长链非编码RNA调控间充质干细胞成软骨分化的研究进展

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Abstract Repair of articular cartilage injury caused by osteoarthritis (OA) has always been a hotspot and difficult point in joint surgery. Mesenchymal stem cells have become the focus of cartilage repair and cell therapy in recent years. Long non-coding RNA (lncRNA) refers to a class of RNA whose transcript length exceeds 200 nt and does not code for proteins. Recent studies have shown that lncRNA is significantly differentially expressed during the differentiation of mesenchymal stem cells into chondrocytes and plays an important role in the process of the differentiation of mesenchymal stem cells into chondrocytes. This paper reviews the research on regulation of lncRNA DANCR, lncRNA HOTAIRM1-1, lncRNA ROCR, lncRNA ZBED3-AS1 and lncRNA HIT in differentiation of mesenchymal stem cells into chondrocytes, and discusses the existing problems in current studies, in order to provide references for the future cell therapy of OA.

Key words： Long non-coding RNA Mesenchymal stem cells Differentiation Chondrocyte

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	YAO Nan1 LI Congcong2 SONG Min2 XU Xuemeng3 LIU Wengang3 CHEN Guocai2 CHEN Guoqian2 YE Guozhu2

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YAO Nan1 LI Congcong2 SONG Min2 XU Xuemeng3 LIU Wengang3 CHEN Guocai2 CHEN Guoqian2 YE Guozhu2. Research progress on regulation of long non-coding RNA in differentiation of mesenchymal stem cells into chondrocytes[J]. 中国医药导报, 2019, 16(27): 33-36.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I27/33

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