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2018 Vol. 15, No. 28
Published: 2018-10-05
 
 
4 Effecf of Qingrun Formula on SIRT/NF-κB signal pathway in liver of diabetic rats
QIU Zonglin WANG Qiuhong SUN Fenghui WANG Ze LIN Lan▲
Objective To study the effect of Qingrun Formula on sirtuin (SIRT)/nuclear factor-κB (NF-κB) signal pathway in livers of rats with diabetes mellitus and insulin resistance. Methods Ninety 12-week old Wistar male rats were selected as objects, 15 rats were as normal group, the other 75 rats were induced by intraperitoneal injection of Streptozotocin (STZ) and gavage with fat milk for 30 days. After successful modeling, 60 rats with diabetes were randomly divided into model group, Metformin group [250 mg/(kg·d)], high dosage of Qingrun Formula group [11.2 g/(kg·d)], middle dosage of Qingrun Formula group [5.6 g/(kg·d)] and low dosage of Qingrun Formula group [2.8 g/(kg·d)], with 12 rats in each group. Each group was given medicine by gavage, once a day, lasting for 8 weeks. The levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in liver tissues of each group were tested by enzyme-linked immunosorbent assay (ELISA). The mRNA and protein expression levels of SIRT1, NF-κB and glucose transporter 4 (GLUT4) in liver tissues of each group were tested by qRT-PCR and Western blot. Results Compared with model group, the level of TNF-α decreased in high dosage of Qingrun Formula group (P ＜ 0.05), the level of IL-6 decreased in high and middle dosage of Qingrun Formula groups (P ＜ 0.05), the mRNA and protein expression levels of SIRT1 increased in each dosage of Qingrun Formula groups (P ＜ 0.05), the mRNA and protein expression levels of GLUT4 increased in high and middle dosage of Qingrun Formula groups (P ＜ 0.05), the mRNA and protein expression levels of NF-κB decreased in the high and middle dosage of Qingrun Formula groups (P ＜ 0.05). Conclusion Qingrun Formula may alleviate the insulin resistance by increasing the expression of SIRT1 and thereby decreasing the expression of NF-κB in the liver of diabetic rats.
2018 Vol. 15 (28): 4-7,12 [Abstract] ( 232 ) HTML (1 KB)  PDF (583 KB)  ( 156 )
8 Influence of down regulation of Neu3′s to PC-3 cell′s proliferation, invasiveness, and its mechanism
LI Xiaojie JIANG Jun ZHU Bei
Objective To investigate the influence of Neu3 gene silencing in growth inhibition of PC-3 cell and to elucidate the underlying mechanisms. Methods Three pieces of siRNA sequences on the Neu3 gene were designed and then a recombinant plasmid carrying siRNA was constructed, which was used to transfer PC-3 cells in order to screen the most effective sequence among the three siRNA sequences against Neu3; PC-3 cell transfection pGCsi-Neu3 plasmid, inverted microscope was used to observe the transfection efficiency, determined by MTT test their effects on cell proliferation and flow cytometry was used to detect the change of cell apoptosis; Transwell migration and invasion assay were performed to detect the migration and invasion cells of groups. Results The siRNA sequences targeted to Neu3 gene were designed and their expression vectors were cloned and verified successfully. Compared with control group, pGCsi-Neu3-3 plasmid significantly inhibited cell proliferation (P < 0.01); pGCsi-Neu3-3 plasmid significantly promoted the apoptosis of PC-3 cells of prostate cancer compared with the blank control group (Mock group), the difference was statistically significant (P < 0.05). pGCsi-Neu3-3 plasmid could inhibit the migration and invasion assay of PC-3 cells of prostate cancer, compared with the control group, with statistically significant difference (P < 0.01). Conclusion Construction, identification and initial study of Neu3, might lay the foundation of experiment for the study of growth and metastasis mechanism of prostate cancer cell.
2018 Vol. 15 (28): 8-12 [Abstract] ( 172 ) HTML (1 KB)  PDF (740 KB)  ( 92 )
13 Effect of cell autophagy on apoptosis of HL-60 cells induced by Jolkinolide B
WANG Jiahe WANG Chao
Objective To investigate the effects of apoptosis of the autophagy-specific inhibitor 3-methyladenine (3-MA) and autophagy agonist rapamycin (RAPA) on the human leukemia cell line HL-60 cells induced by Jolkinolide B. Methods The expressions of autophagy-related protein LC3-Ⅱ/LC3-Ⅰand autophagy regulator Beclin-1 induced by different doses of Jolkinolide B at different time points were detected by Western blot method. The HL-60 cells were divided into blank control group, Jolkinolide B group, Jolkinolide B combined with 5 mmol/L 3-MA group, Jolkinolide B combined with 10 mmol/L 3-MA group, Jolkinolide B combined with 10 nmol/L RAPA group and Jolkinolide B combined with 20 nmol/L RAPA group. Apoptosis of human leukemia cell line HL-60 cells was detected by Annexin V-FITC/PI double staining flow cytometry. Moreover, the activity of Caspase-3 was detected. Results Jolkinolide B could induce autophagy in leukemia cell line HL-60, increase the expression of LC3-Ⅱ and autophagy regulator Beclin-1 (P < 0.05). 3-MA could lower the apoptosis rate of HL-60 cells and the activity of Caspase-3 activity induced by Jolkinolide B (P < 0.05), while RAPA increased the apoptosis rate of HL-60 cells and the activity of Caspase-3 induced by Jolkinolide B (P < 0.05). Conclusion Jolkinolide B can induce autophagy in HL-60 cells, and autophagy plays an important role in the apoptosis of HL-60 cells induced by Jolkinolide B.
2018 Vol. 15 (28): 13-16细胞自噬对岩大戟内酯B诱导的 [Abstract] ( 275 ) HTML (1 KB)  PDF (589 KB)  ( 62 )
17 The research on the effect and mechanism of Panax notoginseng saponins on invasion and metastasis of A549 cells
GONG Chunxiang XU Weiwei SHAO Xin
Objective To investigate the effect and mechanism of Panax notoginseng saponins (PNS) on invasion and metastasis of A549 cells. Methods A549 cells were divided into control group, low dose of PNS group (15 mg/L), medium dose of PNS group (30 mg/L), high dose of PNS group (60 mg/L) according to different culture methods. Transwell cell invasion test was used to detect the invasion and metastasis ability of A549 cells, qRT-PCR and Western blot methods were used to detect the expression levels of miRNA-379-5p, matrix metalloproteinase (MMP)-2 and MMP-9 in A549 cells. Results Compared with control group, the invasion and metastasis ability of A549 cells of low, medium, high dose of PNS groups decreased, the expression of miRNA-379-5p increased, the expression of MMP-2 protein and mRNA decreased, the differences were statistically significant (P ＜ 0.05 or P ＜ 0.01); the expression of MMP-9 protein and mRNA of medium and high dose of PNS groups decreased (P ＜ 0.05). Conclusion PNS could inhibit the invasion and metastasis of A549 cells, and its mechanism may be related to upregulation of miRNA-379-5p expression and downregulation of MMP-2 and MMP-9 expression in A549 cells induced by PNS.
2018 Vol. 15 (28): 17-20 [Abstract] ( 244 ) HTML (1 KB)  PDF (715 KB)  ( 79 )
21 Optimized extraction technology of Chang′an No.Ⅰ based on dose-effect fusion evaluation method
LIU Yu1 ZHENG Rui1 WANG Fengyun2 TANG Xudong2 MA Xiangxue2 SHI Xiaoshuang2 SUN Qiaohong1 JIN Jing1
Objective To optimize the extraction technology of Chang′an No.Ⅰ by pharmacodynamics combined with active ingredient contents, and to explore the correlation between active ingredient contents and pharmacodynamics indicators. Methods The antidiarrheal and analgesic tests were used to optimize the best extraction process. SPSS 17.0 software was used to analyze the Pearson correlation between the active ingredients of Chang′an No.Ⅰ in the treatment of irritable bowel syndrome and pharmacodynamics indicators. Results The best optimal extraction process of Chang′an No.Ⅰ was water extract. There was a positive correlation between paeoniflorin content and analgesic rate (P ＜ 0.01), and there was no significant correlation between paeoniflorin content and diarrhea index (P ＞ 0.05). Conclusion It is scientific and reasonable to evaluate and optimize the extraction process by dose-effect fusion method. It provides a new way to optimize the extraction process of Chinese medicine, and also provides a reliable experimental basis for the clinical application of Chang′an No.Ⅰ.
2018 Vol. 15 (28): 21-24 [Abstract] ( 268 ) HTML (1 KB)  PDF (452 KB)  ( 71 )
25 Research progress of Codonopsis pilosula polysaccharide and its structure modification on immune regulation
HAO Yanyan1 NIE Chunxia2 WU Xiaowei1 LIU Cong1 HAO Xuliang1
Codonopsis pilosula is the root of perennial herbaceous codonopsis pilosula, Codonopsis pilosula, Succulent Codonopsis pilosula and other species in the same genus. Codonopsis polysaccharide component is its main active ingredient, which has functions of regulating immunity, promoting hematopoietic function, anti-oxidation, anti-anoxia, anti-fatigue and other effects. In recent years, studies on the regulation of immune function by polysaccharides and their modification have become a hot topic in the research of polysaccharides. This article focuses on the research progress of polysaccharides and their structure modification on immunoregulation of Codonopsis pilosula, which is commonly used in traditional Chinese medicine, in order to provide a basis for subsequent development of Codonopsis pilosula polysaccharides.
2018 Vol. 15 (28): 25-28 [Abstract] ( 254 ) HTML (1 KB)  PDF (568 KB)  ( 67 )
29 Relationship between adiponectin and diabetes mellitus and its complications
XU Liying1 ZHONG Ping2 CAO Yemin1
Adiponectin is a cytokine secreted by dipocytes. It binds to receptors and has functions to improve sugar and lipid metabolism, increase insulin sensitivity, and protect vascular endothelial cells. It has anti-inflammatory and anti atherogenic effects in cardiovascular system. Adiponectin is associated with insulin resistance, obesity, and the risk of developing type 2 diabetes, and can reduce the risk of developing hypertension. Adiponectin is expressed differently in groups of different races, ages, and genders. Adiponectin has a cardiovascular protective effect and can predict the severity of diabetic large blood vessels. This article reviews adiponectin receptors, signal transduction, and the association between adiponectin and vascular risk factors, diabetic macrovascular and microvascular lesions.
2018 Vol. 15 (28): 29-32 [Abstract] ( 297 ) HTML (1 KB)  PDF (517 KB)  ( 59 )
33 Research on glioma microenvironment
LI Xun1 AI Wenbing2
The glioma is the most common primary intracranial malignancy in adults. Current treatments include surgery, radiotherapy, and oral chemotherapy drug temozolomide. These treatments have a certain cure rate, but there is still the possibility of recurrence. The main reason is that tumor cells can survive and rebuild tumors during the treatment. Therefore, it is essential for the treatment of tumors to know the molecular mechanism that regulates the activity of tumor cells. Glioma stem cells (GSC) tolerance to conventional radiotherapy and chemotherapy may be one of the causes of glioma recurrence. The tumor microenvironment in which GSC located is related to the development of GSC, which also provides a new idea for the treatment of gliomas. This article focuses on the research progress of GSC-related tumor microenvironment and the treatment of gliomas through targeted microenvironment.
2018 Vol. 15 (28): 33-36 [Abstract] ( 194 ) HTML (1 KB)  PDF (515 KB)  ( 139 )
37 Research progress of intra-abdominal hypertension and abdominal compartment syndrome by traditional Chinese medicine
ZHANG Jidan1 LI Liang2 XU Zhibing2
Intra-abdominal hypertension and abdominal compartment syndrome are attracting increasing attention, but there is no Western medicine with remarkable effects, traditional Chinese medicine has been applied widely in clinic as adjuvant therapy of intra-abdominal hypertension and abdominal compartment syndrome, and has achieved good effects. This article analyzes the literatures related to the treatment of intra-abdominal hypertension and abdominal compartment syndrome with traditional Chinese medicine in recent years, the development of intra-abdominal hypertension and abdominal compartment syndrome with traditional Chinese medicine is explained from traditional Chinese medicine decoction, Chinese medicine enema, external treatment of traditional Chinese medicine, acupuncture and combined therapy.
2018 Vol. 15 (28): 37-40 [Abstract] ( 186 ) HTML (1 KB)  PDF (512 KB)  ( 117 )
41 Application of team-based learning combined with situational simulation teaching method in the experimental course of nutrition and food hygiene
ZHOU Xi YI Long MI Mantian
To explore the effect of the teaching method of team-based learning (TBL) combined with situational simulation teaching method in the experimental course of nutrition and food hygiene. Thirty undergraduates of five-year preventive medicine major from Army Medical University were selected and taught in the section of Recipe Preparation. Questionnaires were sent out after class to analyze the teaching results. The results showed that TBL combined with situational simulation teaching method can greatly stimulate the students′ enthusiasm and the inherent potential of the students. The students′ teamwork ability can be trained and professional practical ability can be improved, thereby teaching quality could be improved.
2018 Vol. 15 (28): 41-44,69 [Abstract] ( 234 ) HTML (1 KB)  PDF (690 KB)  ( 59 )
45 Application effect of new “Warrior” manikin in the wound-rescuing teaching and learning course
ZHANG Yang1 FENG Yafei1 TIAN Li1 YANG Xiaojiang1 WANG Jingfu2 ZHAO Yimin2 LEI Wei1
Objective To compare the effect between application of new “Warrior” manikin and traditional methods in the teaching of wound-rescuing course. Methods In October 2017, among 128 undergraduates of grade 2014, clinical medicine major, in the Air Force Medical University, 100 undergraduates were selected by the random number table method and were divided into experimental group and control group, with 50 undergraduates in each group. The experimental group accepted the new “Warrior” manikin teaching system, while the control group accepted the traditional oral teaching, video, and traditional mutual practice. The teaching effect between the two groups was tested by operation assessment analysis, questionnaire was used on evaluating satisfaction and teaching effect. Results The undergraduates in the experimental group were superior to the control group in terms of operational success rate, situational response and humanistic care, that had statistically significant differences (P ＜ 0.05). The final assessment results of the experimental group were significantly better than those in the control group, and the difference was remarkably significant (P ＜ 0.01). Teaching satisfaction questionnaire survey results also showed that students were more willing to use the new “Warrior” manikin, especially on the learning interest, efficiency and strain capacity, which had statistically significant difference (P ＜ 0.05). Conclusion The new “Warrior” manikin in teaching can better simulate the actual treatment to improve the level of military medical university students′ comprehensive war injury treatment. It improves the teaching quality and effect, thereby having very important significance.
2018 Vol. 15 (28): 45-48 [Abstract] ( 246 ) HTML (1 KB)  PDF (807 KB)  ( 122 )
49 Application of self-service experimental teaching method in establishing animal models of renal interstitial fibrosis
DAI Huanzi HE Yani▲
Objective To analyze the effect of self-contained experimental teaching method in establishing animal models of renal interstitial fibrosis. Methods With stratified sampling method, 40 students (8 students on stage 5 of the students′ grade) from  Army Medical University were selected as the research object, the experiment group (20 students) in Grade 2 was given self-help set meal experiment teaching method, the control group (20 students) was given traditional teaching methods, the evaluation score and the comprehensive ability score of two groups were evaluated，and the satisfaction of teaching was counted. Results The assessment scores of animal models of unilateral ureteral obstruction, animal model of chronic aristolochic acid nephropathy and cyclosporin in the experiment group were higher than those in the control group, the differences were statistically significant (P < 0.05). The assessment scores of nephrectomy animal model, analgesic nephrotic animal model and gentamycin induced renal tubular injury and interstitial fibrosis caused by Gentamicin in the experiment group were significantly higher than those in the control group, the differences were statistically significant (P < 0.01). The scores of the five dimensions observation including ability, thinking ability, analyzing and solving problems ability, innovation ability and operational ability in the experiment group were significantly higher than those in the control group, the differences were statistically significant (P < 0.01). The satisfaction rate of experiment teaching of students in the experiment group was higher than that in the control group, the difference was statistically significant (P < 0.05). Conclusion The self-help set meal experiment teaching method can improve the teaching quality of the animal model of renal interstitial fibrosis and enhance the comprehensive ability of the students. It is a positive and effective teaching method, which is worthy of trust and popularization.
2018 Vol. 15 (28): 49-52 [Abstract] ( 201 ) HTML (1 KB)  PDF (664 KB)  ( 58 )
53 Application of CBL combined with PBL teaching method in clinical oncology practice teaching for international students
CHEN Xin1 XIA Jingyu2 CAO Dedong1 HE Xiaoqin1 XU Ximing1
Objective To investigate the application effect of case-based learning (CBL) combined with problem-based learning (PBL) teaching method in clinical oncology practice teaching for international students. Methods From February 2016 to February 2017, 60 international students in Renmin Hospital of Wuhan University were selected, and they were divided into the experiment group (30 cases) and the control group (30 cases) by random number table. The experiment group was given CBL combined with PBL teaching method, while the control group was given the traditional teaching method. Theoretical knowledge examination, case analysis, clinical operating examination and questionnaire investigation were used to evaluate the teaching effect and satisfaction. Results Before teaching, theoretical knowledge, case analysis and clinical operating scores in two groups were compared, the differences were not statistically significant (P > 0.05). Theoretical knowledge scores and case analysis scores in experiment group were higher than  the control group, the differences were statistically significant (P < 0.01). There was no statistically significant difference in the clinical operating scores of two groups (P > 0.05). In addition, the satisfaction rate of improving learning interest, autonomous learning ability, improving clinical thinking and enhancing communication and coordination ability in the experiment group were higher than the control group, the differences were statistically significant (P < 0.05 or P < 0.01). Conclusion CBL combined with PBL teaching mode in clinical oncology international students teaching can improved the quality of clinical teaching, enhanced the students learning initiative and advanced the ability of clinical thinking ability and practical application ability.
2018 Vol. 15 (28): 53-56 [Abstract] ( 268 ) HTML (1 KB)  PDF (668 KB)  ( 59 )
57 Application of standardized patients in PBL teaching of standardized training for residents of gastrointestinal surgery
YANG Xiaojun1,2 HUANG Chaoqun1,2 PENG Chunwei1,2 JIANG Yi′nan1,2 CAI Xiaopeng1,2 FENG Maohui1,2 XIONG Bin1,2
After continuous improvement and development in the past five years from 2013 to 2018, the standardized training system for resident physicians has matured, and various teaching methods including problem-based learning (PBL) have also been continuously developed. In view of the shortcomings of the PBL model in the clinical teaching of the standardization training for resident residents in department of gastrointestinal surgery, this research group introduced the standardized patient (SP) teaching method to form a PBL-SP integrated teaching model and achieved good results. This paper summarizes the relevant experiences of specific implementation from the necessity of SP introduction, the reasons for the SP to improve the teaching effect and the choice and training points of SP, for reference.
2018 Vol. 15 (28): 57-60 [Abstract] ( 257 ) HTML (1 KB)  PDF (663 KB)  ( 55 )
61 Research on teaching methods of Medicinal Botany
ZHAN Liping1 ZHAO Xin2 ZHANG Jianjun1
2018 Vol. 15 (28): 61-64 [Abstract] ( 266 ) HTML (1 KB)  PDF (782 KB)  ( 81 )
65 Research about application of mind maps in standardized training of physicians
LUO Mei WANG Juan ZHANG Ying CAO Guiqiu
Mind map is applied in standardized training of physicians, it is used intuitive charts to indicate the development and evolution of diseases and treatment measures. It is effective measures to learn and master the highlights and key points for resident physicians. This process of adopting this teaching method is demonstrated by the example of "chest pain" and "coronary atherosclerotic disease". Application of mind map is conductive to improving the self-learning enthusiasm, facilitating clinical memory and mastering the key points rapidly. It is suitable for the improving clinical thinking ability and worthy of promotion.
2018 Vol. 15 (28): 65-69 [Abstract] ( 220 ) HTML (1 KB)  PDF (886 KB)  ( 124 )
70 Antiviral effect of Entecavir versus Tenofovir Disoproxil Fumarate in the treatment of chronic hepatitis B and liver cirrhosis
SHEN Enhua WANG Moli WANG Lihong LI Xinshan YUAN Yimeng CHEN Peng YUAN Jing ZHANG Jingfen FU Guangshuang▲
Objective To compare the antiviral effect of Entecavir (ETV) and Tenofovir Disoproxil Fumarate (TDF) in initial treatment patients with chronic hepatitis B and liver cirrhosis. Methods A total of 80 initial treatment patients with chronic hepatitis B and liver cirrhosis who received antiviral therapy with TDF or ETV and were regularly followed up in the FAW General Hospital, from January 2016 to January 2017 were enrolled, and 38 patients were treated with TDF (TDF group) and 42 patients were treated with ETV (ETV group). Laboratory markers were measured before and at 24th, 36th, and 48th week of treatment, including liver and renal function parameters, serum calcium, serum phosphate, creatine kinase, HBV DNA level, hepatitis markers. Adverse drug reactions were also observed. Results At 24th week of treatment, HBsAg of ETV group was lower than that of TDF group (P ＜ 0.05). At 36th, 48th week of treatment, there was no difference in HBsAg of the two groups (P ＞ 0.05). At 24th, 36th, 48th week of treatment, the two groups had no statistical difference in ALT level (P ＞ 0.05). At 24th, 36th week of treatment, HBV DNA level of ETV group was lower than that of TDF group (P ＜ 0.05). At 48th week of treatment, HBV DNA level, proportion of HBeAg positive patients with HBV DNA level below floor level, rate of HBeAg turning negative, rate of HBeAg negative and positive patients with ALT turning normal in the two groups had no statistically difference (P ＞ 0.05). In TDF group, 2 cases occured serum inorganic phosphorus declined slightly, and bone mineral density was detected mild osteoporosi. Conclusion At 24th and 36th week of treatment, ETV restrains HBV DNA better than TDF, while at 48th week there is no differece between the two drugs.
2018 Vol. 15 (28): 70-73 [Abstract] ( 301 ) HTML (1 KB)  PDF (601 KB)  ( 130 )
74 Effect of superior vena cava deformation index on volume therapy during orthotopic liver transplantation
ZHANG Peicai CHEN Yong LI Binfei
Objective To study the effect of superior vena cava deformation index (SCI) on volume therapy during liver transplantation. Methods Forty patients who underwent liver transplantation in Hepatobiliary Surgery from January 2017 to January 2018 were collected as study subjects. They were divided into observation group (20 cases) and control group (20 cases). The control group was given conventional central venous pressure (CVP), orterial bleool pressure (ABP) and Swan-Ganz floating catheters to monitor and guide the volume management in the operation. The observation group was given the monitoring of the deformation of the superior vena cava to guide the volume management during the operation. The infusion capacity and operation status of the two groups were observed. Results The mean arterial pressure (MAP), pulmonary artery pressure (PAP), cardiac output (CO), CVP, and SCI values at anhepatic phase 2 min (T3), anhepatic phase 30 min (T4), neohaptic phase 2 min (T5), and neohaptic phase 30 min (T6) of observation group were significantly higher than those of the control group, and the differences were statistically significant (P ＜ 0.05). The input volume of colloidal fluid, crystalloid fluid and the total input volume of fluid of observation group were significantly lower than those of the control group, and the differences were statistically significant(P ＜ 0.05). The recovery time, tracheal catheter time, ICU stay time and hospitalized time of the observation group were significantly shorter than those of the control group, and the differences were statistically significant (P ＜ 0.05). Conclusion It is feasible to monitor the volumetric treatment of liver transplantation by monitoring the SCI in clinical practice. It can effectively maintain the blood volume and tissue perfusion, and reduce the total amount of infusion during surgery. It can promote the recovery of postoperative function more quickly, and it is worth of high clinical value.
2018 Vol. 15 (28): 74-77 [Abstract] ( 181 ) HTML (1 KB)  PDF (632 KB)  ( 68 )
78 Clinical application of ultrasound-guided axillary vein puncture for PICC catheter implantation
HUANG Zhiyou TIAN Danxing LI Qiongyao MA Bidong HUANG Zhaoming
Objective To explore the application of ultrasound-guided axillary vein puncture for PICC catheter implantation. Methods From January 2017 to January 2018, 76 patients that needed central venous catheterization in Wenzhou Hospital of Traditional Chinese Medicine, Zhejiang Chinese Medical University were selected and randomly divided into experimental group and control group according to random number table method. The experimental group (33 cases) was treated with ultrasound-guided axillary in axillary vein puncture for PICC catheter implantation. The control group (43 cases) was treated with ultrasound-guided axillary in axillary vein puncture for the central venous catheter (CVC) implantation. The success rate of catheterization, indwelling catheter time and complication rate were recorded and compared between the two groups. Results There was no significant difference in the success rate of catheterization between the two groups (P ＞ 0.05); the indwelling catheter time in the experimental group was longer than that of the control group (P ＜ 0.05); the rate of catheter-related complications in the experimental group had no difference with that in the control group (P ＞ 0.05). Conclusion PICC catheter implantation with ultrasound-guided in axillary vein puncture is safe and practical, expanding the area of PICC catheter.
2018 Vol. 15 (28): 78-80 [Abstract] ( 254 ) HTML (1 KB)  PDF (585 KB)  ( 104 )
81 Clinical study of transjugular intrahepatic portosystemic shunt for cirrhosis with portal hypertension
ZHAO Yulong LIU Shunshun YAO Dejiong LIANG Weijun HUANG Hui WANG Zhongwei
Objective To investigate the efficacy of transjugular intrahepatic portosystemic shunt for cirrhosis with portal hypertension. Methods Fifty-four cases of cirrhosis patients with portal hypertension admitted to the First Division Hospital of Xinjiang Production and Construction Corps from January 2015 to December 2016 were selected. According to random number table method, they were divided into observation group and control group, with 27 cases in each group. The observation group was treated by transjugular intrahepatic portosystemic shunt, and the control group was treated by pericardial devascularization. The operation effect, hemodynamic indexes and liver function indexes before and after operation of two groups were compared, and the incidence of adverse events after operation was observed. Results There was no significant difference in total clinical effective rate between the two groups (P ＞ 0.05). After operation, the diameter of portal vein, portal vein blood flow, splenic vein diameter and splenic vein blood flow in observation group were lower than those of control group, while the portal venous flow velocity and the splenic vein velocity were higher than those of control group, the differences were statistically significant (P ＜ 0.05). After operation, the levels of alanine transaminase, aspartate aminotransferase and total bilirubin in observation group were lower than those of control group (P ＜ 0.05). The incidence of adverse events in observation group was significantly lower than that in control group (P ＜ 0.05). Conclusion Transjugular intrahepatic portosystemic shunt is effective in the treatment of cirrhosis with portal hypertension. It can significantly improve the hemodynamic indexes and liver function, and reduce the incidence of postoperative adverse events.
2018 Vol. 15 (28): 81-84 [Abstract] ( 198 ) HTML (1 KB)  PDF (596 KB)  ( 91 )
85 Analysis of prognostic risk factors of middle-aged and elderly inpatients in a general hospital in Shandong Province from 2011 to 2015
CAI Yuehong1 WANG Ping1 YU Lingbo1 ZHANG Wei1 LI Zhihua2▲
Objective To analyze the prognostic risk factors of middle-aged and elderly inpatients in Weifang People′s Hospital, and to provide reference for improving the cure rate and improvement rate. Methods The clinical data of inpatients aged 40 to 79 years old in Weifang People′s Hospital from January 2011 to December 2015 was extracted and imported into SPSS 16.0 software, and the software was used to conduct variable assignments and statistical analysis, the effects of patients′ age, sex, marital status, absence or presence of children, severity of disease, payment method, days of hospitalization on the prognosis of inpatients were analysed by univariate analysis using chi-square test and multivariate analysis using Logistic stepwise regression analysis. Results Totally 214 327 inpatients with completed clinical information were accorded with the inclusive criteria, of which, 11 964 inpatients were uncured or died, accounted for 5.6%. The patients′ age, sex, marital status, absence or presence of children, severity of disease, payment method, days of hospitalization could significantly influence the prognosis of the middle-aged and elderly inpatients. Multivariate Logistic regression analysis revealed that the major risk factors were the critical illness [OR = 9.41, 95%CI (9.00, 9.84)], no medical insurance [OR = 3.09, 95%CI (2.94, 3.25)], no children [OR = 2.10, 95%CI (1.75, 2.52)], divorced or widowed [OR = 1.64, 95%CI (1.45, 1.87)], followed by the male and the old age, while long hospital stay was a protective factor. Conclusion In addition to male, old age and critical illness, the patients without medical insurance, children and spouse have a poor prognosis.
2018 Vol. 15 (28): 85-87 [Abstract] ( 282 ) HTML (1 KB)  PDF (603 KB)  ( 37 )
88 Analysis of fatty liver positive rate and related factors in physical examinees of Chengdu Center for Disease Control and Prevention
ZHU Dan
Objective To explore and study the positive rate of fatty liver and its related factors in 972 physical examinees. Methods A study was carried out on 972 physical examinees in Chengdu Center for Disease Control and Prevention from January to December 2016, the physical examinees were divided into fatty liver group and non fatty liver group according whether they were fatty liver positive or not. The results of general information, laboratory examination and abdominal B ultrasonic examination were analyzed, and SPSS 19.0 software was used for statistical analysis. Results Among the 972 cases, 174 cases of fatty liver were detected, the positive rate was 17.901%, of which, the fatty liver positive rate of male was higher than that of female, the difference was statistically significant (χ2 = 46.100，P ＜ 0.05). The age, levels of fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), gamma glutamyl transferase (GGT) and proportions of alcohol and smoking of fatty liver group were higher than those of non fatty liver group, the differences were statistically significant (P ＜ 0.05). The two classification unconditional Logistic regression analysis showed that advanced age, male, FPG, TC, TG and ALT were associated with the occurrence of fatty liver, and they were risk factors of fatty liver (P ＜ 0.05). Conclusion Advanced age, male, FPG, TC, TG and ALT are closely related to the occurrence of fatty liver, and they are the risk factors of fatty liver.
2018 Vol. 15 (28): 88-91 [Abstract] ( 242 ) HTML (1 KB)  PDF (613 KB)  ( 96 )
92 The influence of tracheotomy non-mechanical ventilation for craniocerebral injury patients by high flow oxygen therapy humidification
TAN Yong XU Liyong▲
Objective To investigate the effect of humidified high flow nasal cannula (HHFNC) on patients with tracheal incision and non-mechanical ventilation. Methods Sixty patients with cranial incision and non-mechanical ventilation who were admitted to Minjiang Central Hospital of Chongqing from March 2016 to March 2018 were selected. Grouped according to treatment measures, control group and the observation group, with 30 cases in each group. Conventional humidified oxygen therapy and HHFNC were performed in the control group and the observation group, respectively. The incidence of hospital acquired pneumonia was observed at 3, 7, 10, 14 d after airway opening in both groups. The average number of sputum aspiration, the formation rate of sputum callus, the viscosity of sputum, and the airway wetting result after offline were observed. Results The incidence of hospital-acquired pneumonia, number of sucking, rate of sputum formation and the viscosity of sputum in the observation group were lower than those in the control group, the airway wetting result of the patients in the group was better than that of the control group, and the differences were statistically significant (P < 0.05). Conclusion HHFNC for patients with craniocerebral injury with tracheotomy and non-mechanical ventilation can reduce the incidence of hospital-acquired pneumonia, the average number of sputum aspiration, and the formation rate of sputum callus, improve the viscosity of sputum, and improve the airway wetting result. It is worthy of clinical application.
2018 Vol. 15 (28): 92-95 [Abstract] ( 241 ) HTML (1 KB)  PDF (637 KB)  ( 146 )
96 Efficacy and safety of low temperature plasma ablation in treating elderly postherpetic neuralgia
YANG Liqiang1 NI Jiaxiang1 LI Xiaolin1 HE Liangliang1 DOU Zhi1 SUN Dongguang2 PANG Haitao3
Objective To compare the clinical efficacy of radiofrequency nerve thermocoagulation and low temperature plasma ablation and to investigate the efficacy and safety of low temperature plasma ablation in treating elderly postherpetic neuralgia. Methods From May 2014 to May 2017, clinical data of 40 elderly patients with postherpetic neuralgia treated in Xuanwu Hospital, Capital Medical University was retrospectively analyzed, they were divided into radiofrequency nerve thermocoagulation (Group A) and low temperature plasma ablation (Group B) according to the treatment method, with 20 cases in each group. The visual analogue scores (VAS) of patients in the two groups were recorded before and 1 d, 1 month and 6 months after surgery; the life satisfaction index B table (LSI-B) scores of patients in the two groups were recorded before and 1 month after surgery; the postoperative complications after surgery of patients in the two groups were recorded. Results Compared with Group A, the VAS score of Group B was significantly lower at 1 d, 1 month and 6 months after surgery, with statistical significance (P < 0.05), and the life satisfaction scores of Group B were higher at 1 month after surgery, with statistical significance (P < 0.05). There were no postoperative complications occurred in Group B, but 8 patients with numbness in Group A. Conclusion Compared with radiofrequency nerve thermocoagulation, low temperature plasma ablation is safer and more effective in the treatment of elderly postherpetic neuralgia patients and has higher life satisfaction.
2018 Vol. 15 (28): 96-98,110 [Abstract] ( 196 ) HTML (1 KB)  PDF (510 KB)  ( 92 )
99 Therapeutic effect of low temperature plasma ablation in conjunction with lumbar sympathetic nerve catheterization on the lumbar discogenic visceral pain
LU Haiyan1 YANG Liqiang1 TANG Yuanzhang1 PENG Kejun2 FANG Shengchun3 NI Jiaxiang1
Objective To discuss the therapeutic effect of low temperature plasma ablation in conjunction with lumbar sympathetic nerve catheterization on the lumbar discogenic visceral pain. Methods Thirty-four patients with lumbar discogenic visceral pain who were treated in the Xuanwu Hospital, Capital Medical University from January 2015 to January 2017 were divided into two groups. Eighteen patients treated with the lumbar sympathetic nerve catheterization were included into Group A, and 16 patients treated with the low temperature plasma ablation in conjunction with lumbar sympathetic nerve catheterization were included into Group B. The numeric rating scales (NRS) depending on the level of pain of two groups before surgery and different periods after surgery (immediately, 1 week, 3, 6 and 12 months) were recorded. The self-rating depression scale (SDS) of two groups before and 12 months after surgery were contrasted. The NRS differentials of two groups before surgery and immediately, 1 week, 3, 6, 12 months after surgery and the SDS scores and differentials of two groups before and 12 months after surgery were analyzed. The NRS/SDS differentials were the NRS/SDS before surgery minus the NRS/SDS after surgery. Adverse reaction and complication after surgery were recorded. Results The NRS differential of 3, 6, 12 months after surgery of Group B were higher than those of Group A, the differences were statistically significant (P = 0.001, 0.001, 0.011). The SDS scores of two groups before surgery showed no statistical significance (P = 0.397). The SDS scores of Group A before and 12 months after surgery showed no statistical significance (P = 0.974). And the SDS scores of Group B before and 12 months after surgery showed statistical significance (P = 0.001). The SDS differential of 12 months after surgery of Group B was higher than that of Group A with statistical significance (P = 0.010). The two groups exhibited no complication such as paresthesia or numbness in corresponding dominating region caused by infection and nerve injury. Conclusion Compared with single lumbar sympathetic nerve catheterization, the low temperature plasma ablation in conjunction with lumbar sympathetic nerve catheterization exhibits a better effect in mid-long-term on lumbar discogenic visceral pain, and can relieve the depression.
2018 Vol. 15 (28): 99-102 [Abstract] ( 204 ) HTML (1 KB)  PDF (577 KB)  ( 100 )
103 The effect of CT-guided low temperature plasma fiber ring plasty in cervical discogenic neck and shoulder pain
HE Liangliang NI Jiaxiang CAO Guoqing GUO Yu′na YANG Liqiang▲
Objective To evaluate the effect of CT-guided low temperature plasma fiber ring plasty in cervical discogenic neck and shoulder pain. Methods From May 2016 to May 2017, 16 patients suffering cervical discogenic neck and shoulder pain in Xuanwu Hospital, Capital Medical University were selected. The pain visual analogue scale (VAS) scores were recorded before surgery, and 1 week, 1 month, 3 months, 6 months after the surgery. The efficacy was evaluated according to Macnab standard 3 months after surgery. Adverse effects were recorded. Results Compared with before the surgery, the pain VAS score obviously decreased 1 week, 1 month, 3 months and 6 months after surgery (P < 0.05), and no differences were observed at different time points after surgery (P > 0.05). According to Macnab standard, the count of excellent, good, average and bad was 8, 5, 2, 1. The percent of excellent and good was 81.2%. No adverse effect was recorded. Conclusion The low temperature plasma fiber ring plasty in cervical discogenic neck and shoulder pain is safe and effective, which is worthy of extension.
2018 Vol. 15 (28): 103-106 [Abstract] ( 221 ) HTML (1 KB)  PDF (494 KB)  ( 44 )
107 Clinical effect of trigeminal ganglion low temperature plasma ablation in the treatment of the third branches lesion of idiopathic trigeminal neuralgia
HE Haili1,2 YANG Liqiang1 HE Liangliang1 NI Jiaxiang1▲ SONG Shengwen3
Objective To discuss the clinical effect and complication of trigeminal ganglion low temperature plasma ablation in the treatment of the third branches (V3) lesion of idiopathic trigeminal neuralgia. Methods Sixty patients with V3 of idiopathic trigeminal neuralgia treated in Department of Pain Management, Xuanwu Hospital, Capital Medical University from January 2017 to March 2018 were enrolled, and they were divided into Group C and Group R by random number table method, with 30 cases in each group. The Group C was given trigeminal ganglion low temperature plasma ablation, the Group R was given radiofrequency thermocoagulation. The VAS, facial numbness score, masticatory muscle strength score before surgery (T0) and immediately (T1), 1 week (T2), 1 month (T3), 3 months (T4) after surgery and patients′ satisfaction were recorded and analyzed. Results The pain of patients in the two groups was significantly relieved, and there was no statistically significant difference between the two groups before and after the surgery (P > 0.05). The scores of facial numbness and masticatory muscle strength at each time point after surgery in Group C were significantly lower than those in Group R, the differences were statistically significant (P < 0.01). The satisfaction of patients in Group C was significantly higher than that in Group R, the difference was statistically significant (P < 0.01). Conclusion CT guided trigeminal ganglion low temperature plasma ablation is a safe and effective treatment for idiopathic trigeminal neuralgia with only V3, it is worthy of further clinical exploration and extension.
2018 Vol. 15 (28): 107-110 [Abstract] ( 218 ) HTML (1 KB)  PDF (521 KB)  ( 151 )
111 Efficacy of low temperature plasma ablation combined with epidural tube in discogenic low back pain
GUO Yu′na1 DOU Zhi1 LI Xiaolin1 TANG Yuanzhang1 YANG Liqiang1 YAN Wei2▲
Objective To observe the effect of low temperature plasma ablation combined with epidural anterior interspace catheterization in the treatment of discogenic low back pain. Methods From January 2016 to January 2017, 80 patients with discogenic low back pain underwent minimally invasive treatment in the Department of Pain Management of Xuanwu Hospital, Capital Medical University were selected and divided into low temperature plasma ablation combined with epidural tube group (Group A, 42 cases) and low temperature plasma ablation group (Group B, 38 cases) by random digital table method. The VAS scores of two groups 1 week, 1 month, 3 and 6 months after operation were compared; reformed Macnab assessment was used to evaluate the treatment effect of two groups  1 month, 3 and 6 months after operation; the complications were recorded. Results The VAS scores difference were statistically significant at 1 week, 1 month, 3 and 6 months after treatment compared with those before operation in two groups (P < 0.05). VAS scores in Group A at each time points after operation were lower than those in the Group B, the differences were statistically significant (P < 0.05). 1 month, 3 and 6 months after operation, the propotion of patients with excellent or good score in the reformed Macnab assessment in Group A were higer than those in Group B, the differences were statistically significant (P < 0.01). There was no complications such as nerve and artery injury or infection was found in the two groups. Conclusion Lumbar low temperature plasma ablation combined with epidural anterior interspace catheterization is safe and effective in the treatment of discogenic low back pain.
2018 Vol. 15 (28): 111-114 [Abstract] ( 208 ) HTML (1 KB)  PDF (493 KB)  ( 140 )
115 Effectiveness of Yisui Granules on low/intermediate risk type Ⅰ myelodysplastic syndromes: clinical trial protocol design features and evaluation
LI Ruibai1 DONG Qing1 LYU Peng1 HU Xiaomei2 YANG Xiupeng2 HOU Li1 ZHANG Yayue1
This paper introduces the clinical trial protocol of Yisui Granules in the treatment of low/intermediate risk type Ⅰ myelodysplastic syndromes, and evaluates its clinical practicability, scientific nature, program design features, which reflects the international synchronization and recognition of traditional Chinese medicine (TCM) theories and western medicine laboratory indicators, and lays a foundation for future clinical promotion and industry recognition. A prospective and pragmatic randomized controlled trial is used, and objective evaluation of the clinical efficacy of Yisui Granules in the treatment of low/intermediate risk type Ⅰ myelodysplastic syndromes is made by good clinic practice (GCP). By using TCM theories and analyzing relevant indicators, the clinical symptoms and signs are combined with modern laboratory indicators, to explore the clinical efficacy and effect mechanism of Yisui Granules in the treatment of low/intermediate risk type Ⅰ myelodysplastic syndromes from the aspects of quality of life and objective curative effect.
2018 Vol. 15 (28): 115-119 [Abstract] ( 191 ) HTML (1 KB)  PDF (669 KB)  ( 94 )
120 Meta analysis on clinical efficacy and safety of Yangxinshi Tablets in the treatment of patients with coronary heart disease and angina pectoris
ZHU Xiule1 LI Yiping2 WANG Xiaolong1 GAO Junjie1
Objective To systematically evaluate the clinical efficacy and safety of Yangxinshi Tablets in the treatment of patients with coronary heart disease and angina pectoris. Methods Databases included CNKI, VIP, CBM, PubMed, and Cochrane Library, etc. The retrieval objects covered both Chinese and English references at home and abroad. The retrieval time limit was from inception to December 2017. Eligibility studies were screened to assess the quality of literatures, and relevant data was statistically analyzed by means of heterogeneity test, meta analysis and sensitivity analysis. Results A total of 13 studies including 1435 cases were enrolled, and the literature quality was relatively low. Meta-analysis results showed that compared with control group, combined application of Yangxinshi Tablets could improve the efficacy of angina pectoris [OR = 3.93, 95%CI (2.51-6.16), P < 0.000 01], ECG efficacy [OR = 2.46, 95%CI (1.69-3.59), P < 0.000 01], and reduce serum total cholesterol [WMD = 0.76, 95%CI (0.23-1.29), P = 0.005], triglyceride [WMD = 0.77, 95%CI (0.20-1.34), P = 0.008], low density lipoproteins [WMD = 1.85, 95%CI (1.77-1.92), P < 0.000 01], hypersensitive C-reactive protein [WMD = 1.23, 95%CI (0.25-2.21), P = 0.01] significantly. During the study, there were total 12 cases with stomach discomfort, most of the studies did not show significant abnormalities in biochemical indicators in liver and kidney function. Conclusion Compared with the single application of the basic treatment of Western medicine, Yangxinshi Tablets can further improve the clinical efficacy of patients with coronary heart disease and angina pectoris, with good safety.
2018 Vol. 15 (28): 120-124,129 [Abstract] ( 221 ) HTML (1 KB)  PDF (1280 KB)  ( 160 )
125 Effect of Bushen Huoxue Recipe on different markers in patients with contrast induced acute kidney injury
FAN Li1 DONG Zhenghua2 YANG Haixia1 WANG Rui3
Objective To investigate the effect of Bushen Huoxue Recipe on different markers in patients with contrast induced acute kidney injury (CIAKI). Methods A total of 243 patients underwent coronary artery enhanced CT and percutaneous coronary intervention (PCI) were enrolled in Xi′an Xidian Group Hospital from October 2016 to January 2018. According to the random number table method, they were randomly divided into two groups: 119 cases in the observation group and 124 cases in the control group. The control group was given 0.9% Sodium Chloride Injection by intravenous drip irrigation, and the observation group was given Bushen Huoxue Recipe based on the treatment of control group. The cystatin c (Cys C), blood urea nitrogen (BUN), serum creatinine (Scr), creatinine clearance rate (Ccr), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), interleukin-6 (IL-6), keyboard input monitor-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in blood before and after treatment in the two groups were recorded and compared. The incidence of CIAKI within 72 h after PCI was recorded in the two groups. Results The levels of peripheral blood Cys C, BUN, Scr, TNF-α, CRP, IL-6, KIM-1 and NGAL of the two groups were higher than those before treatment (P ＜ 0.05), and Ccr, SOD and GSH-Px were lower than those before treatment (P ＜ 0.05). After treatment, the levels of peripheral blood Cys C, BUN, Scr, TNF-α, CRP, IL-6, KIM-1 and NGAL in the observation group were lower than those in the control group (P ＜ 0.05), and Ccr, SOD and GSH-Px were higher than those of the control group (P ＜ 0.05). The incidence of CIAKI in the observation group (4.20%) was significantly lower than the control group (11.29%) (P ＜ 0.05). Conclusion Bushen Huoxue Recipe can help reduce PCI and enhance CT-related CIAKI, which is associated with improved markers.
2018 Vol. 15 (28): 125-129 [Abstract] ( 216 ) HTML (1 KB)  PDF (671 KB)  ( 38 )
130 Study on the medication rules of facial mask prescription of traditional Chinese medicine for acne based on association rules
PEI Yue1 LIANG Haiying2 ZENG Jianbo1 PING Ruiyue1 LI Hongyi2
Objective To analyze the medication rules of facial mask prescription of traditional Chinese medicine for acne. Methods The Chinese medicine prescriptions containing facial mask prescription of traditional Chinese medicine for acne were researched from CNKI, Wanfang, VIP, CBM from January 2012 to March 2018, and the frequency of each prescription, four nature of drugs, five flavors, channel tropism, classification and the association rules between drugs were extracted and analyzed by TCMISS Chinese medicine inheritance assistant platform. Results Two hundred and fifty-one Chinese herbal prescriptions were collected. The high frequency herbs were Radix et Rhizoma Rhei, Radix Salviae Miltiorrhizae, Angelicae Dahuricae, Radix Scutellariae, Flos Lonicerae, Cortex Phellodendri, Fructus Forsythiae, Herba Taraxaci, Rhizoma Coptidis, Flos Chrysanthemi Indici, Radix Sophorae Flavescentis, and so on. The key drug combinations were “Radix et Rhizoma Rhei, Angelicae Dahuricae”, “Radix et Rhizoma Rhei, Radix Salviae Miltiorrhizae”, “Radix et Rhizoma Rhei, Radix Scutellariae”. The distribution of four nature of drugs was mainly cold, cool, warm, calm; the distribution of five flavors was mainly bitter, pungent, sweet, tasteless; the distribution of the channel tropism was mainly liver, stomach, heart, lung, spleen channel. Conclusion The facial mask prescription for external use of acne takes “clearing heat and activating blood” as the main treatment method, and the core drug is mainly for clearing heat; prescription drugs maimly take “clearing heat and removing toxicity, promoting blood circulation for removing blood stasis” as principle.
2018 Vol. 15 (28): 130-132,137 [Abstract] ( 238 ) HTML (1 KB)  PDF (670 KB)  ( 125 )
133 Clinical effects of acupoint stimulation on dynamic constipation in patients with schizophrenia induced by Clozapine Tablets
XU Weijie ZHANG Yan SUN Quan HUA Ying WANG Yan LU Xijin
Objective To explore the clinical effects of acupoint stimulation on dynamic constipation in patients with schizophrenia induced by Clozapine Tablets. Methods According to the random number table method, 120 cases of schizophrenia patients with dynamic constipation caused by Clozapine Tablets were selected from May 2016 to July 2017 in the Second People′s Hospital of Lishui City, who were divided into treatment group and drug group, with 60 cases in each group. The treatment group was treated with acupoint stimulation therapy, while the drug group was given Phenolphthalein Tablets, lasting for 6 weeks. The therapeutic effects of the two groups before treatment and after treatment for 2, 4, 6 weeks were compared. The incidence of adverse events of the two groups was compared during the treatment, including dermatitis, drug rash, and so on. The quality of life before treatment and after 6 weeks of treatment was compared between the two groups, and the adherence to Clozapine Tablets 1 month after the end of treatment was compared. Results The chronic constipation severity (CCS) scores of the treatment group before treatment and after 2, 4, 6 weeks of treatment were significantly lower than those of the drug group (P ＜ 0.05). There was significant difference in the distribution of treatment effect between the two groups (Z = 5.074, P ＜ 0.05). The total incidence of adverse events of the treatment group was significantly lower than that of the drug group (P ＜ 0.05). The patient assessment of constipation quality of life questionnaire (PAC-QOL) scores of psychology, physiology, satisfaction, worry and total score after treatment of the two groups were significantly lower than those before treatment (P ＜ 0.05), and the above indicators of the treatment group after treatment were significantly lower than those of the drug group (P ＜ 0.05). There was significant difference in the distribution of compliance between the two groups (Z = 5.496, P ＜ 0.05). Conclusion The effect of acupoint stimulation on the schizophrenia patients with dynamic constipation caused by Clozapine Tablets is significant, in addition, the compliance and quality of life of the patients are significantly improved, with higher safety.
2018 Vol. 15 (28): 133-137 [Abstract] ( 185 ) HTML (1 KB)  PDF (670 KB)  ( 194 )
138 The prognostic value of esophageal echocardiography in patients with atrial fibrillation in patients with atrial fibrillation
WEN Jia ZHANG Min GUO Liping QIN Lang
Objective To evaluate the predictive value of esophageal echocardiography in patients with atrial fibrillation in patients with atrial fibrillation. Methods A total of 148 patients with atrial fibrillation admitted to the Liuzhou Workers′ Hospital from October 2012 to January 2018 were selected and divided into thrombus group (22 cases) and the non-thrombotic group (126 cases). Trans-esophageal echocardiography and enhanced CT were performed in all patients, and echocardiographic parameters of two groups were observed. As clinical diagnosis was "gold standard", true positive rate, false positive rate, true negative rate, false negative rate, sensitivity, specificity and accuracy of the two examinations in the diagnosis of atrial appendage thrombosis were analyzed. Results Left atrial appendage maximal area (LAA-max) of diastole and the left atrial appendage minimum area (LAA-min) of paradoxical expansion in thrombus group were significant higher than that in non-thrombus group (P < 0.05). There was no statistically significant in the left atrial appendage width (LAA-D) and left atrial appendage length (LAA-L) of two groups (P > 0.05). True positive rate and true negative rate, diagnosis of atrial fibrillation by trans-esophageal echocardiography were 90.91% (20/22) and 90.48% (114/126) respectively, which were apparently higher than those of enhanced CT [63.64% (14/22), 61.90% (78/126), all P < 0.05]. The sensitivity, specificity and accuracy of trans-esophageal echocardiography in diagnosing atrial fibrillation with left atrial appendage thrombosis were 90.91%, 90.48% and 90.54%, which were significantly higher than those of enhanced CT examination (63.64%, 61.90%, 62.16%, all P < 0.05). Conclusion LAA-max and LAA-min were abnormally elevated in atrial fibrillation patients with left atrial appendage. Transesophageal echocardiography has a good predictive value for left atrial appendage thrombosis in patients with atrial fibrillation.
2018 Vol. 15 (28): 138-141 [Abstract] ( 222 ) HTML (1 KB)  PDF (416 KB)  ( 193 )
142 Study of the evaluation value of contrast-enhanced ultrasonography on the stability of carotid atherosclerotic plaque and new blood vessels
ZHANG Yuan DENG Shuhao ZHU Yicheng JIANG Quan
Objective To explore the evaluation value and clinical significance of contrast-enhanced ultrasonography on the stability of carotid atherosclerotic plaque and new blood vessels. Methods From July to October 2017, 200 patients taken the carotid artery ultrasonography examination in Pudong New Area People′s Hospital of Shanghai City were selected. The relationship between carotid artery atherosclerotic plaque, plaque thickness and plaque enhancement were statistically analyzed. Patients with internal carotid artery stenosis were divided into two groups: symptomatic group (n = 74) and asymptomatic group (n = 126), according to whether there were cerebral infarction and transient ischemic attack. The intensity of plaque contrast enhancement (EI), the ratio of the plaques(ratio), and plaque enhancement in the plaques were calculated respectively. Results The plaque echo was low echo and mixed echo, and the ratio of plaque enhancement were significantly higher than that of medium echo and strong echo, and the differences were statistically significant (P < 0.05). Contrast-enhanced ultrasound enhancement ratio of plaque of thickness more than 2.0 mm were significantly higher than that of the thickness of 2.0 mm or less plaques, the difference was statistically significant (P < 0.05). In patients with degree of internal carotid artery stenosis ≥50% (n = 91), the symptom group EI and ratio were significantly higher than the asymptomatic group, the composition of grade 1 plaque enhancement in the symptomatic group was significantly lower than that in the asymptomatic group, and the composition of the grade 3 plaques enhancement was significantly higher than that in the asymptomatic group, the differences were statistically significant (P < 0.01). Conclusion Contrast-enhanced ultrasonography can show the angiogenesis in the plaques, and the enhancement degree of plaque is closely related to the echo, thickness. There is a close relationship between atherosclerotic plaque property, vascular grading in plaques, cerebral infarction, cerebral ischemia and other clinical symptoms.
2018 Vol. 15 (28): 142-145 [Abstract] ( 255 ) HTML (1 KB)  PDF (530 KB)  ( 103 )
146 Error optimization and effectivenes analysis in initial period of informationalized PIVAS
YI Juanjuan XU Jiandong LI Ziye JIANG Xiaowei
Objective To explore the errors in initial period of informationalized pharmacy intravenous admixture services (PIVAS) for reinforcing the security of vein transfusion. Methods From April 2016 to March 2017, a total of 511 cases of errors in initial period of informationalized PIVAS in Jiangwan Hospital in Hongkou District (“our hosipital” for short) were analyzed, meanwhile the types of errors, causes, preventive measures were summarized, and the effects were evaluated by two stages. Results The PIVAS errors were mainly occurred in prescription check, drug dispensing, drug admixture. Considering the errors in each step, improvement measures had been implemented. In the second stage (2016.10-2017.3), the overall error rate decreased by 37.28% compared with that in the first stage (2016.4-2016.9), and the rate of irrational prescription reduced gradually. Conclusion By optimizing information system, developing independent platform of prescription evaluation, strengthening personnel management and system standordized mauagement can reduce the occur of error, and insure the security, rationality, effectiveness of clinical drug use.
2018 Vol. 15 (28): 146-149 [Abstract] ( 225 ) HTML (1 KB)  PDF (588 KB)  ( 161 )
150 An empirical study on patients′ satisfaction with outpatient registration based on patients′ needs
ZHU Xiaobo ZHU Yanping
Objective To explore patients′ satisfaction with outpatient registration based on patients′ needs. Methods The subjects were 2000 patients from June 2016 to June 2017 admitted to the First Affiliated Hospital of Hebei North University, and they were divided into observation group and control group according to the random number table method, with 1000 patients in each group. In the observation group, 1000 patients were registered in the outpatient clinic based on patients′ needs, and the other 1000 patients in the control group were registered in the routine outpatient service which did not carry out the method based on patients′ needs. The time of registration, the degree of satisfaction and subsequence visit registration menthod were explored. Results The time of registration in the observation group was shorter than that of the control group, the difference was statistically significant (P ＜ 0.01) in different periods, and the degree of satisfaction of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.01). The window registration and online appointment rate in the observation group was significantly lower than that in the control group, the difference was statistically significant (P ＜ 0.01), while the rate of other registration methods was higher than that in the control group, and the difference was statistically significant (P ＜ 0.01). Conclusion Applying the registration method based on the patients′ needs can greatly improve the patients′ satisfaction, shorten the registration time and change the registration form of follow-up visit. It is worth of application and promotion.
2018 Vol. 15 (28): 150-153 [Abstract] ( 228 ) HTML (1 KB)  PDF (548 KB)  ( 69 )
154 Research on employee assistance program in hospital management
LI Nan HUANG Wei SHENG Yongjiao HE Jingshu ZHOU Lei
The employee assistance program is an important means of contemporary human resource management. Its purpose is to improve physical and mental health of employees and improve the performance of the organization. This article takes the clinician as the research object, and through literature analysis, points out the necessity of the hospital's implementation of the employee assistance program, identifies the factors that affect the hospital′s implementation of the employee assistance plan, and formulates an effective employee assistance plan that can be applied to the hospital. It could provide theoretical guidance for the implementation of the employee assistance program in the future, and provide security for the hospital′s human resource management system. To a certain extent, it enhances the enthusiasm of employees and improves the hospital′s performance.
2018 Vol. 15 (28): 154-157 [Abstract] ( 227 ) HTML (1 KB)  PDF (554 KB)  ( 130 )
158 Nursing effect of Chinese traditional medicine acupoint sticking on children with recurrent respiratory tract infection
LAN Hong LIN Hong HUO Yan XU Ye
Objective To explore the nursing effect of Chinese traditional medicine acupoint sticking on children with recurrent respiratory tract infection. Methods From November 2015 to December 2016, in General Hospital of Benxi Steel Group Corporation, 110 children with recurrent respiratory tract infection were selected, and they were divided into the control group and the observation group by the random digital table method, with 55 cases in each group. The two groups were treated with routine nursing care. On the basis of this, the children in the observation group were treated with acupoint sticking and comprehensive nursing intervention. The clinical efficacy, disappearance time of symptoms and signs, the number of repeated infection in 1 year and the nursing satisfaction of parents in two groups were observed. Results The effective rate of children in the observation group was higher than the control group, the difference was statistically significant (P < 0.05); the time of disappearance of clinical symptoms, the number of repeated infection in 1 year in the observation group were less than the control group, the differences were statistically significant (P < 0.05); the nursing satisfaction rate of parents in the observation group was significantly higher than the control group, the difference was statistically significant (P < 0.05). Conclusion Traditional Chinese medicine acupoint sticking combined with comprehensive nursing measures can improve the clinical effect of recurrent respiratory infection in children, reduce the number of recurrent infection, improve the nursing satisfaction of the parents, it is worth popularizing in clinical practice.
2018 Vol. 15 (28): 158-160,169 [Abstract] ( 227 ) HTML (1 KB)  PDF (611 KB)  ( 69 )
161 Influence of health education of joint medical responsibility group on patients with atrial fibrillation treated by catheter radiofrequency ablation
WU Yuping1 LI Bin2 LIN Xiaojie1 ZHANG Hong3
Objective To observe the effect of health education of joint medical responsibility group on patients with atrial fibrillation treated by radiofrequency catheter ablation. Methods From February 2015 to February 2016, 54 patients with atrial fibrillation treated by radiofrequency catheter ablation in Hainan Provincial People′s Hospital were selected, they were divided into control group and observation group by random lottery principle, with 27 cases in each group. The control group was given routine education, and the observation group was given health education of joint medical responsibility group, the quality of life of patients in the two groups after health education and the formation of lower extremity venous thrombosis were compared. Results The physical function, physical role, general health, vitality, social function, emotional role and mental health in observation group were significantly better than the control group, the differences were statistically significant (P < 0.01); there was no significant difference in the body pain between the control group and the observation group (P > 0.05); the occurrence rate of lower limb vein thrombosis in the observation group was lower than the control group, the difference was statistically significant (P < 0.05). Conclusion The application of health education of joint medical responsibility group in patients with atrial fibrillation radio frequency catheterization can effectively improve the quality of life of patients, and reduce the proportion of patients with venous thrombosis, it is worthy of clinical application and promotion.
2018 Vol. 15 (28): 161-163,181 [Abstract] ( 206 ) HTML (1 KB)  PDF (705 KB)  ( 87 )
164 A Meta-analysis of effects of music intervention on psychological and physiological responses of patients receiving maintenance hemodialysis
LI Wenxia1 WANG Li2 XI Jing2 ZHANG Qianqian2 YIN Qionghua1▲
Objective To evaluate the effects of music intervention on psychological and physiological responses of patients receiving maintenance hemodialysis. Methods Databases including The Cochrane Library, PubMed, Embase, EBCCO, CBM, CNKI and Wanfang data were searched to collect references about randomized controlled trials related with the effectiveness of music intervention on psychological and physiological responses of patients receiving maintenance hemodialysis. RevMan 5.3 software was used for statistical analysis. Results A total of 17 literatures were included, which involved 1326 patients. The results of Meta-analysis showed that listening to music was able to relieve anxiety (SMD = -1.22, 95%CI: -1.82 - -0.62, P < 0.01) and depression (WMD = -6.73, 95%CI: -8.33 - -5.12, P < 0.01) of MHD patients, and reduce heart rate (WMD = -6.24, 95%CI: -10.42 - -2.05, P = 0.003), systolic pressure (SMD = -0.47, 95%CI: -0.75 - -0.19, P < 0.01), diastolic pressure (SMD = -0.46, 95%CI: -0.71 - -0.20, P < 0.01) and the incidence of complications (RR = 0.41, 95%CI: 0.17-1.01, P = 0.05). Conclusion Music intervention can reduce the anxiety and depression of MHD patients, stabilize the heart rate and blood pressure, decrease the complications rate. However, because of the quality of  studies included in the current research is relative low, further research with larger sample and higher quality is needed to confirm our conclusion.
2018 Vol. 15 (28): 164-169 [Abstract] ( 202 ) HTML (1 KB)  PDF (1632 KB)  ( 131 )
170 Research on teaching effect of diversified infectious diseases emergency training mode 
LIN Dongling1 GUO Jing2 Kalbinur·Litip1 NING Yanhui3▲
Objective To study the teaching effect of diversified infectious diseases emergency training mode. Methods In Xinjiang Medical University, 48 nurses were selected as the research object by cluster sampling method, from January to December 2014, they were given diversified infectious diseases meet an emergency training model, from January to December 2016, they were given regular training mode. The theoretical scores and operational scores, simulated exercise coping ability before and after intervention of the nurses were compared, the psychological resilience and occupation recognition were evaluated by self-made psychological resilience and occupation recognition evaluation questionnaire, the statistical method was used to compare and analyze, technique for order preference by similarity to an ideal solution (TOPSIS) was used to comprehensively evaluate. Results The theoretical score, operation assessment and the response ability of the diversified infectious diseases emergency training mode were better than regular training, the differences were statistically significant (P < 0.05); the professional recognition evaluation of the diversified infectious diseases emergency training mode was lower than regular training, the difference was statistically significant (P < 0.05); the resilience total score, compressive ability and self-determination ability of diversified infectious diseases emergency training mode were higher than regular training, the differences were statistically significant (P < 0.01). The TOPSIS method showed that diversified infectious diseases emergency training mode were higher than regular training. Conclusion The diversified infectious diseases emergency training mode can effectively improve the ability of nurses in Department of Infection to cope with the epidemic disease outbreak, it is worth future application.
2018 Vol. 15 (28): 170-173 [Abstract] ( 164 ) HTML (1 KB)  PDF (631 KB)  ( 51 )
174 Comparative study of nurse standardized training skills in multiple station simulation teaching and traditional teaching
NIE Shaoju TANG Wanzhen
Objective Comparing the difference between "multi-station simulation teaching" and traditional teaching in nurses′ standardized training and operation skills. Methods In Yongchuan Affiliated Hospital of Chongqing Medical University ("our hospital" for short), nurses who graduated in our hospital in September 2017 were selected as experiment group, they were given "multi-station simulation teaching", nurses who graduated in September 2016 were selected as control group, they were given traditional teaching mode. Results The satisfaction of base, assessment of comprehensive skills scores and operating skills scores of nurses with bachelor degree in experiment group were higher than control group, the differences were statistically significant (P < 0.05); the satisfaction of base, emergency skill scores and operating skills scores of nurses with college degree in experiment group were higher than control group, the differences were statistically significant (P < 0.05). Conclusion Compared to traditional teaching methods, the “multi-station simulation teaching” model is more conducive to nurses to master the skills of nursing operations and improve their communication skills, hands-on abilities and comprehensive abilities, "multi-station simulation teaching" has more advantages and it is worth promoting in the teaching of nurses.
2018 Vol. 15 (28): 174-177 [Abstract] ( 287 ) HTML (1 KB)  PDF (627 KB)  ( 110 )
178 Comparison of two sealing methods of implanted port in patients with leukemia
WANG Cui CAO Tingting ZHAO Bo
Objective To compare the effects of heparin sealing and saline sealing in the implantation of intravenous infusion port in children with leukemia. Methods A total of 40 children with leukemia admitted to the Department of Hematology, Children′s Hospital of Capital Institute of Pediatrics, from December 2015 to March 2017, were selected by sampling technique. All children were surgically passed through the Sytech technique in the right neck. The internal vein was implanted into the intravenous infusion port. The first 20 cases were the experimental group, and the last 20 cases were the control group. The experimental group was sealed with 10 mL of normal saline at the end of the daily infusion, and then sealed with 5 mL of normal saline. The control group was routinely pulsed with 10 mL of normal saline, and then sealed with 5 mL of heparin saline (10 U/mL). Whether there were differences in catheter occlusion after the two methods were observed. Results During continuous infusion, there was no significant difference in the occurrence of catheter occlusion between the two groups (P > 0.05). Conclusion During the continuous infusion, the daily use of saline alone for the closure of children with leukemia in the port of intravenous infusion does not increase the incidence of tube blockage, which is worthy of popularization and application.
2018 Vol. 15 (28): 178-180 [Abstract] ( 233 ) HTML (1 KB)  PDF (736 KB)  ( 197 )
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