|
|
Therapeutic effect of low temperature plasma ablation in conjunction with lumbar sympathetic nerve catheterization on the lumbar discogenic visceral pain |
LU Haiyan1 YANG Liqiang1 TANG Yuanzhang1 PENG Kejun2 FANG Shengchun3 NI Jiaxiang1 |
1.Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;
2.Department of Anesthesiology, Youan Hospital, Capital Medical University, Beijing 100069, China;
3.Department of Anesthesiology, Wuhan Children′s Hospital, Hubei Province, Wuhan 430016, China |
|
|
Abstract Objective To discuss the therapeutic effect of low temperature plasma ablation in conjunction with lumbar sympathetic nerve catheterization on the lumbar discogenic visceral pain. Methods Thirty-four patients with lumbar discogenic visceral pain who were treated in the Xuanwu Hospital, Capital Medical University from January 2015 to January 2017 were divided into two groups. Eighteen patients treated with the lumbar sympathetic nerve catheterization were included into Group A, and 16 patients treated with the low temperature plasma ablation in conjunction with lumbar sympathetic nerve catheterization were included into Group B. The numeric rating scales (NRS) depending on the level of pain of two groups before surgery and different periods after surgery (immediately, 1 week, 3, 6 and 12 months) were recorded. The self-rating depression scale (SDS) of two groups before and 12 months after surgery were contrasted. The NRS differentials of two groups before surgery and immediately, 1 week, 3, 6, 12 months after surgery and the SDS scores and differentials of two groups before and 12 months after surgery were analyzed. The NRS/SDS differentials were the NRS/SDS before surgery minus the NRS/SDS after surgery. Adverse reaction and complication after surgery were recorded. Results The NRS differential of 3, 6, 12 months after surgery of Group B were higher than those of Group A, the differences were statistically significant (P = 0.001, 0.001, 0.011). The SDS scores of two groups before surgery showed no statistical significance (P = 0.397). The SDS scores of Group A before and 12 months after surgery showed no statistical significance (P = 0.974). And the SDS scores of Group B before and 12 months after surgery showed statistical significance (P = 0.001). The SDS differential of 12 months after surgery of Group B was higher than that of Group A with statistical significance (P = 0.010). The two groups exhibited no complication such as paresthesia or numbness in corresponding dominating region caused by infection and nerve injury. Conclusion Compared with single lumbar sympathetic nerve catheterization, the low temperature plasma ablation in conjunction with lumbar sympathetic nerve catheterization exhibits a better effect in mid-long-term on lumbar discogenic visceral pain, and can relieve the depression.
|
|
|
|
|
[1] Giamberardino MA. Recent and forgotten aspects of visceral pain [J]. Eur J Pain,1999,3(2):77-92.
[2] 张弘弘,孙艳,徐广银.慢性内脏痛的病理机制研究和临床治疗新进展[J].中国疼痛医学杂志,2017,23(1):2-20.
[3] 卞晶晶,唐元章,武百山,等.大鼠退变髓核腰交感神经干注射对交感神经干炎症因子表达的影响[J].中国实验诊断学,2014,18(10):1567-1570.
[4] Tang Y,Shannon ML,Lai G,et al. Anterior herniation of lumbar disc induces persistent visceral pain:discogenic visceral pain [J]. Chin Med J,2013,126(24):4691-4695.
[5] Sikandar S,Dickenson AH. Visceral pain-the ins and outs,the ups and downs [J]. Curr Opin Support Palliative Care,2012,6(1):17.
[6] Buonocore M,Aloisi AM,Barbieri M,et al. Vertebral body innervation:implications for pain [J]. J Cell Physiol,2010, 222(3):488-491.
[7] 胡有谷,李放,张永刚,等.椎间盘源性腰痛[J].中国脊柱脊髓杂志,2004,14(6):327-330.
[8] Mizuno S,Takebayashi T,Kirita T,et al. The effects of the sympathetic nerves on lumbar radicular pain:a behavioural and immunohistochemical study [J]. J Bone Joint Surg Br,2007,89(12):1666-1672.
[9] Wong-Chung JK,Naseeb SA,Kaneker SG,et al. Anterior disc protrusion as a cause for abdominal symptoms in childhood discitis:a case report [J]. Spine,1999,24(9):918-920.
[10] 徐栋华.浅说腰源性腹痛[J].家庭医学,2018,34(3):22.
[11] 刘雨辰,彭宝淦.椎间盘源性腰痛神经传导通路的研究进展[J].中华外科杂志,2014,15(8):627-628.
[12] 王飞,王丹,王秋彬.低温等离子髓核消融术治疗腰椎间盘突出症的临床效果[J].浙江医学,2017,39(12):1011-1013.
[13] Kasch R,Mensel B,Schmidt F,et al.Disc volume reduction with percutaneous nucleoplasty in an animal model [J]. PLoS One,2012,7(11):e50211.
[14] O′Neill CW,Liu JJ,Leibenberg E,et al. Percutaneous plasma decompression alters cytokine expression in injured porcine intervertebral discs [J]. Spine J,2004,4(1):88-98.
[15] Eichen PM,Achilles N,Konig V,et al. Nucleoplasty,a minimally invasive procedure for disc decompression:a systematic review and meta-analysis of published clinical studies [J]. Pain Phys,2014,17(2):e149-e173.
[16] 王永刚,周海宇,王栓科,等.神经肽Y/降钙素基因相关肽在腰椎间盘中的分布与共表达[J].中国组织工程研究,2012,16(48):9039-9043.
[17] 时培晟,王栓科,王永刚,等.神经肽Y2受体对神经病理痛调制的研究进展[J].现代生物医学进展,2013,13(1):191-193.
[18] 何亮亮,倪家骧.低温等离子射频髓核成形术在椎间盘源性疼痛中的临床应用[J].中国康复医学杂志,2015, 30(7):743-746.
[19] Plourde V,St-Pierre S,Quirion R. Calcitonin gene-related peptide in viscerosensitive response to colorectal distension in rats [J]. Am J Physiol,1997,273(1):191-196. |
|
|
|