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| Clinical effect of Clostridium Butyricum Powder combined with human immunoglobulin in the treatment of children with severe hand，foot and mouth disease |
| YUE Jia1 LIANG Xue2 LIU Jingwei2 PIAO Jinhua3 |
1.Pediatric Clinic, the First Hospital of Jilin University, Jilin Province, Changchun 130000, China;
2.Children ICU, the First Hospital of Jilin University, Jilin Province, Changchun 130000, China;
3.Department of Children Cardiovascular, the First Hospital of Jilin University, Jilin Province, Changchun 130000, China |
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Abstract Objective To investigate the clinical effect of Clostridium Butyricum Powder combined with human immunoglobulin in the treatment of children with severe hand, foot and mouth disease (HFMD). Methods A total of 123 children with severe HFMD admitted to the First Hospital of Jilin University from November 2014 to November 2018 were selected, they were divided into control group (n = 61) and research group (n = 62) according to the random number table method. Children in the control group were treated with human immunoglobulin, while children in the research group were treated with Clostridium Butyricum Powder combined with human immunoglobulin. The clinical efficacy, immune function and intestinal barrier of the two groups were compared. The adverse reactions of children in the two groups during the treatment were recorded. Results The total effective rate of the study group was higher than the control group after 5 days of treatment (P < 0.05). Immunoglobulin (Ig) A and IgG in the study group were higher than those in the control group (P < 0.05), and IgM was lower than that in the control group (P < 0.05). After 5 days of treatment, diamine oxidase, D-lactic acid and endotoxin in the two groups were lower than before treatment, and those in the study group were lower than the control group (P < 0.05). There was no statistically difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion Clostridium Butyricum Powder combined with human immunoglobulin is effective in the treatment of severe HFMD children. It can effectively improve the immune function and intestinal barrier function of children, it has certain clinical application value.
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