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2019 Vol. 16, No. 27
Published: 2019-09-25
 
 
7 Construction on research system of health policy and discussion on implementation path of “integrating health into all policies”
WANG Mingli1 WANG Guoqiang2 ZHANG Ruichun3
The construction research system of health policy and the discussion on the implementation path of “integrating health into all policies” are important guidelines and policies for health policy work in the new era. It is a public health policy formulation method and approach proposed and strongly advocated by WHO to improve the health of the social population and to enjoy fair health services. Taking the implementation of the Outline of “Healthy China 2030” as an opportunity, this paper makes an analysis of the reasons for the establishment a research system of health policysuitable for China′s regional characteristics and its influencing factors and discussing the implementation path and strategy of “integrating health into all policies” in academic field to use the advantages of them for our country. The purpose of this study is to provide academic support and theoretical basis for government departments to formulate relevant health policies and systems.
2019 Vol. 16 (27): 7-12 [Abstract] ( 225 ) HTML (1 KB)  PDF (620 KB)  ( 141 )
13 Preventive and therapeutic effects of Weifuchun Tablets on chronic atrophic gastritis in model rats
XIE Dong1,2,3* LIN Ling4* HAN Tao4 LU Lu1,2,3 YE Guan5 ZHANG Yeqing5 AN Yongtong5 SUN Mingyu1,2,3▲
Objective To explore the preventive and therapeutic effects of Weifuchun on chronic atrophic gastritis in model rats. Methods According to random stratification design, 50 Wistar rats were divided into 5 groups, with 10 rats in each group, namely the normal group (N group), the model group (M group), the high-dose Weifuchun group (WH group), the low-dose Weifuchun group (WL group), and the Vatacoenayme control group (VM group). N group was free to eat and drink water normal, and the other groups were fed 100 mg/L N-methyl-N1- nitro-N- nitrosoguanidine Aqueous Solution and 0.3 g/L Ranitidine feed. The rest groups were constructed by feeding with 100 mg/L N-methyl-N1-nitro-nitrosoguanidine Aqueous Solution and 0.3 g/L Ranitidine, and alternating gavage with 150 g/L sodium chloride solution at 56℃ and 30% ethanol according to the method of 10 mL/kg and combined with starvation and satiation disorder. After 4 weeks of modeling, drug therapy was given, WH group and WL group were respectively given gavage of 1.44 g/kg and 0.72 g/kg of Weifuchun, VM group was given gavage of 0.6 g/kg of Vatacoenayme, and N group was given gavage of 10 mL/kg of normal saline until death. The general situation, pepsin activity, pathological changes of gastric tissue and the changes in mRNA of genes related to inflammation and apoptosis in rats were observed. Results Compared with the M group, the weight gain of the drug group was improved to different degrees, while the WH group and WL group showed significant improvement; compared with the M group, the activity of pepsin in WH group and WL group increased to different degree (P ＜ 0.05), while the WH group increased significantly (P ＜ 0.01). Compared with the M group, the glandular atrophy in the drug group was decreased to different degrees, and compared with the WL group and VM group, the infiltration of lymphocytes, plasma cells and acid cells was decreased in the lamina propria of WH group; compared with the M group, the mRNA levels of nuclear factor-κB (NF-κB), tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), Bcl-2, cyclooxygenase-2 (COX-2), Caspase-3 and Caspase-8 in WH group and WL group were significantly down-regulated (P ＜ 0.05 or P ＜ 0.01) and the mRNA level of Bax in WH group was significantly up-regulated (P ＜ 0.01). Conclusion Weifuchun can enhance the activity of pepsin, and its therapeutic effect may be related to the inhibition of pro-inflammatory factors IL-1, TNF-α and COX-2, the down-regulation of the expression of NF-κB, and the regulation of cell apoptosis.
2019 Vol. 16 (27): 13-17,32 [Abstract] ( 329 ) HTML (1 KB)  PDF (1397 KB)  ( 168 )
18 Establishment and identification of induced pluripotent stem cells sourced fetal amniotic fluid cells of a fetus with severe α-halassemia
ZHANG Juan LAI Chuntian WAND Haiyan ZOU Wenda PENG Juan ZHU Liyu LI Hui
Objective To explore the establishment and identification of induced pluripotent stem cells sourced fetal amniotic fluid cells of a fetus with severe α-halassemia. Methods Ultrasound-guided amniocentesis was performed on pregnant women (16+ weeks) whose fetus was diagnosed with severe α-halassemia(--SEA/--SEA), 10 mL of amniotic fluid was extracted. The amniotic fluid cells of a fetus with severe α-halassemia which were reprogrammed into induced pluripotent stem cells (iPSCs) by non-integrated sendai virus mediated transcription factors of Sox2, Klf4, c-Myc, Oct 3/4. IPSCs were multifunctionally identified by alkaline phosphatase (ALP) test and immunofluorescence (IF) labeling. The ability of iPSCs to differentiate outward from three endodermal cells in vivo was identified by embryoid (EB) formation and spontaneous differentiation test. Cell karyotype analysis and genetic diagnosis of type α-thalassemia were performed. Results Sendai virus could successfully reprogram the amniotic fluid cells of a fetus with severe α-halassemia into non-integrated induced pluripotent stem cells (h-AF-SeV-iPSCs). H-AF-SeV-iPSCs were strongly positive of ALP staining, and embryonic stem cells specific proteins of SOX2, Oct4, SSEA-4 and Tra-1-81 were positive expressed of IF staining. After the suspension culture of h-AF-SeV-iPSCs, the cystic EB body could be formed, and after the adherent culture, it could also differentiate into the three germ layers. The karyotype analysis of chromosome in the 10th and 20th generation of h-AF-SeV-iPSCs were normal (46, XY). H-AF-SeV-iPSCs and its primary amniotic fluid cells were all detected as --SEA/--SEA. Conclusion The h-AF-SeV-iPSCs could be used as an ideal cell model for study of intrauterine treatment of a fetus with severe α-halassemia, and amniotic fluid cells could be used as an ideal cells source for iPSCs.
2019 Vol. 16 (27): 18-23 [Abstract] ( 207 ) HTML (1 KB)  PDF (1028 KB)  ( 61 )
24 Development and experimental study of a new type of semi-closed fine pleural cavity drainage tube
SHI Weicheng HUANG Xujie PENG Xueling ZHAN Wencai LIU Yong
Objective To research and develop the effect of a new type of semi-closed fine pleural cavity drainage tube. Methods A closed pleural cavity simulation system was used to simulate puncture leakage. Experimental group was treated with new semi-enclosed fine pleural cavity drainage tube, control group was treated with pig-tail drainage tube with the same diameter. The volume of air leakage during the operation of the pleural cavity enclosed was recorded, 20 times for each group. Bama miniature pigs was used to simulate the operational performance and safety experiments. Twenty puncture sites with good observation were selected under thoracoscopy, and each puncture site was numbered 3 catheterization sites from bottom to top. Pig tail drainage tube of 12F was used in control group (No.1), a new type of semi-closed fine pleural cavity drainage tube with a tip puncture guide needle of type A was used in experimental group (No.2), a new type of semi-closed fine pleural cavity drainage tube with a tip puncture guide needle of type B was used in experimental group (No.3). The operational performance and the rate of lung injury were observed under thoracoscopy, 20 times for each group. Results The average amount of puncture leakage in the experimental group was significantly lower than that in the control group, and the difference was statistically significant (P < 0.05). All the groups were able to successfully placed into the pleural cavity of bama miniature pig, and the rupture in parietal pleura of experimental group (No.2) and experimental group (No.3) was the same as that of the control group (No.1). When needling at the depth of 10 mm, the rate of injury in the experimental group was lower than that in the control group, the difference was not statistically significant (P > 0.05). When needling at the depth of 20 mm, the rate of injury in the experimental group was lower that in the control group, the difference was statistically significant (P < 0.05). Conclusion The new semi-enclosed fine pleural cavity drainage tube has the advantages of simple structure and accurate prompt, and can effectively reduce the risk of iatrogenic pneumothorax and visceral injury. At the same time, one-step catheterization is simple, safe and has good clinical value.
2019 Vol. 16 (27): 24-27 [Abstract] ( 193 ) HTML (1 KB)  PDF (947 KB)  ( 103 )
28 Research progress of lncRNA in gastric cancer
HAO Cheng1 WANG Jiehong2 ZHAO Weihan1
Gastric cancer is one of the most common malignant tumors in China. The early diagnosis rate of gastric cancer is low, the degree of malignancy is high, and the prognosis is poor, which seriously threatens the health of our people. Long non-coding RNA (lncRNA) is one of the non-coding RNA, which plays an important role in the progress of cancer. Studies have shown that lncRNA plays an important role in the malignant progression of gastric cancer either as an oncogene or as an anti-oncogene gene or plays an important role in tumor resistance. This paper summarizes recent studies on the role of lncRNA in the occurrence and development of gastric cancer, and explores the mechanism of lncRNA, which provides relevant theoretical basis for lncRNA as a biological target for the diagnosis, treatment and prognosis of gastric cancer.
2019 Vol. 16 (27): 28-32 [Abstract] ( 293 ) HTML (1 KB)  PDF (588 KB)  ( 167 )
33 Research progress on regulation of long non-coding RNA in differentiation of mesenchymal stem cells into chondrocytes
YAO Nan1 LI Congcong2 SONG Min2 XU Xuemeng3 LIU Wengang3 CHEN Guocai2 CHEN Guoqian2 YE Guozhu2
Repair of articular cartilage injury caused by osteoarthritis (OA) has always been a hotspot and difficult point in joint surgery. Mesenchymal stem cells have become the focus of cartilage repair and cell therapy in recent years. Long non-coding RNA (lncRNA) refers to a class of RNA whose transcript length exceeds 200 nt and does not code for proteins. Recent studies have shown that lncRNA is significantly differentially expressed during the differentiation of mesenchymal stem cells into chondrocytes and plays an important role in the process of the differentiation of mesenchymal stem cells into chondrocytes. This paper reviews the research on regulation of lncRNA DANCR, lncRNA HOTAIRM1-1, lncRNA ROCR, lncRNA ZBED3-AS1 and lncRNA HIT in differentiation of mesenchymal stem cells into chondrocytes, and discusses the existing problems in current studies, in order to provide references for the future cell therapy of OA.
2019 Vol. 16 (27): 33-36 [Abstract] ( 201 ) HTML (1 KB)  PDF (582 KB)  ( 65 )
37 Function and research progress of ankle protein
Ayimuguli Aini1,2 YE Jianwei3 LI Jing1
Talin (ankle protein) as an important protein in integrin activation and signal transduction, Talin mediates cell movement and is an important regulatory protein in the occurrence and development of motion-related diseases. It controls integrin activation from inside-out and action wire anchoring, and plays an important role in the establishment of mechanical coupling between actin and extracellular matrix. Talin regulates the adhesion and differentiation of endothelial progenitor cells (EPCs), so it is closely related to the onset and progression of various cardiovascular diseases. In addition, Talin also plays an important role in the occurrence, metastasis and treatment of tumors. In this paper, the structure of Talin, its biological characteristics in cell adhesion dynamics, and its regulatory role in related cardiovascular diseases were comprehensively described.
2019 Vol. 16 (27): 37-40 [Abstract] ( 279 ) HTML (1 KB)  PDF (679 KB)  ( 65 )
41 Research progress of experimental animal models of knee osteoarthritis
YU Pei1，2 LIU Lu1 LI Zhijuan1，2 FU Yuanbo1 YUAN Fang1 LI Bin1▲
According to National Standard for Laboratory Animals, knee osteoarthritis models are divided into small animal models, large and medium animal models and primate animal models. The commonly used animal models at home and abroad are classified according to spontaneous model and induced model. Spontaneous model includes natural spontaneous model and genetically modified model, while inductive model includes diet induction model, drug injection induction model, operation induction model, braking induction model and cold induction model. The selection of different models and the application of modeling methods are suitable for different research purposes.
2019 Vol. 16 (27): 41-44 [Abstract] ( 249 ) HTML (1 KB)  PDF (616 KB)  ( 121 )
45 Safety study on anti-HIV retrovirus drugs in pregnant female and infants
LIU Shuaifeng1 GE Xianmin2 SHEN Zhiyong1 DENG Xiao′e3 WU Yufei1
With the continuous research and development of new anti-HIV retrovirus drugs, the effectiveness and safety of drugs are also improving. However, when they are used as preventive drugs for prevention of mother-to-child transmission of HIV, the physiological changes during pregnancy affect drug absorption, distribution, metabolism and secretion. The toxicity and side effects of drugs would aggravate the influence on pregnant female and infants. Under such circumstances, how to choose safe and effective drugs has always been a key issue in our field of health medicine.
2019 Vol. 16 (27): 45-48 [Abstract] ( 175 ) HTML (1 KB)  PDF (582 KB)  ( 131 )
49 Reserch advances in the prevention of contrast nephropathy
MA Mengqing1 CAO Changchun1 WAN Xin2
With the development of medical imaging and interventional diagnosis and treatment technology, the use of contrast agent is more and more extensive. The resulting incidence and mortality of contrast nephropathy are also increasing. It has become the third major cause of iatrogenic acute kidney injury. There is no effective treatment for contrast nephropathy, so prevention is very important. Currently, the main preventive measures include identification of high-risk groups of contrast nephropathy, selection of contrast agents, remote ischemic preconditioning, and prevention of related drugs such as water chemotherapy, alkalization therapy, antioxidants, vasodilators, etc. However, most preventive measures are still controversial and need further study and discussion. This article will focus on the preventive measures of contrast nephropathy.
2019 Vol. 16 (27): 49-52 [Abstract] ( 186 ) HTML (1 KB)  PDF (623 KB)  ( 168 )
53 Research progress of radical prostatectomy in patients with metastatic prostate cancer
ZHANG Chongjian1 BAI Yu2
Radical prostatectomy has always been the main treatment for early prostate cancer. For metastatic prostate cancer (mPCa), most conservative treatments such as endocrine therapy are used. In recent years, with the deep understanding of the mechanism of prostate cancer and the continuous advancement of surgical techniques, the role of surgery in mPCa has gradually been recognized by some scholars. It is now systematically reviewed that the current status of prostatectomy in patients with mPCa through clinical research analysis and basic biological research, and prospects for future research.
2019 Vol. 16 (27): 53-55 [Abstract] ( 215 ) HTML (1 KB)  PDF (569 KB)  ( 92 )
56 Study on the relationship between medication adherence and family cohesion, adaptability of young and middle-aged patients with depression in Taizhou City
CHEN Lu1 LI Changsong2 CHEN Yigang1 XIA Youchun3 ＷEI Fanxin1 YANG Zhengguang1
Technology School, Taizhou Polytechnic College, Jiangsu Province, Taizhou   225300, China; 2.Department of Anesthesiology, Taizhou People′s Hospital, Jiangsu Province, Taizhou   225300, China; 3.Department of Psychiatric, the Forth People′s Hospital of Taizhou City, Jiangsu Province, Taizhou   225300, China
[Abstract] Objective To explore the correlation between medication adherence and family cohesion, adaptability of young and middle-aged patients with depression in Taizhou City. Methods A total of 101 young and middle-aged patients with depression were recruited in the Psychiatric Outpatient of the Forth People′s Hospital of Taizhou City in Jiangsu Province from October 2016 to August 2017. They were investigated with Morisky medication adherence scale and FACESⅡ-CV. Spearman correlation coefficient was used to analyze the relationship between medication adherence and general data, multiple linear regression method was used to analyze the relationship between medication adherence and family cohesion, adaptability, degree of dissatisfaction. Results There were 101 valid questionnaires, with an effective rate of 95.3%. The actual family adaptability, ideal family cohesion and ideal family adaptability of the 101 patients with depression were all lower than the domestic norm (P < 0.01). The dissatisfaction degrees of cohesion and adaptability were higher than the domestic norm (P < 0.01). The scores of medication adherence were positively correlated with both marital status (r = 0.877, P < 0.01) and the times of taking medicine (r = 0.214, P < 0.05), while negatively correlated with educational level (r = -0.808, P < 0.01) and monthly income level (r = -0.212, P < 0.05). The ideal adaptability (t =-2.778, P < 0.01) and the degree of dissatisfaction of cohesion (t = 5.935, P < 0.01) in family model had significant effects on the compliance of taking medicine. Conclusion The education background, marital status, family cohesion and adaptability, the frequency of daily medication and the monthly income level of the young and middle-aged patients with depression in Taizhou City directly affect their medication compliance, so improving the family adaptability and cohesion of family members can increase the medication adherence, as well as enhance the efficacy of treatment.
2019 Vol. 16 (27): 56-60 [Abstract] ( 212 ) HTML (1 KB)  PDF (499 KB)  ( 235 )
61 Influencing factors of blood donation volunteers to join the Chinese Marrow Donor Program
LI Mo1 LIN Minshi1 HE Minjing1 LIANG Shaogang1 LIU Jiajun2 ZHANG Ling2
Objective To investigate the influencing factors of donation of hematopoietic stem cells by voluntary blood donors and their awareness of donation of hematopoietic stem cells, establish the information bank of hematopoietic stem cells donors in Shunde Area of Guangdong Province. Methods The self-designed questionnaires on voluntary blood and hematopoietic stem cell donation were used to anonymously investigate on 1200 volunteer blood donors from March 1st to September 30th, 2018 in Shunde Blood Central of Foshan City, Guangdong Province ("our blood central" for short). And the information data from 685 volunteers who entered the database of our blood central from 2006 when Chinese Marrow Donor Program (CMDP) was established to September 30, 2018, were collected and analyzed. Results A total of 924 questionnaires were included in the study, results showed majority of volunteers were male (54.0%), staff (29.5%) and students (28.8%), most of them had junior degree (39.2%), high school degree or below (35.5%). And young people aged 18-35 years accounted for 74.9%; 685 CMDP volunteers were mainly male (71.1%) and workers (30.1%). Most education level was high school and below (50.5%) and young people aged 18-35 years (65.3%) was more than than other aged. Compared with voluntary blood donors, there were highly statistically significant differences in gender, educational background, occupation and age distribution among CMDP volunteers (P < 0.01). There also were highly statistically significant difference in the number of blood donations between CMDP volunteers and voluntary blood donors (P < 0.01). Conclusion CMDP volunteers are all voluntary blood donors, encouraging voluntary blood donors to join the CMDP should focus on male, middle-aged, low-educated and worker volunteers. The more times people donate blood, the more chances they have to learn about hematopoietic stem cells and the more likely they are to join CMDP. Strengthening volunteers′ understanding of the cause of blood donation and hematopoietic stem cells and protecting their rights and interests are beneficial to the development of blood donation and hematopoietic stem cell donation in Foshan.
2019 Vol. 16 (27): 61-64 [Abstract] ( 151 ) HTML (1 KB)  PDF (454 KB)  ( 124 )
65 Quality appraisal of clinical evidence-based guidelines for diabetes in children and adolescents based on AGREE Ⅱ
DING Xiangyu1 WANG Jianxin2 ZHANG Guying1 LIU Yanhui1
Objective To evaluate the quality of clinical evidence-based guidelines for diabetes in children and adolescents, and to compare the differences in drug treatment between the guidelines, so as to provide references for clinicians and pharmacists. Methods China National Knowledge Infrastucture, Wanfang Data, VIP, CBM database, PubMed database, Excerpta Medica Database and relevant websites such as medlive.cn, GIN, AAP, NGC, NICE were searched by computer ranged from the beginning of the database to the end of December 2018. The Appraisal of Guidelines for Research & Evaluation (AGREEⅡ) instrument was used to evaluate the quality of clinical evidence-based guidelines for diabetes in children and adolescents for the sake of the comparison of recommendations on drug therapy. Results A total of four guidelines were included respectively from the United States AAP, International ISPAD, Malaysia MaHTAS and the United Kingdom NICE. The overall quality of the guidelines was relatively high. Among these guidelines, the quality of MaHTAS and NICE were rated A, while the quality of AAP and ISPAD guidelines were rated B. In all fields, “clarity of presentation” and “scope and purpose” scored well，but the scores of “rigor of development” and “applicability” were relatively low. The drug recommendations in each guideline were basically consistency. Conclusion The quality of inclusion guidelines is relatively high. There is still a lack of evidence-based clinical guidelines for children with diabetes in China. It is suggested that evidence-based methods should be adopted to formulate evidence-based guidelines in line with China′s national conditions so as to provide a basis for the treatment of diabetic children in China.
2019 Vol. 16 (27): 65-68 [Abstract] ( 192 ) HTML (1 KB)  PDF (526 KB)  ( 60 )
69 Occurrence of hypoglycemia in insulin-injecting diabetic patients with persistent vegetative state
LI Guoying1 CHENG Qianpeng2 ZHANG Hui1 LI Huili1
Objective To investigate occurrence and causes of hypoglycemia in insulin-injecting diabetic patients with persistent vegetative state. Methods A total of 40 patients with diabetes mellitus complicated with persistent vegetative state insulin intradermal injection to control blood sugar were selected from February 2017 to March 2018 in Three Departments of Cadre Ward, the Seventh Medical Center in PLA General Hospital. Blood sugar was monitored. According to occurrence of hypoglycemia, the patients were divided into hypoglycemia group (18 cases) and non-hypoglycemia group (22 cases). According to the frequency of hypoglycemia, hypoglycemia patients were divided into multiple-occurrence group (8 cases) and low-occurrence group (10 cases). The incidence and causes of hypoglycemia were counted. Gender, age, course of diabetes, systolic blood pressure, diastolic blood pressure, glycosylated hemoglobin, triglyceride and low density lipoprotein cholesterol were compared among groups. Results There were 18 cases of hypoglycemia (45.00%), 83 times of hypoglycemia, 49 times of postprandial hypoglycemia (59.04%) and 34 times of night hypoglycemia (40.96%). The main cause of postprandial hypoglycemia was nasal feeding reflux. The main causes of night hypoglycemia were hypoglycemia before bed and insulin dosage forms. The course of diabetes mellitus in low-occurrence group was shorter than that in multiple-occurrence group, and the level of glycosylated hemoglobin was higher than that in multiple-occurrence group (P < 0.05). Conclusion Insulin-injecting diabetic patients with persistent vegetative state are more likely to suffer from hypoglycemia with longer course of disease and stricter blood sugar control. Clinical attention should be paid to nasal feeding reflux and insulin dosage form.
2019 Vol. 16 (27): 69-72 [Abstract] ( 163 ) HTML (1 KB)  PDF (442 KB)  ( 47 )
73 Retrospective analysis of clinicopathological features of IgA nephropathy with dyslipidemia
HOU Haizhu1 LUO Jing2 GUO Hui1
Objective To explore the differences in clinicopathological features of IgA nephropathy with different dyslipidemia. Methods The clinicopathological data of 173 patients diagnosed as IgA nephropathy at the Second Hospital of Shanxi Medical University from August 2015 to August 2018 was collected. Patients with dyslipidemia were divided into hypercholesterolemia group, hypertriglyceridemia group, low high-density lipoproteinemia group and mixed hyperlipidemia group, while patients with normal blood lipids were used as a control group. The differences in clinicopathological parameters among five groups were compared, and a multiple stepwise regression model was established to investigate the estimated glomerular filtration rate (eGFR). Results The 24-hour urine protein level in the hypercholesterolemia group was higher than that in the control group, while serum albumin (Alb) was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). The proportion of males, age, body mass index (BMI), serum creatinine (Scr), uric acid (UA), and Oxford classification (T rating) in the hypertriglyceridemia group were higher than those in the control group, while eGFR was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). The proportion of males, BMI, Scr, UA and hemoglobin (Hb) in the low high-density lipoproteinemia group were higher than those in the control group, while the eGFR was lower than that in the control group, and the differences were statistically significant (P ＜ 0.05). BMI, 24 h urine protein quantitation and Hb in the mixed hyperlipidemia group were higher than those in the control group, while eGFR and Alb were lower than those in the control group, and the differences were statistically significant (P ＜ 0.05). The regression equation showed that gender, Hb and eGFR were positively correlated; age, UA, and Oxford classification were negatively correlated with eGFR. Conclusion The degree of clinical pathological damage in patients with IgA nephropathy with different dyslipidemia types is not completely the same, and hypertriglyceridemia might be a risk factor for renal interstitial fibrosis in IgA nephropathy.
2019 Vol. 16 (27): 73-76,80 [Abstract] ( 182 ) HTML (1 KB)  PDF (448 KB)  ( 193 )
77 Expression of PD-L1 in tumor cells and tumor-associated immune cells of bladder cancer and its clinical significance
LI Yanze WANG Lei CHEN Zhiyuan LIU Xiuheng
Objective To detect expressions of programmed cell death ligand 1 (PD-L1) in tumor cells (TC) and tumor-infiltrating immune cells (IC) of bladder cancer and investigate its clinical significance. Methods The paraffin-embedded specimens of 87 patients with bladder cancer undergoing surgery in Renmin Hospital of Wuhan University from January 2018 to December were collected. The expressions of PD-L1 in TC and IC were detected by immunohistochemical SP263 staining. Results The positive rate of PD-L1 expression in bladder cancer IC was higher than that in TC, and the difference was highly statistically significant (P ＜ 0.01), while there was a positive correlation between them (P ＜ 0.01). The positive expressions of PD-L1 in TC of bladder cancer were related to age, gender and pathological grade, and the differences were statistically significant (P ＜ 0.05). While the positive expressions in IC were associated with age, pathological grade, myometrial invasion, and the differences were statistically significant (P ＜ 0.05). Conclusion The abnormal up-regulation of PD-L1 expression in TC and IC of bladder cancer tissues may be closely related to the occurrence and development of bladder cancer.
2019 Vol. 16 (27): 77-80 [Abstract] ( 216 ) HTML (1 KB)  PDF (429 KB)  ( 52 )
81 Analysis of the clinical diagnosis and treatment of humeral supracondylar fracture with brachial artery injury in children
LIU Peng1 ZHU Shu2 LIU Lie1 XIAO Wenjie1 SONG Ningya1 GONG Wei1
Objective To explore the clinical experience of diagnosis and treatment of Gartland Ⅲ on the humerus condyle fracture merge brachial artery injuries in children. Methods From August 2016 to August 2018, 52 cases of Gartland type Ⅲ humerus condyle fracture merge brachial artery injury of children admitted in Baoji Central Hospital in Shaanxi Province were selected. These included 40 children with closed fractures and 12 children with open fractures. The former adopted the method of lateral approach of elbow, the fracture was fixed first, then local hot compress was done, and finally local injection of Papaverine. The latter first debridement, then upper and lower extension of the wound, the broken end of brachial artery was freed, anastomosis, and then fracture reduction and fixation were carried out. Finally with 2-3 kirschner wire cross fixation. The treatment effects of children of the two groups were compared, and Logistic regression analysis was used to analyze the factors affecting the recovery of the children. Results All the 52 cases of fracture healed well, and the recovery rate of elbow joint motion function was 100%. No related complications occurred in the two groups. Logistic multivariate regression analysis showed that the factors affecting the postoperative functional recovery of children with humeral supracondylar fracture included injury to operation time＞ 48 h, postoperative functional exercise time delay and low compliance with medical advice after discharge (P ＜ 0.05). Conclusion The main factors affecting the postoperative functional recovery of children with supracondylar fracture of humerus included injury to operation time, postoperative functional exercise time and discharge compliance. Patients with suspected vascular injury should be carefully continuous dynamic observated, early surgical treatment should be adopt once diagnosed.
2019 Vol. 16 (27): 81-84 [Abstract] ( 168 ) HTML (1 KB)  PDF (504 KB)  ( 39 )
85 Effect of Imrecoxib combined with arthroscopic debridement in the treatment of knee osteoarthritis
WANG Jingliang XU Xiaofeng ZHANG Jiaguo
Objective To investigate the effect of Imrecoxib combined with arthroscopic debridement in the treatment of knee osteoarthritis (KOA). Methods From March 2016 to April 2018, 102 patients with KOA admitted to Dalian Second People′s Hospital of were selected as subjects. According to the random number table method, the patients were divided into the control group (arthroscopic debridement + postoperative placebo treatment, n = 51) and the observation group (arthroscopic debridement + postoperative Imrecoxib treatment, n = 51), with a course of 2 months. The clinical curative effect, joint pain visual simwlation score (VAS) and function Lysholm scors, serum interleukin 1 (IL-1), IL-1β (IL-1β) and tumor necrosis factor -α (TNF-α) levels, joint fluid in the metal matrix protease-2 (MMP-2), matrix metalloproteinases inhibitor protease 1 (TIMP-1) and metal matrix-13 (MMP-13) level changes and the incidence of adverse reactions during treatment of the two groups were compared. Results The total effective rate in the observation group was higher than that in the control group (P ＜ 0.05). VAS scores in both groups were lower after treatment than before treatment, and VAS scores in the observation group were lower than those in the control group (P ＜ 0.05). Lysholm scores in both groups were increased after treatment, and the observation group was higher than the control group (P ＜ 0.05). After treatment, IL-1 and TNF-α in both groups were lower than that before treatment, and those in the observation group were lower than those in the control group (P ＜ 0.05). After treatment, IL-1β in both groups was higher than that before treatment, and that in the observation group was higher than that in the control group (P ＜ 0.05). After treatment, MMP-2, TIMP-1 and MMP-13 in both groups were lower than that before treatment, while those in the observation group were lower than those in the control group (P ＜ 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P ＞ 0.05). Conclusion Imrecoxib combined with arthroscopic debridement is effective in the treatment of KOA, which can reduce pain, improve knee function, lower exudation of inflammatory mediators and the levels of MMP-2 and MMP-13 in articular fluid.
2019 Vol. 16 (27): 85-88 [Abstract] ( 197 ) HTML (1 KB)  PDF (441 KB)  ( 112 )
89 Effect comparison of three methods for measuring the depth of gastric tube placement in neonates fed by oral
WEI Xiuzhen WANG Chaoyun TANG Xiaoyan HU Xilan CHEN Li′na LIU Yanni
Objective To explore the effects of three methods for measuring the depth of gastric tube placement in neonates fed by oral. Methods From June 2017 to June 2018, 180 neonates who received oral feeding in the People′s Hospital of Guangxi Zhuang Autonomous Region were selected. They were divided into three groups according to random number table method, 60 cases in each group. After enrollment, children of the three groups were given the routine physical examination, and sex, age, weight, body length and other general information were recorded. Neonates of the three groups were placed the tube through the mouth. After successful placement, different methods were used to measure the length of stomach tube placement, the distance from median forehead to xiphoid process was measured in Group A; the distance from earlobe to nasal tip + nasal tip to xiphoid process was measured in Group B; the distance from eyebrow (nasal root) to the navel was measured in Group C. The differences between the depth of gastric tube placement and the imaging value were compared among three groups, and the one-time success rate of gastric juice withdrawal after catheterization and the incidence of related feeding complications were counted. Results There were statistically significant differences in the depth of gastric tube placement among the three groups (P < 0.05). The one-time success rate of gastric juice withdrawal of Group C was significantly higher than Group A and B, and the one-time success rate of gastric juice withdrawal of Group B was significantly higher than that of Group A, the differences were highly statistically significant (P < 0.01). The incidence of related feeding complications in Group C was significantly lower than that in Group A and Group B. The incidence of feeding complications in Group B was significantly lower than that in Group A, the differences were statistically significant (P < 0.05). Conclusion The distance between the eyebrows (nose root) and the navel is closer to the physiological and anatomical value of the newborn, and this method can increase the success rate of gastric juice withdrawal after catheterization and reduce the incidence of related feeding complications.
2019 Vol. 16 (27): 89-92 [Abstract] ( 199 ) HTML (1 KB)  PDF (608 KB)  ( 63 )
93 Clinical application of new radial artery puncture technique in infants
HAO Shuai1 HE Haili1 LI Ying2 QUAN Zhefeng1▲
Objective To observe the clinical effect of ultrasound-guided double-line isolation and localization technique in infant radial artery puncture. Methods A total of 40 infants who were treated with radial artery puncture were chosen from March 2017 to December 2018 in Beijing Friendship Hospital, Capital Medical University. The patients were divided into control group and observation group through random number table, with 20 cases in each group. The control group was treated with conventional ultrasound-guided radial artery puncture technique, while the observation group received ultrasound double-line isolation positioning technique for radial artery puncture. The primary observation goal was to compare the success rate of the first attempt, and the secondary observation goal was the failure rate of puncture, the time of ultrasound localization, and the incidence of complications. Results The success rate of first intubation in the observation group was 85%, which was significantly higher than that in the control group (55%), the difference was statistically significant (P < 0.05). The ultrasound localization time in the observation group was significantly shorter than that in the control group, the difference was statistically significant (P < 0.05). The incidences of venipuncture failure and bleeding in the observation group were lower than that in the control group, the differences were statistically significant (P < 0.05). Conclusion Ultrasound-guided double-line isolation and localization technique is not only helpful in shortening the ultrasound localization, but also in improving the success rate of the first puncture of radial artery in infants under ultrasound guidance.
2019 Vol. 16 (27): 93-96 [Abstract] ( 218 ) HTML (1 KB)  PDF (664 KB)  ( 146 )
97 Clinical effect of Clostridium Butyricum Powder combined with human immunoglobulin in the treatment of children with severe hand，foot and mouth disease
YUE Jia1 LIANG Xue2 LIU Jingwei2 PIAO Jinhua3
Objective To investigate the clinical effect of Clostridium Butyricum Powder combined with human immunoglobulin in the treatment of children with severe hand, foot and mouth disease (HFMD). Methods A total of 123 children with severe HFMD admitted to the First Hospital of Jilin University from November 2014 to November 2018 were selected, they were divided into control group (n = 61) and research group (n = 62) according to the random number table method. Children in the control group were treated with human immunoglobulin, while children in the research group were treated with Clostridium Butyricum Powder combined with human immunoglobulin. The clinical efficacy, immune function and intestinal barrier of the two groups were compared. The adverse reactions of children in the two groups during the treatment were recorded. Results The total effective rate of the study group was higher than the control group after 5 days of treatment (P < 0.05). Immunoglobulin (Ig) A and IgG in the study group were higher than those in the control group (P < 0.05), and IgM was lower than that in the control group (P < 0.05). After 5 days of treatment, diamine oxidase, D-lactic acid and endotoxin in the two groups were lower than before treatment, and those in the study group were lower than the control group (P < 0.05). There was no statistically difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Clostridium Butyricum Powder combined with human immunoglobulin is effective in the treatment of severe HFMD children. It can effectively improve the immune function and intestinal barrier function of children, it has certain clinical application value.
2019 Vol. 16 (27): 97-100 [Abstract] ( 253 ) HTML (1 KB)  PDF (571 KB)  ( 98 )
101 Effect of unprotected perineum combined with painless delivery on the outcome and pelvic floor function of primipara
LI Wen1 WANG Jie1 QIN Yang2 WEI Wei1
Objective To study the effect of unprotected perineum combined with painless delivery on delivery outcome and pelvic floor function of primipara. Methods From January 2018 to August,100 primipara who delivered in Suzhou Jiulong Hospital Affiliated to Shanghai Jiao Tong University School of Medicine were selected as observation objects. They were divided into the combined group and the control group by random number table method, 50 cases in each group. The control group adopted unprotected perineal delivery, while the combined group adopted unprotected perineal delivery combined with painless delivery. The delivery outcome, pelvic floor function, perineal injury and complications were compared between the two groups. Results The duration of the second stage of labor, the amount of bleeding within 2 h after delivery and the length of hospitalization in combined group were lower than those in control group (all P < 0.05). The proportion of puerpera with POP-Q score of 0 degree in combined group was higher than that in control group, and the proportion of puerpera with 2 degree was lower than that in the control group, the proportion of puerpera with more than 3 degree was higher than that of the control group (all P < 0.05). The degree of perineal injury in the combined group was significantly lower than that in the control group (P < 0.05). The incidence of postpartum complications in the combined group was lower than that in the control group(P < 0.05). Conclusion Unprotected perineum combined with painless delivery can significantly improve the outcome of delivery of primipara, promote the recovery of pelvic floor function, effectively reduce the degree of perineal laceration, and reduce the risk of complications. It is worthy of clinical application.
2019 Vol. 16 (27): 101-104 [Abstract] ( 179 ) HTML (1 KB)  PDF (568 KB)  ( 86 )
105 Expert suggestions on standardized medication guidance for neonatal jaundice
Expert Recommendation Group for Standardized Medication Guidance of Neonatal Jaundice
Neonatal jaundice is a common jaundice disease in the neonatal period, which is divided into physiological jaundice and pathological jaundice. There is stained yellow skin, mucosa and sclera due to the bilirubin accumulation. What is worse, a part of severe cases may result in bilirubin encephalopathy, permanent neurological damage and disability, or even death, even though most prognosis of neonatal jaundice is well. The treatment of neonatal jaundice includes phototherapy, exchange transfusion and drugs, in order to standardize and guide the use of drugs in primary medical units, this paper makes an expatiation on programmed drugs administration based on principles of treatment, drug application, special therapy, etc.
2019 Vol. 16 (27): 105-110 [Abstract] ( 261 ) HTML (1 KB)  PDF (1001 KB)  ( 159 )
111 Changes of serum levels of visfatin and PGE2 in patients with periodontitis and their clinical significance
ZHANG Peng′en CHEN Hong HE Jing
Objective To investigate the changes of serum levels of visfatin and prostaglandins E2 (PGE2) in patients with periodontitis and the clinical significance of diagnosis and treatment in patients with periodontitis. Methods From January 2013 to December 2017, 80 patients with periodontitis treated in Beihai People′s Hospital of Guangxi Zhuang Autonomous Region (hereinafter referred to as "our hospital") were selected as the periodontitis group. According to the diagnostic criteria of periodontitis, the patients were divided into the active periodontitis group (n = 42) and the inactive periodontitis group (n = 38). Another 50 healthy volunteers who underwent physical examination in our hospital at the same time were selected as the control group. Levels of visfatin, PGE2, interleukin-6 (IL-6), tumer necrosis facfor-α （TNF-α）, and C-reactive protein (CRP) were measured and compared among each group. Pearson test was used to analyze the correlation between visfatin, PGE2, IL-6, TNF-α and CRP levels. Results Serum levels of visfatin, PGE2, IL-6, TNF-α and CRP in the periodontitis group were all higher than those in the control group, with statistically significant differences (P ＜ 0.05). Serum levels of visfatin, PGE2, IL-6, TNF-α and CRP in the active periodontitis group were all higher than those in the inactive group, with statistically significant differences (P ＜ 0.05). By Pearson correlation test, the serum levels of visfatin and PGE2 in patients with periodontitis were positively correlated with the levels of inflammatory factors IL-6, TNF-α and CRP (P ＜ 0.05). Conclusion Serum levels of visfatin and PGE2 in patients with periodontitis are significantly increased, which may be involved in the occurrence and progression of periodontitis, and may be of important reference significance for the diagnosis and evaluation of periodontitis.
2019 Vol. 16 (27): 111-113,125 [Abstract] ( 242 ) HTML (1 KB)  PDF (695 KB)  ( 70 )
114 Clinical effect of tonsil-pecking method on snoring sleep in children
ZHANG Fengying1 YANG Zhimin1 WANG Shimin2 GE Hongzhou3 NIU Jinming1
Objective To explore the clinical effect of tonsil-pecking method on children snoring sleep. Methods From June 2016 to November 2017, 93 children admitted to Otolaryngology Department of Weifang Hospital of Traditional Chinese Medicine in Shandong Province were selected and divided into treatment group (47 cases) and control group (46 cases) by random number table methold. The treatment group was given tonsil-pecking method treatment, the control group was given Azithromycin treatment, 5 d for a course of treatment. The scores of symptoms and positive signs,  size of tonsil and adenoid in the two groups were observed. Results After treatment, the total effective rate in the treatment group was higher than that in the control group, with statistically significant difference (P ＜ 0.05). The improvement of tonsil enlargement and adenoid hypertrophy in the treatment group was better than that in the control group (P ＜ 0.05). Conclusion Tonsil-pecking method can significantly reduce the volume of tonsillar and adenoid, improve the therapeutic effect of snoring sleep in children.
2019 Vol. 16 (27): 114-117 [Abstract] ( 245 ) HTML (1 KB)  PDF (446 KB)  ( 148 )
118 Clinical effect of Alprostadil on ARDS patients with septic shock
WANG Zhi LIU Ye TENG Le MENG Xing
Objective To investigate the clinical effect of Alprostadil on septic shock with acute respiratory distress syndrome (ARDS). Methods From February 2015 to November 2018, 81 cases of ARDS with infectious shock in PLA 964th Hospital were selected, patients were randomly divided into control group (n = 40) and study group (n = 41) by random numerber table method. The control group was given conventional treatment, and the study group was treated with Alprostadil on the basis of the control group. Clinical indicators, respiratory function indicators and inflammatory factor indicators of the two groups were compared, and adverse reactions in the two groups during treatment were recorded. Results Mechanical ventilation duration, length of stay in ICU and total length of stay in the study group were shorter than those in the control group (P ＜ 0.05). However, there was no statistically significant difference in mortality between the two groups (P ＞ 0.05). OI and PaO2 showed a trend of increase and RR showed a trend of decrease after 2 and 3 days of treatment (P ＜ 0.05). RR in the study group was lower than that in the control group after treatment for 2 and 3 d, while PaO2 and OI were higher than that in the control group (P ＜ 0.05). The levels of interleukin-6, procalcitonin, C-reactive protein and tumor necrosis factor-α in both groups decreased after 3 d of treatment, and the levels in the study group were lower than those in the control group (P ＜ 0.05). The difference in adverse reactions between the two groups was no statistically significant (P ＞ 0.05). Conclusion Alprostadil can effectively improve mechanical ventilation time, length of ICU stay, and total length of stay in ARDS patients with septic shock without increasing the incidence of adverse reactions, which may be related to the improvement of respiratory function and inflammatory response.
2019 Vol. 16 (27): 118-121 [Abstract] ( 160 ) HTML (1 KB)  PDF (597 KB)  ( 44 )
122 Effect of Levetiracetam on epilepsy in children and its effect on cognitive function
XING Hongyu1 LIU Pisong2 YANG Yihai3 HAN Hong4
Objective To investigate the efficacy and safety of Levetiracetam in the treatment of epilepsy in children and its effect on cognitive function. Methods From February 2018 to January 2019, 96 pediatric epilepsy patients admitted to the Outpatient Department of Pediatrics and Neurology of Shanxi Children′s Hospital were selected as the study objects. According to the random number table method, the patients were divided into the observation group and the control group, each group with 48 cases. The observation group was given Levethracetam Tablets orally alone, the control group was given Oxazepine in combination on this basis. Both groups were treated for 16 weeks. Clinical efficacy, improvement of EEG before and after treatment, and occurrence of adverse reactions during treatment were compared between the two groups, and cognitive function of the children were evaluated. Results After 16 weeks of intervention, there was no statistically significant difference in clinical efficacy and EEG efficacy between two groups (P ＞ 0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P ＜ 0.05). Operational intelligence quotient (PIQ), verbal intelligence quotient (VIQ), and full intelligence quotient (FIQ) scores of the two groups were all increased after treatment (all P ＜ 0.05). After treatment, FIQ score of the observation group was lower that of the control group (P ＜ 0.05). There was no significant difference in PIQ and VIQ between the two groups after treatment (P ＞ 0.05). Conclusion The treatment effect of Levetiracetam alone in children with epilepsy is equivalent to that of Ocasepine, which can effectively improve the clinical symptoms, enhance the cognitive function of children, reduce the incidence of adverse reactions, and is relatively safe.
2019 Vol. 16 (27): 122-125 [Abstract] ( 228 ) HTML (1 KB)  PDF (629 KB)  ( 256 )
126 Exploring the formula design of traditional Chinese medicine cosmetics based on association rules and entity grammar system
JIA Congmin GUO Hongling CAO Tingting LEI Qiaoling ZHANG Xianbao WANG Yun
Objective To design a safe, reasonable and effective Chinese medicine cosmetics formula containing chinese herbal medicine chemical composition based on association rules and entity grammar system. Methods Data of cosmetic formulations containing Chinese herbal medicine chemical composition from 2014 to 2015 were collected, while association rules were used to discover the formulation rules of various cosmetic products. Based on the discovered rules and the inherent formula structure of cosmetics, a new formula design model of cosmetics was established by combining entity grammar system. Results According to the model, a new formula which accords with the structure and efficacy of acne-removing and whitening lotion formula was designed. The new formula had been screened, quantified, proofed and validated, while good results had been achieved in acne patients after use. Conclusion It is feasible to use association rules and entity grammar system to design formula of acne-eliminating and whitening cosmetics, which provides a reference for the formulation design of other traditional Chinese medicine cosmetics and helps to expand the application of traditional Chinese medicine in cosmetology and skin care.
2019 Vol. 16 (27): 126-129 [Abstract] ( 173 ) HTML (1 KB)  PDF (904 KB)  ( 100 )
130 Systematic evaluation on the effect of moxibustion in the treatment of frequent micturition symptoms in middle-aged and elderly patients
LI Manman1 FENG Feng2▲ GAO Cheng′e3 YANG Mingxia1 CHEN Hui1 SONG Zeru1
Objective To systematically evaluate the efficacy and safety of moxibustion in the treatment of senile frequent micturition symptoms using evidence-based medical method, and to provide evidence-based basis for the care and treatment of frequent micturition in middle-aged and elderly patients. Methods The literatures on moxibustion treatment of frequent micturition in databases PubMed, Embase, Cochrane Library, Medline, ScienceDirect and China Biomedical Literature Database, China Knowledge Network, Wanfang Database, Weipu Database for evaluation were searched by computers. The search was conducted until March 1, 2019, and the research type included in the paper was a randomized controlled trial. The observation indicators included urination times, quality of life, urinary tract symptoms, corresponding tradition Chinese medicine symptoms, or curative effect analysis. Descriptive analysis was used for the intervention methods, acupoint selection and observation indications of the study. Results Seven trials were included, containing 494 participants. The results showed that moxibustion could significantly improve urinary tract symptoms in middle-aged and elderly patients, while reduce urination frequency. Conclusion Moxibustion in the treatment of middle-aged and elderly patients with the symptom of frequent micturition is effective, with less adverse reactions. However, it need sufficient quality and large sample information to further verify.
2019 Vol. 16 (27): 130-133 [Abstract] ( 201 ) HTML (1 KB)  PDF (978 KB)  ( 50 )
134 Effect of Tiaodu Xifeng acupuncture on non-dipper hypertension patients with syndrome of upper hyperactivity of liver yang
LIANG Yan1 BAO Xiaohua2 LI Chenmei3 GAO Hui1 WANG Yanjun4 LI Jia5 LIU Tianli5
Objective To study the effect of Tiaodu Xifeng acupuncture in non-dipper hypertension patients with syndrome of upper hyperactivity of liver yang. Methods Sixty-nine patients met the inclusion criteria from October 2017 to October 2018 in the Three Cardiology Department of Shijiazhuang Hospital of Traditional Chinese Medicine were selected. A total of 60 patients completed the clinical study and they were divided into treatment group and control group by using stratified random method, with 30 cases in each group. The control group was given Levamlodipine Maleate Tablets, the treatment group was given Levamlodipine Maleate Tablets combined with Tiaodu Xifeng acupuncture, all the patients were treated for 4 weeks. Blood samples were taken from the two groups before and after treatment to measure the levels of nitric oxide (NO) and endothelin (ET), and the changes in blood pressure and blood pressure drop rate before and after treatment were recorded. Results Compared with before treatment, the decrease rate of nocturnal systolic blood pressure in the two groups was significantly increased (P ＜ 0.05). Compared with the control group, the decrease rate of nocturnal systolic blood pressure in the treatment group was significantly increased (P ＜ 0.05). The rate of non-dipperhypertension changing to dipper hypertension in the treatment group was 56.7% (17/30), which was higher than the control group [26.7% (8/30)], the difference was statistically significant (P ＜ 0.05). Compared with before treatment, the content of ET in both groups decreased, the content of NO increased, and the differences were statistically significant (P ＜ 0.05). Compared with the control group, the content of NO in the treatment group was significantly increased and the content of ET was significantly decreased (P ＜ 0.05). Conclusion Tiaodu Xifeng acupuncture can adjust the circadian rhythm of blood pressure and improve the damaged vascular endothelial function in patients with hypertension.
2019 Vol. 16 (27): 134-137,142 [Abstract] ( 183 ) HTML (1 KB)  PDF (843 KB)  ( 86 )
138 Si Tuyi′s experience of treating endometriosis dysmenorrhea with benefiting qi and mass-eliminating method  
XU Mingtao1 ZHENG Weilin2 LIANG Xuefang1
Endometriosis is a common gynecological disease. Dysmenorrhea is a typical symptom of endometriosis, and it is aggravated year by year with the increase of local lesions. Professor Si Tuyi believes that endometriosis dysmenorrhea is mostly a mixture of intermingled deficiency and excess syndrome. The main pathogenesis of endogenous dysplasia is “blood stasis” and “qi deficiency”, qi deficiency is the basis and blood stasis is the external. Professor Si Tuyi advocates benefiting qi, removing blood stasis and mass-eliminating as the major treatment for endometriosis dysmenorrhea, eliminating and supplementing, with the regulation of menstrual cycle, benefiting qi root-securing, regulating qi and blood, expelling blood stasis and mass-eliminating, determination of etiologic factors based on differentiation, suiting measures to individual conditions. Professor Si Tuyi has rich experience in the diagnosis and treatment of endometriosis dysmenorrhea, and its curative effect is remarkable. It is worthy of inheritance and promotion.
2019 Vol. 16 (27): 138-142 [Abstract] ( 269 ) HTML (1 KB)  PDF (802 KB)  ( 174 )
143 A comparative study of treatment of traditional Chinese medicine and Dai medicine on apoplectic hemiplegia sequelae
LIU Yucheng1 WEI Wei2 YI Nashuang2 WANG Deheng1
This article reviews and summarizes the treatment of apoplectic hemiplegia sequelae (Long Dai Fen Geng Heng) from the aspects of etiology and pathogenesis, external treatment, internal treatment, clinical research of Dai and etiology and pathogenesis, oral prescriptions, acupuncture, massage, fumigation, acupoints sticking, nursing of traditional Chinese medicine, and so on. This article further compares the similarities and differences and their respective characteristics between traditional Chinese medicine and Dai medicine in treating apoplectic hemiplegia sequelae. The results show that traditional Chinese medicine and Dai medicine have different treatments in apoplectic hemiplegia sequelae, but their basic theories have something in common. Therefore, this paper hopes to promote the perfect combination of the traditional Chinese medicine and Dai medicine through excavating the advantages of them and provide new ideas and methods for the treatments of apoplexy.
2019 Vol. 16 (27): 143-146,163 [Abstract] ( 214 ) HTML (1 KB)  PDF (1126 KB)  ( 141 )
147 Discussion on the medicinal value of water in many ancient herbal books
XU Jia1 CHENG Wei2
As one of the common substances in nature, water can be roughly divided into natural water and artificial water. The water recorded in many ancient books of materia medica is mostly natural water. Later, due to changes in the social age, improved medical standards and rich experience in life, some processed water or liquids, namely artificial water, have been added. From the “Ming Yi Bie Lu” earliest records, of only two kinds of water medicinal, after continuous development and supplement, the medical records of water experienced three stages: preliminary cognition, gradual attention, and reflective innovation. There are 43 records of the medicinal use of water in Li Shizhen′s “Compendium of Materia Medica” which is the peak work of ancient herb books, and water has begun to apply to clinical. The article takes the natural water and artificial water liquid recorded in the ancient herbal books of the original as the research object. We can learn from the past only by scientific understanding of the medicinal use of water, taking its essence and abandon the dross, analysis the therapeutic value, health value and auxiliary value dialectically. In order to select essence to assist the developing of modern Chinese medicine. In the process of inheritance and innovation of traditional Chinese medicine, in order to promote the development of modern Chinese medicine.
2019 Vol. 16 (27): 147-150 [Abstract] ( 193 ) HTML (1 KB)  PDF (778 KB)  ( 60 )
151 Introduction on clinical experience of professor Liu Xiaohong in the treatment of chronic obstructive pulmonary disease
HUANG Aisi1 ZHAN Shaofeng2 ZHANG Tiange1 HONG Haidu1 ZHENG Wenjiang1 ZHUANG Hongfa3 LIU Xiaohong1
This paper introduces professor Liu Xiaohong′s clinical experience in treating chronic obstructive pulmonary disease by differentiation of symptoms and signs. Professor Liu combines the principles and methods of traditional Chinese medicine with the actual situation in Lingnan area in the clinical to embody the thought of "the theory of the three categories of etiologic factors" in traditional Chinese medicine, stressing that deficiency of lung and spleen is the main pathogenesis of chronic obstructive pulmonary disease, and deficiency of Qi and phlegm is the key factor in the formation and development of chronic obstructive pulmonary disease, and promoting simultaneous treatment of lung and spleen in clinic, and herbs with Lingnan characteristics are chosen according to the actual situation.
2019 Vol. 16 (27): 151-154 [Abstract] ( 224 ) HTML (1 KB)  PDF (776 KB)  ( 111 )
155 Clinical effect of Fu′s subcutaneous needling in the treatment functional constipation
TAN Yi1,2 YUAN Longjian2,3 FU Zhonghua2,4
Objective To observe the clinical effect of Fu′s subcutaneous needling in the treatment of functional constipation. Methods Sixty patients with functional constipation admitted to Outpatient Department of Digestive Medicine and Outpatient Department of Acupuncture and Moxibustion of Guangdong Chinese Medicine Hospital from June 2016 to May 2018 were selected. The patients were randomly divided into treatment group and control group with 30 cases in each group by sealed envelope method. Treatment group was treated with Fu′s subcutaneous needling, while control group was treated with routine acupuncture. The efficacy, adverse reactions and patient-assessment of constipation quality of life (PAC-QOL) scores of constipation patients before and after treatment were compared between two groups. Results There was no statistically significant difference in total effective rate between two groups (P > 0.05). After treatment, total score of PAC-QOL, scores of physical discomfort, social psychological discomfort, anxiety and satisfaction of two groups were lower than those before treatment, and the differences were statistically significant (P < 0.05). Total score of PAC-QOL, scores of physical discomfort and anxiety in treatment group were lower than those in control group, and the differences were statistically significant (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between two groups (P > 0.05). Conclusion Fu′s subcutaneous needling can improve the clinical symptoms and quality of life of patients with functional constipation, and it is worthy of clinical application.
2019 Vol. 16 (27): 155-158 [Abstract] ( 221 ) HTML (1 KB)  PDF (815 KB)  ( 56 )
159 Clinical effect of needle-knife combined with heat-sensitive moxibustion on waist and back muscle fasciitis
WEI Ye1 GE Hengqing1 LI Kaiping2 WANG Yanping1
Objective To observe the clinical effect of needle-knife combined with heat-sensitive moxibustion on waist and back muscle fasciitis. Methods Forty patients diagnosed as waist and back muscle fasciitis admitted to outpatient Department of Jiangsu Province Hospital on Integration of Chinese and Western Medicine from January to December 2018 were divided into the observation group and the control group by random number table method, with 20 patients in each group. The observation group received needle-knife loosening of waist and back fascia and heat-sensitive moxibustion, while the control group received heat-sensitive moxibustion only. Once a week, both groups were treated for 4 weeks. Before and after treatment, pain scale index (PRI), visual analogue scale (VAS) score, current pain intensity (PPI) score, lesion tissue development area under magnetic resonance imaging and the number of heat sensitive points were observed. Results After treatment, the PRI, VAS score and PPI score of the two groups were significantly lower than those before treatment (all P ＜ 0.01), and PRI, VAS score and PPI score of the observation group were significantly lower than those of the control group after treatment, the differences were highly statistically significant (all P ＜ 0.01). The number of heat sensitive points in the two groups after treatment was significantly reduced (all P ＜ 0.01), and the number of heat sensitive points in the observation group after treatment was significantly less than that in the control group, the difference was highly statistically significant (P ＜ 0.01). The lesion tissue development area under magnetic resonance imaging of the two groups decreased significantly after treatment (all P ＜ 0.01), and the lesion tissue development area in the observation group was significantly smaller than that in the control group after treatment, the difference was highly statistically significant (P ＜ 0.01). The total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). Conclusion The clinical effect of needle-knife combined with heat-sensitive moxibustion in treating waist and back muscle fasciitis is better than heat-sensitive moxibustion only, which has the value of clinical promotion.
2019 Vol. 16 (27): 159-163 [Abstract] ( 162 ) HTML (1 KB)  PDF (466 KB)  ( 119 )
164 Clinical effect of Guxi needle-knife therapy combined with cupping in the treatment of waist and back muscle fasciitis
SU Jian LIU Bin CHEN Shizhong
Objective To observe the clinical effect of Guxi needle-knife combined with cupping in the treatment of waist and back muscle fasciitis. Methods Eighty-two patients with waist and back muscle fasciitis admitted to Department of Spine, Zhongshan Hospital Affiliated to Guangzhou University of Chinese Medicine from October 2013 to March 2014 were divided into the treatment group (41 cases) and the control group [39 cases (fall off in 2 cases)] by random number table method. The treatment group was treated with Guxi needle-knife therapy combined with cupping. The control group was treated with local blockade injection and small needle-knife therapy. The average number of treatment and clinical effect between the two groups were compared, and visual analogue scale (VAS) score and Oswestry disability index (ODI) were recorded before and one month after treatment. Results The average number of treatment in the treatment group was less than that in the control group (P ＜ 0.05); VAS score and ODI in the two groups had no statistically significant differences before treatment (P ＞ 0.05), and VAS score and ODI in the two groups after treatment were lower than those before treatment (P ＜ 0.05), but VAS score and ODI in the two groups after treatment had no statistically significant differences (P ＞ 0.05). There was no statistically significant difference in the total effective rate between the two groups (P > 0.05). Conclusion Both therapies can alleviate the pain and dysfunction of patients with waist and back muscle fasciitis, but compared with local blockade injection and small needle-knife therapy, Guxi needle-knife therapy combined with cupping can improve the symptoms of patients in fewer times of treatment, and achieve a good clinical effect.
2019 Vol. 16 (27): 164-166,172 [Abstract] ( 190 ) HTML (1 KB)  PDF (854 KB)  ( 168 )
167 Construction and database management of standardized data acquisition system for breast cancer screening in Jilin Province
YU Deli1 ZHENG Yonghuan2 YIN Chunxia3 JIANG Yujuan1 GAO Hongying4
Objective To explore the construction and significance of standardized data acquisition system and large data platform for breast cancer screening in Jilin Province. Methods From January 2016 to December 2018, the Information Collection Form of Breast Cancer Screening promulgated by the former National Health Planning Commission was compiled into the Standardized Data Collection System of Breast Cancer Screening in JAVA language. It was embedded in the portable color ultrasound diagnostic system of iustar 130, which can be directly connected to the internet. In the process of screening, the identification of the screened person and the collection of screening data (included image, numerical value, text description, etc.) was completed simultaneously. After special security processing, the collected data was transmitted to the cloud for storage, and the cloud data was retrieved and utilized with limited privileges by a variety of Internet terminal devices. The screening data of various cities and counties in the Jilin Province form the large data of breast cancer screening in the province after being aggregated by cloud server. Results From 2016 January to 2018 December, the detection rate of breast cancer and precancerous lesions in eight prefectures, cities and districts in Jilin Province was 80.24/100 000, and early breast cancer accounted for 63.89%. The standardized data acquisition system of breast cancer screening in Jilin Province realized the standardization of screening process, provided key quality control nodes for data acquisition, and made the standardized collection, transmission and storage of screening data complete at one time. It ensured the accuracy of data acquisition and improved the efficiency of data acquisition and use. Conclusion The Standardized Data Acquisition System of Breast Cancer Screening in Jilin Province is a practical, efficient and safe data acquisition, management and application system, as well as a basic tool for building a professional large data platform. Screening data are real and effective, which can provide data support for clinical research, public health planning, management and decision-making.
2019 Vol. 16 (27): 167-172 [Abstract] ( 186 ) HTML (1 KB)  PDF (945 KB)  ( 160 )
173 Based on the CNKI database medical record management professional research status of the literature map analysis
DAI Qingxia
Objective To analyze literature map analysis based on CNKI database medical record management professional research status. Methods From 2000 to 2018, relevant literatures on medical record management in China were retrieved through CNKI database. Literature map was analyzed from the dimension of publishing time and quantity, publishing organization, research method, researchers, research hotspot and publishing journal. Results A total of 408 valid literatures were retrieved, and the number of published literatures increased steadily, hospitals and schools alike; Qualitative research is the main research method, and more recent empirical research has been carried out; “Medical record management” “disease classification” and “talent training” have become the main research hotspots; “Chinese medical records” became the main journal. Conclusion The research on medical record management has attracted the attention of scholars, and it is urgent to strengthen the research on interdisciplinary, inter-institutional and frontier issues, and strengthen the construction of medical record management professional journals.
2019 Vol. 16 (27): 173-176,188 [Abstract] ( 165 ) HTML (1 KB)  PDF (1050 KB)  ( 91 )
177 Research on the supply of old-age education based on developmental pension needs
WANG Xianju SI Jianping
With the acceleration of the aging process and the escalation of the demand for old-age education, the development of old-age education is an inevitable requirement to cope with the aging of population and improve the supply system of old-age services. This paper on the basis of consulting the relevant literature, starting with the theory and reality of the demand for the development-oriented old-age care, and through the realistic evaluation of the supply of the old-age education, puts forward the practical innovation of the supplementary board of the old-age education, and enriches the content system of the old-age education，the aim is to continuously improve the effective supply of education for the aged and achieve the goal of learning for the aged.
2019 Vol. 16 (27): 177-180 [Abstract] ( 194 ) HTML (1 KB)  PDF (643 KB)  ( 70 )
181 Application of medical translation team model in training and selecting medical translation talents
GUO Zikai CHEN Chen
As globalization is increasingly deepening, medical translation activities have become more and more active. However, now in China, there are some false understandings and practices in the way of training and selecting medical translators/interpreters. This paper points that there should be no excessive pursuit of the combination of language skills and medical knowledge, and it is necessary to build a medical translation team including translators/interpreters, medical counselors and corpus technicians. The feasibility of the team is also analyzed from the perspective of corpus. In the model of the medical translation team, competent translators/interpreters are the core of competence, medical counselors are responsible for the preciseness of medical knowledge, and corpus producers accumulate corpus resources. With their close relations and cooperation, medical translation and interpretation tasks can be better delivered.
2019 Vol. 16 (27): 181-183 [Abstract] ( 193 ) HTML (1 KB)  PDF (584 KB)  ( 275 )
184 Relationship CT scan non-uniform density hematoma and clinical prognosis of patients with primary cerebral hemorrhage in basal ganglia between on plain
HE Min1 CHEN Houqin1 SHAO Lingyun1 ZUO Jian1 HAN Jiangquan2
Objective To explore the relationship between non-uniform density hematoma on plain CT scan and the clinical prognosis of patients with primary cerebral hemorrhage in basal ganglia. Methods From January 2014 to October 2018, a total of 146 patients with primary cerebral hemorrhage in basal ganglia and within 6 h admitted to Wuhu NO.1 People′s Hospital were selected. According to the modified Rankin Scale (mRS), they were divided into 77 patients of good clinical prognosis group (0-2 points) and 69 patients of poor prognosis group (3-6 points). One-way ANOVA and multivariate Logistic regression analysis were used to screen risk factors for poor clinical prognosis. Results The systolic blood pressure on admission, baseline of the national institutes of health stroke scale (NIHSS) scores, positive rate of non-uniform density hematoma, positive rate of hematoma mixed character, positive rate of hematoma black holes), rate of early neurologic deterioration, hematoma expansion rate, 3 weeks NIHSS score, mRS score in poor prognosis group were higher than those in good prognosis group, while the computed tomography (CT) for the first time and completion time is shorter than good prognosis group, baseline hematoma volume was larger than good prognosis group, the differences were statistically significant (all P ＜ 0.05). Positive rate of non-uniform density hematoma and systolic blood pressure at admission were influencing factors of hematoma enlargement, early deterioration of neurological function and poor prognosis at 6 months in patients with cerebral hemorrhage at basal ganglia (P ＜ 0.05). Conclusion CT non-uniform density hematoma (black hole sign or blend sign) is an risk factor for poor prognosis of spontaneous cerebral hemorrhage.
2019 Vol. 16 (27): 184-188 [Abstract] ( 185 ) HTML (1 KB)  PDF (721 KB)  ( 88 )
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