|
|
|
| Advances in neuroimaging studies of early onset schizophrenia |
| CHEN Zhenzhu1 YANG Hong2 |
1.Department of Mental Health, Affiliated Dayi Hospital of Shanxi Medical University, Shanxi Province, Taiyuan 030001, China;
2.Department of Mental Health, Shanxi Academy of Medical Sciences Shanxi Dayi Hospital, Shanxi Province, Taiyuan 030032, China |
|
|
|
Abstract In recent years, early-onset schizophrenia as a research sample, to explore the pathogenesis of schizophrenia is the current research focus. Neuroimaging has become an important technique in the study of early-onset schizophrenia due to its noninvasive and intuitive advantages. This paper summarizes the research progress of structural neuroimaging and functional neuroimaging of early-onset schizophrenia, and found the changes of some brain regions in patients with early-onset schizophrenia through various methods of brain imaging data analysis, to explore the possible association with the disease.
|
|
|
|
|
|
[1] 沈渔邨.精神病学[M].5版.北京：人民卫生出版社，2009： 506-507.
[2] Liu D，Xu Y，Jiang K. Advances in neuroimaging research of schizophrenia in China [J]. Shanghai Arch Psychiatry，2014，26（4）：181-193.
[3] Fusar-Poli P，Meyer-Lindenberg A. Forty years of structural imaging in psychosis：promises and truth [J]. Acta Psychiat Scand，2016，134（3）：207-224.
[4] Ordó?觡ez AE，Sastry NV，Gogtay N，et al. Functional and clinical insights from neuroimaging studies in childhood-onset schizophrenia [J]. CNS Spectr，2015，20（4）：442-450.
[5] 杨春林，潘伟刚，马俊芳，等.青少年精神分裂症头部CT异常者临床特征与影像学表现[J].北京医学，2016，38（11）：1159，1163.
[6] 杨春林，潘伟刚，马俊芳，等.青少年首发精神分裂症患者脑结构异常及其相关因素研究[J].临床和实验医学杂志，2016，15（24）：2451-2454.
[7] Badura F，Trott GE，Mehler-Wex C，et al. A study of cranial computertomograms in very early and early onset schizophrenia [J]. J Neural Transm (Vienna)，2001，108（11）：1335-1344.
[8] 杜海霞，郭素芹，李强，等.脑室扩大与儿童精神分裂症的关系[J].实用儿科临床杂志，2008，38（24）：1908-1910.
[9] 程祖胜，夏国园，曹世林，等.松果体钙化与青少年精神分裂症的CT相关分析[J].浙江中西医结合杂志，2016， 26（12）：1114-1116.
[10] 王潇，张燕，孙梦夕，等.青少年精神分裂症首次发病患者脑灰质体积与认知功能的相关性[J].临床精神医学杂志，2016，26（6）：365-367.
[11] 王潇.青少年首发未用药精神分裂症患者脑灰质体积与认知功能的相关性研究[D].新乡：新乡医学院，2017.
[12] Vidal CN，Rapoport JL，Hayashi KM，et al. Dynamically Spreading Frontal and Cingulate Deficits Mapped in Adolescents With Schizophrenia [J]. Arch Gen Psychiatry，2006，63（1）：25-34.
[13] El-Sayed M，Steen RG，Poe MD，et al. Brain volumes in psychotic youth with schizophrenia and mood disorders [J].J Psychiatr Neurosci，2010，35（4）：229-236.
[14] 朱俊敬，郭素芹，梁颖慧，等.首发儿童精神分裂症患者行为特征与颅脑结构的关系[J].中国学校卫生，2018， 39（7）：1018-1021.
[15] Juuhl-Langseth M，Rimol LM，Rasmussen IA，et al. Comprehensive segmentation of subcortical brain volumes in early onset schizophrenia reveals limited structural abnormalities [J]. Psychiatry Res，2012，203（1）：14-23.
[16] Greenstein D，Lenroot R，Clausen L，et al. Cerebellar development in childhood onset schizophrenia and non-psychotic siblings [J]. Psychiatry Res，2011，193（3）：131-137.
[17] Janssen J，Yasser Alemán-Gómez，Reig S，et al. Regional specificity of thalamic volume deficits in male adolescents with early-onset psychosis [J]. Br J Psychiatry，2012， 200（1）：30-36.
[18] Marquardt RK，Levitt JG，Blanton RE，et al. Abnormal development of the anterior cingulate in childhood-onset schizophrenia：a preliminary quantitative MRI study [J]. Psychiatry Res，2005，138（3）：221-233.
[19] Crespo-Facorro B，Kim J，Andreasen NC，et al. Insular cortex abnormalities in schizophrenia：a structural magnetic resonance imaging study of first-episode patients [J]. Schizophr Res，2000，46（1）：35-43.
[20] Shenton ME，Gerig G， McCarley RW，et al. Amygdala–hippocampal shape differences in schizophrenia：the application of 3D shape models to volumetric MR data [J]. Psychiatry Res，2002，115（1/2）：15-35.
[21] 张海三，李炎，李云，等.儿童青少年精神分裂症患者眶额脑回沟区结构模式[J].中国神经精神疾病杂志，2018，44（3）：161-165.
[22] Thompson PM，Vidal C，Giedd JN，et al. Mapping adolescent brain change reveals dynamic wave of accelerated gray matter loss in very early-onset schizophrenia [J]. Proc Natl Acad Sci U S A，2001，98（20）：11650-11655.
[23] Gogtay N. Cortical Brain Development in Schizophrenia：Insights From Neuroimaging Studies in Childhood-Onset Schizophrenia [J]. Schizophr Bull，2008，34（1）：30-36.
[24] Zang YF，He Y，Zhu CZ，et al. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI [J]. Brain Dev，2007，29（2）：83-91.
[25] 简凤清，谢世平，曹栋.低频振幅方法在精神分裂症fMRI研究中的应用[J].精神医学杂志，2014，27（1）：71-73.
[26] Zheng J，Zhang Y，Guo X，et al. Disrupted amplitude of low-frequency fluctuations in antipsychotic-na?觙ve adolescents with early-onset schizophrenia [J]. Psychiatry Res Neuroimaging，2016，249：20-26.
[27] 熊燕兵.早发精神分裂症静息态脑功能低频振幅及局部一致性研究[D].太原：山西医科大学，2016.
[28] Wang S，Zhang Y，Lv L，et al. Abnormal regional homogeneity as a potential imaging biomarker for adolescent-onset schizophrenia：A resting-state fMRI study and support vector machine analysis [J]. Schizophr Res，2018， 192：179-184.
[29] 崔晓红，熊燕兵，杨红，等.早发精神分裂症静息态脑功能局部一致性研究[J].中国药物与临床，2019，19（16）：2710-2712.
[30] Wang X，Zhang Y，Long Z，et al. Frequency-specific alteration of functional connectivity density in antipsychotic-naive adolescents with early-onset schizophrenia [J]. J Psychiatr Res，2017，95：68-75.
[31] Tang J，Liao Y，Song M，et al. Aberrant Default Mode Functional Connectivity in Early Onset Schizophrenia [J]. PLoS One，2013，8（7）：e71061.
[32] Zhou B，Tan C，Tang J，et al. Brain functional connectivity of functional magnetic resonance imaging of patients with early-onset schizophrenia [J]. Zhong Nan Da Xue Xue Bao Yi Xue Ban，2010，35（1）：17-24.
[33] 程龙.早发与成人精神分裂症的静息态功能比率低频振幅及功能连接研究[D].太原：山西医科大学，2017.
[34] Rashid B，Damaraju E，Pearlson GD，et al. Dynamic connectivity states estimated from resting fMRI Identify differences among Schizophrenia，bipolar disorder，and healthy control subjects [J]. Front Hum Neurosci，2014， 8：897.
[35] 戴立彬，程祺，吴灿灿，等.首次发病儿童青少年精神分裂症患者脑白质弥散张量成像特点研究[J].影像研究与医学应用，2019，3（14）：46-47.
[36] 杨毅，何明颖，黄莹，等.早发精神分裂症的钩束磁共振弥散张量FA值变化及意义[J].功能与分子医学影像学：电子版，2017，6（3）：1244-1247.
[37] 姜红燕，李宗芳，杨涛，等.首发儿童青少年精神分裂症脑磁共振弥散张量成像研究[J].重庆医学，2014，43（24）：3130-3132. |
|
|
|
