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| Research on glioma microenvironment |
| LI Xun1 AI Wenbing2 |
1.Medical College of China Three Gorges University, Hubei Province, Yichang 443000, China;
2.Yiling Hospital of Yichang City, Hubei Province, Yichang 443000, China |
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Abstract The glioma is the most common primary intracranial malignancy in adults. Current treatments include surgery, radiotherapy, and oral chemotherapy drug temozolomide. These treatments have a certain cure rate, but there is still the possibility of recurrence. The main reason is that tumor cells can survive and rebuild tumors during the treatment. Therefore, it is essential for the treatment of tumors to know the molecular mechanism that regulates the activity of tumor cells. Glioma stem cells (GSC) tolerance to conventional radiotherapy and chemotherapy may be one of the causes of glioma recurrence. The tumor microenvironment in which GSC located is related to the development of GSC, which also provides a new idea for the treatment of gliomas. This article focuses on the research progress of GSC-related tumor microenvironment and the treatment of gliomas through targeted microenvironment.
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