, knee joint function and complications were compared between the two groups. Results The excellent and good rate of the group A at 12 months after operation was higher than that of the group B, and the difference was statistically significant (P ＜ 0.05). The times of fluoroscopy in the group A was less than that in the group B, the time of operation and fracture healing after operation was shorter than that in the group B, and the ratio of cross-section diameter of before and after operation was lower than that in the group B, with statistically significant differences (all P ＜ 0.05). However, there was no statistically significant difference in intraoperative blood loss between the two groups (P ＞ 0.05). There were statistically significant differences in the comparison between groups, in the comparison at time points and in the interaction between the two groups (all P < 0.05). Compared with two weeks after operation, HSS scores of patients in the two groups and 6 and 12 months after operation were increased, and the special surgical hospital scoring system in the United States (HSS) scores of patients in the two groups 12 months after operation were higher than 6 months after operation, with statistically significant differences (all P ＜ 0.05). Two weeks after the operation, there was no statistical difference in HSS score between the two groups (P ＞ 0.05). HSS scores in the group A at 6 and 12 months after the operation were higher than those in the group B, with statistically significant differences (all P ＜ 0.05). The incidence of anterior knee pain in the group A was lower than that in the group B （P ＜ 0.05）. Conclusion Suprapatellar approach is better than transpatellar ligament approach with intramedullary nail in the treatment of middle and lower tibial fracture. It has the advantages of shorter operation time and shorter healing time after operation. It is conducive to the recovery of knee joint function, and it has lower incidence of anterior knee pain after operation, so it is worthy of clinical application.
		2020 Vol. 17 (12): 85-88,104 [Abstract] ( 148 ) HTML (1 KB) PDF (880 KB) ( 154 )

	89	Effect of external fixator pinning in anterior process of calcaneus combined with mini-open reduction and internal fixation in treatment of distal tibia comminuted fracture
		ZHANG Haisen1 LIU Chang1 LIANG Dongqi2 WANG Huailiang3 PEI Baojing3 LIU Hui4 LIU Ying5
		Objective To investigate clinical effect of external fixator pinning in anterior process of calcaneus combined with mini-open reduction and internal fixation in treatment of distal tibia comminuted fracture. Methods The clinical data of 19 patients with closed distal tibial comminuted fracture who received external fixator pinning in anterior process of calcaneus combined with mini-open reduction and internal fixation in the Derpatment of Orthopedics, Cangzhou Central Hospital in Hebei Province from January 2014 to January 2016 were retrospectively analyzed. During the operation, external fixation screws of the distal end of the fractures were placed in medial posterior side of the calcaneus and about 1 cm of sustentaculum of talus of calcaneus. A limited incision was made in the anterior medial side of the ankle, and screw fixation was adopted after the anatomical reduction of the distal articular surface fracture of the tibia. External fixator was relaxed for 1 time per week after postoperative 4 weeks in order to exercise motion of ankle. The perioperative data and follow-up data were analyzed to evaluate the postoperative clinical effect. Results The mean operation time was (58.6±15.4) min, the average intraoperative blood loss was (201.5±78.6) mL, and the average hospitalization time was (14.2±2.8) d. Two cases (10.5%) had postoperative superficial inflammatory reaction around fibular incision, and one case (5.3%) had postoperative infection of external fixation screw track, which healed well after treatment. No neurological or vascular injury complications occurred in all patients. The incidence of perioperative complications was 15.8%. The patients were followed up for 13 to 15 months. All fractures were healed without loss of reduction. There was no statistically significant difference between the Lowa ankle score and the visual analogue scale pain score at each postoperative follow-up time point (P ＞ 0.05). According to the Maryland score, the good rate of the curative effect was 84.2%. Conclusion External fixator pinning in anterior process of calcaneus combined with mini-open reduction and internal fixation in treatment of distal tibia comminuted fracture has good clinical effect, reliable fixation and low complication rate, which is an alternative surgical treatment method.
		2020 Vol. 17 (12): 89-92 [Abstract] ( 189 ) HTML (1 KB) PDF (525 KB) ( 62 )

	93	Analysis of the effect of self-designed Huoxue Xiuduan Decoction in treatment of closed fracture and its influencing factors
		ZHU Kang WANG Xiaotong MA Hujing DU Haishan
		Objective To explore the effect of Huoxue Xiuduan Decoction in the treatment of closed fractures, analyze the factors influencing the curative effect and the intervention strategies. Methods A total of 83 patients with closed fractures who were treated in Beijing Changping Hospital of Traditional Chinese Medicine from May 2016 to January 2018 were selected for observation and divided into the control group (41 cases) and the experimental group (42 cases) according to the random number table method. The control group was treated with conventional therapies such as closed reduction combined with splint external fixation, conventional antibiotics and bone protecting capsules. On the basis of the control group, the experimental group was treated with self-designed Huoxue Xiuduan Decoction. The clinical efficacy, inflammatory factors, pain and swelling degree of the two groups were observed. Logistic regression was used to test the influencing factors of the treatment effect of the experimental group. Results The total effective rate of the experimental group was higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the levels of interleukin-6 and interleukin-8 in the experimental group were significantly lower than those in the control group, with statistically significant differences (all P ＜ 0.05). After 1 day of treatment, there was no statistically significant difference between the two groups in pain score and swelling degree score (P ＞ 0.05). After 7 days of treatment, the pain and swelling degree scores of the two groups were lower than those after 1 day of treatment, and the experimental group was significantly lower than the control group, with statistically significant differences (all P ＜ 0.05). The reasons for the ineffective treatment in the experimental group were not correlated with gender, age, and cause of injury (P ＞ 0.05), and were correlated with the patients′ sleep time and whether they ate raw, cold, sour and spicy food (P ＜ 0.05). Logistic regression analysis showed that sleep time ＜ 8 h and frequent consumption of cold, sour and spicy food were risk factors for treatment failure (P ＜ 0.05). Conclusion The effect of self-designed Huoxue Xiuduan Decoction in the treatment of closed fracture is good, and it is worth popularizing in clinic. When using this treatment, the patient should follow the doctor's advice, follow a strict diet, and get enough sleep
		2020 Vol. 17 (12): 93-96 [Abstract] ( 159 ) HTML (1 KB) PDF (484 KB) ( 168 )

	97	Analysis of metabolism factors related to gestational diabetes mellitus and/or non-alcoholic fatty liver diease and diagnostic value of TyG index in pregnancy
		NIU Tong WANG Wan LI Tiantian ZHU Yihan XIN Yaping
		Objective To investigate the metabolism factors related to gestational diabetes mellitus (GDM) and/or non-alcoholic fatty liver diease (NAFLD) and diagnostic value of Triglyceride-glucose (TyG) index in pregnancy. Methods From June 2018 to September 2019, Pregnant women who labor examination and delivery in the Second Affiliated Hospital of Zhengzhou University (“our hospital” for short) were selected. Pregnant women with GDM were divided into GDM group (137 cases), NAFLD group of pregnant women with NAFLD (70 cases), pregnant women with GDM combined with NAFLD were in complex group (73 cases), the healthy pregnant women who came to our hospital for labor examination at the same time were selected as normal group (73 cases). Fasting blood glucose (FBG), fasting insulin (FINS), glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST) and alanine aminotransferase (ALT), serum uric acid (SUA) in 24-28 weeks pregnancy were compared, the homeostasis model of insulin resistance index (HOMA-IR) and TyG index were calculated. Results FBG, HbA1c, HOMA-IR and TyG index in GDM group were higher than those in normal group. ATL, SUA, TG, HOMA-IR and TyG index of NAFLD group were higher than those of normal group. ATL, SUA, TG, FBG, HbA1c, HOMA-IR and TyG index in complex group were higher than those in normal group and GDM group and FBG, HbA1c, HOMA-IR and TyG index were higher than those in NAFLD group, with statistically significant differences (all P < 0.05). FINS and the incidence of macrosomia in GDM group, NAFLD group and complex group were higher than those in normal group, and the differences were statistically significant (P < 0.05). Pearson correlation analysis showed that TyG index was positively correlated with HOMA-IR and HbA1c (r = 0.473, 0.472, P < 0.001). Logistic regression analysis showed that FBG (OR = 1.707, 95%CI:1.202-2.424, P = 0.003) and TG (OR = 1.386, 95%CI:1.031-1.862, P = 0.031) were risk factors for NAFLD in pregnant women with GDM. ROC curve showed that HOMA-IR and TyG index had diagnostic value for the occurrence of GDM and/or NAFLD. Conclusion Pregnant women with GDM combined with NAFLD have severe IR and metabolic disorders, FBG and TG are involved in occurrence of NAFLD in pregnant women with GDM. Therefore, effective measures should be taken to control clinically. TyG index can initially identify IR and assess blood glucose level.
		2020 Vol. 17 (12): 97-101,108 [Abstract] ( 164 ) HTML (1 KB) PDF (611 KB) ( 58 )

	101	Correlation between matrix metalloproteinases and onset of preeclampsia
		JI Mingjie WU Jun SUN Lijun ZUO Jinling
		Objective To analyze the correlation between matrix metalloproteinases (MMPs) and onset of preeclampsia. Methods From February 2016 to February 2018, 51 cases with preeclampsia patients in Tangshan Maternal and Child Health Hospital of Hebei Province were randomly selected for the study. According to the severity of disease, they were divided into severe group (n = 22) and mild group (n = 29). Women with normal term pregnancy at the same time were included in control group (n = 30). The levels of serum MMP-2 and MMP-9 were compared among three groups. The correlation between serum levels of MMP-2, MMP-9 and onset of preeclampsia was analyzed. The predictive value of MMP-2 and MMP-9 levels on severe preeclampsia was evaluated. Results The levels of serum MMP-2 and MMP-9 in severe group were lower than those in mild group and control group, and the levels serum MMP-2 and MMP-9 in mild group were lower than those in control group (all P < 0.05). Spearman correlation analysis showed that serum MMP-2 and MMP-9 levels were negatively correlated with onset of preeclampsia and disease severity (r = -0.839, -0.747; P < 0.001). The cut-off value of serum MMP-2 level was 54.89 pg/mL in predicting severe preeclampsia, and the sensitivity, specificity were 0.818, 0.828. The cut-off value of serum MMP-9 level was 175.62 pg/mL in predicting severe preeclampsia, and the sensitivity, specificity were 0.818, 0.897. Conclusion The levels of serum MMP-2 and MMP-9 are closely related to the onset of preeclampsia and severity of preeclampsia, which has certain predictive value for severe preeclampsia.
		2020 Vol. 17 (12): 101-104 [Abstract] ( 131 ) HTML (1 KB) PDF (643 KB) ( 189 )

	105	Effect of early comprehensive intervention on neurodevelopment in children with premature brain injury
		YANG Huiting HU Chunwei▲
		Objective To evaluate the effects of early integrated intervention on neuromotor and mental development in children. Methods From January to June 2018, 140 cases with brain injury in premature infants who treated in Department of Pediatric Neurology and Rehabilitation, Baoji Women and Children′s Health Care Center of Shaanxi Province were selected. They were randomly divided into intervention group and control group, according to single and double day method, with 70 cases in each group. Control group was given routine intervention, and intervention group was given early comprehensive intervention. After interventions for 6, 12 months, the development of neuromotor development, mental development index (MDI), and psychomotor dewelopment index (PDI), cerebral palsy, and mental retardation were evaluated. Results The incidence of neuromotor dysplasia in intervention group after 6, 12 months intervention was lower than that of control group (P ＞ 0.05). After 12 months of intervention, MDI and PDI scores of two group were higher than those after 6 months of intervention (P < 0.05), and the incidence of cerebral palsy and mental retardation of intervention group was lower than that of control group (P < 0.05). Conclusion Early comprehensive interventions such as pediatric massage, active exercise therapy, and occupational therapy can significantly improve the comprehensive developmental quotient of children with premature brain injury, and can significantly reduce the incidence of sequelae such as cerebral palsy and mental retardation, and improve the prognosis of children.
		2020 Vol. 17 (12): 105-108 [Abstract] ( 161 ) HTML (1 KB) PDF (582 KB) ( 41 )

	109	Clinical effect of internal and external treatment for enuresis in children of xiayuan xuhan type
		LI Haitian1 ZHANG Man1 MA Jianqiang1 LYU Zhongli1 LIU Xiaomei2▲
		Objective To evaluate the clinical effect of internal and external treatment for enuresis in children of xia yuan xu han type. Methods From January 2016 to December 2018, 92 cases with enuresis children who admitted to Beijing children′s Hospital, Capital Medical University were selected as the research object. According to the random number table method, they were divided into control group (45 cases) and observation group (47 cases). Control group was received oral Desmopressin therapy, and observation group was received combined acupuncture therapy on the basis of control group. They were treated for 4 weeks, and the clinical efficacy was observed. The scores of enuresis times, sleep failure and traditional Chinese medicine (TCM)syndrome were compared between two groups. Results The clinical effect of observation group was better than that of control group, and the difference was statistically significant (P < 0.05). Before treatment, there was no statistically significant difference between two groups in the scores of enuresis times, sleep failure and TCM syndromes (P > 0.05). After treatment, the scores of enuresis times, sleep failure and TCM syndromes in two groups were lower than those before treatment, and observation group was lower than control group, with statistically significant differences (all P < 0.05). Conclusion Internal and external treatment can significantly improve the hypoxic cold syndrome of enuresis children, and can significantly reduce the clinical symptoms of enuresis children.
		2020 Vol. 17 (12): 109-111,115 [Abstract] ( 133 ) HTML (1 KB) PDF (637 KB) ( 72 )

	112	Correlation between food conversion and intelligence development in preterm infants
		SUN Yalian HE Xiaoying▲ WU Cuiling LIU Ke ZENG Lingyan MA Jing
		Objective To explore the correlation between food conversion and intelligence development in preterm infants. Methods From January to June 2017, 300 cases with preterm infants who corrected aged 18-24 months were born in Foshan Women and Children Hospital of Guangdong Province were enrolled. A retrospective study was conducted to ask premature infants about food conversion, the subjects were evaluated with Children′s Neuropsychological Behavior Checklist 2016. Multiple linear regression was used to analyze the correlation between factors of food conversion and general movement development, fine motor, adaptability, language and social behavior. Results There was no correlations between food conversion factors and general movement development. There was a negative correlations between the introduction of block food time and the fine motor development quotient (β = -0.549, P = 0.023). There was a negative correlations between the time of vegetables introduction and adaptability DQ (β = -0.820, P = 0.005) . There was a negative correlations between the time of complementary foods introduction and DQ of language (β = -1.319, P = 0.047). There was a negative correlation between the complementary foods introduction time and social behavior DQ (β = -1.827, P = 0.001). Conclusion Food conversion affects the developments of fine motor, adaptability, language and social behavior of preterm infants via food diversity, food textures conversion and feeding mode change, so as to provide new ideas for clinical improvement of preterm infants′intelligent development.
		2020 Vol. 17 (12): 112-115 [Abstract] ( 157 ) HTML (1 KB) PDF (620 KB) ( 45 )

	116	Effect of Roy′s adaptation model on glycemic control and pregnancy outcomes in patients with gestational diabetes mellitus
		ZHANG Yi PAN Huirong▲ LI Yan
		Objective To investigate the effect of Roy′s adaptation model on glycemic control and pregnancy outcomes in patients with gestational diabetes mellitus (GDM). Methods From January to September 2018, 301 cases who diagnosed GDM for the first time in the First Maternity and Infant Hospital Affiliated to Tongji University were seletced. They were divided into control group (154 cases) and intervention group (147 cases) according to the result of lottery. Control group was treated with routine medical intervention, and intervention group was treated with Roy′s adaptation model (RAM) on the basis of control group. Body mass index (BMI) in early pregnancy, weight gain during pregnancy and fasting blood glucose, 2 h postprandial blood glucose, and HbA1c level after 8 weeks of intervention were compared between two groups. Treatment, pregnancy complications and pregnancy outcomes were compared between two groups. Results There was no significant difference in BMI between two groups in early pregnancy (P > 0.05). After 8 weeks of intervention, pregnancy weight gain and HbA1c levels in intervention group were lower than those in control group, with statistically significant differences (P < 0.05). There was no significant difference in fasting blood glucose and 2 h postprandial blood glucose between two groups (P > 0.05). There was no significant difference in the number of blood ketone positive cases between the two groups (P > 0.05). The number of cases treated with insulin and HbA1c higher than 6% in pregnancy in intervention group were less than those in control group, with statistically significant differences (P < 0.05). There was no statistically significant difference in the incidence of prenatal fever, excess amniotic fluid, postpartum hemorrhage, premature delivery, fetal distress and neonatal asphyxia between the two groups (P > 0.05). The incidence of hypertension during pregnancy, macromacroia and hyperbilirubinemia in neonates in intervention group was lower than that in control group, with statistically significant differences (P < 0.05). Conclusion RAM intervention can reduce blood glucose level, reduce the use of insulin, reduce the occurrence of pregnancy complications, and improve pregnancy outcome in GDM patients, which is worthy of promotion.
		2020 Vol. 17 (12): 116-119 [Abstract] ( 186 ) HTML (1 KB) PDF (585 KB) ( 105 )

	120	Effect of different eye massage nursing methods on intraocular pressure and success rate of glaucoma after trabeculectomy
		ZHANG Ting1 JIN Wen1 ZHAO Di2▲
		Objective To explore the influence of different eye massage nursing methods on intraocular pressure and success rate of glaucoma patients after trabeculectomy. Methods A total of 50 cases of glaucoma patients treated with trabeculectomy in Beijing Chaoyang Hospital, Capital Medical University from January 2017 to December 2018 were selected as the subjects, they were divided into study group and control group by random allocation method, with 25 cases (25 eyes) in each group. The study group self-received eye massage and the control group family members participated in assisting eye massage. After the intervention, the intraocular pressure and functional follicular formation of the two groups were compared. At 90 days after the operation, the compliance of patients of the two groups to the nursing behavior were followed up in the form of investigation scale. Results The intraocular pressure of the study group was significantly reduced on 90 days after operation compared with that at discharge (P ＜ 0.05). The intraocular pressure of the control group was significantly higher on 90 days after the operation (P ＜ 0.05). The intraocular pressure of the study group was significantly lower than that of the control group at 90 days after surgery (P ＜ 0.05). The nursing compliance of the study group was higher than that of the control group at 90 days after operation (P ＜ 0.05). The formation of functional filtration vesicles at 90 days after operation in the study group was significantly higher than that in the control group, and the success rate of operation was higher than that in the control group (P ＜ 0.05). Conclusion In the nursing work of eye massage after trabeculectomy for glaucoma patients, the patients′ own eye massage treatment method compliance is higher, and the postoperative success rate of the patients using this method is higher.
		2020 Vol. 17 (12): 120-123 [Abstract] ( 172 ) HTML (1 KB) PDF (442 KB) ( 106 )

	124	Effect of Ibuprofen combined with Minocycline Hydrochloride on basic treatment and inflammatory factors of severe chronic periodontitis
		PU Lili1 CHEN Danhua2 XUE Jing1
		Objective To investigate the effect of Ibuprofen combined with Minocycline Hydrochlorideon basic treatment and inflammatory factors of severe chronic periodontitis. Methods A total of 78 patients with severe chronic periodontitis diagnosed and treated in Jinhua Central Hospital of Zhejiang Province from March 2017 to March 2019 were selected. They were divided into study group (39 cases) and control group (39 cases) according to the random number table method. The control group was given periodontal mechanical therapy. The study group was treated with Ibuprofen on the basis of the control group. After 4 weeks of treatment, the clinical effect, inflammatory factor level, immune function, periodontal index and adverse reactions were compared between the two groups. Results The total clinical effective rate of the study group was higher than that of the control group after 4 weeks of treatment (P ＜ 0.05). Compared with before treatment, interleukin (IL)-6, IL-8, tumour necrosis factor-α and hypersensitive C-reactive protein in both groups were decreased after 4 weeks of treatment, and the study group were lower than those of the control group (P ＜ 0.05). Compared with before treatment, CD4+ and CD4+/CD8+ in both groups were increased after 4 weeks of treatment, while CD8+ was decreased (P ＜ 0.05). The CD4+ and CD4+/CD8+ in the study group were higher than those in the control group, while CD8+ was lower than that in the control group (P ＜ 0.05). Compared with before treatment, the gingival sulcus bleeding index, plaque index and periodontal pocket depth of the two groups were all reduced after 4 weeks of treatment, and the study group were lower than those of the control group (P ＜ 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Ibuprofen combined with Minocycline Hydrochloride in the treatment of severe chronic periodontitis can effectively improve the immune function and alleviate inflammatory reaction, and the drug is safe and effective.
		2020 Vol. 17 (12): 124-127 [Abstract] ( 146 ) HTML (1 KB) PDF (447 KB) ( 108 )

	128	Systematic review and meta-analysis of the effect of Tripterygium Glycoside Tablets on IL-23/IL-17 axis related cytokines in the treatment of rheumatoid arthritis
		WANG Hanzhou1 ZHU Guangzhao2 YANG Yuzheng3 GAO Yang1 HAN Xiaochen4 SHI Bai5 HOU Jialun6 WANG Hailong1
		Objective To evaluate the effect of Tripterygium Glycoside Tablets on the expression of pro-inflammatory cytokines and anti-inflammatory cytokines related to interleukin (IL)-23/IL-17 inflammatory axis in rheumatoid arthritis (RA) treatment. Methods Search through Chinese and English databases such as CNKI, VIP, WanFang, SinoMed, EMbase, PubMed, Clinical Trials, Web of Science, Cochrane Library, etc. With a period of time from the establishment of the databases to December 22, 2019. Randomized controlled trials （RCT） of Tripterygium Glycoside Tablets for RA were included, from which the data was extracted. Methodological quality evaluation was performed using the “bias risk” assessment tool recommended by Cochrane Collaboration, and RevMan 5.3 software was used for meta-analysis. Results Compared with using Methotrexate alone, Tripterygium Glycoside Tablets combined with Methotrexate had an advantage in reducing the levels of IL-1, IL-6 and tumor necrosis factor-α, the difference were statistically significant (P ＜ 0.05). While in comparison with using Methotrexate or Leflunomide alone, Tripterygium Glycoside Tablets combined with Methotrexate or Leflunomide had shown no statistically marked difference regarding the effect on IL-10（P ＞ 0.05）. Conclusion Tripterygium Glycoside Tablets combined with Methotrexate or Leflunomide can significantly reduce the expression of IL-23/IL-17 axis related to pro-inflammatory cytokines. However, there are rare RCTs that have reported the effect of Tripterygium Glycoside Tablets on anti-inflammatory cytokines, and the existing evidence can not reach the conclusion that Tripterygium Glycoside Tablets can improve the level of anti-inflammatory cytokines.
		2020 Vol. 17 (12): 128-132 [Abstract] ( 168 ) HTML (1 KB) PDF (1734 KB) ( 158 )

	133	Clinical effect and safety of Shugan Weian Recipe in adjuvant treatment of gastro esophageal reflux disease
		WANG Guangming SUN Gang HUANG Yuzhen LIU Wanli▲
		Objective To explore the clinical effect and safety of Shugan Weian Recipe in the adjuvant treatment of gastro esophageal reflux disease (GERD). Methods A total of 120 patients GERD who were treated in the Outpatient Service of Nanjing Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine from March 2017 to March 2019 were selected as the research objects. They were divided into control group and the observation group by random number table method, with 60 cases in each group. The control group was treated with routine western medicine, while the observation group was treated with routine western medicine combined with Shugan Weian Recipe. Before and after treatment, the reflux disease questionnaire (RDQ) and 24-hour esophageal pH of two groups were surveyed. After treatment, gastroscopic efficacy, total RDQ score, pH test results and adverse reactions were compared between the two groups. Results The total effective rate of the observation group was significantly higher than that of the control group, but the difference was not statistically significant (P ＞ 0.05); after treatment, the total RDQ score of the two groups was significantly lower than that before treatment (P ＜ 0.05), and the total RDQ score of the observation group was significantly lower than that of the control group (P ＜ 0.05); after treatment, the percentage of total time of pH＜4, times of reflux duration ≥ 5 minutes, longest reflux duration and DeMeester score in both groups were significantly lower than those before treatment (P ＜ 0.05), and the longest reflux duration and DeMeester score in the observation group were significantly lower than those in the control group (P ＜ 0.05). After treatment, the difference in the rate of adverse reactions between the two groups was not statistically significant (P ＞ 0.05). Conclusion Shugan Weian Decoction combined with Western medicine has a good clinical effect in the treatment of GERD. It can not only alleviate the clinical symptoms of GERD patients, improve the quality of life of patients, but also has certain safety.
		2020 Vol. 17 (12): 133-136 [Abstract] ( 147 ) HTML (1 KB) PDF (505 KB) ( 63 )

	137	Effect of Anrotinib combined with paclitaxel and Carboplatin in the treatment of advanced lung adenocarcinoma
		SHU Guijun ZHU Yongdong XIE Hua
		Objective To explore the clinical effect of Anlotinib combined with paclitaxel and Carboplatin in the treatment of advanced lung adenocarcinoma. Methods A total of 80 patients with negative driving gene of advanced lung adenocarcinoma who were admitted to the People′s Hospital of Xuancheng City of Anhui Province from May 2018 to September 2019 were selected and divided into control group and treatment group according to the random number table method, with 40 cases in each group. The control group was given paclitaxel + carboplatin treatment, while the treatment group was given Anrotinib combined with paclitaxel + Carboplatin treatment, 21 d was a course of treatment, while both groups were given 3 courses of treatment continuously. The clinical efficacy of the two groups after treatment, KPS scores, serum carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), vascular endothelial growth factor (VEGF) levels and the incidence of toxic and side effects during treatment were compared before and after treatment. Results The total remission rate of the treatment group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). The KPS scores of the two groups after treatment were higher than that before treatment, while the treatment group was higher than the control group, the differences were statistically significant (P ＜ 0.05). The levels of serum CEA, NSE and VEGF after treatment in the two groups were lower than those before treatment, while the treatment group was lower than the control group, the differences were statistically significant (P ＜ 0.05). There was no statistically significant difference in the incidence of side effects during treatment between the two groups (P ＞ 0.05). Conclusion Anlotinib combined with paclitaxel and Carboplatin has a significant clinical effect in the treatment of advanced lung adenocarcinoma, which can significantly improve the patient′s quality of life, reduce serum CEA, NSE, VEGF levels, and has good safety.
		2020 Vol. 17 (12): 137-140 [Abstract] ( 276 ) HTML (1 KB) PDF (540 KB) ( 123 )

	141	Application of fuyang theory in external treatment of Chinese medicine
		YE Bo1 WANG Hongxia2 ZHAO Zhihong3 FANG Jin4 LI Haixia5
		The external treatment of traditional Chinese medicine is to use various external methods to apply drugs or energy to the skin, orifices, shu points and other parts, so as to play its role in clearing channels and collaterals, harmonizing qi and blood, detoxifying and removing blood stasis, strengthening the healthy and removing pathogenic factors, readjusting and improving the imbalance of yin and yang in the viscera, so as to promote the recovery of body functions and achieve the purpose of treatment. The external treatment of traditional Chinese medicine has a long history. The emergence of Li Yue Pianwen by Wu Shangxian in the Qing Dynasty marks the formation of a complete theoretical system, in which, the concept of supporting yang is embodied. The application of fuyang theory in the external treatment of traditional Chinese medicine can be divided into two categories to guide the clinical practice: first, it is mainly used for warming and removing blood stasis, including acupuncture, scraping, massage, walking on stilts, chiropractic and qigong; second, it is mainly used for warming and invigorating yang, including moxibustion, medicine bath, Chinese medicine sticking, paraffin therapy, etc.
		2020 Vol. 17 (12): 141-144,164 [Abstract] ( 139 ) HTML (1 KB) PDF (834 KB) ( 117 )

	145	Study on plasma metabolomics of liver cancer patients with syndrome of dampness excessiveness due to spleen deficiency based on UPLC-HDMS
		WANG Dong LI Jingjie LYU Shuqin
		Objective To study the pathogenesis of liver cancer with syndrome of dampness excessiveness due to spleen deficiency by metabonomics and the molecular biological effect of the intervention of invigorating spleen for eliminating dampness. Methods Fifty persons with peace quality of blank group were selected from the physical examination center of Chinese Medicine Hospital of Xinjiang Medical University (hereinafter referred to as “our hospital”) from June 2017 to June 2019. 50 cases of liver cancer patients with spleen deficiency and dampness syndrome in our hospital were taken as control group and 50 cases of liver cancer patients taking Sijunzi Decoction for one month were taken as observation group. Metabonomics analysis of plasma samples from three groups of participants was carried out by using the technology of ultra-high performance liquid chromatography-high definition mass spectrometry. Results Nineteen potential biomarkers such as glutathione and L-glutamic acid were identified in the blood samples of the selected subjects. Compared with blank group, 6 of control group showed an upward trend and 13 showed a downward trend (P < 0.05 or P < 0.01). After intervention of Sijunzi Decoction, 17 of them had callback effect, and the adjustment difference was statistically significant (P < 0.05 or P < 0.01). According to these 17 callback biomarkers, 6 related metabolic pathways including D-glutamine and glutamate metabolism, taurine and taurine metabolism were found. Conclusion There are disorders of amino acid metabolism, arachidonic acid metabolism, fatty acid metabolism and glutathione metabolism in liver cancer of syndrome of dampness excessiveness due to spleen deficiency. Sijunzi Decoction may regulate the disorders by above metabolic pathways in liver cancer of syndrome of dampness excessiveness due to spleen deficiency.
		2020 Vol. 17 (12): 145-148 [Abstract] ( 155 ) HTML (1 KB) PDF (809 KB) ( 83 )

	149	Clinical effect of transcutaneous electric acupoint stimulation in the treatment of cancer-related fatigue after chemotherapy
		LI Yan ZHANG Haibo LIU Yihong ZHANG Fuli HU Limin LIU Huanyi YUAN Li LI Haixu
		Objective To investigate clinical effect of transcutaneous electric acupoint stimulation in the treatment of patients with cancer-related fatigue after chemotherapy. Methods Randomized study was used. From October 2018 to June 2019, 116 cancer patients who met the standard were screened in Oncology Department of Guangdong Provincial Hospital of Traditional Chinese Medicine. According to the random number table method, they were divided into two groups, with 58 cases in each group, 8 cases of abscission in each group, 53 cases in final control group and 55 cases in final experimental group. Control group was given routine diagnosis and treatment nursing in Oncology Department, On this basis, experimental group was treated with transcutaneous acupoint electrical stimulation. zhōngw?觍n, qìh?觍i, gu?觀nyu?觃n, bilateral neìgu?觀n, bilateral zús?觀nlǐ and bilateral s?觀nyīnji?觀o acupoints were selected. They were treated during and before chemotherapy, 20 minutes one time, once a day, for 5 days. Treatment period of two groups was 5 days. The fatigue state and quality of life of the patients were evaluated by Piper fatigue revised scale and functional assessment of cancer therapy-general (FACT-G) scale before and after treatment. Results There were significant differences between two groups in scores of overall and all dimensions of Piper fatigue revised scale after treatment (P < 0.05). In control group, overall scores and emotional fatigue score of Piper fatigue revised scale after treatment were higher than those before treatment, and in experimental group, overall score and all dimensions scores of Piper fatigue revised scale after treatment were lower than those before treatment, the differences were statistically significant (P < 0.05). There were significant differences between two groups in total scores of FACT-G and physiological status scores after treatment (P < 0.05). In experimental group, the score of physiological condition was lower than that before treatment, and the score of functional condition was higher than that before treatment; total score of FACT-G and the score of physiological status in control group were lower than those before treatment, and the score of functional status was higher than that before treatment, the differences were statistically significant (P < 0.05). Conclusion Transcutaneous electric acupoint stimulation can alleviate cancer-related fatigue and improve the quality of life of tumor patients after chemotherapy.
		2020 Vol. 17 (12): 149-152,168 [Abstract] ( 186 ) HTML (1 KB) PDF (788 KB) ( 92 )

	153	Professor Luo Xiaorong′s experience in treatment of neurotic urinary frequency of children from gallbladder
		LI Rongzhen1，2 LIU Jingwei1，2 XU Kaisi2，3 CHEN Hanhua3▲
		Neurotic urinary frequency is one of the most common psychological behaviour diseases in children, having a bad influence on the life of a family. However, the overall curative effect is unsatisfactory at present. Professor Luo puts forward the theory of treating neurotic urinary frequency in children from gallbladder, based on the long-term clinical practice and Shaoyang theory. She considers that the disease is mainly caused by sudden panic, resulting in phlegm and qi counterfiow and deficiency heat disturbing spirit. Thus, she created the Chaishao Wendan Decoction, the function of which is to regulate qi and resolve phlegm, tranquilize mind and reduce urination simultaneously. It creates a new way of thinking in treating neurotic urinary frequency in children. This article introduces the experience of professor Luo treating neurotic urinary frequency in children from three aspects: etiology pathogenesis, therapeutic method and prescriptions and threeproven cases.
		2020 Vol. 17 (12): 153-156 [Abstract] ( 145 ) HTML (1 KB) PDF (810 KB) ( 224 )

	157	Clinical study of Yiqi Shujin Decoction combined with massage in the treatment of neck-shoulder and lumbocrural pain
		TIAN Bingsheng QI Chunlei
		Objective To explore clinical effect of Yiqi Shujin Decoction combined with massage in the treatment of neck-shoulder and lumbocrural pain. Methods One hundred and three patients with neck-shoulder and lumbocrural pain admitted to Affiliated Hospital of Shandong Academy of Medical Sciences from January 2014 to December 2018 were selected as study objects. The patients were divided into control group (51 cases) and study group (52 cases) according to random number table method. Control group was treated with massage. Study group was treated with Yiqi Shujin Decoction on the basis of control group. Two groups were treated for 30 days. After treatment, the total clinical effective rate of two groups was counted. Visual analogue scale (VAS) score, frequency of pain onset, duration of pain and quality of life score were evaluated before and after treatment. The adverse reaction of two groups during treatment was observed. Results The total clinical effective rate of study group was significantly higher than that of control group, and the difference was statistically significant (P < 0.05). After treatment, the frequency of VAS and pain attack in two groups were lower than those before treatment, and those in study group was lower than those in control group, and the differences were statistically significant (P < 0.05). After treatment, the duration of pain in two groups was shorter than that in control group, which in study group was shorter than that in control group, the differences were statistically significant (P < 0.05). After treatment, the scores of anxiety state, depression state, life ability and social activity in two groups were lower than those before treatment, which in study group were lower than those in control group, the differences were statistically significant (P < 0.05). No serious adverse reactions occurred in both groups during the treatment. Conclusion Yiqi Shujin Decoction combined with massage is effective in the treatment of neck-shoulder and lumbocrural pain. It can obviously relieve pain, reduce the frequency of attacks, improve the quality of life, and has good safety.
		2020 Vol. 17 (12): 157-160 [Abstract] ( 133 ) HTML (1 KB) PDF (765 KB) ( 89 )

	161	Hotspots and frontiers of Ba Duanjin research based on citespace
		ZHOU Jing1，2，3 LI Jia4 WU Miao2，3 WEI Meng4 CAO Biwei2，3
		Objective To explore the development, the research hotspot and dynamic frontier of the field in the recent 20 years through analyzing the researches of Ba Duanjin, which can provide experience and reference for late-stage study. Methods Based on 994 research literatures of Ba Duanjin collected by CNKI (searching medical subject word was “Ba Duanjin”, data from January 1999 to January 2019, citespace Ⅴ was used to analyze the co-occurrence of keywords and draw relevant knowledge map. Results In the recent 20 years, the volume of Ba Duanjin research papers had increased year by year. Research hotspots in the field focused on “type 2 diabetes”, “elderly”, “quality of life”. The three frontier topics were “coronary heart disease”，“cardiac rehabilitation”，“meta analysis”. Conclusion The scholars paid more and more attention to the effectiveness of Ba Duanjin in the heart field and evidence-based medical evidence of Ba Duanjin. However, most of the previous studies quality are low, it is necessary to strengthen cooperation among research teams and conduct more high-quality research to provide evidence support for the clinic.
		2020 Vol. 17 (12): 161-164 [Abstract] ( 179 ) HTML (1 KB) PDF (1202 KB) ( 272 )

	165	Exploration on the experience of Prunellae Spica in the treatment of goiter disease
		LI Xin′ai1 QI Shuo2 CHEN Xiaoheng2 LI Zhe2 LI Huilong2 DING Zhiguo2
		Prunellae Spica is a commonly used traditional Chinese medicine for the treatment of goiter disease. It has the effects of clear away heat and purge pathogenic fire, improving eyesight, fights swelling. Modern research shows that it has antibacterial and antiviral effects, promoting blood circulation and removing blood stasis, anti-inflammatory and anti-immune effects, and has a concentrated understanding of its mechanism. It plays a role in promoting gene expression, promoting apoptosis, and blocking the proliferation of cancer cells. Its prescriptions have been widely used in clinical practice, and its clinical efficacy has been affirmed. This paper summarizes the effectiveness of Prunellae Spica treatment in rickets by consulting ancient books, referring to modern experimental research, and combining with the clinical experience of professor Ding Zhiguo. It can be used as a reference for clinical Chinese medicine treatment of thyroid diseases.
		2020 Vol. 17 (12): 165-168 [Abstract] ( 235 ) HTML (1 KB) PDF (816 KB) ( 164 )

	169	Application of traditional Chinese medicine thought in the ideological and political education of college students in the new era
		YAN Peizheng1 MENG Ningning2 LIU Changyue2 SU Na′na3
		Ideological and political education plays an extremely important role in the cultivation of college talents. This paper analyzes the value and significance of traditional Chinese medicine thought in the ideological and political education of college students in the new era, taps into the essence of China′s excellent traditional culture, starting from the concepts of “holistic view”, “treatment based on syndrome differentiation”, “great medical sincerity” and “prevention of disease” in traditional Chinese medicine thoughts, directes against the dilemma of ideological and political education for college students in the new era, and provides guidance in theory and practice from three dimensions: the content of education, the educator, and the mode of education. It has a certain reference significance for improving the effectiveness of ideological and political education for college students in the new era. At the same time, it shows the historical significance and value of traditional culture.
		2020 Vol. 17 (12): 169-172 [Abstract] ( 143 ) HTML (1 KB) PDF (798 KB) ( 128 )

	173	A case of Israeli actinomycete infection and literature review with pneumonia as the main manifestation
		FENG Yi1 LI Xinyang2 WANG Kaijin3▲
		Israeli actinomycetes is a kind of actinomycetes, which can cause chronic suppurative granulomatous disease of the lung, forming single or multiple pulmonary nodules. It is relatively rare to cause bronchial pneumonia. In addition, the widespread application of penicillin reduces the reported cases of pulmonary actinomycosis, but it still exists in remote areas. If early diagnosis and early treatment are not possible, it may lead to to poor prognosis, lung function decline, loss of labor force, and even endanger the lives of patients, so it is crucial to raise awareness of the disease. However, the infection caused by this pathogen is mostly chronic suppurative granulomatous infection, which is mostly manifested as nodules or cavitary lesions with air floating signs, and the imaging has no specificity. Therefore, to do early diagnosis, early treatment, only to improve the awareness of the disease. The imaging manifestation of this patient is pneumonia, which is more rare. In this paper, the basic knowledge of actinomycetes, the basic information of patient, the diagnosis and treatment process, treatment prognosis, literature review and other aspects of the disease are elaborated in depth, so as to increase clinicians′ understanding of the disease.
		2020 Vol. 17 (12): 173-175,184 [Abstract] ( 160 ) HTML (1 KB) PDF (926 KB) ( 113 )

	176	Analysis on the influence of Beijing medicine reform on the medical expenses of patients in tertiary hospitals
		SUN Shuxue1 LIU Haiyan2 XU Jide3 ZHAO Guanhong4
		Objective To analyze the impact of the medical separation reform in April 2017 on the medical expenses of patients in grade tertiary hospitals in Beijing, and to provide advice on medical cost management and medical service pricing reform. Methods Descriptive analysis method was used to analyze the medical cost data of Beijing grade tertiary hospitals from 2014 to 2018, and Patients′ costs before the reform (2014-2016), during the reform (2017) and after the reform (2018) were compared. Results After the reform of separating medicine from medicine, the average cost of outpatient service and hospitalization in tertiary hospitals increased by 2.65% and 2.44% respectively, and the proportion of outpatient and inpatient drugs decreased to 55.67% and 26.54% respectively, and the proportion of inpatient materials expenses decreased to 32.43%. The proportion of hospitalization expenses covered by medical insurance was 72.54%. Conclusion After the reform of separating medicine from medicine, the level of medical expenses in tertiary hospitals has been increased in a controllable way, the medical cost structure has been optimized, and the medical burden on patients has been steadily reduced. It is suggested that we should continue to deepen the reform of medical price, standardize and adjust the medical service fees, and strengthen the control of the growth of medical expenses, so as to better realize the transformation of hospital compensation mechanism.
		2020 Vol. 17 (12): 176-179 [Abstract] ( 138 ) HTML (1 KB) PDF (677 KB) ( 84 )

	180	Construction and practice effect evaluation of informatization service system of outpatient and emergency department blood collection
		MAO Li′na1 YU Aifang2▲ WEN Sufang3 TANG Yi3
		Objective To construct the information service system of blood collection in outpatient and emergency department, to study its practical effects and to explore its optimization and promotion. Methods Since August 2017, the outpatient and emergency depantment blood collection information service system have been build in Affiliated Hospital of Guilin Medical University (“our hospital” for short), which includes blood collection consultation, call queue, automatic assurance, inspection result return time monitoring and management. The unqualified samples, overdue samples of outpatient and emergency blood collection were compared before the implementation (from May to July 2017) and after the implementation (from April to June 2019) from April 1 to April 30, 2019, 200 patients with outpatient and emergency blood collection in our hospital were taken as the investigation subjects, and patients′ satisfaction was analyzed. Results After the establishment of the information service system of outpatient and emergency blood collection in our hospital, the rate of unqualified samples and the rate of overdue samples both decreased after the implementation, with high statistically significant differences (all P ＜ 0.01). Two hundred questionnaires were distributed, and 200 were returned. The overall evaluation of the outpatient and emergency depatment blood collection information system and nursing service was (4.49±0.84) scores. Conclusion The establishment of outpatient and emergency department blood collection information service system can improve the work efficiency of nurses and patients′ satisfaction, reduce the work pressure of nurses, provide high-quality services for patients, and provide basis and reference for building the system model of outpatient and emergency blood collection information service.
		2020 Vol. 17 (12): 180-184 [Abstract] ( 132 ) HTML (1 KB) PDF (690 KB) ( 105 )

	185	Influencing factors of left ventricular hypertrophy and the predictive value of RDW and hs-CRP in maintenance hemodialysis patients
		LU Jin ZHANG Hongxu ZHANG Yuqin LIU Yiran ZHANG Chaoqun
		Objective To explore the influencing factors of left ventricular hypertrophy (LVH) and the predictive value of red blood cell distribution width (RDW) and serum hypersensitive C-reactive protein (hs-CRP) in maintenance hemodialysis (MHD) patients. Methods A total of 135 patients with end-stage renal disease who were admitted to Anhui No.2 Provincial People′s Hospital for MHD≥3 months from June 2016 to June 2019 were collected. According to the left ventricular mass index (LVMI), they were divided into LVH group (69 cases) and non-LVH group (66 cases), while patient demographic data, laboratory indicators, and imaging studies were collected. Demographic data, laboratory indicators and imaging examination of each group were collected. Logistic regression was used to analyze the influencing factors of LVH in MHD patients, and the receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of RDW and hs-CRP to LVH. Results The age, systolic blood pressure, RDW, uric acid, total cholesterol, triacylglycerol, left ventricular end-diastolic diameter and hs-CRP in the LVH group were higher than those in the non-LVH group, and the differences were statistically significant (P < 0.05). Age, systolic blood pressure, history of hypertension, history of diabetes, RDW, hs-CRP were independent risk factors for LVH in MHD patients (P < 0.05). The areas under the curve of RDW and hs-CRP were 0.900 (0.871-0.929) and 0.837 (0.799-0.876), respectively, while the predictive value of joint detection was higher [0.934 (0.913-0.954)]. Conclusion Age, systolic blood pressure, history of hypertension, history of diabetes, RDW and hs-CRP are independent risk factors of LVH in MHD patients. Early combined detection of RDW and hs-CRP has predictive value for LVH in MHD patients.
		2020 Vol. 17 (12): 185-188 [Abstract] ( 182 ) HTML (1 KB) PDF (748 KB) ( 101 )

	189	Construction of vocational colleges campus community based on career development
		QIU Lanlan LI Mingmei▲
		Campus characteristic associations are the important carrier of campus culture construction and specialty construction in higher vocational colleges, which play an important role in improving the comprehensive quality, professional quality and social adaptability of college students. They play an important role in improving college students′ comprehensive quality, professional quality and social adaptability. However, there are relatively few studies on promoting students′ career development in the characteristic associations of higher vocational colleges. This article studies the construction of characteristic societies in higher vocational colleges based on career development orientation, discusses the background characteristics and significance of the construction of college societies, and on the basis of perfecting the strategy of constructing characteristic societies on campus, takes the pharmaceutical societies of Jiangsu Vocational College of Medicine as an example to study the construction plan of characteristic societies on campus as well as the development status of associations. Finally, this paper puts forward constructive opinions on the problems existing in the construction of pharmacy associations, in order to improve the professional skills and employability of pharmacy students, provide certain references and references for the construction of characteristic associations in vocational colleges, and promote the construction of campus culture construction in higher vocational colleges in our country and the society′s development.
		2020 Vol. 17 (12): 189-191,196 [Abstract] ( 138 ) HTML (1 KB) PDF (690 KB) ( 64 )

	192	Effect of photodynamic therapy combined with self-made traditional Chinese medicine in the treatment of verruca plantaris and its influence on the levels of serum TGF-β, IFN-γ, CD28 and CD40 in patients
		SUN Yan
		Objective To observe effect of photodynamic therapy combined with self-made traditional Chinese medicine in the treatment of verruca plantaris and its influence on the levels of serum TGF-β, IFN-γ, CD28 and CD40 in patients. Methods Eighty-five cases of verruca plantaris admitted to Langfang People′s Hospital in Hebei Province from March 2018 to March 2019 were divided into control group (42 cases) and study group (43 cases) by drawing lots. Control group was treated with photodynamic therapy, and study group was treated with self-made traditional Chinese medicine on the basis of control group. Total area of skin lesions before and after treatment was compared between two groups, clinical effect was evaluated, the levels of serum TGF-β, IFN-γ, the proportion of CD28 and CD40 before and after treatment were compared between two groups, and the side effects and recurrence of two groups were compared. Results The total area of skin lesions in two groups after treatment was smaller than that before treatment, and study group was smaller than control group, the differences were statistically significant (P < 0.05). Clinical effect of study group was better than that of control group, the difference was statistically significant (P < 0.05). After treatment, the serum TGF-β level in two groups was lower than that before treatment, which in study group was lower than that in control group, the differences were statistically significant (P < 0.05). After treatment, the serum IFN-γ level of two groups was higher than that before treatment, which of study group was higher than that of control group, the differences were statistically significant (P < 0.05). The percentage of CD28 in two groups after treatment was lower than that before treatment, which in study group was lower than that in control group, the differences were statistically significant (P < 0.05). The percentage of serum CD40 in two groups after treatment was higher than that before treatment, which in study group was higher than that in control group, the differences were statistically significant (P < 0.05). There was no significant difference in incidence of side effects between two groups (P > 0.05). Follow up for 3 months, the recurrence rate of study group was lower than that of control group (P < 0.05). Conclusion Photodynamic therapy combined with traditional Chinese medicine can reduce the area of skin lesions, reduce the inflammatory reaction, improve the immune function, and reduce the recurrence rate. The curative effect of photodynamic therapy is significantly better than that of photodynamic therapy alone.
		2020 Vol. 17 (12): 192-196 [Abstract] ( 192 ) HTML (1 KB) PDF (636 KB) ( 53 )

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