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| Application of pattern electroretinogram in measuring the thickness of retinal nerve fiber layer in patients with primary open-angle glaucoma and analysis of influencing factors |
| XIONG Yunfan LI Qing |
| Department of Ophthalmology, the First Affiliated Hospital of Kunming Medical University, Yunnan Province, Kunming 650000, China |
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Abstract Objective To analyze the application and influencing factors of pattern electroretinogram (PERG) in measuring the thickness of retinal nerve fiber layer in patients with primary open-angle glaucoma, and to provide corresponding theoretical guidance for clinical practice. Methods A total of 60 patients (120 eyes) with early primary open-angle glaucoma admitted to Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University from July 2018 to June 2019 were selected as the observation group, and 60 normal people admitted during the same period were selected as the control group. The thickness of retinal nerve fibers was detected by PERG, respectively. The detection conditions of PERG in the two groups were compared, and the influencing factors of PERG detection were analyzed by single and multiple factors. Results The amplitude and time of N95 in the observation group were lower than those in the control group, and the differences were statistically significant (all P ＜ 0.05). Age, course of disease, diopter, intraocular pressure of the two groups were compared, and the differences were statistically significant (all P ＜ 0.05). There was no significant difference in gender, ophthalmic complications and previous surgical history (P ＞ 0.05). Gender, age, course of disease and diopter were regarded as independent variables, while the accuracy of test was regarded as dependent variables. Logistic multivariate regression analysis showed that age and diopter were influencing factors (all P ＜ 0.05). Conclusion The determination of open-angle glaucoma by PERG is highly sensitive, but it is easily affected by age, diopter and other factors. Multiple methods of combined detection can effectively improve the early diagnosis rate of open-angle glaucoma, which is worthy of clinical promotion.
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