蒙药斯日西防治实验性胃溃疡作用及机制研究

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Abstract Objective To study the preventive and therapeutic effect of Mongolian medicine Sirixi on gastric ulcer and its possible mechanism. Methods A total of 25 Wistar rats were selected to make rat acute gastric ulcer model induced by indomethacin. Changes of gastric mucosa were observed by hematoxylin-eosin staining. A total of 25 Kunming mice were selected to observe the changes of myeloperoxidase (MPO) activity, glutathione (GSH) level and peripheral blood T lymphocyte level in gastric tissues in the ethanol/HCL-induced acute gastric ulcer model. A total of 20 Wistar rats were selected and the expression levels of inflammatory tumor necrosis factor-α (TNF-α) and intercellular adhesion molecule 1 (ICAM-1) in gastric tissues were determined by enzyme-linked immunosorbent assay in a acetic acid-burning chronic gastric ulcer model. Results Compared with the model group, the gastric mucosal lesions were alleviated in the Sirixi Powder group. Compared with the model group, the gastric tissue MPO activity, the expression levels of TNF-α and ICAM-1 in the gastric mucosa of the Sirixi Powder group were decreased, and the expression levels of GSH were increased, the differences were highly statistically significant (all P ＜ 0.01). Compared with the model group, the thymus, spleen weight index and the expression levels of peripheral blood CD4+ cells were increased in the Sirixi Powder group, with statistically significant differences (P ＜ 0.05 or P ＜ 0.01), while there was no significant difference in the expression levels of CD3+, CD4+/CD8+ and CD8+ between the two groups (P ＞ 0.05). Conclusion The mechanism of action of Sirixi Powder in the prevention and treatment of gastric ulcer may be realized by promoting defense factor, inhibiting damage factor and improving immune ability.

Key words： Sirixi Myeloperoxidase Glutathione T lymphocytes Tumor necrosis factor-α Intercellular adhesion molecule 1

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	Aodengqimuge WANG Hairong Wuhanqimuge Tegexibaiyin

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Aodengqimuge WANG Hairong Wuhanqimuge Tegexibaiyin. Study on the effect and mechanism of Mongolian medicine Sirixi in preventing and treating experimental gastric ulcer[J]. 中国医药导报, 2020, 17(12): 23-27.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2020/V17/I12/23

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