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2018 Vol. 15, No. 9
Published: 2018-03-25
 
 
4 Primary study of Astragalus polysaccharides in inhibiting myocardial oxidative stress of diabetes mellitus 
CHEN Wei1▲ JU Jing1 WANG Hao2 WANG Liying2 YANG Yehong3 YE Hongying3 LI Yiming3 ZHANG Yu1▲
Objective To investigate the effect of Astragalus polysaccharides for myocardial oxidative stress of diabetes mellitus. Methods Sixteen male healthy transgenic SOD2+/-KO mice aged 6-8 weeks old (C57BL/6J) were randomly divided into transgenic group and Astragalus polysaccharides transgenic group by random number table method (n = 8). The 24 normal control mice were divided into control group, diabetes mellitus group and Astragalus polysaccharides diabetes mellitus group (n = 8). Single intraperitoneal injection of Streptozotocin was utilized to establish mice model with diabetes mellitus in diabetes mellitus group and Astragalus polysaccharides diabetes mellitus group, after the diabetes mellitus model was made successfully, the mice in Astragalus polysaccharides diabetes mellitus group and Astragalus polysaccharides transgenic group were treated with Astragalus Polysaccharides Injection for 16 weeks, and the other groups were given equal amount of normal saline. Echocardiography was used to detect cardiac function, HE staining was used to observe the structure of myocardial tissue, ultrasonic electron microscopy was used to observe the myocardial ultrastructure, immunohistochemistry was used to detect the proliferative activity of cardiomyocytes, TUNEL method was used to detect apoptosis of cardiomyocytes; fluorescent quantitative assay was used to detect the contents of myocardial reactive oxygen species (ROS), Western blot was used to detect the contents of myocardial SOD2 protein, calbiochem SOD assay kit Ⅱ was used to detect the activity of myocardial SOD2. Results Compared with the control group, LVSP and ±LVdp/dt in diabetes mellitus group and transgenic group were decreased, and LVEDP was increased, myocardial tissue and ultrastructure were seriously damaged, the degree of cells apoptosis and necrosis was increased, and the activity of SOD2 was significantly inhibited. However, the indices above in the Astragalus polysaccharides were all signifcantly improved (P ＜ 0.05). Conclusion Astragalus polysaccharides can inhibit the myocardial oxidative stress injury of diabetes mellitus.
2018 Vol. 15 (9): 4-7 [Abstract] ( 240 ) HTML (1 KB)  PDF (541 KB)  ( 131 )
8 Protective effect of remote ischemic preconditioning on spinal cord ischemia reperfusion injury and its possible mechanism in a rabbit model
YU Qijing1 TIAN Wenhua2 YANG Yunzhao1
Objective To investigate the protective effect of remote ischemic preconditioning (RIPC) on spinal cord ischemia reperfusion injury (SCIRI) and its possible mechanism in a rabbit model. Methods Thirty-six rabbits were randomly divided into sham operation group (Sham group), ischemia reperfusion group (IR group), IR+ RIPC group, 12 rats in each group. On the 2 sec and 5th day after reperfusion, 6 animals were sacrificed respectively. Animals in Sham group were exposed abdominal aorta (without interruption), IR group and IR+RIPC group received abdominal aortic clamp 30 min, and established SCIRI model. IR + RIPC group underwent RIPC before aortic clamp 1 h. All animals were evaluated for hindlimb function scores in postoperative 2 days and 5 days, according to the Tarlov standard, and then were sacrificed and the L3 - L5 segment of the spinal cord were detected to observe the pathological changes of spinal cord tissues. Meanwhile, the SOD1 activity and the expression level of SOD1 mRNA were detected. Results On the same timepoint, compared with the Sham group, the neurological function scores and pathological grading of spinal cord tissue in IR group were significantly decreased (P < 0.01）, but compared with the IR group, the neurological function scores and pathological grading of spinal cord tissue in IR+ RIPC group were significantly improved (P < 0.01). On the second day after operation, compared with the Sham group, the activity of SOD1 and the expression level of SOD1 mRNA in the IR+RIPC group were all significantly increased (P < 0.01), whereas there was no significant change in the IR group (P > 0.05). On the 5th day after operation, compared with the Sham group, the activity of SOD1 and the expression level of SOD1 mRNA in the IR group were all significantly decreased (P < 0.01), and there was no significant change in the IR+RIPC group (P > 0.05). Compared with IR group, the SOD1 activity and the expression level of SOD1 mRNA were all significantly increased in the RIPC group (P < 0.01). The change of SOD1 mRNA expression in spinal cord was positively related to the change of SOD1 activity in IR group or IR+ RIPC group (R=0. 96 or 0.97, all P < 0.01). Conclusion RIPC has a certain preventive effect on rabbit SCIRI, and its mechanism is related to enhancing the expression of SOD1 in ischemic region of spinal cord tissues.
2018 Vol. 15 (9): 8-12 [Abstract] ( 228 ) HTML (1 KB)  PDF (767 KB)  ( 64 )
13 Effect of optimized myocardial energy metabolismon on the expression of hypoxic induction factor-1 and vascular endothelial growth factor in rats with superior mesenteric venous thrombosis
YU Xiangyang XIE Zongyuan CHEN Jianli ZHANG Guozhi CAO Wenbin DAI Liang HE Yanfang▲
Objective To study the effect of optimized myocardial energy metabolism on the expression of hypoxic induction factor-1 (HIF-1) and vascular endothelial growth factor (VEGF) in rats with superior mesenteric venous thrombosis. Methods Forty-five healthy adult SD rats were divided into control group, model group and treatment group by random number table. The model group animals were tested for the model, which were fed after subcutaneous injection of 0.2 mL/100 g of physiological saline solution. After the animals were formed, the tail vein was injected with Trimetazidine (10 mg/kg) in the treatment group. The control group was only opened the abdominal cavity, but was not block the blood transport, then injected the physiological saline with 0.2 mL/100 g. Each group was given a 12 h interval for drug intervention until 72 h after surgery. General state, abdominal cavity condition and pathological condition were observed, HIF-1, VEGF and malondialdehyde (MDA), creatine kinase (CK), and adenosine triphosphate (ATP) levels were determined. Results The general situation, peritoneal condition and intestinal histopathological observation of control group were normal, while intestinal of the model group was necrosis, the part region was perforation, consciousness and activity of treatment group, blood transport of intestinal was basically normal, and there was no bleeding edema and no necrosis. Compared with the control group, the levels of HIF-1, VEGF, MDA and CK in the model group were significantly higher, ATP level was decreased, with statistically significant difference (P < 0.05). Compared with the model group, the levels of HIF-1, VEGF, MDA and CK in the treatment group were decreased significantly, ATP level was higher, with statistically significant difference (P < 0.05). Conclusion Optimize energy metabolizer Trimetazidine can remove free radical damage to myocardial cells, and can significantly reduce VEGF and hif-1 levels, improve the condition of venous thrombosis in animal intestines with good effect.
2018 Vol. 15 (9): 13-17 [Abstract] ( 232 ) HTML (1 KB)  PDF (1114 KB)  ( 102 )
18 Effect and its related mechanism of TNF-α on programmed necrosis of osteoblasts
LIU Kai1 ZHUO Hongwu1 LIU Jianzhong2 KE Dianshan2▲
Objective To explore the effect and its related mechanism of TNF-α on programmed necrosis of osteoblasts. Methods Mice osteoblasts were isolated and cultured from suckling mice, and TNF-α was used to induce programmednecrosis of osteoblasts, Nec-1 was used to inhibit cell necrosis. Normal cultured osteoblasts were used as normal control group, and MTT assay was used to detect the cell proliferation. Tunel and Caspase 3 double staining was used to detect the programmed necrosis of osteoblasts. The expression of RIP1, RIP3 and MLKL were detected by Western blot. Results Compared with the normal control group, the proliferation activity of TNF-α group was decreased and the number of programmed necrosis was increased (P < 0.05). After the Nec-1 treatment, the proliferative activity was significantly increased compared with TNF-α group, and the number of programmed necrosis was decreased (P < 0.05). As time went on, the differences between the groups became more pronounced (P < 0.05). Compared with the normal control group, expression of RIP3 and MLKL protein in TNF-α group was significantly lower than that in normal control (P < 0.05). After the Nec-1 treatment, the expression of RIP3 and MLKL protein had significantly differences compared with TNF-α group (P < 0.05). Conclusion TNF-α can inhibit osteoblast proliferation and promote programmed necrosis of osteoblasts, which may be accomplished by reducing the expression of RIP3 and MLKL proteins in osteoblasts.
2018 Vol. 15 (9): 18-21,40 [Abstract] ( 309 ) HTML (1 KB)  PDF (1165 KB)  ( 62 )
22 Research progress of ligamentous fixator in promoting the tendon-to-bone healing
SHI Fengtian1 WEI Min2 ZHANG Mei1 CHAI Shuyu1 WEI Yafei1 LI Dengyun1
In the reconstruction of ligament, autograft, allograft and artificial ligament all have enough mechanical properties to meet the needs of reconstructive surgery. Ligament fixation devices become the key elements to decide whether the operation is successful or not. This paper briefly introduces several kinds of commonly used clinical ligament fixation devices, and describes how to restrain from "wiper effect" "bungee effect" and "joint fluid infusion", reduce the extent of bone tunnel expansion, focuses on the description of the human effort to promote the tendon-to-bone healing effect by improving the way to use the fixation devices, material selection, structure design, etc. The efforts are expected to provide help for the development of a new type of fixer.
2018 Vol. 15 (9): 22-25 [Abstract] ( 259 ) HTML (1 KB)  PDF (534 KB)  ( 303 )
26 Research progress on the evaluation and evaluation of the standardized training of newly enrolled nurses
XIAO Hui1,2 WEN Xianxiu2 GOU Li2 LUO Hui2,3
Nurses standardized training is an effective way to train qualified clinical nursing talents. The quality of training and the guarantee of training effect lie not only in the effective training process, but also in the scientific evaluation. At present, the evaluation of the effect of standardized training on nurses in our country is still at the exploratory stage in terms of assessment indicators, ways and means of assessment and assessment models, and yet no standard assessment system has been established. And the training assessment is an important part of nurses standardized training, which is of great significance to improve the operational skills and overall quality of new nurses. Therefore, the author will analyze and summarize the research status quo of the standardized training appraisal and evaluation of newly recruited nurses both at home and abroad, and put forward the enlightenment of constructing the standardized appraisal and evaluation system of nurses so as to guide the new recruiting nurse training outline (Trial) document Under the normative training assessment, to provide theoretical basis and practical guidance for improving and developing the standardized training of nurses in our country.
2018 Vol. 15 (9): 26-30 [Abstract] ( 268 ) HTML (1 KB)  PDF (565 KB)  ( 95 )
31 Research progress on the correlation between gene polymorphism and venous thrombosis
WANG Lu1,2 GE Weihong1 XU Hang1
Venous thromboembolism is polygenetic hereditary diseases, and the correlation of its genes has become a famous in academic research. This summary presents a review of literatures reported at home and abroad between ABO, F2, G20210A, PAI-1 in system gene polymorphism and venous thrombosis. This paper reviews the relevant research and provides new targets and new ideas for clinical prevention, diagnosis and disease treatment.
2018 Vol. 15 (9): 31-35 [Abstract] ( 223 ) HTML (1 KB)  PDF (550 KB)  ( 149 )
36 The related research progress of epidermal growth factor receptor - extracellular signal regulated kinase signaling pathway in the ischemic cerebrovascular disease
ZHANG Qin AO Ting XIAO Shuying XU Na ZHANG Ruihua▲
Ischemic cerebrovascular disease (ICD) is a common chronic disabling disease. This disease seriously affects the quality of lives of patients. The research shows that the epidermal growth factor receptor-extracellular signal regulated kinase (EGFR-ERK) pathway plays an important role on the pathophysiology process in ICD. However, the mechanism is still unclear. This article reviews the progress of the EGFR-ERK pathway in ICD, which provides references for further basic research and clinical treatment of ICD.
2018 Vol. 15 (9): 36-40 [Abstract] ( 207 ) HTML (1 KB)  PDF (547 KB)  ( 113 )
41 Study on the effect of mental resilience on the health behavior ability of hypertensive patients in rural areas
CHEN Juan1 LI Lijun2
Objective To investigate the clinical status of the healthy behavior ability of hypertensive patients in rural areas, in order to analyze the effect of psychological elasticity on them. Methods The Chinese version of the self rating health checklist and Resilience Scale were used to investigate 189 rural hypertensive patients in Pangang Gpoup General Hospital from March 2016 to May 2017. Results The average score of health behaviors of the 189 cases was (70.86±12.01)Points, and the average score of resilience was (68.90±9.15) points, and the scores of each dimension were positively correlated (P < 0.05). The results of multiple linear regression analysis showed that, besides the degree of culture and the course of high blood pressure, the dimensions of mental resilience also had positive predictive effects on the patients′ healthy behavior (P < 0.05). Conclusion Hypertension patients in rural areas have relatively poor health behavior ability. Clinical nurses should focus on low level of education and newly diagnosed patients, and pay attention to enhance their resilience, so as to improve their health behavior and clinical effect.
2018 Vol. 15 (9): 41-44 [Abstract] ( 231 ) HTML (1 KB)  PDF (445 KB)  ( 74 )
45 Investigation and analysis of tobacco use in the first episode schizophrenia of Xinjiang Uygur male population
ZHAO Zhiqiang WANG Li Rayhan·Abulaiti MA Ruichen XU Xiangdong▲
Objective To investigate the tobacco use in Uyghur men with first-episode schizophrenia and to investigate and analyze the prevalence of combined tobacco dependence. Methods A total of 273 Uygur men who were treated in Xinjiang Mental Health Center from January to December in 2016 were enrolled in this study, the status of tobacco use in patients with schizophrenia was investigated and analyzed by the General Self-made Scale, FNDT, and Russell Smoking Questionnaire (RRSQ). They were diagnosed according to the diagnosis of "tobacco use disorders" in the International Statistical Classification of Diseases and Related Health Problems (ICD-10) Criteria and screening positive patients (FTND ≥ 4) , and was RRSQ used for analysis of the reasons for smoking in patients. Results The lifetime smoking rate was 74.72% (204 cases) in 273 patients. Sixty-four cases were diagnosed as "tobacco use disorders" by ICD-10, accounting for 23.44%. In the questionnaire RRSQ of, for patients with FTND≤4 and FTND > 4, there was highly statistically significant difference between the two groups in psychological imagery, addiction, autoimmunity and dependence (P < 0.01). Conclusion Tobacco use is common in Uyghur men with first-episode schizophrenia, especially in tobacco-dependent comorbidities, which should arouse people′s attention; especially for the treatment of patients with schizophrenia complicated by tobacco dependence should arouse sufficient attention of psychiatrists, so as to provide a favorable basis for the further study.
2018 Vol. 15 (9): 45-48 [Abstract] ( 204 ) HTML (1 KB)  PDF (452 KB)  ( 114 )
49 The effect of tolterodine combined with estrogen in free urine flow rate in the treatment of adult female patients with overactive bladder
MA Guang XU Hui MA Hongliang HAN Bing LIU Ying WANG Zhiyong
Objective To investigate the free urine flow rate of tolterodine combined with estrogen in the treatment of adult female patients with overactive bladder (OAB). Methods From September 2012 to September 2014, 144 cases of OAB patients with frequent micturition and urgency treated in the Department of Urology, Nephrology and Gynecology of Affiliated Hospital of Chengde Medical College were selected as the research object and divided into the observation group and the control group accorded to the random draw envelope principle, with 72 cases in each group. The control group was given estrogen therapy, while the observation group was given tolterodine combined with estrogen. Both groups were treated for 3 months. The therapeutic effects, adverse reactions, the free urine flow rate, frequency of urination and urgency at night between the two groups were compared. Results After treatment, the total effective rate in the observation group (98.6%) was higher than that of control group (84.7%), with statistically significant difference (P ＜ 0.05). Before treatment, there were no statistically significant differences between the two groups in the free urine flow rate, frequency of urination and urgency at night (P ＞ 0.05). After treatment, the free urine flow rate in both groups were all higher than those of before treatment, the symptoms of frequency of urination and urgency at night in both groups were lower than those of before treatment, and the indicators above in the observation group improved much more remarkably, with statistically significant differences (all P ＜ 0.05). During the treatment, the incidence of adverse reactions such as dry mouth and constipation in the observation group were lower than those of control group, but with no significant differences (P ＞ 0.05). Conclusion Tolterodine combined with estrogen in the treatment of adult female patients with OAB can increase the free urine flow rate, improve the clinical symptoms, promote the curative effect and has good security. It is worthy of clinical promotion and application.
2018 Vol. 15 (9): 49-52 [Abstract] ( 248 ) HTML (1 KB)  PDF (342 KB)  ( 119 )
53 Effect of transarticular decompression fusion combined with Dynesys dynamic stabilization system in the treatment of patients with lumbar degenerative disease
DU Xinchong1 WANG Jun1 LI Huaguang1 WANG Yanbo1 YANG Yipeng2 ZhANG Peinan1
Objective To explore and analyze the effect of transarticular decompression fusion combined with Dynesys dynamic stabilization system in the treatment of patients with lumbar degenerative disease. Methods From August 2014 to August 2015, 100 patients with lumbar degenerative disease admitted to the First Affiliated Hospital of Hebei North University were selected as the research subjects and divided into the control group and the observation group by the random number table, with 50 cases in each group. The control group treated with transarticular decompression treatment, while the observation group treated with transarticular decompression fusion combined with Dynesys dynamic stabilization system. The overall lumbar activity, lumbar segment activity, adjacent intervertebral activities, adjacent intervertebral height and lumbar function score (ODI) were compared preoperative, posteoperative of 1, 12 month and 24 month between the two groups. Results Before operation, there was no statistically signicant difference in the overall lumbar activity between the two groups (P ＞ 0.05); after operation of 1, 12 month and 24 month, the overall lumbar activity in the two groups were all lower than those of before operation; and with the extension of time, the overall lumbar activity in the two groups were all increased, and the indicator in the observation group increased much more significantly than that of control group, with statistically signicant difference (P ＞ 0.05). Before operation, there was no statistically signicant difference in the lumber segment activity between the two groups (P ＞ 0.05); after operation of 1, 12 month and 24 month, the lumber segment activity in the two groups were all lower than those of before operation; and with the extension of time, the lumber segment activity in the two groups were all increased, and the indicator in the control group increased much more significantly than that of observation group, with statistically signicant difference (P < 0.05). Before operation, there was no statistically signicant difference in the adjacent intervertebral activities between the two groups (P ＞ 0.05); after operation of 1, 12 month and 24 month, the adjacent intervertebral activities in the two groups were all higher than those of before operation; and with the extension of time, the adjacent intervertebral activities in the two groups were all increased, and the indicator in the observation group increased much more significantly than that of control group, with statistically signicant difference (P ＞ 0.05). There was no statistically signicant difference in the adjacent intervertebral height between the two groups before and after operation of 1, 12 month and 24 month (P ＞ 0.05). Before operation, there was no statistically signicant difference in the score of ODI between the two groups (P ＞ 0.05), after operation of 1, 12 month and 24 month, the scores of ODI were all lower than those of before operation; and the scores of 1 month and 12 month in the observation group decreased much more significantly than that of control group, with statistically signicant difference (P ＜ 0.05). Conclusion Transarticular decompression fusion combined with Dynesys dynamic stabilization system can effectively increase the lumbar range of motion in patients with lumbar degenerative disease, relieve the postoperative pain and improve the clinical efficacy of patients. It is worthy of clicical promotion and application.
2018 Vol. 15 (9): 53-56 [Abstract] ( 186 ) HTML (1 KB)  PDF (485 KB)  ( 130 )
57 Comparison of the force property between bamboo splint fixation and plaster fixation based on MSP430
XIE Chengcheng1 MIAO Wenxing2 ZHAO Yong3 LI Lindong4 XUE Junwei4 HUANG Chenyang4
Objective To compare the force property between bamboo splint fixation and plaster fixation. Methods A muscular edema simulation system based on MSP430 was designed to carry out experiments.By simulation of human body muscle edema, the pressure on the muscles were compared between the simulation experiment of bamboo splint and plaster fixation. Results A tatol of 15 sets of comparative experiments were carried out. After the experimental, results were averaged, quadratic function fitting was performed. The fitting force of the bamboo plates showed a good linearity. With the same initial pressure, the force of the bamboo plates decrease much slower than plaster group. Conclusion Experiments shows that the force of bamboo splints is more durable and stable for muscles.
2018 Vol. 15 (9): 57-61 [Abstract] ( 223 ) HTML (1 KB)  PDF (1017 KB)  ( 93 )
62 Factors analysis of operation effect of micro fracture of articular cartilage underwent arthroscopy
LI Lei WU Hao▲
Objective To explore the related factors of operation effect of micro fracture of articular cartilage underwent arthroscopy. Methods The clinical data of 300 patients treated in the Central Hospital of Enshi Automous Prefecture from March 2012 to April 2016 were analyzed retrospectively and divided into the effective group (258 cases) and the invalid group (42 cases) according to the standard of modern orthopaedics. The scores of Lysholm, Tegner, visual analogue and knee flexion degree before and after the operation were compared. The single factor descriptive analysis was used to analyze the related factors of micro fracture of articular cartilage underwent arthroscopy and the Logistic regression analysis was used to analyze the risk factors. Results After operation, the scores of Lysholm, Tegner and knee flexion degree were all significantly higher than those of before operation, and the visual analogue score was significantly lower than that of before operation, with statistically significant differences (P ＜ 0.05). The propotion of age over 60, combined with trauma, meniscus injury, cartilage defect size more than 4 cm2, cartilage damage grade Ⅲ-Ⅳ, joint effusion, diffuse tenderness, joint swelling, previous treatment history, combined with coronary heart disease or osteoporosis in the invalid group were all higher than those of effective group, with statistically significant differences (all P ＜ 0.05). The Logistic regression analysis showed that the factors above were all the independent risk factors of clinical efficacy (all P ＜ 0.05). Conclusion Arthroscopic micro fracture treatment can significantly improve the function and flexion of the knee joint, reduce the pain, but there are more risk factors affecting the therapeutic effect.
2018 Vol. 15 (9): 62-65,73 [Abstract] ( 316 ) HTML (1 KB)  PDF (873 KB)  ( 98 )
66 Analysis of relevant factors of abnormal component factors in metabolic syndrome in pre- and post-menopausal women
ZHANG Jingfei1 BAI Wenpei1▲ SHAO Sujun2 ZHANG Tingyue3 DIAO He1 CHEN Xing4
Objective To study the relevant risk factors of metabolic disorders in pre- and post-menopausal women. Methods Eighty-four healthy women aged 45-55 years from 1st to 30th, June 2016 in Beijing Shijitan Hospital, Capital Medical University were chosen as the research object. According to the guidelines of the 2013 Chinese Diabetes Society (CDS) in metabolic syndrome (MS) diagnostic criteria, women were divided into normal metabolic group (n=39) and abnormal metabolic group (n=45). The general condition, reproductive history, past history, lifestyle and menopause symptoms were recorded through questionnaire and physical examination was done. Blood testing was performed, including anti Mullerian hormone (AMH), sex hormone, blood lipid, blood routine, blood biochemistry, etc. Univariate and multiple Logistic regression analysis were used for estimating odds ratios for the association of abnormal component  factors in metabolic syndrome and the various factors. Results Univariate analysis showed that history of uterine leiomyoma, sitting time, frequencies of eating fruit, platelet count, platelet volume, platelet distribution width, uric acid, gamma glutamyl transferase and creatinine, the difference was statistically significant between group (P < 0.05). Multivariate Logistic regression showed that history of uterine leiomyoma (OR=9.219; 95%CI: 1.232-68.991; P=0.031) and increase of serum uric acid (OR=1.019; 95%CI: 1.003-1.035; P=0.019) were positively related to abnormal metabolic factors of metabolic syndrome. Conclusion Sedentary behavior, history of uterine leiomyoma and hyperuricemia may be the risk factors of metabolic abnormality in pre-and post-menopausal women. Fruit intake may have protective effect on metabolic syndrome. However, there was no correlation between ovarian function and metabolic syndrome.
2018 Vol. 15 (9): 66-69 [Abstract] ( 216 ) HTML (1 KB)  PDF (593 KB)  ( 92 )
70 Diagnostic value of serum HE4 in early endometrial carcinoma
YANG Shuli MIAO Jinwei HE YUE LI Wei WU Yumei▲
Objective To explore the diagnostic value of serum human epididymis protein 4 (HE4) in early endometrial carcinoma. Methods Thirty-six cases of stage Ⅰ endometrium carcinoma (endometrial carcinoma group), 19 cases of endometrium atypical hyperplasia (endometrium atypical hyperplasia group) and 45 cases of normal endometrium (normal endometrium group) from May to December 2014 in Bejing Obstetrics and Gynecology Hospital, Capital Medical University were selected, the levels of serum HE4 of patients in each group were detected by enzyme-linked immunosorbent assay (ELISA). The diagnostic value of serum HE4 levels were analyzed. Results The level of HE4 in endometrial carcinoma group [(65.01±40.54) pmol/L] was significantly higher than that in endometrium atypical hyperplasia group [(41.01±15.23) pmol/L] and the normal endometrium group [(40.03±19.03) pmol/L], the differences were statistically significant (P < 0.01). There was no statistically significant difference in serum level of HE4 between the endometrium atypical hyperplasia group and endometrium atypical hyperplasia group (P > 0.05). In endometrial carcinoma group, the levels of serum HE4 were different in patients with different Myometrial infiltration depth, degree of tissue differentiation and vascular clearance. The AUC under the ROC curve was 0.733, and according to the ROC curve  the cut-off of HE4 was 46.25 pmol/L, the sensitivity of early diagnosis of endometrial cancer was 68.4%, the specificity was 76.6%. Conclusion The level of serum HE4 in Endometial carcinoma patients is significantly increased, it can be used as biological markers of early diagnosis of endometrial carcinoma, the serum level of HE4 may assist to predict and evaluate risk factors before operation.
2018 Vol. 15 (9): 70-73 [Abstract] ( 237 ) HTML (1 KB)  PDF (604 KB)  ( 116 )
74 Parturition analysis of vaginal birth after cesarean section 
REN Weijuan ZHANG Wei▲ XUN Shengli SUN Xiao WANG Yifang
Objective To guide the clinical management of birth process of cesarean delivery after cesarean section to improve the safety of TOLAC, it focuses on the labor course of vaginal delivery after cesarean section. Methods A retrospective analysis was conducted on the maternal births delivered at the Maternal and Child Health Hospital of Yangzhou from January 2016 and July 2017: vaginal birth after cesarean section (VBAC), and no previous cesarean section 30 cases were VBAC group. 30 cases of vaginal delivery of non-scarring uterus during the same period were selected as the maternal group and 30 cases of primipara. The three groups were all natural labor, labor without oxytocin and artificial rupture of membranes and other interventions. The total production process, the first stage of labor, the second stage of labor, the third stage of labor were compared among three groups, postpartum hemorrhage and neonatal score were also compared. Results The total length of labor in the VBAC group was significantly shorter than that in the primipara group (P < 0.01), but there was no significant difference between the VBAC group and the multipara group (P > 0.05). The duration of the second stage of labor was significantly longer than that of the multipara group (P < 0.01). There was no significant difference between the VBAC group and the primipara group (P > 0.05). There was no significant difference in the third stage of labor between the three groups. Postpartum hemorrhage, neonatal Apgar score difference was not statistically significant (P > 0.05). Conclusion The clinical manifestations of the first stage labor of VBAC are similar to those of non-scarred vaginal delivery. The normal fetal heart rate allows for full vaginal trial. The second stage of labor of VBAC is similar to that of primipara and requires more patient observation of the second Labor. It is conducive to improving vaginal delivery rate after cesarean section, but large sample studies are necessary
2018 Vol. 15 (9): 74-77 [Abstract] ( 249 ) HTML (1 KB)  PDF (581 KB)  ( 146 )
78 Effect evaluation of anime demonstration on the compliance of newborn jaundice parents and improvement of neonatal outcome
LIN Chunqiu LU Liqun▲ LIU Xuechun JIANG Wenxiu
Objective To explore the effect of animation demonstration on the compliance of newborn jaundice parents and the improvement of neonatal outcomes. Methods From July 2016 to July 2017, 90 neonatal jaundice children and their parents in First Affiliated Hospital of Chengdu Medical College were selected as the research subjects, according to the random table methods, the children were divided into control group and observation group, with 45 cases in each group. The control group was given routine teaching methods, and the observation group was given the animation demonstration method to carry out the method of neonatal jaundice propaganda education. The compliance of the parents of the two groups, the serum bilirubin changes and the outcome of the newborn were observed and compared. Results The compliance rate of the parents in observation group was higher than control group, and the difference was statistically significant (P < 0.05). There was no significant difference in serum bilirubin between control group and observation group before intervention (P > 0.05). After the treatment, the serum bilirubin in observation group was lower than control group, the difference was statistically significant (P < 0.05). The duration of jaundice, the fading time of jaundice and the average length of hospitalization in the observation group were better than those of the control group, and the difference were statistically significant (P < 0.05). Conclusion The animation demonstration method can improve parents compliance and neonatal jaundice neonatal outcomes significantly, reduce the serum bilirubin of neonatal, reduce the duration of neonatal jaundice and hospitalization time, shorten the time of jaundice, it is worthy of popularizing in the clinic.
2018 Vol. 15 (9): 78-80,84 [Abstract] ( 219 ) HTML (1 KB)  PDF (630 KB)  ( 111 )
81 Assessment of physical and mental health status of school aged children with primary epilepsy
XU Bei1 CHEN Qiang1 ZHOU Yang2 JIA Xiaoyu2 WANG Guilan2
Objective To evaluate the physical and mental healthy state of children with primary epilepsy at school age. Methods Clinical data of 110 children were collected in the First Hospital of Qinhuangdao at the age of 7-12 from June 2015 to December 2016. Fifty-three children diagnosed with epilepsy were selected as epilepsy group and fifty-seven children without epilepsy were selected into control group. The standard deviation ratio of height, weight and BMI in the two groups were compared. The 6-minute walk tests, self rating anxiety scale (SAS), self rating depression scale (SDS) and Rosenberg self-esteem scale were conducted and analyzed. Results The mean height standard deviation score between the epilepsy group and the control group had no difference (P > 0.05). The standard deviation scores of weight and BMI of epilepsy group was greater than those of the control group (Pweight = 0.05, PBMI < 0.05). The heart rate after the 6-minute walk test of the epilepsy group was faster than that of the control group and the distance of the epilepsy group was shorter than that of the control group (P < 0.05). The scores of SAS and SDS of the epilepsy group were higher than those of the control group respectively (P < 0.05), and the score of Rosenberg self-esteem scale of the epilepsy group was lower than that of the control group (P < 0.05). Conclusion The higher physical obesity preference, weaker movement tolerance and exercise capacity in combination with the higher anxiety and depression score of the epilepsy group children indicating that children with epilepsy need to be provided appropriate social support, to guide them to achieve body and mental healthily development and growth.
2018 Vol. 15 (9): 81-84 [Abstract] ( 273 ) HTML (1 KB)  PDF (628 KB)  ( 161 )
85 HPV genotyping in 143 cases of unusual types carcinoma of the uterine cervix
LIAO Xin ZOU Juan HUANG Anliang YU Na SUN Liang▲
Objective To provide more evidence for the estimation of potential impact of HPV vaccine, by analyzing the distribution of HPV genotypes in unusual types of cervical cancer. Methods From September 2014 to September 2017, in West China Second Hospital of Sichuan University, unusual types of cervical cancer were collected, HPV genotyping was done by use of PCR and Luminex fluorescence technique. Relative contribution of HPV types in ICCs was expressed as the percentages of type-specifc cases among HPV-positive cases. Multiple infections were incorporated into single infection using the method of proportional weighting attribution (PWA). Results In the study, 143 invasive cervical cancer cases were included, and 130 (90.91%) cases were positive for HPV DNA, among them, 60 (46.15%) cases were adenocarcinoma (ADC), 46 (35.38%) cases were adenosquamous cell carcinoma (ADSCC), 8 (6.15%) cases were neuroendocrine carcinoma (NECA) and 16 (12.31%) cases were mixed type, 109 (83.84%) cases were present as single infections and 21 (16.15%) cases were present as multiple infections. HPV types 16 and 18 were the major types in each histological group. The PWA of HPV 16/18 to ADC, ADSCC, NECA and mixed type were 85.88%, 93.39%, 100.00% and 83.32%, respectively. Conclusion HPV 16 and 18 infections are predominant in these unusual types of cervical cancer. The 9-valent HPV vaccine has some improvement for prevention of these unusual types of cervical cancer.
2018 Vol. 15 (9): 85-88 [Abstract] ( 278 ) HTML (1 KB)  PDF (631 KB)  ( 140 )
89 Analysis of risk factors for occurrence of exanthema subitum
SUN Hairong1 WANG Fang2 ZHOU Zichen3
Objective To analyze the risk factors of occurrence of exanthema subitum, for clinical early recognition. Methods From August 2015 to July 2017, in Departemnt of Paediatrics, the Fifth People′s Hospital of Wuxi and the Third People′s Hospital of Huishan District, the clinical data of 175 less than 2 years old children with high fever, good mental state were collected and retrospectively analyzed, the factors such as gender, age, season, body temperature at admission, mental state, pharyngeal hyperemia, tonsillar exudation, neutrophil count, lymphocyte cell percentage and so on which could predict the exanthema subitum diagnosis were analyze by Logistic regression analysis model. Results In 175 children, 132 cases were diagnosed as exanthema subitum, the composition ratio was 75.4%. The results showed that the differents of mental states appetite, tonsil exudation and neutrophil counts of single factors were statistically significant (P < 0.05), the multivariate Logistic regression analysis showed that the seasons (OR = 3.393, P < 0.05), mental appetite (OR = 0.043, P < 0.01), tonsil exudation (OR = 0.179, P < 0.01) and neutrophil count (OR = 0.318, P < 0.05) were dangerous factors of < 2 years old children with high fever got exanthema subitum. Conclusion The season, mental appetite, tonsil exudation and neutrophil count are dangerous factors of < 2 years old children with high fever get exanthema subitum. Reasonable treatment and timely communication with parents can relieve parents' panic, avoid overcheck and overtreatment, avoid irrational drug use and abuse of antibiotics.
2018 Vol. 15 (9): 89-92 [Abstract] ( 235 ) HTML (1 KB)  PDF (586 KB)  ( 135 )
93 The intervention effect of the Tell-Show -Do model on children with primary tooth orthodontic movement
XIA Huiling1 LIAO Rui2▲
Objective To investigate the intervention effect of the Tell-Show-Do model on children with primary tooth orthodontic movement. Methods One hundred and sixty children with primary tooth orthodontic movement from September 2016 to October 2017 in Hangzhou Dental Hospital were selected and divided into control group (80 cases) and experimental group (80 cases) according to the children admission time. Routine clinical intervention or treatment was performed in the control group and Tell-Show-Do diagnosis and treat model was performed in the experimental group. The therapeutic demand index (IOTN scale), children's fear survey scale (CFSS-DS scale), treatment compliance (Frankl scale), treatment completion (Houpt scale) and psychological states (EPQ scale) between the two groups were compared before and after orthodontic treatment. Results After orthodontic treatment, the CFSS-DS scale in the experimental group was lower than the control group, the Frankl and Houpt scores were higher than the control group, the differences were statistically significant (P ＜ 0.05). The differences in control group (L scale) and in experimental group (P, E, N, L scale) before and after orthodontic treatment were statistically significant (P ＜ 0.05). The control-norm group (E, L scale before orthodontic), the experimental-norm group (P scale after orthodontic, E, L score before and after orthodontic, N score after orthodontic) indexes were statistically significant (P ＜ 0.05). The differences in the scores of each scale (P scale, E scale, N scale and L scale after orthodontic) in the two groups were statistically significant (P ＜ 0.05). There were statistically significant differences in knowledge dimension and behavioral dimension between the two groups (P ＜ 0.05). The score of  the children in the experimental group was significantly higher than that in the control group, and the difference of healthy self-management ability between the two groups was statistically significant (P ＜ 0.05). Conclusion The Tell-show-do model and traditional methods have certain influence on the psychology and emotion of children with orthodontics. However, Tell-show-do model is more effective in promoting the psychological state, treatment compliance and healthy self-management, it can be further applied in clinic.
2018 Vol. 15 (9): 93-96,100 [Abstract] ( 264 ) HTML (1 KB)  PDF (594 KB)  ( 122 )
97 Content determination of gas chromatography-mass spectrometry for 4 kinds of dicarboxylic acid in human urine
MA Zhenjing1 HUANG Jianming2 LIN Sui1 DENG Sishan1 LIU Hongxu1 QUE Huiqing1
Objective To establish an analytical method for the determination of organic acids dicarboxylic acid in human urine. Methods The content of dicarboxylic acid in the urine was detected by ion bombardment (EI) ion source mass spectrometry. Urine sample pretreatment: by using internal standard method, the sample was taken α-ketoxime reaction first, and then sulfuric acid methanol solution was carried out the process of methyl esterification, chloroform was used for extraction of organic dicarboxylic acid. Results The content of suberic acid in mitochondrial myopathy group was lower than that in normal group and myasthenia gravis group (P ＜ 0.05). The concentration of pimelic acid in mitochondrial myopathy group and myasthenia gravis group were significantly lower than those in normal group (P ＜ 0.05). The intra-day RSD was 1.00%-2.84%, and the inter-day RSD was 2.01%-3.87%. The average recovery rate of the added standard was 88.47%-104.09%, and RSD was 1.24%-4.19%. Conclusion The method of gas chromatography-mass spectrometry for determination of urinary dicarboxylic acid organic acid compounds is simple, accurate, with good reproducibility, which can be used to help screening carnitine circulating enzyme deficiency inherited metabolic diseases in clinic.
2018 Vol. 15 (9): 97-100 [Abstract] ( 321 ) HTML (1 KB)  PDF (431 KB)  ( 189 )
101 The effect of Febuxostat combined with Etoricoxib in the treatment of patients with gout arthritis and its effect on serum inflammatory factors
LAI Aiyun XU Jian TAO Li
Objective To observe the clinical effect of Febuxostat combined with Etoricoxib in the treatment of patients with gout arthritis and its effect on serum inflammatory factors. Methods Seventy-six patients with gout arthritis from October 2015 to October 2016 in the First Affiliated Hospital of Kunming Medical University were selected and randomly divided into control group and observation group by the odd even method, with 38 cases in each group. Patients in the control group were treated with Etoricoxib, 120 mg/time, once per day, for 1 week in a row. The observation group was treated with a combination of Febuxostat on the basis of the control group, 40 mg/time, once per day, for 1 week in a row. The clinical efficacy, pain relief and uric acid (UA), interleukin 1 (IL-1β), tumor necrosis factor (TNF-α), erythrocyte sedimentation rate (ESR), c-reactive protein (CRP) level of the two groups were observed and the adverse reaction were compared. Results The total effective rate of observation group was higher than control group, the difference was statistically significant (P ＜ 0.05). After treatment, the visual simulation score (VAS score) of the two groups was significantly reduced, and the VAS score in the observation group was lower than that in the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the level of UA, IL-1β, TNF-α, ESR and CRP level in two groups were significantly lower than before treatment, and the levels of each factor in the observation group were better than those in the control group, the differences were statistically significant (P ＜ 0.05). There was no statistically significant of adverse reaction rates between the two groups (P ＞ 0.05). Conclusion The efficacy of Febuxostat combined with Etoricoxib in the treatment of gout arthritis has significantly efficiency, it is superior to use Etoricoxib singly. The clinical symptoms and serum inflammatory factors were significantly improved, and the safety is good, which is worthy of clinical promotion.
2018 Vol. 15 (9): 101-104 [Abstract] ( 327 ) HTML (1 KB)  PDF (432 KB)  ( 134 )
105 The clinical observation of Suhuang Cough Capsules combined with Salmeterol/Fluticasone Propionate in the treatment of cough variant asthma
CHEN Huifen XIE Yanping FU Huanqin YAO Wei
Objective To explore the clinical effect of Suhuang Cough Capsules combined with Salmeterol/Fluticasone Propionate in the treatment of cough variant asthma (CVA). Methods Sixty patients diagnosed with CVA from December 2015 to August 2017 in First People′s Hospital of Huzhou were selected and randomly divided into two groups, with 30 cases in each group. Patients in the observation group were treated with Salmeterol 50 μg/Fluticasone Propionate 250 μg inhalation combined with Suhuang Cough Capsules. Patients in the control group were treated with Salmeterol 50 μg/Fluticasone Propionate 250 μg inhalation, both groups were treated for 4 weeks. After two weeks of continuous drug treatment, the cough symptom score was observed in both groups. After 4 weeks, patients of the two groups were evaluated by the asthma control test (ACT) questionnaire, and the levels of total serum IgE, TNF-α, IL-4 and IL-6 were measured and the percentage of sputum eosinophils was induced. Results The total efficiency of the observation group (93.33%) was higher than that of the control group (73.33%), the difference was statistically significant (P ＜ 0.05). After treatment, the scores of both groups were significantly lower than those before treatment, and the observation group was significantly lower than the control group (P ＜ 0.05). The ACT score of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P ＜ 0.05). After treatment, the sputum eosinophil percentage, serum IgE, TNF-α levels in two groups were lower than those before treatment (P ＜ 0.05), and the observation group was significantly lower than the control group (P ＜ 0.05). Conclusion Suhuang Cough Capsules combined with Salmeterol/Fluticasone Propionate can reduce the level of serum IgE, TNF-α and the sputum eosinophil percentage in adult patients with cough variant asthma, reduce airway inflammation and improve cough symptoms, so as to improve the therapeutic effect.
2018 Vol. 15 (9): 105-108 [Abstract] ( 266 ) HTML (1 KB)  PDF (470 KB)  ( 50 )
109 Analysis on professor Zhao ling′s herbal administration regularity for diabetic peripheral neuropathy by using Traditional Chinese Medicine inheritance support system
XING Chen1 ZHAO Ling2 HUANG Shaofang2 LI Jinjin1
Objective To analyze the herbal administration regularity of professor Zhao ling in the treatment of diabetic peripheral neuropathy (DPN) by using Traditional Chinese Medicine inheritance support platform software, and summarize their academic experience. Methods From January 2015 to March 2017, the first prescriptions that were diagnosed with DPN in Guangdong Province Hospital of Traditional Chinese Medicine were collected, and a prescription′s database established. The selected prescriptions were analyzed with the drug by the Traditional Chinese Medicine inheritance support system, and get the conclusion. Results A total of 87 prescriptions were screened, involving 139 kinds of herbs, counted the frequency of prescriptions, commonly used herbal and their combinations, and evolved 10 new prescriptions. Conclusion It is clearly showed that the sweet-flavored and warm-natured herbs often were used by professor Zhao ling to treat diabetic peripheral neuropathy from Traditional Chinese Medicine inheritance support system. And the main treatment idea is invigorate the spleen and eliminating dampness, improve blood circulation. It provides new treatment ideas for the treatment of DPN by Chinese medicine.
2018 Vol. 15 (9): 109-113 [Abstract] ( 214 ) HTML (1 KB)  PDF (689 KB)  ( 85 )
114 Experience summary on integrated Chinese and western medicine in the treatment of acute-on-chronic liver failure by Professor Li Yong
SUN Huanna LI Yong▲
Acute-on-chronic liver failure is a common severe liver disease in our country, with high clinical mortality. Through many years of clinical practice, according to the Chinese and western pathogenesis of acute-on-chronic liver failure, Professor Li Yong adopts comprehensive treatment method of integrated Chinese and western medicine, takes advantage of curative effect of traditional Chinese medicine, treats disease based on syndrome differentiation according to the characteristics of pathogenesis, and takes therapy of combination of disease and syndrome according to different pathological stages. He also uses modern artificial liver technology, pays attention to etiological treatment, nursing of living and diet, emphasizes early diagnosis, early treatment and active prevention for all kinds of complications, which has significant clinical effect and greatly reduce the mortality of patients with acute-on-chronic liver failure.
2018 Vol. 15 (9): 114-117,122 [Abstract] ( 341 ) HTML (1 KB)  PDF (710 KB)  ( 112 )
118 Clinical characteristics analysis of polycystic ovary syndrome with syndrome of phlegm dampness
XU Fang1 HOU Lihui1 LIU Yinghua2 WANG Mengsi1 DING Chunli1 NIU Jingyun1
Objective To investigate the clinical characteristics, sex hormones and glucose and lipid metabolism characteristics of PCOS patients with syndrome of phlegm dampness. Methods From September 2013 to August 2015, the data of gynecological outpatient patients with PCOS from Clinical Research Information Integration System of First Affiliated Hospital, Heilongjiang University of Chinese Medicine were analyzed retrospectively. All the patients were divided into two groups according to the diagnostic criteria of PCOS with syndrome of phlegm dampness. The clinical characteristics, sex hormones and abnormal metabolism of glucose and lipid were compared and analyzed. Results Among 617 cases of PCOS, 393 cases (63.7%) were PCOS with syndrome of phlegm dampness, and 224 cases (36.3%) were non phlegm dampness. The body mass index, waist hip ratio, systolic blood pressure, diastolic blood pressure, incidence of acanthosis, excessive fat, insulin resistance, impaired glucose tolerance, testosterone, fasting blood glucose, fasting insulin, insulin resistance index, total cholesterol, triglyceride, low density lipoprotein cholesterol, total cholesterol high density lipoprotein, triglyceride/high density lipoprotein cholesterol, low density lipoprotein cholesterol/high density lipoprotein cholesterol and lipid accumulation index in the phlegm dampness syndrome PCOS group were higher than those in non phlegm dampness syndrome PCOS group (P < 0.05). The hairy incidence, luteinizing hormone, follicle stimulating hormone, luteinizing hormone/follicle stimulating hormone, sex hormone binding globulin, high density lipoprotein cholesterol levels in phlegm dampness PCOS group were lower than those in the non phlegm dampness syndrome PCOS group (P < 0.05). Conclusion Phlegm dampness syndrome is one of the main syndromes of PCOS patients; PCOS patients with syndrome of phlegm dampness have obvious sex hormones and glucose and lipid metabolism abnormality. Besides insulin resistance is an important metabolic characteristic of PCOS with syndrome of phlegm dampness.
2018 Vol. 15 (9): 118-122 [Abstract] ( 246 ) HTML (1 KB)  PDF (709 KB)  ( 137 )
123 The effect of Yangxue Qufeng Decoction in the treatment of blood deficiency and wind dryness eczema
WANG Jingjing YAO Chunhai TIAN Fengyan QU Yun CHEN Shaojun SHE Yaunyao▲
Objective To observe the clinical effect of Yangxue Qufeng Decoction of traditional Chinese medicine in the treatment of blood deficiency and wind dryness eczema. Methods Sixty-two patients with chronic eczema in department of dermatology, XIyuan Hospital CACMS from June 2016 to July 2017 were selected and divided into two groups by random number table method, with 31 cases in each group. The treatment group received oral administration of Yangxue Qufeng Decoction, 200 mL/time, twice per day. The control group received oral administration of Loratadine 10 mg/d. Patients in two groups were administrated topical medication with Hydrocortisone butyrate, twice per day. The main symptom scores were observed and compared between the two groups, and the efficacy was evaluated. Results There was no statistically significant difference between the two groups before treatment of the main symptom integral (including pruritus degree, psoriasis area, skin lesion shape) (P ＞ 0.05). After treatment, the main symptom integral of the two groups were lower than those before treatment (P ＜ 0.05), and the score of treatment group were lower than those in control group, the differences were statistically significant (P ＜ 0.05). After treatment, the total effective rate in the treatment group was higher than that in control group, the difference was statistically significant (P ＜ 0.05). Conclusion Yangxue Qufeng Decoction has remarkable effect in the treatment of blood deficiency and wind dryness eczema, and can improve the quality of life and the clinical symptoms of patients, which is worthy of clinical promotion.
2018 Vol. 15 (9): 123-125,137 [Abstract] ( 289 ) HTML (1 KB)  PDF (964 KB)  ( 84 )
126 Effects of Buzhongyiqi decoction and Wuweixiaodu decoction on the postoperative inflammatory factors of elderly limbs fracture
ZHU Hualiang ZHOU Zongbo
Objective To analyze the effect of Buzhong Yiqi Decoction and Wuwei Disinfection Decoction on the inflammatory factors in elderly patients with limb fractures. Methods From January 2015 to January 2017, 96 elderly patients with limb fractures admitted to Haikou Branch of Yueyang Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Haikou Traditional Chinese Medicine Hospital were selected, and divided into control group and test group by random number table, with 48 cases in each group. The control group was treated with conventional therapy, and the test group was treated with Buzhong Yiqi Decoction and Wuwei Disinfection Decoction on the basis of the control group, the two groups were treated continuously for 14 days. The clinical efficacy of the patients, the time of remission of clinical characterization, the adverse reaction and the time of fracture healing, and the levels of interleukin-1 (IL-1), interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), insulin growth factor (IGF), bone morphogenetic protein (BMP), typeⅠprocollagen carboxyterminal peptide (PICP) and bone alkaline phosphates (ALP) were observed. Results After treatment, the total effective rate of the test group and the control group was 93.75% and 79.17%, respectively, there were statistically significant differences between the two groups (P < 0.05). The time of remission of clinical characterization after treatment in the test group were all shorter than that of the control group, the difference was statistically significant (P < 0.05). The levels of IL-1, IL-6, CRP, TNF-α after treatment in two groups were lower than before treatment (P < 0.05), and the test group was lower than control group, the difference was statistically significant (P < 0.05). The levels of IGF, BMP-2, PICP, ALP after treatment in two groups were higher than before treatment (P < 0.05), and the test group was higher than control group, the difference was statistically significant (P < 0.05). The time of fracture healing in two groups were compared, the difference was statistically significant (P < 0.05). The adverse reaction in the test group was 2.08%, lower than that in the control group (8.33%)(P < 0.05). Conclusion The effect of Buzhong Yiqi Decoction Shuwei flavored drink flavor disinfection drinks in the aged limbs fracture is affirmed, it can reduce the level of inflammatory cytokines, prevention and treatment of complications, and promote fracture healing.
2018 Vol. 15 (9): 126-129 [Abstract] ( 193 ) HTML (1 KB)  PDF (641 KB)  ( 81 )
130 Analysis of the use condition of adjuvant drugs in a traditional Chinese medical hospital from 2014 to 2016
LIU Yang ZHAO Hongxi
Objective To explore the condition of the use of adjuvant drugs in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (hereinafter referred to as "our hospital") from 2014 to 2016, and to guide rational drug use. Methods The utilization of top 10 adjuvant drugs in the list of consumption sum and defined daily doses (DDDs) in our hospital from 2014 to 2016 were analyzed. Results From 2014 to 2016, the top 10 adjuvant drugs in the list of consumption sum were injections and oral Chinese patent medicines, the varieties were mainly composed of neurotrophic, cardio-cerebrovascular drugs and other Chinese patent medicines. Drugs were more used in the department of cardiovascular medicine, encephalopathy rehabilitation and neurology. In terms of top 10 adjuvant drugs in the list of DDDs, oral Chinese patent medicines rank high. The defined daily cost (DDC) is mainly for injection, and the sequencing ratio (B/A) of these drugs was poor and drug price was high. The incidence of adjuvant drugs induced adverse reaction (ADR) was high, and exceeded 60% for three consecutive years. Conclusion The synchronicity of adjuvant drugs consumption sum and DDDs is good. However, attention should be paid to the overuse of adjuvant drugs and strengthen the monitoring, so as to promote rational drug use.
2018 Vol. 15 (9): 130-133 [Abstract] ( 297 ) HTML (1 KB)  PDF (635 KB)  ( 128 )
134 Clinical effect of comprehensive rehabilitation therapy combined with small needle knife for scoliosis of professional athlete
WANG Jian1 YANG Jianquan2
Objective To explore the application effect of comprehensive rehabilitation therapy combined with small needle knife in the treatment of athletes with scoliosis. Methods Sixty cases of athletes with scoliosis taken rehabilitation therapy in Shaanxi Rehabilitation Hospital and Affiliated Hospital of Xi'an Medical University from June 2016 to May 2017 were selected and they were divided into the observation group (30 cases) and the control group (30 cases) by the random number method. The control group was given mechanical traction, the observation group was given comprehensive rehabilitation therapy combined with small needle knife. The therapeutic effect, improvement of Cobb angle, and the improvement of pain and disability between the two groups were observed and compared. Results The total effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the Cobb angle of the observation group was significantly smaller than that of the control group, the difference was statistically significant (P ＜ 0.05). After treatment, the scores of visual analogue scale (VAS), pain sensation (S), pain emotion (A), total pain score (T), present pain intensity (PPI) and Oswestry pain & disability questionnaire (OPDQ) in the observation group were significantly lower than those in the control group, the differences were statistically significant (P ＜ 0.05). Conclusion Comprehensive rehabilitation therapy combined with small needle knife for the treatment of athletes with scoliosis can not only significantly improve the pain symptoms, but also improve the disability, thus enhance the effectiveness.
2018 Vol. 15 (9): 134-137 [Abstract] ( 282 ) HTML (1 KB)  PDF (421 KB)  ( 137 )
138 Clinical anatomic study of acupotomy lysis in lumbar ligamentum flavum of human
ZHU Xinyue1,2 LIU Zixiang1,2 GU Peiliang3 ZHANG Weiguang3 LI Shiliang1
Objective To explore the anatomical path of acupotomy for lumbar ligamentum flavum (LF) and provide a safer and reliable minimally invasive treatment of Chinese medicine for lumbar disc herniation (LDH) and lumbar spinal stenosis (LSCS). Methods Ten cadavers including 4 females and 6 males with age from 60 to 90 years old [(70.50±14.17) years old in an average] without formalin fixation were selected. The specimens were derived from the Donor Center of School of Basic Medical Sciences, Peking University from September 2016 to January 2018. According to the body surface of the human anatomy, the first approach was to insert the needle from the facet joint to the spinous process in the direction of the vertical axis of the vertical body. The second direction was parallel to the longitudinal direction of the human body from the side of the spinous process and a transverse direction from the tail side to the head. Those methods loosened L3/L4, L4/L5, L5/S1 three segments of ligamentum flavum. The angle for acupotomy and the depth of needle penetration, the distance between the puncture point and spinous process, and the distance between the puncture point and cornua sacralia on cadavers were measured. The resulting data was processed and analyzed. Results After dissection, no obvious blood vessels and nerves were observed in the paracentesis path, and the spinal dural membrane was intact. There was no significant difference between the left and right measurement data (P ＞ 0.05). The penetration depth of the vertical longitudinal axis approach was less than the depth of the parallel longitudinal axis approach (P ＜ 0.01). The distance between the puncture point and cornua sacralia for the vertical longitudinal axis was greater than that of the parallel longitudinal axis (P ＜ 0.01). Vertical and parallel longitudinal axis measuremented of L3/L4, L4/L5, and L5/S1 showed no significant difference in needle insertion angle, needle depth, and spinous process distance for the three segments (P ＞ 0.05). Conclusion The vertical longitudinal axis approach of loosening the ligamentum flavum by the needle knife is better than the parallel longitudinal axis approach. Before clinical treatment, reference can be made to the measurement results obtained in this study to obtain a more accurate insertion point for lumbar ligamentous ligament release.
2018 Vol. 15 (9): 138-142 [Abstract] ( 203 ) HTML (1 KB)  PDF (514 KB)  ( 73 )
143 One case of prepuce edema induced by ceftriaxone sodium
LIU Guiping ZHANG Lin ZHANG Guoling▲
In October 2017, a patient with edema of the foreskin visited the outpatient clinic of the 309th Hospital of Chinese PLA. Before the onset of the disease, the patient was treated with ceftriaxone sodium intravenous infusion for acute upper respiratory tract infection, edema of the foreskin was found and gradually aggravated after 5 days of continuous medication. Combined with medical history, clinical manifestation, laboratory examination and differential diagnosis, the patient was diagnosed as prepuce edema induced by adverse drug reaction of ceftriaxone sodium, and the treatment measures such as cessation of ceftriaxone sodium, outpatient observation, follow-up were given. The symptoms of edema of the foreskin were gradually reduced after 2 days of withdrawal, and the symptoms disappeared completely after 3 days of withdrawal, and the symptoms were not reappeared for 28 days. Through reviewing and summarizing of cases, ceftriaxone sodium is widely used in respiratory tract infection, septicemia, abdominal infection, pyelonephritis, pelvic inflammatory diseases, bone and joint infections, skin and soft tissue infections, central nervous system infection in patients with clinical treatment, and have exact effect, but its adverse reactions have been reported, even in severe cases, can not be ignored. In order to ensure the safety of drug use, when using ceftriaxone sodium, we should strictly grasp indications and contraindications, do well in monitoring adverse reactions and timely and effective treatment.
2018 Vol. 15 (9): 143-145 [Abstract] ( 266 ) HTML (1 KB)  PDF (353 KB)  ( 160 )
146 Study on the equity of community health resources distribution in Beijing by population distribution
ZHUANG Qian JIANG Yan XU Jiayan MA Can XU Yue CHENG Wei
Objective To analyze and evaluate the equity of community health resources distribution in Beijing, and to provide reference basis for the rational allocation of community health resources in Beijing. Methods Data sources came from 2016 Beijing Community Health Service Management Center "Beijing Community Health Service routine monitoring data" and 2016 Beijing Statistical Office’s statistics. Drew Lorenz curve and calculated the Gini coefficient, the balance and fairness of the indexes such as number of community health institutions, number of health technicians, number of beds, and expenditure for Community health Service are analyzed from the angle of population distribution. Results From the point of view of population distribution, the distribution of health technicians was the most balanced,Gini coefficient was 0.121, in which the Gini coefficient of doctors and allied insurance personnel was 0.167 and 0.159 respectively. The second was equipment allocation, organization allocation and expenditure for community health service, Gini coefficient was 0.179, 0.248 and 0.251. While the Gini coefficient of expenditure for community public health services was 0.400, and the Gini coefficient of beds was 0.424, all of which show unfairness. Conclusion The community health resources distribution in Beijing are fairly fair by population distribution, among which the expenditure for community public health service is not fair enough, the investment of urban area is higher than that of suburb, and the reasonable allocation of public health service outlay should be considered more.
2018 Vol. 15 (9): 146-150 [Abstract] ( 175 ) HTML (1 KB)  PDF (916 KB)  ( 105 )
151 Analysis of proportion of drugs in hospitalization expenses before and after the intervention in a grade-A tertiary hospital
LIU Guoqiang1 WANG Xiaoli1 LU Lianjun2
Objective To emphasize the importance of decreasing the proportion of drugs, reduce hospitalization fees and control the rapid growth of hospitalization costs, in order to improve patients′ satisfaction and social benefits of hospital. Methods Through drug changes from 2012 to 2015 in Third Hospital of Hebei Medical University, different years of data were included and analyzed, such as hospital costs and drug costs, etc. 2012 was selected as the pre-reform control group, the measures of drug proportion, changes of drug and reducing drug proportion were discussed. Results After taking relevant measures, the hospital drug proportion in 2013 to 2015 were lower than 2012, and it decreased year by year, which was effectively controlled. Conclusion Only by realizing clinical norms diagnosis and treatment, formulating normative medication and comprehensive management, the proportion of medicine is effectively controled.
2018 Vol. 15 (9): 151-153,180 [Abstract] ( 244 ) HTML (1 KB)  PDF (771 KB)  ( 132 )
154 Predicament and continuing medical education and its countermeasures in new media time
ZHANG Jingyi
In recent years, new media gradually play an irreplaceable role in the field of continuing medical education, it overturns the traditional pattern of continuing medical education. But in the practice, the continuing medical education system still has the obvious flaw. This article finds the main problems of continuing medical education in nowadays society, through discussing new media's role in the continuing medical education, and puts forward countermeasures of new media promoting the development of continuing medical education, in order to promote the construction of continuing medical education system in our country, and provide reference for government decision.
2018 Vol. 15 (9): 154-157 [Abstract] ( 189 ) HTML (1 KB)  PDF (698 KB)  ( 146 )
158 The research on Guangdong enterprise and institutions′ pressure investigation and reducing pressure project
WU Xing1 WU Ying2 HUANG Xiaomei2 LIAO Shengwu1
Mental pressure is a popular research direction in current society. However, there are only a few literatures about the psychological pressure focusing on enterprise and institutions′ staffs in China. The research on the psychological pressure of enterprise and institutions′ staffs in Guangdong province is almost blank. This paper is a pioneering exploration of the investigation of employee pressure and reducing pressure project in enterprises and institutions in Guangdong Province, and using the method of four levels rating to evaluate psychological stress level of enterprise and institutions′ staffs in Guangdong province, to help employees of enterprise and institutions′ staffs to understand their psychological pressure and reasons, so as to provide help for the prevention of the mental disease from stress. In the meanwhile, dynamic psychological management, emotional catharsis, controlling emotions, relieving stress, resolving the crisis and other series of stress relief projects would be used to help these enterprise and institution′s workers change their sub-health condition and prolong their life-span thereby improve these employees′ health quality.
2018 Vol. 15 (9): 158-162 [Abstract] ( 194 ) HTML (1 KB)  PDF (706 KB)  ( 96 )
163 A control study of the mental health and cognitive function in the first-degree relatives of patients with high and sporadic incidence of obsessive-compulsive disorder
LIU Changcheng ZHANG Xinfeng XU Liming LU Xuemei▲
Objective To investigate the mental health status and the cognitive function in the first-degree relatives of patients with obsessive-compulsive disorder. Methods From June 2015 to June 2017, 72 first-degree relatives of patients with obsessive-compulsive disorder in Jingzhou Mental Health Center were selected as research objects and divided into the high incidence family group (48 cases) and the sporadic incidence family group (24 cases) according to the presence of others in the family. Hamilton anxiety scale (HAMA) and Yale-Brown obsessive compulsive scale (Y-BOCS) were used to assess the anxiety and compulsive symptoms. Stroop color word test (Stroop), Wisconsin card sorting test (WCST), continuous performance test (CPT) and brief visuospatial memory test-revised (BVMT-R) were applied to evaluate the cognitive function. Results ①The total scores of HAMA and Y-BOCS in the high incidence family group were all higher than those of sporadic family group, with statistically significant differences (2.6965, P ＜ 0.05). ②In the Stroop, the scores of B and C in the high incidence family group were lower than those of sporadic family group, with statistically significant differences (P ＜ 0.05). The WCST scale showed that the number of correctness and completed categories in the high incidence family group were lower than those of sporadic family group, with statistically significant differences (P ＜ 0.05), while significantly higher as regards the number of persistent error and random error (P ＜ 0.05). ③The score of CPT in the high incidence family group was significant lower than that of sporadic family group, with statistically significant difference (P ＜ 0.05).④BVMT-R showed that in terms of associative learning, group image free recall and memorizing the characteristics of human pictures in the high incidence family group were significant lower than those of sporadic family group, with statistically significant differences (P ＜ 0.05). Conclusion The first-degree family members of patients with high incidence of obsessive-compulsive disorder are more likely to show signs of anxiety and obsessive-compulsive symptom and more likely to suffer from cognitive impairment, such as attention and memory.
2018 Vol. 15 (9): 163-166 [Abstract] ( 754 ) HTML (1 KB)  PDF (771 KB)  ( 102 )
167 Prospects of cancer screening in China
KONG Ziren WANG Yu MA Wenbin WANG Renzhi
Cancer is one of the most lethal diseases in China. Prevention, early detection and early treatment are the keys to cancer control. Cancer screening relies on techniques such as visualization, radiographic imaging, cancer biomarker measuring, directly or indirectly looking for cancer in people who have no symptoms. Screening can reduce cancer morbidity and mortality, since the treatment of cancer at early stage is less aggressive and more effective. Lung cancer, gastric cancer, liver cancer, esophageal cancer and colorectal cancer are cancers with the highest morbidity and mortality in China, while abundant evidence suggests that screening and early treatment of these cancers can significantly improve the prognosis of patients. In addition, breast cancer and cervical cancer also have a relatively high incidence in female, and simultaneously with mature screening and prevention methods. According to Chinese national condition, with reference to the cancer screening evidence together with the cancer screening guidelines existed, it is recommended to start the early screening of lung cancer, breast cancer, gastric cancer, esophageal cancer, liver cancer, colorectal cancer, cervical cancer in China.
2018 Vol. 15 (9): 167-171 [Abstract] ( 250 ) HTML (1 KB)  PDF (781 KB)  ( 227 )
172 Study on evaluation index system construction of consultation competence of training of general practitioners based on analytic hierarchy process
WANG Meirong1 DU Juan1 LIU Yingjie1 ZHANG Dandan1 XU Xiaojingyuan1 GE Caiying2
Objective To determine the weight of the evaluation index system of consultation competence of standardized training of general practitioners (“compliance training” for short), it based on the standardized training of general practitioners. Methods The analytic hierarchy process was used to determine the evaluation indexes and their weights for 10 specialists, and calculate the general index. Results Among the 8 first level indicators, the weight of interpersonal and communication skills, medical history taking and analysis, physical examination and basic operation skills, diagnostic strategies, interpretation and treatment of patients' problems, individual health education, outpatient medical records and professional attitudes were 0.1314, 0.1387, 0.1325, 0.1549, 0.1280, 0.0928, 0.0714 and 0.1503, respectively. The results of the judgment matrix given by the specialists meet the consistency index ＜0.10 and random index ＜0.10, all the indexes were satisfied the consistency check. Conclusion This study is building a set of objective quantitative indexes to evaluate the consultation competence of compliance training of general practitioners, which is expected to measure the training effect comprehensively and objectively.
2018 Vol. 15 (9): 172-175 [Abstract] ( 247 ) HTML (1 KB)  PDF (762 KB)  ( 68 )
176 Study on the influence and strategy of mine set on the safety of hemodialysis nursin
ZhOU Qun XIAO Guanghui ZHU Yan LI Ziqi
This paper expounds the influence of the mind-set on hemodialysis nursing safety from the aspects of setting parameters of hemodialysis nursing, preventing and controling nosocomial infection, monitoring vital signs, monitoring of blood coagulation in vitro, nursing indwelling catheter and internal fistula puncture, etc. Then puts forward a series of targeted intervention strategy, such as improving the level of divergent thinking, improving the hospital infection prevention and control system, setting up the risk consciousness, establishing the early warning mechanism, improving the ability of self-supervision and strengthening business training, so as to provide guidance to eliminate the influence of the mind-set in the future.
2018 Vol. 15 (9): 176-180 [Abstract] ( 219 ) HTML (1 KB)  PDF (709 KB)  ( 81 )
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