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| Influencing factors of left ventricular hypertrophy and the predictive value of RDW and hs-CRP in maintenance hemodialysis patients |
| LU Jin ZHANG Hongxu ZHANG Yuqin LIU Yiran ZHANG Chaoqun |
| Department of Nephrology, Anhui No.2 Provincial People′s Hospital, Anhui Province, Hefei 230011, China |
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Abstract Objective To explore the influencing factors of left ventricular hypertrophy (LVH) and the predictive value of red blood cell distribution width (RDW) and serum hypersensitive C-reactive protein (hs-CRP) in maintenance hemodialysis (MHD) patients. Methods A total of 135 patients with end-stage renal disease who were admitted to Anhui No.2 Provincial People′s Hospital for MHD≥3 months from June 2016 to June 2019 were collected. According to the left ventricular mass index (LVMI), they were divided into LVH group (69 cases) and non-LVH group (66 cases), while patient demographic data, laboratory indicators, and imaging studies were collected. Demographic data, laboratory indicators and imaging examination of each group were collected. Logistic regression was used to analyze the influencing factors of LVH in MHD patients, and the receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of RDW and hs-CRP to LVH. Results The age, systolic blood pressure, RDW, uric acid, total cholesterol, triacylglycerol, left ventricular end-diastolic diameter and hs-CRP in the LVH group were higher than those in the non-LVH group, and the differences were statistically significant (P < 0.05). Age, systolic blood pressure, history of hypertension, history of diabetes, RDW, hs-CRP were independent risk factors for LVH in MHD patients (P < 0.05). The areas under the curve of RDW and hs-CRP were 0.900 (0.871-0.929) and 0.837 (0.799-0.876), respectively, while the predictive value of joint detection was higher [0.934 (0.913-0.954)]. Conclusion Age, systolic blood pressure, history of hypertension, history of diabetes, RDW and hs-CRP are independent risk factors of LVH in MHD patients. Early combined detection of RDW and hs-CRP has predictive value for LVH in MHD patients.
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