牙周炎患者血清中内脂素、PGE2水平变化及临床意义

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Abstract Objective To investigate the changes of serum levels of visfatin and prostaglandins E2 (PGE2) in patients with periodontitis and the clinical significance of diagnosis and treatment in patients with periodontitis. Methods From January 2013 to December 2017, 80 patients with periodontitis treated in Beihai People′s Hospital of Guangxi Zhuang Autonomous Region (hereinafter referred to as "our hospital") were selected as the periodontitis group. According to the diagnostic criteria of periodontitis, the patients were divided into the active periodontitis group (n = 42) and the inactive periodontitis group (n = 38). Another 50 healthy volunteers who underwent physical examination in our hospital at the same time were selected as the control group. Levels of visfatin, PGE2, interleukin-6 (IL-6), tumer necrosis facfor-α （TNF-α）, and C-reactive protein (CRP) were measured and compared among each group. Pearson test was used to analyze the correlation between visfatin, PGE2, IL-6, TNF-α and CRP levels. Results Serum levels of visfatin, PGE2, IL-6, TNF-α and CRP in the periodontitis group were all higher than those in the control group, with statistically significant differences (P ＜ 0.05). Serum levels of visfatin, PGE2, IL-6, TNF-α and CRP in the active periodontitis group were all higher than those in the inactive group, with statistically significant differences (P ＜ 0.05). By Pearson correlation test, the serum levels of visfatin and PGE2 in patients with periodontitis were positively correlated with the levels of inflammatory factors IL-6, TNF-α and CRP (P ＜ 0.05). Conclusion Serum levels of visfatin and PGE2 in patients with periodontitis are significantly increased, which may be involved in the occurrence and progression of periodontitis, and may be of important reference significance for the diagnosis and evaluation of periodontitis.

Key words： Periodontitis Visfatin Prostaglandin Inflammatory factors Correlation analysis

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	ZHANG Peng′en CHEN Hong HE Jing

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ZHANG Peng′en CHEN Hong HE Jing. Changes of serum levels of visfatin and PGE2 in patients with periodontitis and their clinical significance[J]. 中国医药导报, 2019, 16(27): 111-113,125.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2019/V16/I27/111

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