穴位刺激治疗氯氮平片所致精神分裂症患者动力性便秘的临床效果

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Abstract Objective To explore the clinical effects of acupoint stimulation on dynamic constipation in patients with schizophrenia induced by Clozapine Tablets. Methods According to the random number table method, 120 cases of schizophrenia patients with dynamic constipation caused by Clozapine Tablets were selected from May 2016 to July 2017 in the Second People′s Hospital of Lishui City, who were divided into treatment group and drug group, with 60 cases in each group. The treatment group was treated with acupoint stimulation therapy, while the drug group was given Phenolphthalein Tablets, lasting for 6 weeks. The therapeutic effects of the two groups before treatment and after treatment for 2, 4, 6 weeks were compared. The incidence of adverse events of the two groups was compared during the treatment, including dermatitis, drug rash, and so on. The quality of life before treatment and after 6 weeks of treatment was compared between the two groups, and the adherence to Clozapine Tablets 1 month after the end of treatment was compared. Results The chronic constipation severity (CCS) scores of the treatment group before treatment and after 2, 4, 6 weeks of treatment were significantly lower than those of the drug group (P ＜ 0.05). There was significant difference in the distribution of treatment effect between the two groups (Z = 5.074, P ＜ 0.05). The total incidence of adverse events of the treatment group was significantly lower than that of the drug group (P ＜ 0.05). The patient assessment of constipation quality of life questionnaire (PAC-QOL) scores of psychology, physiology, satisfaction, worry and total score after treatment of the two groups were significantly lower than those before treatment (P ＜ 0.05), and the above indicators of the treatment group after treatment were significantly lower than those of the drug group (P ＜ 0.05). There was significant difference in the distribution of compliance between the two groups (Z = 5.496, P ＜ 0.05). Conclusion The effect of acupoint stimulation on the schizophrenia patients with dynamic constipation caused by Clozapine Tablets is significant, in addition, the compliance and quality of life of the patients are significantly improved, with higher safety.

Key words： Acupoint stimulation Dynamic constipation Schizophrenia Clozapine Tablets

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	XU Weijie ZHANG Yan SUN Quan HUA Ying WANG Yan LU Xijin

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XU Weijie ZHANG Yan SUN Quan HUA Ying WANG Yan LU Xijin. Clinical effects of acupoint stimulation on dynamic constipation in patients with schizophrenia induced by Clozapine Tablets[J]. 中国医药导报, 2018, 15(28): 133-137.

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http://www.yiyaodaobao.com.cn/EN/ OR http://www.yiyaodaobao.com.cn/EN/Y2018/V15/I28/133

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