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| Research progress of the functional characteristics and the treatment of rheumatoid arthritis of mesenchymal stem cells |
| DA Gula1 XIE Xianda2▲ WANG Jing1▲ |
| 1.Department of Rheumatology, the Affiliated Hospital of Inner Mongolia Medical University, Inner Mongolia Autonomous Region, Hohhot 010000, China; 2.Department of Rheumatology, Chenzhou NO.1 People′s Hospital, Hu′nan Province, Chenzhou 423000, China |
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Abstract Mesenchymal stem cells (MSCs) have self-renewal ability and multi-directional differentiation potential, and they play an important role in immune regulation, inflammation control and cartilage destruction. MSCs produce a large number of soluble membrane-binding factors, some of which inhibit immune responses, induce immune tolerance, and exert important immunomodulatory effects. Due to the biological characteristics and immunomodulatory effects of MSCs, the efficacy and safety of MSCs in the treatment of rheumatoid arthritis have been confirmed in animal experiments and clinical studies in recent years. This article briefly reviews the functional characteristics of MSCs and the related research progress in the treatment of rheumatoid arthritis.
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[1] Zeng QY，Chen R，Darmawan J，et al. Rheumatic diseases in China [J]. Arthritis Res Ther，2008，10（1）：R17.
[2] Pistoia V，Raffaghello L. Mesenchymal stromal cells and autoimmunity [J]. Int Immunol，2017，29（2）：49-58.
[3] Urban VS，Kiss J，Kovacs J，et al. Mesenchymal stem cells cooperate with bone marrow cells in therapy of diabetes [J]. Stem Cells，2008，26（1）：244-253.
[4] da Silva Meirelles L，Chagastelles PC，Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues [J]. J Cell Sci，2006，119（Pt11）：2204-2213.
[5] de Bari C. Are mesenchymal stem cells in rheumatoid arthritis the good or bad guys? [J]. Arthritis Res Ther，2015， 17：113.
[6] Le Blanc K，Rasmusson I，Sundberg B，et al. Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells [J]. Lancet，2004， 363（9419）：1439-1441.
[7] Cras A，Farge D，Carmoi T，et al. Update on mesenchymal stem cell-based therapy in lupus and scleroderma [J]. Arthritis Res Ther，2015，17：301.
[8] DI Nicola M，Carlo-Stella C，Magni M，et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli [J]. Blood，2002，99（10）：3838-3843.
[9] Krampera M，Glennie S，Dyson J，et al. Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide [J]. Blood，2003，101（9）：3722-3729.
[10] Gao F，Chiu SM，Motan DA，et al. Mesenchymal stem cells and immunomodulation：current status and future pros-pects [J]. Cell Death Dis，2016，7：e2062.
[11] Caprnda M，Kubatka P，Gazdikova K，et al. Immunomodulatory effects of stem cells：Therapeutic option for neurodegenerative disorders [J]. Biomed Pharmacother，2017， 91：60-69.
[12] Corcione A，Benvenuto F，Ferretti E，et al. Human mesenchymal stem cells modulate B-cell functions [J]. Blood，2006，107（1）：367-372.
[13] Ciccocioppo R，Cangemi GC，Kruzliak P，et al. Ex vivo immunosuppressive effects of mesenchymal stem cells on Crohn′s disease mucosal T cells are largely dependent on indoleamine 2,3-dioxygenase activity and cell-cell contact [J]. Stem Cell Res Ther，2015，6：137.
[14] Gimeno ML，Fuertes F，Barcala Tabarrozzi AE，et al. Pluripotent Nontumorigenic Adipose Tissue-Derived Muse Cells have Immunomodulatory Capacity Mediated by Transforming Growth Factor-β1 [J]. Stem Cells Transl Med，2017，6（1）：161-173.
[15] Saldanha-Araujo F，Haddad R，Farias KC，et al. Mesenchymal stem cells promote the sustained expression of CD69 on activated T lymphocytes：roles of canonical and non-canonical NF-κB signalling [J]. J Cell Mol Med，2012，16（6）：1232-1244.
[16] Augello A，Tasso R，Negrini SM，et al. Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis [J]. Arthritis Rheum，2007，56（4）：1175-1186.
[17] Sonomoto K，Yamaoka K，Oshita K，et al. Interleukin-1β induces differentiation of human mesenchymal stem cells into osteoblasts via the Wnt-5a/receptor tyrosine kinase-like orphan receptor 2 pathway [J]. Arthritis Rheum，2012， 64（10）：3355-3363.
[18] Fukuyo S，Yamaoka K，Sonomoto K，et al. IL-6-accelerated calcification by induction of ROR2 in human adipose tissue-derived mesenchymal stem cells is STAT3 dependent [J]. Rheumatology（Oxford，England），2014，53（7）：1282-1290.
[19] Choi JR，Yong KW，Choi JY. Effects of mechanical loading on human mesenchymal stem cells for cartilage tissue engineering [J]. J Cell Physiol，2018，233（3）：1913-1928.
[20] Tanaka Y. Human mesenchymal stem cells as a tool for joint repair in rheumatoid arthritis [J]. Clin Exp Rheumatol，33（4 Suppl 92）：S58-S62.
[21] Yan X，Cen Y，Wang Q. Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated IκB expression [J]. Sci Rep，2016，6：28915.
[22] Shin TH，Kim HS，Kang TW，et al. Human umbilical cord blood-stem cells direct macrophage polarization and block inflammasome activation to alleviate rheumatoid arthritis [J]. Cell Death Dis，2016，7（12）：e2524.
[23] Zhang X，Yamaoka K，Sonomoto K，et al. Local delivery of mesenchymal stem cells with poly-lactic-co-glycolic acid nano-fiber scaffold suppress arthritis in rats [J]. PLoS ONE，2014，9（12）：e114621.
[24] Contreras RA，Figueroa FE，Djouad F，et al. Mesenchymal Stem Cells Regulate the Innate and Adaptive Immune Responses Dampening Arthritis Progression [J]. Stem Cells Int，2016，2016：3162743.
[25] Wang L，Wang L，Cong X，et al. Human umbilical cord mesenchymal stem cell therapy for patients with active rheumatoid arthritis：safety and efficacy [J]. Stem Cells Dev，2013，22（24）：3192-3202.
[26] Sun Y，Deng W，Geng L，et al. Mesenchymal stem cells from patients with rheumatoid arthritis display impaired function in inhibiting Th17 cells [J]. J Immunol Res，2015，2015：284215.
[27] Alvaro-Gracia JM，Jover JA，Garcia-Vicuna R，et al. Intravenous administration of expanded allogeneic adipose-derived mesenchymal stem cells in refractory rheumatoid arthritis （Cx611）：results of a multicentre，dose escalation，randomised，single-blind，placebo-controlled phase Ib/IIa clinical trial [J]. Ann Rheum Dis，2017，76（1）：196-202.
[28] Cosenza S，Toupet K，Maumus M，et al. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis [J]. Theranostics，2018，8（5）：1399-1410.
[29] Li T，Xia M，Gao Y，et al. Human umbilical cord mesenchymal stem cells：an overview of their potential in cell-based therapy [J]. Expert Opin Biol Ther，2015，15（9）：1293-1306. |
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