|
|
|
| A control study of the mental health and cognitive function in the first-degree relatives of patients with high and sporadic incidence of obsessive-compulsive disorder |
| LIU Changcheng ZHANG Xinfeng XU Liming LU Xuemei▲ |
| the Second Female Ward of Psychological Department, Jingzhou Mental Health Center, Hubei Province, Jingzhou 434000, China |
|
|
|
Abstract Objective To investigate the mental health status and the cognitive function in the first-degree relatives of patients with obsessive-compulsive disorder. Methods From June 2015 to June 2017, 72 first-degree relatives of patients with obsessive-compulsive disorder in Jingzhou Mental Health Center were selected as research objects and divided into the high incidence family group (48 cases) and the sporadic incidence family group (24 cases) according to the presence of others in the family. Hamilton anxiety scale (HAMA) and Yale-Brown obsessive compulsive scale (Y-BOCS) were used to assess the anxiety and compulsive symptoms. Stroop color word test (Stroop), Wisconsin card sorting test (WCST), continuous performance test (CPT) and brief visuospatial memory test-revised (BVMT-R) were applied to evaluate the cognitive function. Results ①The total scores of HAMA and Y-BOCS in the high incidence family group were all higher than those of sporadic family group, with statistically significant differences (2.6965, P ＜ 0.05). ②In the Stroop, the scores of B and C in the high incidence family group were lower than those of sporadic family group, with statistically significant differences (P ＜ 0.05). The WCST scale showed that the number of correctness and completed categories in the high incidence family group were lower than those of sporadic family group, with statistically significant differences (P ＜ 0.05), while significantly higher as regards the number of persistent error and random error (P ＜ 0.05). ③The score of CPT in the high incidence family group was significant lower than that of sporadic family group, with statistically significant difference (P ＜ 0.05).④BVMT-R showed that in terms of associative learning, group image free recall and memorizing the characteristics of human pictures in the high incidence family group were significant lower than those of sporadic family group, with statistically significant differences (P ＜ 0.05). Conclusion The first-degree family members of patients with high incidence of obsessive-compulsive disorder are more likely to show signs of anxiety and obsessive-compulsive symptom and more likely to suffer from cognitive impairment, such as attention and memory.
|
|
|
|
|
|
[1] 王振，张海音.中国强迫症防治指南2016解读：心理治疗[J].中华精神科杂志，2017，50（4）：253-255.
[2] Stein DJ，Koen N，Fineberg N，et al. A 2012 evidence-based algorithm for the pharmacotherapy for obsessive-compulsive disorder [J]. Curr Psychiatry Rep，2012，14（3）：211-219.
[3] 田丽，胡纪泽.强迫症的认知理论[J].中国健康心理学杂志，2013，21（7）：1120-1121.
[4] Vakili Y，Gharaee B，Habibi M. Acceptance and commitment therapy，selective serotonin reuptake inhibitors and their combination in the improvement of obsessive-com?鄄pulsive symptoms and experiential avoidance in patients with obsessive-compulsive disorder [J]. Iran J Psychiatry，2015，9（2）：e845.
[5] 世界卫生组织.ICD-10精神与行为障碍分类[M].北京：人民卫生出版社，1993.
[6] 王娜，毛佩贤，李占江.认知行为治疗或支持性心理治疗联合药物治疗老年抑郁症的随机对照研究[J].中华精神科杂志，2017，50（5）：371-376.
[7] 侯祥玺，曹中昌.强迫症症状维度的相关研究进展[J].精神医学杂志，2017，30（2）：157-160.
[8] 张媛，沈芳.精神分裂症患者一级亲属认知功能调查[J].中国医药导报，2015，12（27）：55-58.
[9] 谢孟杰，邹义壮，王志仁，等.中文版剑桥前瞻性记忆测试量表计算机测量用于慢性精神分裂症患者的信效度[J].中国康复理论与实践，2014，20（10）：950-954.
[10] 张丽丽，张云淑，贾海玲，等.精神病超高危人群及精神分裂症一级亲属的认知功能研究[J].中华精神科杂志，2016，49（2）：71-75.
[11] 杨建明，兰光华.耶鲁-布朗强迫症状清单调查强迫症状的初步应用[J].中国健康心理学杂志，2014，22（7）：1030-1031.
[12] Levy HC，Radomsky AS. Are all safety behaviours created equal? A comparison of novel and routinely used safety behaviours in obsessive-compulsive disorder [J]. Cogn Behav Ther，2016，45（5）：367-379.
[13] Öst LG，Havnen A，Hansen B，et al. Cognitive behavioral treatments of obsessive-compulsive disorder. A systematic review and meta-analysis of studies published 1993-2014 [J]. Clin Psychol Rev，2015，40（6）：156-169.
[14] Paast N，Khosravi Z，Memari A，等.强迫症患者、强迫型人格障碍患者和健康对照者之间的认知灵活性和计划能力比较[J].上海精神医学，2016，28（1）：28-34.
[15] 刘英，刘蔚，杨世昌.强迫症患者疾病严重程度与家庭功能的相关研究[J].精神医学杂志，2014，27（5）：356-358.
[16] 雷辉，朱熊兆，张小崔.强迫症自知力与临床特征、认知及神经生理功能的关系[J].中国临床心理学杂志，2017， 25（4）：780-779.
[17] 褚文浩.帕罗西汀与氯米帕明治疗强迫症的效果及安全性比较[J].中国医药导报，2014，11（3）：89-91.
[18] 高睿，范青，张宗凤，等.强迫症的认知功能及其研究方法述评[J].临床精神医学杂志，2016，26（5）：355-357.
[19] Pinto A，Liebowitz MR，Foa EB，et al. Obsessive compulsive personality disorder as a predictor of exposure and ritual prevention outcome for obsessive compulsive disorder [J]. Behav Res Ther，2011，49（8）：453-458.
[20] 黎华柱，杨孝，易焕文.强迫症患者直系亲属心理健康状况分析及干预[J].齐齐哈尔医学院学报，2014，35（10）：1525-1526. |
|
|
|
