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2020 Vol. 17, No. 6 Published: 2020-02-25

	4	Molecular mechanism of Qufeng Jiejing Prescription in regulating γδT cells to inhibit airway hyperresponsiveness in asthmatic mice
		FAN Changzheng1 MAO Qing1 HONG Qiaoyu2 CUI Yun1 HE Yi1 ZHANG Qiong1 ZHANG Wenjiang1
		Objective To investigate the molecular mechanism of Qufeng Jiejing Prescription in regulating γδT cells to inhibit airway hyperresponsiveness in asthmatic mice. Methods The Balb/c mouse model of asthma was established with the method of ovalbumin nasal drip, and the intervention was conducted with the drugs of Qufeng Jiejing Prescription. The intervention effect of Qufeng Jiejing Prescription on the molecular phosphorylation level of signaling pathway during activation of γδT cells was compared. Thirty experimental mice method was divided into 6 groups according to random number table, each group of 5 mice, respectively for the blank control group, asthma model group, Prednisone Acetate group (0.27 mg/d), Qufeng Jiejing Prescription low dose group (0.59 g/d), Qufeng Jiejing Prescription medium dose group (1.18 g/d), Qufeng Jiejing Prescription high dose group (2.36 g/d). Each group was treated 1 time/d and intervention for 7 days. After administration, the mice were anesthetized and sacrificed, and the γδT cells in the lung airway tissues were isolated, purified and amplified. The proliferation activity of the γδT cells was detected by CCK-8, and the phosphorylation levels of molecules in different signaling pathways were detected by Western blot. Results Compared with the blank control group, the activity of γδT cells in the asthma model group was significantly increased, with statistically significant difference (P ＜ 0.05). Compared with the asthma model group, there was no significant difference in the activity of γδT cells in the Qufeng Jiejing Prescription low dose group (P ＞ 0.05), while the activity of γδT cells in the medium, high dose groups of Qufeng Jiejing Prescription and the Prednisone Acetate group were significantly decreased (P ＜ 0.05). Compared with the blank control group, the protein expression levels of p-ERK1/2, p-P38 and β-catenin in the asthma model group increased, with statistically significant difference (P ＜ 0.05), while the protein expression levels of ERK1/2 and P38 showed no statistically significant difference (P ＞ 0.05). Compared with the asthma model group, the protein expression levels of p-ERK1/2, p-P38 and β-catenin in the low, medium and high dose groups of Qufeng Jiejing Prescription and the Prednisone Acetate group were decreased, with statistically significant differences (P ＜ 0.05). However, ERK1/2 protein expression level increased in the middle and high dose groups of Qufeng Jiejing Prescription and Prednisone Acetate group, and P38 protein expression level increased in the Qufeng Jiejing Prescription low dose group and Prednisone Acetate group, the differences were statistically significant (all P ＜ 0.05). Conclusion The possible molecular signaling pathway mechanism of the regulation of T cells to inhibit airway hyperresponsiveness in asthmatic mice is to inhibit the protein expression levels of p-ERK1/2, p-P38 and β-catenin, so as to reduce airway hyperresponsiveness in asthmatic mice and achieve the treatment of asthma.
		2020 Vol. 17 (6): 4-8 [Abstract] ( 317 ) HTML (1 KB) PDF (652 KB) ( 133 )

	9	Inhibitory effect of ganoderma lucidum polysaccharide on renal tubular endothelial-to-mesenchymal transition of diabetic nephropathy mice
		ZHONG Tao1 ZHANG Guoxin1 ZHOU Diyi2 ZHU Tiane1▲
		Objective To investigate the effect of ganoderma lucidum polysaccha-ride (GLP) on epithelial-to-mysenchymal transition (EMT) of renal tubular epithelial cells in diabetic nephropathy (DN) mice. Methods Forty C57BL/KsJ-db/db mice were randomly divided into 5 groups by weight. Normal group was fed with normal feed. Model group, GLP low (100 mg/kg), high (400 mg/kg) dose groups and Irbesartan group (50 mg/kg, Irbesartan) were given high-sugar dieat. Each group was given the drug by gavage daily for 8 weeks after successful modeling of DN mice. The changes of renal function, blood lipid and other physiological indexes were measured. The protein expression and mRNA level of E-cadherin, α-SMA, TGF-β1, Fibronectin, Vimentin, N-cadherin, TGF-β1, p-Smad2, p-Smad3, Smad2 and Smad3 were measured by Western Blot and Real-time PCR. Results Compared with the model group, the renal function and blood lipid metabolism in GLP low and high doses group were significantly decreased (P ＜ 0.05). Compared with the model group, the levels of E-cadherin protein and mRNA were increased in the GLP low and high doses group and the Irbesartan group, while the levels of α-SMA, Fibronectin, Vimentin, N-cadherin protein and mRNA were decreased (P ＜ 0.01). The expression levels of Smad2 and Smad3 were unchanged. Conclusion GLP inhibits EMT maybe via inhibition of TGF-β1/Smad signaling pathway.
		2020 Vol. 17 (6): 9-12 [Abstract] ( 331 ) HTML (1 KB) PDF (785 KB) ( 127 )

	13	Human umbilical cord blood mesenchymal stem cell protects apoptosis of AECⅡ induced by LPS via inhibition of MEK/ERK-mediated pathway
		LIU Jian1 LONG Tingting2 LI Chenyan1 YI Jun1 PAN Ziyang1 YANG Genhui1 HE Xiqiang1
		Objective To discuss the effect of human umbilical cord blood mesenchymal stem cells (hUC-MSC) on alveolar type Ⅱ epithelial cells (AEC Ⅱ) apoptosis induce by lipopolysaccharide (LPS), and the role of MEK/ERK signaling pathway. Methods The AECⅡ apoptosis model was established by LPS co-cultured with A549 cells. The apoptosis model was randomly divided into 6 groups according to random number method, they were co-cultured with MSC conditioned medium (MSC-CM), MEK/ERK pathway inhibitor (PD98059) and PBS, which were named A549+LPS+MSC, A549+LPS+PBS, A549+LPS+PD98059, and the negative control groups were A549+PBS, A549+MSC, A549+PD98059. Apoptosis of A549 cells was detected by Annexin V/PI staining flow cytometry 48 h later. MEK/ERK pathway and apoptosis-related signals (BAX/BCL-2, FAS, caspase 3 and caspase 8) were examined by qPCR. The groups of A549+LPS+MSC, A549+LPS+PBS, A549+PBS, and A549+MSC were selected for Western blot detecting. Results The apoptosis model was established by A549+LPS. Compared with A549+LPS+PBS, the apoptosis rate of A549+LPS+MSC and A549+LPS+PD98059 were decreased significantly (P < 0.05). The mRNA expression levels of MEK, ERK, BAX/BCL-2, caspase 3 and caspase 8 in A549+LPS+MSC and A549+LPS+PD98059 were significantly lower than those in A549+LPS+PBS (P < 0.05). The expression of FAS, BAX, cleaved Caspase 3, p-MEK, and p-ERK protein in the A549+LPS+MSC and A549+LPS+PD98059 were significantly lower than A549+LPS+PBS(P < 0.05). There was no significant different in TNF-R1 among each group (P > 0.05). Conclusion hUC-MSCs may inhibit the phosphorylation of MEK/ERK signaling pathway affecting mitochondria pathway and FAS/FASL pathway by paracrine action, thereby attenuating apoptosis of AECⅡ induced by LPS.
		2020 Vol. 17 (6): 13-18 [Abstract] ( 354 ) HTML (1 KB) PDF (1404 KB) ( 124 )

	19	Correlation analysis between NF-κBIA gene polymorphism and neonatal bacterial meningitis susceptibility
		LI Wenjuan MEI Jiaping YANG Yong YE Sufen
		Objective To investigate the relationship between NF-κBIA gene polymorphism and neonatal bacterial meningitis susceptibility. Methods From March 2016 to March 2019, 211 cases admitted to the Department of Neonatology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University. Among them, 67 cases of neonatal meningitis were in the case group, 69 normal neonates were in the control group, and 75 cases with non-meningitis inflammatory febrile neonates were in the fever group. Two SNP sites (rs3138053 and rs2233406) of NF-κBIA gene were genotyped by PCR amplification using Sanger sequencing. The genotype sequencing results of different sites and the susceptibility analysis of neonates bacterial meningitis were observed. Results rs3138053 and rs2233406 were in good agreement with the expected value and the observed value in three groups, which were consistent with Hardy-Weinberg equilibrium (P > 0.05). rs3138053 was correlated with the susceptibility of neonatal bacterial meningitis (P < 0.05). Conclusion NF-κBIA gene polymorphism is associated with susceptibility to neonatal bacterial meningitis.
		2020 Vol. 17 (6): 19-22 [Abstract] ( 263 ) HTML (1 KB) PDF (824 KB) ( 51 )

	23	Research progress on the safety of moxa smoke produced by conventional moxibustion
		MO Xuerui1 CHEN Junchao2 JIN Ming1 WEI Jianzi1 MAO Huijuan1
		Moxibustion, among therapies of traditional Chinese medicine (TCM), has a good clinical efficacy. There remains controversy over the safety of moxa smoke and its potential effects on human health. This artical reviewed the research on safety of moxibustion in recent ten years. It indicated that high concentration of moxa smoke would pollute the air and certain concentration range of moxa smoke was safe for the treatment of diseases. While the harm of moxa smoke environment on long-term exposure to the human body was unclear. In some animal toxicology tests and cell experiments of extract from moxa smoke showed that the toxic side effects of moxa smoke were related to the concentration of moxa smoke. However, the clinical safety of moxa smoke needed to be investigate and study with large sample and long-term follow-up.
		2020 Vol. 17 (6): 23-25,43 [Abstract] ( 371 ) HTML (1 KB) PDF (673 KB) ( 320 )

	26	Progress in the treatment of nonalcoholic fatty liver disease
		ZHOU Qian SU Juan▲ JI Mengyao
		Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in developed countries. The current treatment strategy focused on weight lose through lifestyle management and on the optimization of the components of metabolic syndrome. Various hypothetical pathogenic mechanisms have been proposed to develop new drug targets with potential for effective treatment of non-alcoholic steatohepatitis (NASH) patients. These experimental drugs and molecules that target specific mechanism pathways are used to effectively treat NASH. Currently, clinical trials of many drugs are underway. This article focuses on the current status of treatment of NAFLD and the progress of new drug research.
		2020 Vol. 17 (6): 26-29 [Abstract] ( 253 ) HTML (1 KB) PDF (660 KB) ( 232 )

	30	Relationship of VEGF-C, VEGFR3 expression and its prognostic significance in lung cancer
		LI Jingbo1,2 XIA Hui2 LIU Yang1,3
		Among the currently known members of the vascular endothelial growth factor (VEGF) family, the biological effects of VEGF-C and vascular endothelial growth factor receptor 3 (VEGFR3) attract more and more attention. VEGF-C and VEGFR3 are not only the most important signaling pathways regulating lymphangiogenesis, but also important factors affecting prognosis. Studies on lung adenocarcinoma have shown that high expression of VEGF-C and VEGFR3 may be associated with higher lymph node metastasis rate, and there is a positive correlation with the density of microlymphatic vessels, leading to low survival rate and poor prognosis in patients. Therefore, inhibition of VEGF-C and VEGFR3 high expression in lung adenocarcinoma can effectively reduce tumor lymphangiogenesis and metastasis. However, the relationship between VEGF-C and VEGFR3 expression and prognosis in lung squamous cell carcinoma has been controversial. This study explores the relationship between VEGF-C and VEGFR3 expression and prognosis in different types of lung cancer, and provids ideas for later treatment.
		2020 Vol. 17 (6): 30-32,52 [Abstract] ( 395 ) HTML (1 KB) PDF (667 KB) ( 104 )

	33	Advances in neuroimaging studies of early onset schizophrenia
		CHEN Zhenzhu1 YANG Hong2
		In recent years, early-onset schizophrenia as a research sample, to explore the pathogenesis of schizophrenia is the current research focus. Neuroimaging has become an important technique in the study of early-onset schizophrenia due to its noninvasive and intuitive advantages. This paper summarizes the research progress of structural neuroimaging and functional neuroimaging of early-onset schizophrenia, and found the changes of some brain regions in patients with early-onset schizophrenia through various methods of brain imaging data analysis, to explore the possible association with the disease.
		2020 Vol. 17 (6): 33-36 [Abstract] ( 375 ) HTML (1 KB) PDF (686 KB) ( 97 )

	37	Progress in clinical research on the treatment of pediatric pneumonia with traditional Chinese medicine
		LYU Kaifeng ZHANG Wei CHEN Hong
		Pediatric pneumonia is one of the most common diseases of pediatric respiratory system, with morbidity and mortality ranking the first. It is listed as one of the three important pediatric diseases by the world health organization. Clinical fever, cough, shortness of breath, dyspnea and lung fixed moist rales were the main manifestations. The treatment of pediatric pneumonia is the focus and hotspot of pediatric clinical research and its prevention and treatment has made new progress in recent years. According to the characteristics and clinical application of internal and external treatment in traditional Chinese medicine, this paper summarizes the research progress of five basic theories and other treatments on pediatric pneumonia. In order to provide a certain theoretical reference for clinical treatment of pediatric pneumonia.
		2020 Vol. 17 (6): 37-39 [Abstract] ( 268 ) HTML (1 KB) PDF (643 KB) ( 199 )

	40	Research progress of the functional characteristics and the treatment of rheumatoid arthritis of mesenchymal stem cells
		DA Gula1 XIE Xianda2▲ WANG Jing1▲
		Mesenchymal stem cells (MSCs) have self-renewal ability and multi-directional differentiation potential, and they play an important role in immune regulation, inflammation control and cartilage destruction. MSCs produce a large number of soluble membrane-binding factors, some of which inhibit immune responses, induce immune tolerance, and exert important immunomodulatory effects. Due to the biological characteristics and immunomodulatory effects of MSCs, the efficacy and safety of MSCs in the treatment of rheumatoid arthritis have been confirmed in animal experiments and clinical studies in recent years. This article briefly reviews the functional characteristics of MSCs and the related research progress in the treatment of rheumatoid arthritis.
		2020 Vol. 17 (6): 40-42 [Abstract] ( 277 ) HTML (1 KB) PDF (696 KB) ( 73 )

	44	Reserch progress on the training of specialist nurses of intravenous therapy in China
		NAN Ruiling1,2 PEI Juhong1 HAN Chunyan1 CHEN Haixia1,3 ZHANG Yabin1 GOU Ling1 DOU Xinman1,4
		Intravenous infusion therapy is a clinically highly specialized technique that is often used to treat diseases and rescue patients. The specialist nurses of intravenous therapy are the key to ensuring high-quality intravenous infusion therapy care. In recent years, the training of specialists in intravenous therapy has attracted the attention of nursing managers. This article summarizes the concept and development, qualification certification, practice standards and training of the specialist nurses of intravenous therapy, focusing on its training needs, training status and training content, and puts forward the prospect of the training of specialist nurses of intravenous therapy in China. It is hoped to provide a certain reference for the training and professional development of nurses specializing in intravenous therapy in China.
		2020 Vol. 17 (6): 44-47 [Abstract] ( 463 ) HTML (1 KB) PDF (654 KB) ( 92 )

	48	Research progress on mechanism of gastrodin in the prevention and treatment of ischemic brain injury
		CHENG Yangyang KONG Weijia
		Gastrodin is a phenolic glycoside compound, which is the main active component of Gastrodiae Rhizoma. It is used in treatment of headache, dizziness, epilepsy, convulsion and other neurological diseases. Cerebral ischemia is one of the most important disabling and fatal diseases in the world. It leads to the loss of oxygen and energy, triggering the release of excitatory amino acids, oxidative stress, inflammation, cell apoptosis and other harmful cascade reactions, aggravating brain tissue damage. Gastrodin can reduce ischemic brain injury by inhibiting excitotoxicity, anti-oxidation, anti-inflammatory, cell apoptosis, maintaining glial cell homeostasis, promoting neurogenesis, and protecting the integrity of blood-brain barrier. It is suggested that gastrodine can regulate the pathophysiological process of ischemic brain injury by multi-target and multi-layer, providing a new idea for the treatment of ischemic brain injury.
		2020 Vol. 17 (6): 48-52 [Abstract] ( 282 ) HTML (1 KB) PDF (657 KB) ( 113 )

	53	Residents′ survey on service expectations and influencing factors of aged agencies
		YANG Wenju WANG Xiaofan WANG Yisi SUN Jingkai YOU Jiangnan
		Objective To understand the residents′ expectation of service to the pension institutions and the individual factors that affect the service expectations. Methods The data were collected by questionnaire survey. From September to October 2018, a survey was conducted in Beijing on the service expectations of residents aged 20 and over on the care institutions for the elderly, and SPSS 17.0 was used for statistical analysis. Results 500 questionnaires were returned, and the effective questionnaire was 472, with an effective rate of 94.4%. There was difference in residents′ expectations for various services in the elderly institutions (P ＜ 0.05). Residents′ expectations for catering services, living services, medical services, communication services, equipment and facilities were higher than those for entertainment services and special services, and the expectations for entertainment services were higher than the special services, and the differences were statistically significant (P ＜ 0.05). There were statistically significant differences in the expectations of different genders on the service expectations of catering services, medical services, equipment and facilities (P ＜ 0.05). The comparison of service expectations of residents with different education backgrounds and incomes in catering services, living services, medical services, communication services and equipment and facilities were statistically significant differences (P ＜ 0.05). There were statistically significant differences in the service expectations of residents of different marital status on catering and communication services (P ＜ 0.05). There were statistically significant differences in the residents′ expectations for communication services and medical services in different institutions (P ＜ 0.05). Conclusion Residents′ expectations for catering services, living services, medical services, communication services and equipment are significantly higher than those for entertainment services and special services. Individual factors such as gender, education, and income affect service expectations. The willingness to support the elderly affects the expectations of residents for medical services and communication services
		2020 Vol. 17 (6): 53-57 [Abstract] ( 220 ) HTML (1 KB) PDF (637 KB) ( 67 )

	58	Relation among mobile phone addiction, parental attachment, regulatory emotional self-efficacy of medical students
		DING Xiaotong1 KAN Houming2 LI Xianwen1 LIN Yuhua1
		Objective To explore the relationship between mobile phone addiction, parental attachment and regulatory emotional self-efficacy in medical students. Methods A total of 260 medical students from Nanjing Medical University from April to July 2019 were selected by convenient sampling method. General information questionnaire, the mobile phone addiction index (MPAI), the inventory of parent and peer attachment (IPPA) and emotion regulation self-efficacy scale (RES-C) were used for measurement. Results The score of mobile phone addiction of medical students was (46.66±12.18) points, among which 17.4% of medical students were mobile phone addiction. There was a statistically significant difference in mobile phone addiction scores among medical students with highly different anxiety states (P ＜ 0.01). Correlation analysis showed that mobile phone addiction was positively correlated with mother-child alienation and father-child alienation (P ＜ 0.01), and negatively correlated with regulatory emotional self-efficacy (P ＜ 0.05). Regulatory emotional self-efficacy was positively correlated with mother-child attachment, mother-child trust, mother-child communication, father-son attachment, father-son trust, father-son communication (P ＜ 0.01). Regulatory emotional self-efficacy was negatively correlated with mother-child alienation and father-child alienation (P ＜ 0.01). Conclusion Mobile phone addiction is correlated with parent-child attachment and regulatory emotional self-efficacy in medical students.
		2020 Vol. 17 (6): 58-61 [Abstract] ( 330 ) HTML (1 KB) PDF (634 KB) ( 46 )

	62	The prognostic value of geriatric nutrition risk index in elderly patients with esophageal cancer undergoing radiotherapy
		TANG Mengjun DING Shubo HU Wangyuan▲
		Objective To explore the effect of the geriatric nutrition risk index (GNRI) on clinical prognosis of elderly patients with esophageal cancer undergoing radiotherapy. Methods The clinical data and survival information of 70 elderly patients (ages≥70 years old) with esophageal cancer undergoing radical radiotherapy at Jinhua Municipal Central Hospital from January 2012 to December 2016 were retrospectively analyzed. The patients were divided into low nutrition risk group (GNRI≥92) and high nutrition risk group (GNRI＜92) according to GNRI. The general data, treatment response and 1-year, 2-year survival rates between the two groups were compared. Results The differences in hemoglobin and C-reactive protein between the two groups were statistically significant differences (all P ＜ 0.05). The 1-year and 2-year survival rates of patients in low nutrition risk group were higher than those patients in high nutrition risk group (P ＜ 0.05), while high GNRI was significantly associated with better clinical outcomes. Multivariate analysis indicated that GNRI, TNM stage, concurrent chemotherapy and treatment response were independent prognostic factors (P ＜ 0.05). Conclusion The patients with high GNRI have good prognosis. GNRI is an effective prognostic index for elderly esophageal cancer patients undergoing radical radiotherapy.
		2020 Vol. 17 (6): 62-65 [Abstract] ( 340 ) HTML (1 KB) PDF (660 KB) ( 58 )

	66	The role of psychological detachment in the care burden and fatigue of the primary caregivers of patients with cancer
		LI Lu1,2 LI Huiping1 SONG Guiqi2 ZHANG Pengnian2 CHU Xiafei2 ZHANG Maomao1 WU Danyan1
		Objective To explore the mediating role of the psychological detachment of the main caregivers of cancer patients in their care burden and fatigue, and to provide a basis for alleviating the fatigue. Methods A total of 242 the main caregivers of cancer patients who were treated in the First Affiliated Hospital of USTC from December 2017 to April 2018 were selected as research objects convenient by sampling method. The general information question questionnaire, psychological detachment (PD), Zarit caregiver burden interview (ZBI), and fatigue scale-14 (FS-14) were used to investigated. Multivariate regression analysis of mediating effects and Bootstrap method were used for verification. Results Caregiver fatigue score were (6.40±3.61) points. Correlation analysis showed that the care burden was negatively correlated with psychological detachment (r = -0.59, Ρ ＜ 0.01); there was a positive correlation between care burden and fatigue (r = 0.51, Ρ ＜ 0.01); psychological detachment and fatigue was negatively correlated (r = -0.81, Ρ ＜ 0.01). The psychological detachment score played a full mediating role in the care burden and fatigue, and the mediating effect occurred 82.71%. Conclusion Psychological detachment is a mediator of the care burden and fatigue of the main caregivers of cancer patients.
		2020 Vol. 17 (6): 66-69 [Abstract] ( 383 ) HTML (1 KB) PDF (651 KB) ( 35 )

	70	Correlation analysis of postoperative stigma and benefit finding in young patients with cervical cancer
		YANG Fenyan1 CAI Jing1 LIU Qin1 SU Jianping2
		Objective To investigate the status quo of postoperative stigma and benefit finding in young patients with cervical cancer, and to analyze the correlation. Methods A total of 128 young cervical cancer patients who had undergone total hysterectomy and pelvic lymph node dissection from January to August 2018 in the Gynecological Oncology Area of the Cancer Hospital Affifiated to Xinjiang Medical University were selected as research object by the group sampling method. The questionnaire survey method was adopted. The general information questionnaire, social impact scale (SIS) and benefit finding scale (BFS) were used to collect the scores of postoperative stigma and benefit findings in patients, while the correlation between stigma and benefit findings in young patients with cervical cancer was analyzed. Results The total scores of stigma after surgery in 128 young cervical cancer patients were (57.72±7.37) points, of which the inner stigma dimension scored the highest were (2.62±0.71) points, the benefit finding scores were (60.43±6.40) points. The total score and the score of each dimension and benefit finding of postoperative stigma in young cervical cancer patients were correlated (P ＜ 0.05). Conclusion The total score of postoperative stigma and the score of each dimension of young patients with cervical cancer are negatively correlated with benefit finding, suggesting that clinical medical workers should prevent or reduce the patients′ level of stigma.
		2020 Vol. 17 (6): 70-72,76 [Abstract] ( 363 ) HTML (1 KB) PDF (652 KB) ( 103 )

	73	Systematic evaluation of the quality of clinical treatment guidelines for hypertension in children and adolescents
		DING Xiangyu1 WANG Jianxin2 FENG Chao1 ZHANG Guying1
		Objective To systematically review the methodological quality guidelines on the hypertension guidelines in children and adolescents, to compare the recommendations and to provide a reference for clinical physicians and pharmacists. Methods CNKI, Wanfang Database, VIP, CBM, PubMed, Excerpta medica database (EMBASE) and relevant websites such as medlive.cn, guideline international network (GIN), American academy of pediatrics (AAP), national guideline clearinghouse (NGC), national institute for health and clinical excellence (NICE) were searched by computer ranged from inception to October 2018. The methodological quality of included guidelines were evaluated according to the appraisal of guidelines for research and evaluationⅡ (AGREEⅡ) instrument, and the differences between recommendations were compared. Results The three guidelines are from the European socienty of hypertension (ESH), American academy of pediatrics (AAP), Canadian hypertension education program (CHEP), respectively. In the six major areas of the AGREEⅡ system, only the “clearness” and “range and purpose” scores were high. The AAP and CHEP guidelines were level B, and the ESH guidelines was level C. The recommended treatment recommendations of the guidelines are basically the same. Conclusion The quality of the included guidelines needs to be further improved. In the future development of guidelines for hypertension in children and adolescents, rigor of development and applicability of the guidelines should be strengthened. It is better to use evidence-based evaluation to obtain high-quality guidelines, so as to provide the best evidence for clinical treatment of hypertension in children.
		2020 Vol. 17 (6): 73-76 [Abstract] ( 308 ) HTML (1 KB) PDF (686 KB) ( 137 )

	77	Correlation research of neck circumference and benign prostatic hyperplasia in type 2 diabetic mellitus patients
		SHANG Shuxia1 WEI Junfeng2▲ ZHAO Junkui3 DUAN Lijun1 NIU Yun1 SUN Qiujie4 ZHOU Hao5
		Objective To investigate the correlation between neck circumference (NC) and benign prostatic hyperplasia (BPH) in patients with type 2 diabetes mellitus (T2DM). Methods From September 2015 to June 2017, 216 cases with T2DM in Jizhong Energy Fengfeng Group Hospital were recruited. According to whether BPH was combined or not, they were divided into N-BPH group (n = 118) and BPH group (n = 98). According to the NC measurement levels, they were divided into Q1 subgroup: 33.4 cm≤NC≤35.7 cm (n=53), Q2 subgroup: 35.7 cm＜NC≤39.1 cm (n = 56), Q3 subgroup: 39.1 cm＜NC≤39.9 cm (n = 51), Q4 subgroup: 39.9 cm＜NC≤43.9 cm (n = 56). The general and clinical data of all subjects were collected, and the NC levels were measured. All subjects underwent B-ultrasound examination of prostate, and the international prostate symptom score (IPSS) was performed for all subjects. Logistic regression analysis was used for correlation analysis. Results NC, body mass index (BMI), waist circumference, waist-hip ratio, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the levels of glycosylated hemoglobin, fasting plasma glucose (FPG), high density lipoprotein cholesterd (HDL-C)， total cholesterol and triglyceride in BPH group were significantly higher than those in N-BPH group, with statistically significant differences (all P < 0.05). The prostate volume (PV) of Q2, Q3 and Q4 subgroups was higher than that of Q1 subgroup, the postvoid residual (PVR) and IPSS scores of Q3 and Q4 subgroups were higher than those of Q1 subgroup, the PV of Q3 and Q4 subgroups was higher than that of Q2 subgroup, and the IPSS scores of Q4 subgroup were higher than those of Q2 and Q3 subgroups, with statistically significant differences (all P < 0.05). Logistic regression analysis showed that NC, BMI, SBP and FPG were risk factors for BPH. Conclusion NC is significantly increased in T2DM patients with BPH. NC may become an influencing factor for T2DM patients with BPH, which has clinical significance.
		2020 Vol. 17 (6): 77-80 [Abstract] ( 402 ) HTML (1 KB) PDF (375 KB) ( 93 )

	81	Clinical application of unilateral and bilateral approach percutaneous vertebroplasty in senile pathological spinal fractures
		FAN Liying XUE Jianli CHENG Bin ZHANG Chun WU Hao DONG Jun
		Objective To investigate the clinical effect of unilateral and bilateral approach percutaneous vertebroplasty (PVP) in the treatment of senile pathological spinal fractures. Methods A total of 46 vertebral bodies of 38 patients with senile spinal fractures admitted to the Third department of Orthopedics, the Second Affiliated Hospital of Xi′an Jiaotong University from January 2016 to December 2018 and followed up were selected as subjects. According to the random number table method, they were divided into the unilateral approach percutaneous vertebroplasty group (hereinafter referred to as “unilateral group”) and the bilateral approach percutaneous vertebroplasty group (hereinafter referred to as the “bilateral group”), with 23 cases in each group. The operation time and bone cement perfusion volume of the two groups were observed and compared, and the visual analogue score (VAS) and Oswestry dysfunction index (ODI) were recorded and compared before surgery, on the first and second day after surgery, and at the follow-up 6 months after surgery. The efficacy of the patients was evaluated comprehensively. Results The operation time and bone cement injection amount of the unilateral group were significantly less than that of the bilateral group, with highly statistically significant difference (P ＜ 0.01). The difference in time and interaction between the two groups was highly statistically significant (P ＜ 0.01), suggesting that the postoperative efficacy of the two groups was significant, and the efficacy increased gradually with the extension of time. There was no statistically significant difference in interaction between the two groups (P ＞ 0.05), suggesting that there was no significant difference in efficacy between the two groups. Further pairwise comparison showed that 1 d, 2 d and 6 months after surgery were lower than before surgery, 2 d and 6 months after surgery were lower than 1 d and 6 months after surgery were lower than 2 d after surgery, and the differences were highly statistically significant P ＜ 0.01). There was no significant difference in interaction between the two groups at each time point (P ＞ 0.05). Conclusion Unilateral pedicle approach PVP has the advantages of shorter operation time, less radiation damage, less injection of bone cement, and lower treatment cost. However, in the long run, unilateral and bilateral PVP have significant efficacy in the treatment of pathological vertebral compression fractures.
		2020 Vol. 17 (6): 81-84 [Abstract] ( 242 ) HTML (1 KB) PDF (520 KB) ( 139 )

	85	Meta analysis of the effect of elastic intramedullary nail internal fixation and plate internal fixation in the treatment of ulnar and radial fractures in children
		GAO Zhuo1 WANG Yongqing2 REN Liang1 DU Bosong3 Basanta Sapkota4
		Objective To systematically evaluate the effect of elastic intramedullary nail internal fixation and plate internal fixation on the treatment of ulnar and radial double fractures in children. Methods A computer search was conducted on the relevant literatures of CNKI, VIP, WanFang and PubMed, EMBase and Cochrane Library. The retrieval period was from the establishment of the database to September 2019. RevMan5.3 software was used to analyze and compare the total effective rate, operation time, hospital stay, adverse reactions, intraoperative blood loss and incision length of elastic intramedullary nail internal fixation and plate internal fixation on the treatment of ulnar and radial double fractures in children. Results A total of 8 literatures were included in the study, all of which were randomized controlled trials with a total of 650 patients (325 in the elastic intramedullary nail internal fixation group and 325 in the plate internal fixation group). The differences of the total effective rate [OR = 3.80，95%CI（2.07,6.96），P ＜ 0.0001], operation time [MD = -29.13，95%CI（-34.03, -24.24），P ＜ 0.000 01], hospital stay [MD = -8.70，95%CI（-13.00, -4.41），P ＜ 0.0001], intraoperative blood loss [MD = -83.62，95%CI（-162.81, -4.43），P = 0.04] and incision length [MD = -8.72，95%CI（-10.94, -6.51），P ＜ 0.000 01] between the two groups were statistically significant. The elastic intramedullary nail internal fixation group was superior to the plate internal fixation group. There was no significant difference in postoperative adverse reactions between the two groups [OR = 0.69, 95%CI (0.26, 1.84), P = 0.46]. Conclusion In the treatment of children with ulnar and radial double fractures, elastic intramedullary nail internal fixation has the advantages of short operation time, small incision length, less intraoperative blood loss and high total effective rate compared with plate internal fixation, and does not increase the incidence of postoperative adverse reactions. Due to the limited number and quality of included literatures, the above conclusions need to be verified by more studies of higher quality.
		2020 Vol. 17 (6): 85-90 [Abstract] ( 253 ) HTML (1 KB) PDF (1229 KB) ( 96 )

	91	Clinical effect of Taohong Jiegu Capsules combined with internal fixation in the treatment of Colles fracture
		LONG Dawei1 ZHOU Zhengxin2 LI Chunfeng1 HAO Guangxing1 YAO Xianjie1
		Objective To investigate the clinical effect of Taohong Jiegu Capsules combined with internal fixation in the treatment of Colles fracture. Methods From January 2016 to December 2018, 90 patients with Colles fracture admitted to Taihe Hospital of Traditional Chinese Medicine in Anhui Province were selected and divided into control group and study group according to the random number table method, with 45 cases in each group. The control group was given routine internal fixation surgery, and the study group was given Taohong Jiegu Capsules on this basis. The clinical efficacy, fracture healing quality and bone mineral density, visual analogue score (VAS) and Oswestry dysfunction index (ODI) were compared between the two groups, and the complications during treatment were recorded. Results The total clinical effective rate of the study group was higher than that of the control group 6 weeks after surgery, and the difference was statistically significant (P ＜ 0.05). There was no statistically significant difference between the two groups of patients in ulnar deviation angle, palmar inclination angle and radial styloid process height of the affected limb before and 6 weeks after surgery (P ＞ 0.05). The ulnar deviation angle, palmar inclination angle and radial styloid process height of the affected limb in the two groups increased 6 weeks after the operation compared with that before the operation, and the differences were statistically significant (all P ＜ 0.05). There was no significant difference in preoperative bone mineral density, VAS and ODI between the two groups (P ＞ 0.05). The bone mineral density of the patients in the two groups at 6 weeks after surgery increased compared with that before surgery, and the VAS and ODI decreased compared with that before surgery, with statistically significant differences (all P ＜ 0.05). The bone mineral density of the study group at 6 weeks after surgery was higher than that of the control group, while the VAS and ODI were lower than that of the control group, with statistically significant differences (all P ＜ 0.05). There was no significant difference in complication rate between the two groups (P ＞ 0.05). Conclusion Taohong Jiegu Capsules combined with internal fixation surgery for the treatment of Colles fracture patients, the effect is accurate, can effectively improve the pain symptoms of patients, improve bone density, clinical application value is higher.
		2020 Vol. 17 (6): 91-94 [Abstract] ( 327 ) HTML (1 KB) PDF (518 KB) ( 105 )

	95	Effect of minimally invasive injection of pulmonary surfactant through gastric tube in the treatment of neonatal respiratory distress syndrome
		ZHANG Pei XIA Shiwen ZHU Huaping PENG Sicong
		Objective To investigate the effect of minimally invasive injection of pulmonary surfactant through gastric tube in the treatment of neonatal respiratory distress syndrome. Methods Forty preterm infants with respiratory distress syndrome (RDS) diagnosed by neonatal intensive care unit (NICU) in Hubei Maternal and Child Health Hospital from May 2017 to May 2018. According to the random number table method, they were divided into two groups, namely, minimally invasive injection of pulmonary surfactant through gastric tube (LISA group, 20 cases) and tracheal intubation-pulmonary surfactant-extubation (INSURE group, 20 cases). In LISA group, 5F gastric tube was inserted into trachea under direct laryngoscope and pulmonary surfactant (PS) was slowly injected into trachea under nasal continuous positive airway pressure (NCPAP). In INSURE group, PS was injected through tracheal intubation and NCPAP was performed after extubation. The changes of ventilator parameters, adverse reactions incidence of and complications after treatment were observed. Results In LISA group, the decrease of oxygen saturation (SpO2) in 1 case, bradycardia in 1 case, apnea in 0 cases and mechanical ventilation in 72 hours after birth were significantly lower than those in INSURE group SpO2 in 9 cases, bradycardia in 8 cases, apnea in 7 cases; in LISA group, the decrease of oxygen concentration in 6 hours was 19%, higher than that in INSURE group (13%), with significant difference (P ＜ 0.05). There was no significant difference in the incidence of re-use of PS, mortality, air leakage, bronchopulmonary dysplasia, necrotizing enterocolitis, retinopathy of premature infants, intracranial hemorrhage between the two groups (P ＞ 0.05). Conclusion LISA is a safe and effective method for the treatment of RDS.
		2020 Vol. 17 (6): 95-98,114 [Abstract] ( 268 ) HTML (1 KB) PDF (791 KB) ( 96 )

	99	Discussion of the surgical methods of 13 young patients with locally advanced cervical squamous cell carcinoma
		KANG Haili1 ZHAO Qun1 WU Yumei1 RUAN Xiangyan2 DUAN Wei1
		Objective To explore the surgical stage of young patients with locally advanced cervical cancer while preserving reproductive endocrine function. Methods From May 2016 to March 2018, 13 cases of locally advanced cervical cancer patients ＜ 40 years old admitted to Beijing Obstetrics and Gynecology Hospital, Capital Medical University were selected. Laparoscopic surgical staging and ovarian cryopreservation were performed before radiotherapy. Case data were reviewed to evaluate the accuracy of CT/MRI in judging lymph node metastasis and the feasibility of preserving reproductive endocrine function. Results The sensitivity of lymph metastasis in patients with locally advanced cervical cancer was 66.7% by CT/MRI and Specificity was 70.0%. Thirteen patients underwent ovarian cryopreservation, and two underwent ovarian transplantation after treatment, with stable hormone levels and complete remission of menopausal symptoms. Conclusion CT/MRI is not sensitive and specific enough to evaluate lymph node metastasis. Laparoscopic pelvic and para-aortic lymph node resection for locally advanced cervical cancer is an important means to evaluate lymph node metastasis. Ovarian cryopreservation can be a new option to save and restore reproductive endocrine function in young cervical cancer patients.
		2020 Vol. 17 (6): 99-102 [Abstract] ( 308 ) HTML (1 KB) PDF (504 KB) ( 90 )

	103	Effect of five elements of music combined with cognitive psychological counseling on the efficacy of foetus preservation in late threatened abortion of depressed pregnant women
		ZHENG Lijuan LI Hui SU Minyi HUANG Biqiong JIANG Xuewei HU Pinjia HU Zurong
		Objective To observe the effect of five elements of music combined with cognitive psychological counseling on depression threatened abortion in the third trimester, and to explore its effect on maternal sleep quality, serum progesterone and progesterone induced blocking factor (PIBF). Methods A total of 120 pregnant women with advanced threatened abortion admitted to the Department of Obstetrics of Guangdong Provincial Maternal and Child Health Hospital from March 2017 to March 2019 were selected and divided into the conventional treatment group (control group, 60 cases) and the five-element music combined cognitive psychological intervention group (observation group, 60 cases) according to the random number table method. After two weeks of treatment, the time of disappearance of contractions, the length of gestation weeks and the effective rate of treatment were compared. Pittsburgh sleep quality index (PSQI) score, depression self-rating depression scale (SDS), serum progesterone level and PIBF concentration before and after treatment were compared. Results There was no significant difference in age, gestational age, gestational duration, birth duration and SDS score between the two groups (P ＞ 0.05). Compared with the control group, contractions disappeared earlier in the observation group, gestation was prolonged longer, and treatment efficiency was higher (P ＜ 0.05). After treatment, the PSQI score and SDS score of the two groups were lower than that of the control group, and the differences were statistically significant (P ＜ 0.05). After 2 weeks of treatment, SDS score and proportion of moderately depressed pregnant women in both groups were significantly lower than before treatment, while proportion of non-depressed pregnant women was higher (P ＜ 0.05). The distribution of PSQI score and degree in the control group was not significantly different from that before treatment (P ＞ 0.05). The PSQI score in the observation group after treatment was lower than that before treatment, and the proportion of pregnant women with good sleep was higher (P ＜ 0.05). There was no significant difference in serum progesterone and PIBF between the two groups before treatment (P ＞ 0.05). After 2 weeks of treatment, the levels of progesterone and PIBF in the two groups of pregnant women were significantly higher than those before treatment, and the levels of progesterone and PIBF in the observation group were higher than those in the control group (P ＜ 0.05). Conclusion Five elements of music combined with cognitive psychological intervention therapy can improve the depression mood of pregnant women with late-stage threatened abortion with depression, improve the quality of sleep, thus increase the release of progesterone, reduce the immune rejection reaction, improve the treatment efficiency.
		2020 Vol. 17 (6): 103-106 [Abstract] ( 228 ) HTML (1 KB) PDF (506 KB) ( 164 )

	107	Incidence of chorionic amnitis in patients with premature rupture of fetal membranes and the correlation between NLRP3 expression and Inflammatory cytokines, proteases
		CAI Shumei1 WANG Yamin1 CHEN Hui2 MENG Yuanyuan1 ZOU Changjun1 LI Yan1▲ ZHANG Jinling1
		Objective To investigate the incidence of chorionic amnitis in patients with premature rupture of fetal membranes and the correlation between NLRP3 expression and Inflammatory cytokines, proteases. Methods From March 2017 to February 2019, 138 cases of pregnant women with premature rupture of fetal membrane admitted to Handan Maternal and Child Health Hospital in Hebei Province were selected. The occurrence of chorionic amnitis in pregnant women with premature rupture of fetal membrane was retrospectively analyzed, and the patients were divided into infection group (49 cases) and non-infection group (89 cases). Placenta tissue expression of NLRP3 inflammatory corpuscle, inflammatory cytokines[interleukin 6 (IL-6) and IL-8 and IL-18, tumor necrosis factor-α (TNF-α)], protease[neutrophil elastase(NE), matrix metalloproteinase-2(MMP-2) and matrix MMP-9] levels in serum and amniotic fluid specimens between two groups were compared. Pearson test was used to evaluate the correlation between expression of NLRP3 inflammatory corpuscle and disease-related indicators in patients with premature rupture of membranes and chorionic amnitis. Results Expression level of NLRP3 inflammatory corpuscle in infected group was higher than that in non-infected group (P ＜ 0.05). Levels of IL-6, IL-8, IL-18 and TNF-α in serum and amniotic fluid were higher than those in non-infected group; levels of NE, MMP-2 and MMP-9 were higher than those of non-infected group (P ＜ 0.05). Correlation analysis showed that the expression of NLRP3 inflammasome in placental tissues of premature rupture of membranes patients combined with chorionic amnitis was positively correlated with the levels of IL-6, IL-8, IL-18, TNF-α, NE, MMP-2 and MMP-9(rNLRP3=0.674, 0.718, 0.698, 0.829, 0.759, 0.726, 0.882；rASC = 0.704, 0.783, 0.627, 0.599, 0.771, 0.804, 0.837；rcaspase-1=0.667, 0.572, 0.782, 0.705, 0.812, 0.632, 0.576, all P ＜ 0.05). Conclusion High expression of NLRP3 inflammasome may be one of the important mechanisms of premature rupture of membranes in pregnant women with chorionic amnitis.
		2020 Vol. 17 (6): 107-110 [Abstract] ( 327 ) HTML (1 KB) PDF (539 KB) ( 58 )

	111	Application of pattern electroretinogram in measuring the thickness of retinal nerve fiber layer in patients with primary open-angle glaucoma and analysis of influencing factors
		XIONG Yunfan LI Qing
		Objective To analyze the application and influencing factors of pattern electroretinogram (PERG) in measuring the thickness of retinal nerve fiber layer in patients with primary open-angle glaucoma, and to provide corresponding theoretical guidance for clinical practice. Methods A total of 60 patients (120 eyes) with early primary open-angle glaucoma admitted to Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University from July 2018 to June 2019 were selected as the observation group, and 60 normal people admitted during the same period were selected as the control group. The thickness of retinal nerve fibers was detected by PERG, respectively. The detection conditions of PERG in the two groups were compared, and the influencing factors of PERG detection were analyzed by single and multiple factors. Results The amplitude and time of N95 in the observation group were lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). Age, course of disease, diopter, intraocular pressure of the two groups were compared, and the differences were statistically significant (all P ＜ 0.05). There was no significant difference in gender, ophthalmic complications and previous surgical history (P ＞ 0.05). Gender, age, course of disease and diopter were regarded as independent variables, while the accuracy of test was regarded as dependent variables. Logistic multivariate regression analysis showed that age and diopter were influencing factors (all P ＜ 0.05). Conclusion The determination of open-angle glaucoma by PERG is highly sensitive, but it is easily affected by age, diopter and other factors. Multiple methods of combined detection can effectively improve the early diagnosis rate of open-angle glaucoma, which is worthy of clinical promotion.
		2020 Vol. 17 (6): 111-114 [Abstract] ( 226 ) HTML (1 KB) PDF (459 KB) ( 27 )

	115	Development and application of the ophthalmic outpatients reentry queue system
		WU Peiyu1 FENG Kemi1 DAI Meiquan1 XU Hong2▲
		Objective To develop the ophthalmic outpatients check for regression reentry queue system and to establish an orderly outpatient environment. Methods Before the application of the intelligent design regression ophthalmic outpatients check for regression reentry queue system in the Eye Disease Outpatient, Eye Hospital, Wenzhou Medical University, the nurses investigated and recorded the environment of the outpatient clinic of common eye disease, the first diagnosis area and the outpatient clinic of the same group of visiting physicians in October 2018, by using the convenient sampling method. The number of patients and their family members in and out of the clinic and diagnosis area, the total outpatient treatment time, and the waiting time after examination were recorded for 30 times. After the application of the software in clinical practice in November 2018, the effect of the software implementation was evaluated. Results The total number of patients and their families in and out of the clinic, the waiting environment in the diagnosis area, the total visiting time of the clinic and the waiting time of the examination were significantly improved after the ophthalmic outpatients check for regression reentry queue system was applied in the outpatient department, with statistically significant differences (all P ＜ 0.05). Conclusion The number of patients and their family members in and out of the diagnosis area and clinic is reduced obviously by the application of the ophthalmic outpatients check for regression reentry queue system. The environment of outpatient clinic changes from noisy to quiet, and the total outpatient time and the waiting time of examination is reduced.
		2020 Vol. 17 (6): 115-118 [Abstract] ( 198 ) HTML (1 KB) PDF (911 KB) ( 49 )

	119	Analysis and comparison of volatile constituents in aboveground parts of Capparis spinosa L. from different producing areas by headspace-solid-phase microextraction-gas chomatogragh-mass spectrometer
		SHI Yinji1 HE Jiang1 ZHANG Xuanchen2 YANG Weijun1
		Objective To investigate the differences of volatile components in stems, leaves and flowers of Capparis spinosa L. from different puoducing areas. Methods Volatile constituents from the stems, leaves and flowers of Capparis spinosa L. were extracted by headspace-solid phase microextraction, then the qualitatively were analyzed by gas chromatography-mass spectrometry, and the relative percentage were calculated by peak area normalization method. Results A total of 44 components were identified from the stem, 30 components from the leaves and 33 components from the flowers. The stems, leaves and flowers of Capparis spinosa L. generally contained a higher proportion of isothiocyanates, among which the total content in the flowers was the highest, and the content of methyl isothiocyanate in the leaves was higher. The proportion of isopropylisothiocyanate and and sec-butyl isothiocyanate were higher in flowers. Conclusion This reseach provides foundation for the developing and utilizing of the aboveground parts of Capparis spinosa L..
		2020 Vol. 17 (6): 119-122 [Abstract] ( 206 ) HTML (1 KB) PDF (547 KB) ( 74 )

	123	Optimization of extraction process for Xiangxiong Gel Plaster by orthogonal test
		YANG Xiaori LI Yongmei ZHANG Junsheng MA Jiede XU Lingxiang
		Objective To optimize the extraction process of Xiangxiong Gel Plaster. Methods The ethanol extraction process was used, the extraction rate of ferulic acid and flavone glycoside and the extract rate of prescription as the indexes, the orthogonal experimental design was used to investigate the influence of ethanol concentration, extraction times, extraction time and other conditions in the extraction process on each index, and the optimal extraction process was optimized. And a verification test was carried out. Results The optimal ethanol extraction process was to add 8 times of 60% ethanol and extract twice, with 1.5 h each time. Conclusion The process is reasonable and feasible, the effective component extraction rate is high, the repeatability is good. It can provide technical reference for the development of Xiangxiong Gel Plaster.
		2020 Vol. 17 (6): 123-126 [Abstract] ( 235 ) HTML (1 KB) PDF (518 KB) ( 86 )

	127	Meta-analysis of Pitavastatin in the treatment of hyperlipemia mixed with type 2 diabetes mellitus
		PAN Dan1 CHEN Kuixia1 LI Li1 SU Weiwei2 WANG Qian1 LU Shan1 YUAN Ying3 ZHAO Kexin1
		Objective To systematically evaluate the effect and safety of Pitavastatin in the treatment of hyperlipemia mixed with type 2 diabetes mellitus. Methods CNKI database, VIP database, Wanfang database, Cochoran Library, EMbase database and PubMed database were searched, and the search time was from November 1999 to June 2018. Randomized controlled tirals comparing Pitvastatin with Atorvastatin in the treatment of hyperlipemia mixed with type 2 diabetes mellitus were collected. The literatures were read and the information was extracted independently by two reviewers, a third party was requested to assist in case of disagreement. RevMan 5.0 statistical software was used to conduct a meta-analysis on the changes of fasting plasma glucose, glycosylated hemoglobin, total cholesterol and low density lipoprotein cholesterol and the occurrence of adverse reactions in the two groups. Results A total of 13 studies involving 1472 patients were included. Fasting plasma glucose levels of the test group were lower than those of the control group, with statistically significant differences (MD = -0.81, 95%CI: -1.20, -0.41, P < 0.0001). Glycosylated hemoglobin levels of the test group were lower than those of the control group, with statistically significant differences (MD = -0.37, 95%CI:-0.53, -0.21, P ＜ 0.000 01). There was no significant difference in total cholesterol levels between the two groups （MD = -0.01，95%CI:-0.06, 0.04，P > 0.05）. There was no significant difference in low density lipoprotein cholesterol levels between the two groups（MD = -0.00，95%CI:-0.06, 0.06，P > 0.05）. There was no significant difference in the incidence of adverse reaction between two groups(OR = 0.48, 95%CI:0.19, 1.20，P > 0.05). Conclution Pitavastatin is better Atorvastatin of lowering blood glucose in patients with dyslipidemia and diabetes inellitus, and the safety of the two drugs is similar.
		2020 Vol. 17 (6): 127-130,135 [Abstract] ( 296 ) HTML (1 KB) PDF (1476 KB) ( 87 )

	131	Clinical effect of Di′ao Xinxuekang Soft Capsules combined with routine western medicine on angina pectoris after coronary intervention
		YAN Jiesong ZHOU Dong TANG Xiangrui GUO Hongyi
		Objective To observe the clinical effect of Di′ao Xinxuekang Soft Capsules combined with routine western medicine on angina pectoris after coronary intervention. Methods From April 2017 to January 2019, 123 cases with angina pectoris after coronary intervention were selected from 3201 Hospital Affiliated to Medical College of Xi′an Jiaotong University. According to the random number table method, They were divided into control group (n = 61) and study group (n = 62). All patients were given routine treatment after admission, with instructions on routine nutrition diet, bed rest and precautions. Controls group was treated with routine western medicine treatment. Study group was given Di′ao Xinxuekang Soft Capsule on the basis of control group. Both groups were treated for 3 months. The clinical effect, electrocardiogram effect, serological index, quality of life, angina pectoris attack and adverse reactions of the two groups were compared. Results The total effective rate of clinical efficacy and electrocardiogram efficacy of study group after treatment were higher than those of control group, with statistically significant differences (all P < 0.05). There was no significant difference in superoxide dismutase (SOD), malondialdehyde (MDA) and hypersensitive c-reactive protein (hs-CRP) levels in two groups before treatment (P > 0.05). After treatment, MDA and hs-CRP levels in two groups were lower than those before treatment, while SOD levels were higher than those before treatment. The levels of MDA and hs-CRP in study group were lower than those in control group, while the levels of SOD were higher than those in control group, with statistically significant differences (all P < 0.05). Before treatment, there was no statistically significant difference between two groups in limited physical activity, stable angina pectoris, treatment satisfaction, angina pectoris attack and disease awareness (P > 0.05). The above scores in two groups after treatment were higher than those before treatment, and study group were higher than control group, with statistically significant differences (all P < 0.05). There were no significant difference in the frequency and duration of angina pectoris between two groups before treatment (P > 0.05). After treatment, the frequency and duration of angina pectoris attacks in two groups were lower than those before treatment, and study group was lower than control group, with statistically significant differences (all P < 0.05). There was no significant difference in adverse reactions between the two groups (P > 0.05). Conclusion Di′ao Xinxuekang Soft Capsule, combined with routine western medicine in the treatment of angina pectoris after coronary intervention can rapidly improve the clinical symptoms, the curative effect is definite. It can also improve the level of lipid peroxide and reduce inflammatory factors.
		2020 Vol. 17 (6): 131-135 [Abstract] ( 423 ) HTML (1 KB) PDF (486 KB) ( 362 )

	136	Clinical application of modified Shenqi Dihuang Decoction in renal disease
		LI Ji YUAN Tong FU Qiang GAO Yanyu
		In recent years, the incidence of end-stage renal disease is increasing year by year, which seriously affects the physical and mental health of patients. It has become an urgent problem for doctors to actively prevent and treat primary diseases and find new ways to treat kidney diseases. The author find that the course of kidney disease is prolonged and the pathogenesis of traditional Chinese medicine is complicated. In order to find the root cause, qi and yin deficiency is more common. Combined with many years of clinical experience, the author find that modified Shenqi Dihuang Decoction has a significant effect on kidney disease of deficiency of both qi and yin. This paper summarizes the research progress of modified Shenqi Dihuang Decoction in the treatment of kidney diseases with deficiency of qi and yin based on the existing clinical research results, combined with its own clinical experience, in order to provide effective clinical basis for the prevention and treatment of kidney diseases.
		2020 Vol. 17 (6): 136-139 [Abstract] ( 318 ) HTML (1 KB) PDF (731 KB) ( 128 )

	140	Analysis on the characteristics, status and development of traditional Chinese medicine culture industry
		WANG Weijiao ZHANG Honglei
		This paper has presented the definition of Chinese medicine culture industry. It has pointed out the high value-added, strong integration, intellectual property, welfare characteristics, practicality and extensiveness of Chinese medicine culture industry. The advantages in the development of Chinese medicine culture industry are supported by government policies, a long history, and the across-the-board support of Chinese medicine culture talents. The disadvantage in the development of Chinese medicine culture industry are unsatisfactory consumption of Chinese medicine culture, standardization of market environment, lack of effective integration of Chinese medicine culture and technology, and lack of professional talents. In that case, this paper has made some suggestion like expand the consumption of traditional Chinese medicine culture, enhance the cultural identity of traditional Chinese medicine, increase the policy guidance and support, build a nice policy environment, enhance the confidence in traditional Chinese medicine culture, develop a new type of traditional Chinese medicine cultural industry, improve the quality of practitioners, present the advanced culture, pay more attention to improve social effect to develop traditional Chinese medicine cultural industry.
		2020 Vol. 17 (6): 140-143,148 [Abstract] ( 501 ) HTML (1 KB) PDF (791 KB) ( 97 )

	144	Clinical effect on milli-fire needle acupuncturing at the focus of tendon knot in treating cervical headache
		LIANG Shufen1 FU Min2 LYU Yanan3
		Objective To observe the clinical effect of milli-fire needle acupuncturing at the focus of tendon knot in treating cervical headache under the guidance of Jingjin region theory. Methods Fifty-nine patients with cervical headache who were admitted to the Rehabilitation Centre, the People′s Hospital of Guangxi Zhuang Autonomous Region from November 2017 to December 2018 and met the inclusion criteria for cervical headache were selected as the subjects. They were divided into milli-fire needle acupuncturing at the focus of tendon knot group (29 cases) and milli-fire needle acupuncturing at the conventional point group (30 cases) by the random number table method. In the milli-fire needle acupuncturing at the focus of tendon knot group, the hand and foot Taiyang Jingjin, hand and foot Shaoyang Jingjin, hand and foot Yangming Jingjin proximal and distal ganglion lesions around the head and neck were selected treated with millimite acupuncture under the guidance of Jingjin theory. In the milli-fire needle acupuncturing at the conventional point group, tianzhu point, fengchi point, gungu point, shouljing point, hegu point, taichong point, and zulinqi point were routinely selected for mile-fire acupuncture treatment. Once every 3 days, 9 days was a course of treatment. The digital headache score, headache duration, headache frequency, neck range of motion and clinical effect before and after treatment were compared between the two groups after 2 courses of treatment. Results After treatment, per week on average headache, headache every time duration, and degree of headache digital score of the two groups was significantly decreased before treatment, and milli-fire needle acupuncturing at the focus of tendon knot group was lower than milli-fire needle acupuncturing at the conventional point group (P ＜ 0.05). After treatment, the neck range of motion score of the two groups was significantly higher than those before treatment, and milli-fire needle acupuncturing at the focus of tendon knot group was hihger than milli-fire needle acupuncturing at the conventional acupoint group (P ＜ 0.05). The clinical effect of milli-fire needle acupuncturing at the focus of tendon knot group was higher than that of milli-fire needle acupuncturing at the conventional acupoint group (P ＜ 0.05). Conclusion The curative effect of milli-fire needle acupuncturing at the focus of tendon knot in treating cervical headache is significant, which can obviously improve the clinical symptoms of patients with cervical headache.
		2020 Vol. 17 (6): 144-148 [Abstract] ( 307 ) HTML (1 KB) PDF (745 KB) ( 60 )

	149	Summary of national medical master Xuan Guowei′s experience in treating vulvar lichen sclerosus
		SI Weizhen DANG Ruonan LU Jiping LI Hongyi WU Yuansheng
		Vulvar lichen sclerosus is a common skin disease in clinic. Professor Xuan points out that the dysfunction of liver and kidney is the key to the disease, and wind, heat, dryness and dampness are the important factors of the disease. The main pathogenesis of vulva lichen sclerosus is dampness and heat of liver channel, deficiency of liver and kidney yin. According to different stages of syndrome differentiation and treatment, in the acute stage, heat clearing, dampness removing and itching relieving are the main methods, which are supplemented and reduced by modified Skin Detoxification Decoction, righted in the middle and late stage without forgetting to remove pathogenic factors, and the key is to invigorate the liver and kidney, and also to detoxify and itch relieving, which is supplemented and reduced by modified Zhibai Dihuang Decoction. The combination of internal and external treatment, combined with traditional Chinese medicine fumigation, washing, wiping and other comprehensive treatment, the clinical effect is satisfactory.
		2020 Vol. 17 (6): 149-152 [Abstract] ( 490 ) HTML (1 KB) PDF (738 KB) ( 95 )

	153	Research on identification of common Chinese herbal medicines based on 3D technology
		GUO Lixiao1 SHEN Yajun1 SU Chang1 HOU Fangjie1 SUN Baohui2 ZHENG Yuguang1 ZHENG Qian1，3
		Objective In order to quickly and accurately determine the varieties of traditional Chinese medicine at low cost, 3D technology is applied to the identification of the true and false of traditional Chinese medicine. Methods As well as depth of field synthesis software, microscope and photographic equipment were used for 3D photographing and identification of common Chinese herbal medicines and their confusions. Results Through 3D technology, the distinction between the authentic and the confusions of traditional Chinese medicine had been completed, and the authenticity of traditional Chinese medicine can be preliminarily identified. Conclusion This method is simple and practical, improves work efficiency and reduces work cost. It is very suitable for popularization at the grass-roots level.
		2020 Vol. 17 (6): 153-156 [Abstract] ( 269 ) HTML (1 KB) PDF (1239 KB) ( 160 )

	157	Data mining of external application of traditional Chinese medicine for malignant ascites based on medication rules and factor analysis
		WANG Gui1，2 YU Ran1，2 LOU Yanni2 LI Yuan2 JIA Liqun2
		Objective To explore the medication rules of external treatment of traditional Chinese medicine for malignant ascites. Methods Taking “malignant ascites” and “external treatment of traditional Chinese medicine” as the theme words, comprehensive search of the database of CNKI, Wanfang and VIP from its inception to June 2019 was conducted. The formulas of external treatment of traditional Chinese medicine for malignant ascites were included and the association rule, clustering and factor analysis were carried out. Results A total of 73 prescriptions meeting the inclusion criteria were collected, among which 20 high-frequency drugs with frequency ≥ 10 were used, including Cinnamon (35 times), Astragalus (32 times), Kansui (31 times), Petunia (28 times), Poria (25 times), Curcuma (22 times) were the most commonly used, most of which were warm drugs and bitter drugs, mostly attributed to spleen and lung meridian. Association rule analysis found that there were 8 drug pair combinations with support > 16% and 17 drug pair combinations with promotion > 3. Cluster analysis can be classified into 4 categories, and factor analysis extracted 10 common factors. Conclusion The principle of external treatment of malignant ascites is mainly “warming yang and benefiting qi”, “benefiting water infiltration and dampness”, and “promoting blood circulation and removing blood stasis”.
		2020 Vol. 17 (6): 157-160,164 [Abstract] ( 322 ) HTML (1 KB) PDF (1223 KB) ( 84 )

	161	Clinical effect of acupuncture in the treatment of acute urinary incontinence after cerebral infarction
		LIU Qilin JIN Jing JIANG Lei LIU Jianghua ZHANG Wen
		Objective To observe clinical effect of acupuncture in the treatment of acute urinary incontinence after cerebral infarction. Methods One hundred and four outpatients and inpatients with acute urinary incontinence after cerebral infarction were selected from Encephalopathy Department of Wuhan Hospital of Traditional Chinese Medicine from July 2017 to July 2018 and divided into treatment group and control group according to the random number table method, 52 cases in each group, except 6 cases of falling off. Finally, 48 cases in treatment group and 50 cases in control group were counted. Control group was treated with oral Tolterodine Tartrate Tablets combined with bladder training, and treatment group was treated with baihui acupoint and bilateral parietal line 1 supplemented with electroacupuncture stimulation. Urodynamic indexes, clinical symptom scores and therapeutic effects between two groups before and after treatment were compared. Results Vfs, Vmax and Pdetmax before and after treatment within two groups were compared, Vfs, Vmax and Pdetmax after treatment between two groups were compared, the differences were statistically significant (P ＜ 0.05). After treatment, clinical symptom scores of two groups were lower than before treatment, and treatment group was lower than that control group, the difference was statistically significant (P ＜ 0.05). The effect of treatment group was better than that of control group, the difference was statistically significant (P ＜ 0.05). Conclusion Electro-acupuncture at baihui and bilateral lateral line 1 of vertex can effectively relieve clinical symptoms, and improve the urodynamicparameters for cerebral infarction patients with urge urinary incontinence.
		2020 Vol. 17 (6): 161-164 [Abstract] ( 233 ) HTML (1 KB) PDF (776 KB) ( 121 )

	165	Treatment of optic nerve contusion with hormone combined with multiple drugs: a case report
		WEN Hang LIU Jiang XIANG Minhong
		This article retrospectively analyzed a case of optic nerve contusion. The patient was hit on the head and face due to syncope, and was admitted to the Department of Emergency, Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine for multiple injuries. Later, the patient was diagnosed as optic nerve contusion after detailed physical examination and auxiliary examination due to decreased vision and visual field defects. After treatment with high-dose hormone combined with multi-drug, the vision acuity and visual field improved significantly. In this case, the visual acuity decreased and the visual field defect occurred after the fall injury, which was diagnosed as optic nerve contusion after detailed physical examination and auxiliary examination. Optic nerve contusion is not common in clinic, and it is easy to be covered up by systemic disease and ignored. Timely and accurate diagnosis of the disease can greatly save the visual acuity and visual function of patients. Clinicians need to further improve their understanding of the disease in their daily work，conduct systematic ophthalmic physical examination and relevant auxiliary examinations, weigh the advantages and disadvantages of surgery or drugs, and try to improve the prognosis of optic nerve contusion.
		2020 Vol. 17 (6): 165-167 [Abstract] ( 288 ) HTML (1 KB) PDF (326 KB) ( 98 )

	168	Visualization analysis of literature related tosinusoidal endothelial cells
		YAN Xiaoyu1,2 LIU Yutong1,2 LYU Wenliang1
		Objective Through visual analysis of related literature, the main research directions and hot spots of sinusoidal endothelial cells in recent 47 years were explored. Methods The forward search method was used to search the relevant literature of SCI-E in WOS from January 1972 to December 2018, the key words were “hapatic sinusoidal endothelial cell” or “liver sinusoidal endothelial cell” or “HSEC” or “LSEC”, index: SCI-EXPANDED. The full records and references of search results were exported in plain text format. The co-occurrence of authors, organizations and keywords were analyzed by using CiteSpace 5.4.R3. Results A total of 3474 related literatures were obtained, reaching the peak of citations in nearly 47 years in 2018. The most productive institution was the University of Sydney, and the most prolific author was Smedsrod B. The most cited journal was HEPATOLOGY. The hot key words were sinusoidal endothelial cells, lipid storage cells, liver regeneration, etc., which could form 9 clusters. Conclusion CiteSpace is used to analyze the literature related to sinusoidal endothelial cells, showing the current cooperation countries and institutions, revealing the research hotspot, providing a reference for the follow-up research, which is of great significance for the research of sinusoidal endothelial cells.
		2020 Vol. 17 (6): 168-173 [Abstract] ( 329 ) HTML (1 KB) PDF (1544 KB) ( 89 )

	174	The value and application of electronic medical records in the construction of disease-oriented outpatient clinic
		ZHANG Dongxiao1 JIA Nan2 MA Hongyu2 SUN Yujian1 FU Na1 DONG Hao1 ZHAO Wenjie1 HUANG Qiao1
		Disease-oriented outpatient clinic is a rapidly developing outpatient service mode in recent years. Electronic medical record has many advantages, such as large sample size, more in line with clinical practice and so on. The combination of the model electronic medical record and the disease-oriented outpatient clinic can be used to collect a specific disease case, which is of great significance to the improvement of the special disease efficacy and development of new drugs. This paper discusses the value and application of electronic medical record in the construction of disease-oriented outpatient clinic, taking the plasma cell mastitis of galactophore department of Beijing Traditional Chinese Medicine Hospital, Capital Medical University as an example. From the two aspects of the template design, operation process and application effect of the electronic medical record in the disease-oriented outpatient clinic. It is found that the electronic medical record in the disease-oriented outpatient clinic can effectively form a high-quality clinical data set of specific diseases. To improve the level of disease awareness, prevent diseases before they occur; form clinical decision-making; optimize the clinical pathway; enrich materials for teaching and improve the teaching level. The accumulation of electronic medical records plays an important role in the construction of disease-oriented outpatient clinic and is an important way to enhance the strength of the discipline.
		2020 Vol. 17 (6): 174-176,192 [Abstract] ( 209 ) HTML (1 KB) PDF (791 KB) ( 62 )

	177	Discussion on the “dual track integration” education mode of graduate students majoring in interventional medicine in non directly affiliated cancer hospital
		MA Junli HU Hongtao LI Hailiang GUO Chenyang YAO Quanjun GENG Xiang CAO Qiuying ZHAO Yuqing YUAN Hang
		Combined with the particularity of non directly affiliated hospital and the characteristics of interventional medicine as a new discipline, according to the connotation of “dual track integration”, this paper explores and studies from three aspects of hospital and department management, tutor and graduate students. By strengthening the construction of teaching office and facilities, conducting regular training for teachers and setting up tutor groups, etc.; by strengthening the construction of teachers, and providing scientific research platforms and topics, encouraging graduate students to actively participate in scientific research practice to improve their scientific research ability, so as to achieve the purpose of urging graduate students to advance in clinical technology and scientific research skills, and promoting implementation of “dual track integration” education mode in non directly affiliated hospitals. Through the continuous development and practice, combined with the characteristics of interventional medicine, non directly affiliated hospitals gradually form in line with their own actual teaching and assessment mechanism.
		2020 Vol. 17 (6): 177-180 [Abstract] ( 242 ) HTML (1 KB) PDF (715 KB) ( 50 )

	181	Research on the path of health poverty alleviation of traditional Chinese medicine from the perspective of collaborative governance
		SHEN Weiwei WANG Jingyu KE Fei SUN Wanjun ZHOU Liangrong
		Returning to poverty due to illness has become the most difficult bone in the battle to get rid of poverty, calling for precise response and increasing the efforts of healthy poverty alleviation. In the new era, we need to take advantage of the characteristics of traditional Chinese medicine services to meet the health needs of rural poor people in the whole life cycle and health process. Based on the theory of coordinated governance, this paper analyzes the current situation of health poverty alleviation and the development of traditional Chinese medicine, and puts forward that the party and government organs should promote the work of health poverty alleviation of traditional Chinese medicine at a high level, the functional departments should scientifically formulate complementary policies, the county medical association should strengthen the service ability of traditional Chinese medicine, the poor patients should improve the health literacy of traditional Chinese medicine, and the social groups should actively integrate into the health of traditional Chinese medicine poverty alleviation, in order to continuously optimize the path of traditional Chinese medicine health poverty alleviation, and promote the dual strategy of “healthy China” and “rural revitalization”.
		2020 Vol. 17 (6): 181-184 [Abstract] ( 155 ) HTML (1 KB) PDF (780 KB) ( 121 )

	185	Research on the development of traditional Chinese medicine fashion health care industry in Heilongjiang Province
		GUAN Xiaoguang1 HUANG Qi2 HE Chang1 LI Ang1 LIU Bo1
		With the improvement of living standard and health care awareness, health care industry has become a sunrise industry with great development prospects. Traditional Chinese medicine fashion health care industry integrates traditional Chinese medicine health care industry with fashion industry, innovates industrial development mode, and creates a new industrial development format. Heilongjiang Province is rich in traditional Chinese medicine resources, rich in traditional Chinese medicine culture, rich in fashion health care projects, and unique in health care tourism. It has the basic conditions and unique advantages to develop the industry of traditional Chinese medicine fashion health care. Based on the investigation of the health care industry of traditional Chinese medicine in Heilongjiang Province, it is found that there are many problems in the health care industry, such as the small scale of health care institutions, the low level of specialization of employees, the lack of innovation ability, and the weakening of industry supervision. Heilongjiang Province should rely on the resources of traditional Chinese medicine, give full play to its comparative advantages, according to the top-level planning, unified leadership, policy linkage, technical support, outstanding advantages step by step implementation of the strategy, and continue to promote the standardized development of traditional Chinese medicine fashion health industry in Heilongjiang Province.
		2020 Vol. 17 (6): 185-188 [Abstract] ( 201 ) HTML (1 KB) PDF (780 KB) ( 73 )

	189	Tactics and thinking on management promotion of the head of department based on discipline development strategy in new period
		QIAN Hongying1 HUANG Pei2
		The head of department is the academic leader and the administrative manager of the hospital department. This article elaborats the new connotation and new ability of the head of department of hospital in the new period, and then put forward the promotion way of management level the head of department from discipline development strategy, including that the head of department shoud attach great importance to the learning management, respect the head of department fully, assign a “management assistant” to the head of department, provide the decision support system, standardize the selection access of the head of department and set up an effective incentive and constraint mechanism.
		2020 Vol. 17 (6): 189-192 [Abstract] ( 221 ) HTML (1 KB) PDF (716 KB) ( 42 )

	193	Discussion on taking full use of the educational function of tradeunion for improving the psychological quality of the teaching staff in research institutes
		DING Weiming JIA Shuying ZHANG Guilan KANG Tian
		This topic combines the important exposition made by general secretary XI Jinping on the work of trade unions and the spirit of“the 19th National Congress of the Communist Party of China” report, in order to adapt to the development of socialism with Chinese characteristics in the new era. To innovate the work mechanism of the union oriented. This paper expounds the importance of giving full play to the educational function of trade union to improve the psychological quality of faculty and staff in scientific research institutes, and combine with reality, analyzes the present situation and existing problems of faculty and staff′s psychological quality and mental health in scientific research institutes. This paper probes into the effective ways to improve the psychological quality of teachers and staff in scientific research institutes by giving full play to the role of trade unions in the new era and the new situation. It is of great significance to provide the reference and theoretical guidance for the trade union to carry out the related work in the next step.
		2020 Vol. 17 (6): 193-196 [Abstract] ( 252 ) HTML (1 KB) PDF (717 KB) ( 82 )

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