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| Overview of animal model study of Alzheimer′s disease and analysis of non-experimental causes of death |
| ZHANG Huiye1 CHONG Wenqiang1 LI Ang1 WANG Mengjing1 ZHAO Xian1 XING Wenwen2 LIU Qi1 |
1.Academy of Acupuncture, Shaanxi University of Chinese Medicine, Shaanxi Province, Xi′an 712046, China;
2.College of Basic Medical, Shaanxi University of Chinese Medicine, Shaanxi Province, Xi′an 712046, China |
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Abstract This paper briefly introduces the animal model of Alzheimer′s disease (AD) and analyzes the non-experimental death factors in animal experiments. By consulting, sorting out and summarizing a large number of literatures, this paper gives a overview of the common animal models for AD, while investigates the correlation between environmental factors, motor factors and non-experimental causes of death in AD animal models. The animal feeding density and regular exercise in environmental factors affect the survival rate and experimental results of AD model animals. Establish an ideal AD animal model, in order to provide a reference for the scientific selection of AD animal models in experimental research. In addition, the control of animal population density feeding and regular exercise are adopted to evaluate the safety of high-model animals to better ensure the objectivity of the experimental results.
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