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2023 Vol. 20, No. 33 Published: 2023-11-25

	4	Effect of six-segment transmembrane epithelial antigen of prostate 4 on proliferation of prostate cancer cells in inflammatory environment
		SUN Xinghua1 YU Tao2 ZHANG Xuexin3 CHANG Hongyan1 HONG Yueguang1 LI Weiwei4
		DOI: 10.20047/j.issn1673-7210.2023.33.01
		Objective To investigate the role of six-segment transmembrane epithelial antigen of prostate 4 (STEAP4) in the development of prostate cancer in the inflammatory microenvironment induced by lipopolysaccharide (LPS). Methods The inflammatory environment of prostate cancer cells PC3 and VCaP was induced by LPS. PC3 and VCaP cells were divided into control group, LPS treated group (PC3 and VCaP cells were exposed to 1 μg/ml LPS), transfection control group(LPS+transfection si-con) and transfection silence group (LPS+transfection si-STEAP4). The STEAP4 level was detected 24 h after transfection by Western blot. The expression levels of cytokines interleukin (IL)-6, IL-8 and tumor necrosis factor-α(TNF-α) were detected by enzyme-linked immunosorbent assay. Cell proliferation was detected by CCK-8 and EdU staining. The expression level of cyclic guanosine monophosphate(cGMP)-cGMP-dependent protein kinase(PKG) signaling pathway related proteins was detected by Western blot. Results STEAP4 protein expression level of PC3 and VCaP cells in LPS treated group was significantly higher than that in control group (P＜0.05). There was no significant difference in the expression level of STEAP4 protein in PC3 and VCaP cells in LPS treated group compared with transfection control group (P＞0.05). The expression level of STEAP4 protein in PC3 and VCaP cells in transfection silence group was significantly lower than that in transfection control group (P＜0.05). The expression levels of IL-6, IL-8, and TNF-α in PC3 and VCaP cells in LPS treated group were significantly higher than those in control group (P＜0.05). There were no significant differences in the expression levels of IL-6, IL-8, and TNF-α in PC3 and VCaP cells between LPS treated group and transfection control group (P＞0.05). The expression levels of IL-6, IL-8, and TNF-α in PC3 and VCaP cells in transfection silence group were significantly lower than those in transfection control group (P＜0.05). The proliferation activity of PC3 and VCaP cells in LPS treated group was significantly higher than that in control group at 24, 48, and 72 h (P＜0.05). There was no significant difference in the proliferation activity of PC3 and VCaP cells at 24, 48, and 72 h between LPS treated group and transfection control group (P＞0.05). The proliferation activity of PC3 and VCaP cells in transfection silence group was lower than that in transfection control group at 24, 48, and 72 h (P＜0.05). The proliferation activity of PC3 and VCaP cells in LPS treated group was significantly higher than that in control group (P＜0.05). There was no significant difference in the proliferation activity of PC3 and VCaP cells between LPS treated group and transfection control group (P＞0.05). The proliferation activity of PC3 and VCaP cells in transfection silence group was significantly lower than that in transfection control group (P＜0.05). The relative expression levels of cGMP, PKG1, PKG2, and phosphorylated vasodilator stimulated phosphoprotein (pVASP)/VASP in PC3 and VCaP cells of LPS treated group were significantly lower than those of control group (P＜0.05). There were no significant differences in the relative expression levels of cGMP, PKG1, PKG2, and pVASP/VASP in PC3 and VCaP cells between transfection control group and LPS treated group (P＞0.05). The relative expression levels of cGMP, PKG1, PKG2, and pVASP/VASP in PC3 and VCaP cells of transfection silence group were significantly higher than those of transfection control group (P＜0.05). Conclusion STEAP4 silencing inhibits the proliferation and inflammatory response of prostate cancer cells induced by LPS. Downregulation of STEAP4 may inhibit LPS-induced tumorigenesis by reducing cell proliferation and inflammatory response.
		2023 Vol. 20 (33): 4-10 [Abstract] ( 14 ) HTML (1 KB) PDF (1892 KB) ( 157 )

	11	Medication laws of patented Chinese medicine compound prescription in treating intracerebral hemorrhage
		FANG Ziru1 XU Peng2 DING Xikang2 WANG Jian2
		DOI: 10.20047/j.issn1673-7210.2023.33.02
		Objective To explore the rule of using patented Chinese medicine compound prescription in treating cerebral hemorrhage, and to provide reference for developing new clinical prescription. Methods The data of the patented traditional Chinese medicine compound for the treatment of cerebral hemorrhage were retrieved from the database of China Patent Publication Network of the State Intellectual Property Office from October 2022. Microsoft Office Excel 2019 and IBM SPSS Statistics 20.0 software were used for drug and efficacy category frequency statistics and systematic cluster analysis. The tra- ditional Chinese medicine inheritance platform v2.5 was used to carry out the statistics of medicinal properties, medicinal tastes and menstrual conversion frequency. The Apriori association rule in IBM SPSS Modeler 18.0 software was used for modeling analysis. The complex core network of traditional Chinese medicine co-occurrence was constructed by Cytoscape 3.9 software, and the closely related traditional Chinese Medicine groups were extracted. Results A total of 85 traditional Chinese medicine compound prescription were included, involving 332 flavors. The high frequency traditional Chinese medicine included Floslarthami, Radix Angelicae Sinensis, Radix Astragaliseu Hedysari, etc. The main categories of Chinese medicine were activating blood circulation and removing blood stasis, calming liver, and calming wind, and tonifying deficiency. The taste of Chinese medicine was mainly warm and bitter, which belonged to liver channel. The commonly used pairs weree Rhizomu Gastrodiae-Ramulus Uncariae Cum Uncis, Rhizoma Ligustici Chuan Xiong-Semen Persicae, etc. Common drug groups included Floslarthami-Radix Angelicae Sinensis-Radix Astragaliseu Hedysari, Radix Angelicae Sinensis- Semen Persicae-Floslarthami, etc.; four new traditional Chinese medicine groups were obtained by systematic cluster analysis. Conclusion The main therapeutic methods of the patented Chinese medicine compound in the treatment of cerebral hemorrhage are promoting blood circulation and removing blood stasis, calming liver and calming wind, and tonifying qi and blood, which can be used as reference for further prescription medicine.
		2023 Vol. 20 (33): 11-15,38 [Abstract] ( 13 ) HTML (1 KB) PDF (1680 KB) ( 134 )

	16	Expression of miR-30a in gastrointestinal stromal tumors and its mechanism of regulating cell proliferation, invasion and apoptosis
		REN Hua1 MA Ming1 WANG Chao1 WANG Zhaojun2
		DOI: 10.20047/j.issn1673-7210.2023.33.03
		Objective To observe the expression of microRNA-30a (miR-30a) in gastrointestinal stromal tumors (GIST) and explore its effects on cell biological behaviors and possible mechanisms. Methods Thirty patients with GIST who underwent surgical resection in the Fifth People’s Hospital of Datong from November 2021 to November 2022 were selected as the study object, and the normal tissues removed by surgery (＞ 5 cm away from the edge of GIST tissue) were taken as the control. The expression of miR-30a in GIST tissues and normal tissues was compared. The logarithmic phase GIST-T1 cell line was taken, and the cells transfected with miR-30a negative control plasmid miR-30a NC, overexpression plasmid miR-30a mimics, and silencing plasmid miR-30a inhibitor were set as miR-30a NC group, miR-30a mimics group, and miR-30a inhibitor group, respectively. The cells without treatment were taken as the control group. The proliferation, invasion and apoptosis of each group were detected. The expression of transforming growth factor β1 (TGF-β1), p-Smad2/Smad2 protein were detected. The target relationship between miR-30a and TGF-β1 was verified. Results Compared with normal tissues, the expression of miR-30a in GIST tissues was decreased (P＜0.05). There were no significant differences in proliferation rate at 24, 48 and 72 h, number of transmembrane stained cells, apoptosis rate, TGF-β1 protein expression, and P-Smad2 /Smad2 between miR-30a NC group and control group (P＞0.05). Compared with the control group, the proliferation rate of miR-30a mimics group at 24, 48, 72 h were decreased, the number of stained cells passing through the membrane was reduced, the apoptosis rate was increased, the proliferation rate of miR-30a inhibitor group at 24, 48, 72 h were increased, the number of stained cells passing through the membrane was increased, the apoptosis rate was decreased (P＜0.05). Compared with the control group, the expression of TGF-β1 protein and p-Smad2/Smad2 in miR-30a mimics group was decreased, while those in miR-30a inhibitor group were increased (P＜0.05). Dual luciferase assay showed that TGF-β1 was a target gene of miR-30a. Conclusion The expression of miR-30a in GIST is decreased, which may regulate cell proliferation, invasion and apoptosis by targeting TGF-β signaling pathway.
		2023 Vol. 20 (33): 16-21 [Abstract] ( 10 ) HTML (1 KB) PDF (1094 KB) ( 169 )

	22	Study of the mechanism of mulberry leaf alkaloids on abnormal glucose tolerance and insulin resistance in mice with gestational diabetes mellitus based on AMPK-GLUT4 axis
		QIAO Yanhua1 BAI Zhangying2▲ WANG Junfang3 LI Xiaomin4 TIAN Ying5
		DOI: 10.20047/j.issn1673-7210.2023.33.04
		Objective To explore the mechanism of mulberry leaf alkaloids on abnormal glucose tolerance and insulin resistance (IR) in mice with gestational diabetes mellitus (GDM) based on the AMP-activated protein kinase (AMPK)- glucose transporter 4 (GLUT4) axis. Methods Sixty SPF C57BL/6 female mice and 30 male mice with body weight of (20±3) g and age of six weeks were selected. According to the random number table method, 50 female mice in estrus were selected, after being fed a high-glycemic diet for six weeks, 25 male mice were caged overnight. After five days of fasting for 12 h, 45 female mice with successful pregnancy were injected with 35 mg/kg streptozotocin solution peritoneally to induce GDM model. After the modeling, 25% glucose was given to the stomach with 1 ml, and the 2-hour postpranpranal blood glucose (2hPBG) was measured, if 7.8 mmol/L≤2hPBG＜11.1 mmol/L, and the modeling lasted for one week, the modeling was successful. According to random number table method, 40 female mice were divided into model group, mulberry leaf alkaloids low-dose group, mulberry leaf alkaloids high-dose group, and positive drug group, with ten mice in each group; the remaining ten female mice who did not participate in modeling and had successful pregnancy were selected as control group. Mulberry leaf alkaloids low-, high-dose groups and positive drug groups were injected with 100, 200 mg/kg, and 100 mg/kg drug solution through tail vein, respectively; control group, and model group were given equal volume sterile saline. Once a day for eight weeks. Oral glucose tolerance test was performed at the 7th week of administration, and blood glucose levels were detected at 0.5, 1 h, and 2 h; the expression levels of homeostasis model assessment for insulin resistance (HOMA-IR), homeostasis model assessment-pancreatic β-cell function (HOMA-β), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), AMPK and GLUT4 mRNA in liver tissues, and AMPK, phosphorylated adenylate protein kinase (p-AMPK), and GLUT4 protein in liver tissues of mice in all groups were compared at the 8th week of administration. Results Overall analysis showed that there were significant differences in blood glucose time, intergroup, and interaction between control group and model group (P＜0.05). Intra-group comparison: the level of blood glucose at 2 h in control group was lower than that at 0.5 and 1 h, and the differences were statistically significant (P＜0.05); the pairwise comparison of the levels of blood glucose at different time points in model group had statistical significance (P＜0.05). Comparison between groups: the levels of blood glucose at 0.5, 1 h, and 2 h in model group were higher than those in control group, and the differences were statistically significant (P＜0.05). Overall analysis showed that there were significant differences in blood glucose time, intergroup, and interaction between model group and drug administration group (P＜0.05). Intra-group comparison: the pairwise comparison of the levels of blood glucose in mulberry leaf alkaloids low-, high-dose groups at different time points showed statistical significance (P＜0.05). Comparison between groups: the levels of blood glucose in mulberry leaf alkaloids low-, high-dose groups at 0.5, 1 h, and 2 h were lower than those in model group; the levels of blood glucose at 0.5, 1 h, and 2 h in mulberry leaf alkaloids high-dose group were lower than those in mulberry leaf alkaloids low-dose group, and the differences were statistically significant (P＜0.05). HOMA-IR and the levels of CRP, TNF-α, IL-6 in model group were higher than those in control group; HOMA-β, GLUT4 mRNA， and the levels of p-AMPK and GLUT4 protein in liver tissues were lower than those in control group, and the differences were statistically significant (P＜0.05). HOMA-IR and the levels of CRP, TNF-α, IL-6 in mulberry leaf alkaloids low-, high-dose groups were lower than those in model group; HOMA-β, GLUT4 mRNA, and the levels of p-AMPK and GLUT4 protein in liver tissue weres higher than those in control group, and the differences were statistically significant (P＜0.05). HOMA-IR and the levels of CRP, TNF-α, IL-6 of mulberry leaf alkaloids high-dose group were lower than those of mulberry leaf alkaloids low-dose group; HOMA-β, GLUT4 mRNA，and the levels of p-AMPK and GLUT4 protein in liver tissues were higher than that of mulberry leaf alkaloids low-dose group, and the differences were statistically significant (P＜0.05). There were no significant differences in AMPK mRNA and protein in liver tissues among all groups (P＞0.05). Conclusion Mulberry leaf alkaloids can improve blood glucose level and inflammatory response, reduce IR and promote glucose metabolism in a dose-dependent manner in female GDM mice. The improvement may be effected by activation of the AMPK-GLUT4 axis.
		2023 Vol. 20 (33): 22-27 [Abstract] ( 16 ) HTML (1 KB) PDF (840 KB) ( 129 )

	28	Mechanism of action of triple therapy with radiotherapy and Gemcitabine combined with immune checkpoint inhibitors on the microenvironment of triple-negative breast cancer
		WU Miaomiao1 FANG Kun2
		DOI: 10.20047/j.issn1673-7210.2023.33.05
		Objective To investigate the effect of triple therapy of radiotherapy, Gemcitabine (Gem) combined with immune checkpoint inhibitors on the microenvironment of triple-negative breast cancer, and to reveal its possible mechanism. Methods A total of 29 SPF BALB/c mice aged five weeks and weighing 18-20 g were selected. On the first day of the experiment, about 1×106 4T1 cells were injected subcutaneously into the left abdomen to establish triple-negative breast cancer transplant tumor model. When the tumor volume increased to 100 mm3, the mice were divided into control group (five mice), anti-programmed death receptor ligand 1 (aPD-L1) group (six mice), radiotherapy (RT) +aPD-L1 group (six mice), Gem +aPD-L1 group (six mice), and triple group (six mice) by random number method. In addition to the control group, the other four groups were injected with drugs (Gem 5 mg/kg, aPD-L1 3 mg/kg) in the tumor at the 6th, 8th, and 10th days of the experiment. Twenty-four hours after each injection, RT (2 Gy) was administered to the RT+aPD-L1 group and the triple group. On the 30th day of the experiment, the animals were killed, the tumor weight of each group was weighed, and the main organs were stained with hematoxylin-eosin. The absolute percentage of CD3+CD8+ T cells in peripheral blood and tumor was detected by flow cytometry. The expression of interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in peripheral blood and tumor were detected by enzyme-linked immunosorbent assay. The expressions of Ki-67, microvessel density(MVD)-CD31, and γH2AX were detected by immunohistochemistry, and apoptosis was evaluated by TUNEL detection. The expression of vascular endothelial growth factor (VEGF) and hypoxia inducible factor-1 α (HIF-1α) were detected by Western blot analysis. Results There was no significant difference in body weight among all groups (P＞0.05). At the end of the experiment, the tumor weight of RT+aPD-L1 group and triple group were lower than those of aPD-L1 group, and those of triple group were lower than those of RT+aPD-L1 group (P＜0.05). Hematoxylin-eosin staining showed no obvious damage to the heart, liver, spleen, and kidney in each group. The absolute percentage of CD3+CD8+ T cells , TNF-α, and IL-6 in peripheral blood of aPD-L1 group were higher than those of control group. Peripheral blood IL-6 in RT+aPD-L1 group was higher than that in aPD-L1 group, and absolute percentage of CD3+CD8+ T cells , IFN-γ, and IL-6 of peripheral blood in triple group were higher than those in aPD-L1 group. The absolute percentage of CD3+CD8+ T cells of peripheral blood in triple group was higher than that of RT+aPD-L1 group and Gem+aPD-L1 group, and IL-6 was higher than that of Gem+aPD-L1 group (P＜0.05). The absolute percentage of CD3+CD8+ T cells , IFN-γ, TNF-α, and IL-6 of tumor in aPD-L1 group were higher than those in control group. The absolute percentages of CD3+CD8+ T cells of tumor in RT+aPD-L1 group, Gem+aPD-L1 group, and triple group were higher than those in aPD-L1 group, and TNF-α and IL-6 of tumor in triple group were higher than those in aPD-L1 group. The absolute percentage of CD3+CD8+ T cells and IL-6 of tumor in triple group were higher than those in RT+aPD-L1 group and Gem+aPD-L1 group, and IFN-γ was higher than those in RT+aPD-L1 group (P＜0.05). Immunohistochemical staining and TUNEL detection showed that the expression of Ki-67 decreased and the apoptotic cells increased in the tumor tissues of triple group. MVD-CD31 in triple group was lower than that in aPD-L1 group, γH2AX was higher than that in aPD-L1 group and Gem+aPD-L1 group (P＜0.05). VEGF in aPD-L1 group was lower than that in control group, VEGF in RT+aPD-L1 group, Gem+aPD-L1 group, and triple group was lower than that in aPD-L1 group, and HIF-1α in triple group was lower than that in aPD-L1 group and RT+aPD-L1 group (P＜0.05). Conclusion The triple therapy of radiotherapy, Gem combined with immune checkpoint inhibitors can delay tumor growth, increase the absolute percentage of CD3+CD8+ T cells in peripheral blood and tumor, promote the release of inflammatory factors in serum and tumor, improve intratumor hypoxia and inhibit tumor microvascular growth in mouse triple-negative breast cancer transplant tumor model.
		2023 Vol. 20 (33): 28-33 [Abstract] ( 9 ) HTML (1 KB) PDF (1559 KB) ( 65 )

	34	Analysis of Professor Liu Yanqiao’s medication rules in the treatment of polycystic ovary syndrome based on data mining
		AN Qing1 LI Chang1 JIN Yi1 DANG Huimin2 LIU Yanqiao2 MU Siqi1
		DOI: 10.20047/j.issn1673-7210.2023.33.06
		Objective To analyze Professor Liu Yanqiao’s prescription medication rules in the treatment of polycystic ovary syndrome (PCOS) based on data mining analysis. Methods The PCOS medical cases treated by Professor Liu Yanqiao from the Second Affiliated Hospital of Xi’an Jiaotong University from October 2019 to February 2023 were screened, and input into Excel to establish a database, prescription drug frequency, efficacy classification, flavor and meridian tropism were counted; R language and SPSS Statistics software were used for association rules and cluster analysis. Results A total of 131 prescriptions were collected, including 115 flavors of traditional Chinese medicine, and 20 flavors were used more than 40 times, the highest frequency was Shanyao and Xiangfu 90 times, most of which belonged to tonifying deficiency drugs and promoting blood circulation and removing blood stasis drugs, with sweet and bitter tastes, mainly warm and cold drugs, and most of them were attributed to liver (gallbladder) channel. Association rule analysis showed that there were 13 common drug pairs, and the support of angelica-Chuanxiong was the highest, and there were 13 kinds of three kinds of medicine combination, and the support of Xiangfu-angelica-Chuanxiong was the highest. Based on cluster analysis, three groups of cluster prescriptions were obtained, corresponding to kidney deficiency and blood stasis type, phlegm stasis block type, and spleen deficiency and phlegm dampness type respectively. Conclusion In the treatment of PCOS, Professor Liu Yanqiao combines with promoting blood circulation and resolving stasis, dispelling dampness and resolving phlegm, etc. on the basis of tonifying the kidney, strengthening the spleen, and soothing the liver, in order to comply with the physiological process of follicle growth, development, and excretion.
		2023 Vol. 20 (33): 34-38 [Abstract] ( 17 ) HTML (1 KB) PDF (1075 KB) ( 14 )

	39	Research progress on the mechanism of drug resistance to paclitaxel chemotherapy in cervical cancer
		XU Jianqing WANG Ming XU Shuiqing ZHANG Jingjing HE Yue▲ WU Yumei▲
		DOI: 10.20047/j.issn1673-7210.2023.33.07
		Cervical cancer is one of the most common malignant tumors of the female reproductive system. Although this is despite breakthroughs in early screening and prevention, the incidence and mortality rates of cervical cancer are still on the rise in developing countries. Paclitaxel is a first-line chemotherapy drug for the treatment of cervical cancer, and because it is easy to produce chemotherapy resistance, it seriously affects the therapeutic effect and prognosis of patients. Therefore, it is of great significance to understand the molecular mechanism of chemotherapy resistance. In this paper, the research progress on the mechanism of chemotherapy resistance of paclitaxel in cervical cancer was reviewed, in order to provide new ideas for overcoming chemotherapy resistance of cervical cancer.
		2023 Vol. 20 (33): 39-42,47 [Abstract] ( 17 ) HTML (1 KB) PDF (559 KB) ( 112 )

	43	Research progress on the relationship between the expression level of cell division cycle related gene 8 and tumor development and prognosis
		ZHANG Hanqiang1 GU Huiquan2 CHEN Qianhua1 YANG Shaoyin1 CHEN Neng1 LIU Qiang3▲
		DOI: 10.20047/j.issn1673-7210.2023.33.08
		Abnormal expression levels of cell division cycle related gene 8 (CDCA8) can affect multiple signaling pathways, particularly in promoting proliferation during the occurrence and development of various cancers. The relevant mechanisms mainly include influencing the cell division cycle, acting as common regulatory factors for PI3K, p53, and other signaling pathways to accelerate cancer occurrence and development, and affecting chemokine cell pathways. Meanwhile, there is a correlation between the expression level of CDCA8 and tumor prognosis. This article reviews the relationship and mechanism of action between CDCA8 and the occurrence and development of bladder cancer, female reproductive system tumors, prostate cancer, and other diseases, as well as the relationship between CDCA8 and poor prognosis, pathological staging, etc., and provides new ideas for the treatment and prognosis prediction of various tumors.
		2023 Vol. 20 (33): 43-47 [Abstract] ( 14 ) HTML (1 KB) PDF (623 KB) ( 43 )

	48	Research progress on influencing factors, evaluation methods, and intervention measures of fatigue in peritoneal dialysis patients
		AO Man WANG Huiming LIANG Wei XIANG Cuizhi HUANG Rongfang LI Zhengkang YANG Lianhua▲
		DOI: 10.20047/j.issn1673-7210.2023.33.09
		Fatigue is one of the common complications of peritoneal dialysis patients, with a high incidence rate and adverse effects on the quality of life of peritoneal dialysis patients. It is of great significance to evaluate and correctly identify the influencing factors of fatigue in peritoneal dialysis patients and apply the correct intervention measures. This article mainly sorts out and summarizes the influencing factors, evaluation methods, and intervention measures of peritoneal dialysis patients’ fatigue comprehensively and systematically, and analyzes and summarizes the evaluation tools, aiming to provide some theoretical reference for clinical medical workers and new ideas for peritoneal dialysis patients’ fatigue management.
		2023 Vol. 20 (33): 48-51 [Abstract] ( 12 ) HTML (1 KB) PDF (609 KB) ( 15 )

	52	Research progress on the mechanism of action of acupuncture in the treatment of mammary gland hyperplasia
		YU Chuan ZHANG Rui▲
		DOI: 10.20047/j.issn1673-7210.2023.33.10
		Mammary gland hyperplasia is the most common benign breast disease in clinic. In recent years, the incidence rate has gradually increased and become younger, which has affected women’s physical and mental health. Clinical research shows that acupuncture has significant effect on mammary gland hyperplasia, but there is no systematic summary of the mechanism of acupuncture on mammary gland hyperplasia. This article reviews the traditional Chinese medicine etiology and pathogenesis of mammary gland hyperplasia, as well as the acupoint selection rules for acupuncture in the treatment of mammary gland hyperplasia. This article summarizes and sorts out the regulatory mechanisms of action of acupuncture on hormone levels, hormone receptors, signaling pathways, and other aspects of the endocrine system, as well as immune function, gene expression, blood circulation, and peripheral nervous system. This article aims to provide a reference for in-depth research on acupuncture in the treatment of mammary gland hyperplasia.
		2023 Vol. 20 (33): 52-55 [Abstract] ( 16 ) HTML (1 KB) PDF (594 KB) ( 14 )

	56	Research advances in early markers for the diagnosis of acute kidney injury
		HAN Yunbiao1 ZHAO Yiwen2 XU Libin1
		DOI: 10.20047/j.issn1673-7210.2023.33.11
		Acute kidney injury (AKI) is an acute and critical illness in the department of nephrology. Although most physicians have improved their understanding of AKI, there is still a high missed diagnosis rate and mortality rate. Some patients may experience chronic changes. Creatinine and urine volume is the main diagnostic indicator, which is single and hysteresis, lacks the specificity of renal tubular injury, and is easily disturbed by many factors. It is difficult to evaluate AKI early, but with the discovery of some early markers, the early diagnosis and treatment of AKI is possible. This paper summarizes some of the new diagnostic markers, describes the possible pathophysiological processes of different markers in AKI, expounds the feasibility of predicting AKI with some markers, and proposes some checking points for AKI treatment, which will provide guidance for the diagnosis and treatment of AKI in the future.
		2023 Vol. 20 (33): 56-59 [Abstract] ( 12 ) HTML (1 KB) PDF (547 KB) ( 81 )

	60	Research progress on anticancer effect and mechanism of oleanolic acid
		YUAN Bin1 WEI Yanfei1 ZHOU Fengling1 HUANG Delun2
		DOI: 10.20047/j.issn1673-7210.2023.33.12
		The oleanolic acid (OA) is a natural pentacyclic triterpenoid acid, which has outstanding anticancer pharmacological effects, it has the advantages of broad antitumor spectrum, little side effects and abundant sources. Through the interaction with specific molecular targets, OA plays an anticarcinogenic role in inducing apoptosis, inhibiting proliferation, inhibiting invasion and metastasis, suppressing angiogenesis and so on. Its anti-tumor mechanism is diversified and involves a wide range of related pathway factors. Exploring the specific molecular mechanism of OA antitumor effect and developing higher activity and easy absorption OA derivatives will have important clinical significance on its application for carcinoma therapy.
		2023 Vol. 20 (33): 60-62,66 [Abstract] ( 13 ) HTML (1 KB) PDF (526 KB) ( 22 )

	63	Progress in the study of recobinant isoleucinyl-tRNA synthetase gene variants
		JIANG Jinsong1 GAO Jingbo2 GUO Rong2 CAO Guizhi2 GUO Min1 ZHAO Chenyue1 ZHANG Lixue1 XUE Huiqin2
		DOI: 10.20047/j.issn1673-7210.2023.33.13
		Recobinant isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine and specific tRNA to bind and regulate protein synthesis, and also regulates intracellular signaling pathways and participates in intracellular metabolic processes. IARS gene variation is very rare in animals and humans. The deficiency of IARS caused by IARS mutation is a rare autosomal recessive genetic disease, resulting in severe developmental delay, impaired intellectual development, hypotonia, and abnormal liver function. And the specific amino acid therapy after IARS gene mutation has also become a current research hotspot. This article reviews the research progress in this field, with a view to summarizing the phenotypes associated with IARS gene variation, clarifying the association between genotype and phenotype, and the possible pathogenesis, and providing references for the etiology research.
		2023 Vol. 20 (33): 63-66 [Abstract] ( 14 ) HTML (1 KB) PDF (513 KB) ( 43 )

	67	Research progress of molecular spectroscopy in the detection of Chlorpromazine
		ZHANG Huifeng SONG Zhifeng
		DOI: 10.20047/j.issn1673-7210.2023.33.14
		Chlorpromazine is widely used psychoactive substance in clinical practice, which has become a hot topic of clinical attention due to its inhibitory effect on virus and its abuse. Molecular spectroscopy is not only an important means for the construction of detection system and the analysis of reaction mechanism, but also the basis for the development of new detection technologies. Based on the phenomena of absorption, emission, and scattering generated by molecular motion, this paper reviews the application progress of ultraviolet visible spectroph-otometer, molecular fluorescence, chemiluminescence, surface enhanced Raman scattering, resonance Rayleigh scattering, and other spectral technologies in Chlorpromazine analysis from the aspects of determination principle and conditions, and discusses and prospects the application prospect of molecular spectroscopy in chlorpromazine related research. In order to provide reference for the detection, pharmacology, toxicology, and risk assessment of Chlorpromazine.
		2023 Vol. 20 (33): 67-70,75 [Abstract] ( 13 ) HTML (1 KB) PDF (602 KB) ( 77 )

	71	Reliability and validity of Morisky8 medication compliance scale for traditional Chinese medicine decoction in patients taking traditional Chinese medicine decoction
		QIAN Cheng1 ZHOU Haifeng1 WU Jianbo1 HAN Li2 ZHANG Min1 WANG Ziyu1 CHEN Zhilong1 ZHENG Songbai3
		DOI: 10.20047/j.issn1673-7210.2023.33.15
		Objective To verify the reliability and validity of Morisky medication adherence scale-8 (MMAS-8) for patients taking traditional Chinese medicine decoction. Methods The outpatient patients in the Department of Traditional Chinese Medicine of Huadong Hospital Affiliated to Fudan University from August to December 2021 were selected as the research objects, and the medication compliance of traditional Chinese medicine decoction version MMAS-8 was evaluated. The reliability and validity of the scale were verified by item analysis, reliability analysis, validity analysis, and confirmatory factor analysis in sequence. Results The critical ratio of each item of MMAS-8 was ＞ three (P＜0.01). The correlation between the scores of each item and the total score of the scale was ＞ 0.4 (P＜0.01). Cronbach’s α coefficient (Cronbach’sα) was 0.851, standardized Cronbach’s α was 0.851, and retest reliability was 0.780 (P＜0.01). The Bartlett sphericity test value was 1 048.445 (P＜0.01), the sampling appropriateness was 0.844, and the calibration correlation was 0.613 (P＜0.01). Two common factors were extracted from the scale, which could explain 70.377% of the total variance. The Chi-square degree of freedom ratio, approximate error root mean square, root mean square residual, goodness of fit index, comparative fit index,and value-added fit index were 2.789, 0.024, 0.009, 0.957, 0.967, and 0.967, respectively. Conclusion Traditional Chinese medicine decoction version MMAS-8 has reliable reliability and validity, and can be used in the evaluation of patients taking traditional Chinese medicine decoction.
		2023 Vol. 20 (33): 71-75 [Abstract] ( 16 ) HTML (1 KB) PDF (792 KB) ( 74 )

	76	Relationship between physical activity and sexual function in infertile women
		CHEN Hongxia1 TANG Yanlan2 YE Xiping1 WANG Xuemei3 WU Caiyun3 SHAO Shanshan2 PAN Weijun1 HUANG Cun1▲
		DOI: 10.20047/j.issn1673-7210.2023.33.16
		Objective To analyze the relationship between physical activity and sexual function in infertile women. Methods A total of 1 040 infertile women who visited the Reproductive Center of Ma anshan Maternal and Child Health Hospital in Anhui Province, and the Reproductive Medicine Center, the 901th Hospital of the Joint Logistics Support Force of Chinese People’s Liberation Army from December 2020 to March 2022 were included in the study. Their physical activity level and sexual function status were evaluated using the international physical activity questionnaire short form (IPAQ-SF) and the female sexual function index (FSFI), respectively. The relationship between physical activity levels and sexual function were evaluated using the univariate ANOVA analysis and multiple linear regression analysis. Results The age of 1 040 infertile women was (31.47±5.41) years. The results of single factor analysis showed that the total FSFI score of infertile women with different marital status and smoking had statistical significance (P＜0.05). The scores of sexual desire, sexual excitement, and FSFI score of infertile women with different levels of physical activity had statistical significance (P＜0.05). The results of multiple linear regression analysis showed that after controlling for marital status and smoking, physical activity level was the influential factor of libido, sexual excitement scores and FSFI score (P＜0.05). Conclusion There is a positive correlation between the level of physical activity and the sexual function of infertile women. It is recommended that infertile women improve their physical activity levels to improve their sexual function.
		2023 Vol. 20 (33): 76-79 [Abstract] ( 16 ) HTML (1 KB) PDF (454 KB) ( 29 )

	80	Development and reliability testing of self-reported outcome scale for patients with cervical spondylotic radiculopathy
		MA Lin HUANG Xueyan▲ GAO Caixiang ZHANG Jingying
		DOI: 10.20047/j.issn1673-7210.2023.33.17
		Objective To develop a scientific and feasible self-reported outcome scale for patients with cervical spondylotic radiculopathy and test its reliability and validity. Methods The concept structure was defined based on the theory of dyspeptic symptoms, the item pool was constructed through literature review and semi-structured interview, and the initial scale was formed after two rounds of expert correspondence. From October 2021 to June 2022, a total of 172 patients with cervical spondylotic radiculopathy were conveniently selected for formal investigation to test the reliability and validity of the scale. Results There were 24 items in three dimensions in the self-reported outcome scale of cervical spondylotic radiculopathy patients. Three common factors were extracted by exploratory factor analysis, and the cumulative variance contribution rate was 61.380%. The content validity of the items was 0.812-1.000, and the content validity of the scale was 0.964. The Cronbach’s α coefficient of the total volume table was 0.890, and the retest reliability was 0.832. Conclusion The self-reported outcome scale of cervical spondylotic radiculopathy patients has good reliability and validity, and can provide reference for the evaluation tool of this population.
		2023 Vol. 20 (33): 80-83,116 [Abstract] ( 12 ) HTML (1 KB) PDF (730 KB) ( 51 )

	84	Analysis of standardized construction of children’s eye health outpatients in Gansu Province based on the diagnosis and treatment experience of medical service personnel
		GAO Chen1 WANG Dengting1 WEI Man2 ZHENG Zhongli1 CHEN Tao1 ZHAO Lin1 CHEN Jianming1 ZHENG Jiqi1
		DOI: 10.20047/j.issn1673-7210.2023.33.18
		Objective To understand the status of children’s eye health outpatient service in medical institutions in Gansu province, to analyze the construction norms and service operation problems of children’s eye health outpatient service, and provide scientific basis for promoting the standardized construction of children’s eye health outpatient service in Gansu province. Methods From August to December 2022, the ophthalmic clinics and eye health medical personnel of hospitals at all levels in Gansu province were randomly selected by different layers to collect quantitative and qualitative data about children’s eye health outpatient in their institutions. The survey data were statistically described and analyzed by SPSS 26.0 software. Results A total of 195 questionnaires were effectively answered by ophthalmological medical staff from 108 hospitals, and the effective questionnaire recovery rate was 91.98%. The institutions that had carried out the work of children’s eye health outpatient accounted for 30.77%, and 84.20% of the respondents have the intention to build children’s eye health outpatient. There was statistical significance in the proportion of academic qualifications and job categories in different hospitals (P＜0.05). The proportion of different hospital categories participating in screening children’s eye diseases and establishing children’s eye health records was compared, and the differences were statistically significant (P＜0.05). There was statistical significance in the scores of equipment use in different hospital categories and types (P＜0.05). There was statistical significance in the score of start-up capital deficiency in different hospitals (P＜0.05). Conclusion The outpatient rate of children’s eye health outpatient in medical institutions in Gansu Province is low, the existing service capacity is uneven, and the overall operation is at a low level. The standardized construction is necessary and urgent.
		2023 Vol. 20 (33): 84-87 [Abstract] ( 16 ) HTML (1 KB) PDF (576 KB) ( 15 )

	88	Survey on situation of preconception health care services in maternal and child health care institutions at district and county levels in Chongqing
		GU Huayan WANG Jian▲ ZHANG Haiyan WANG Wei HE Dan
		DOI: 10.20047/j.issn1673-7210.2023.33.19
		Objective To understand the status quo of pre-pregnancy health care services in maternal and child health institutions in Chongqing. Methods A questionnaire survey was conducted among the participants of the 2021 Chongqing pre-pregnancy health training course. The contents mainly include: personal information, the status quo of pre-pregnancy inspection in maternal and child health institutions in various districts and counties, and the knowledge of pre-pregnancy. According to the principles of economic development, road traffic conditions, resource and environment carrying capacity, close level of development and geographical location, 38 administrative districts and counties in Chongqing were divided into main urban area group and non-main urban areas group. The status quo of pre-pregnancy examination and knowledge of pre-pregnancy were compared between the two groups. Results A total of 109 questionnaires were sent out, and 101 were effectively collected, with an effective recovery rate of 92.66%. All hospitals carried out free pre-pregnancy eugenic check-ups, but the return rate of at-risk groups was low. There were statistically significant differences between the two groups in the rate of return visits, follow-up forms and the proportion of multimedia publicity among pre-pregnancy specialist clinics, psychological assessment, free pre-pregnancy risk groups in the same hospital(P＜0.05). The total score of related knowledge before pregnancy and the score of part B in the main urban area group were higher than those in the non-main urban area group, and the differences were statistically significant (P＜0.05). Conclusion The pre-pregnancy health care service capacity of Chongqing district and county maternal and child health institutions needs to be further improved.
		2023 Vol. 20 (33): 88-91 [Abstract] ( 21 ) HTML (1 KB) PDF (571 KB) ( 31 )

	92	Clinical effect of Calcitriol on early type 2 diabetic nephropathy
		HUANG Cheng1 SHAO Yunxia2 WU Yan2 XING Changying1▲
		DOI: 10.20047/j.issn1673-7210.2023.33.20
		Objective To observe the clinical effect of Calcitriol on early type 2 diabetic nephropathy. Methods A total of 90 type 2 diabetic nephropathy patients admitted to the First Affiliated Hospital of Nanjing Medical University and the Wuhu Second People’s Hospital from August 2019 to May 2022 were selected as the study objects, and they were divided into two groups by random number table method， with 45 cases in each group. The control group received Olmesartan Ester on the basis of conventional treatment, and the observation group received Calcitriol on the basis of the control group, the treatment course of both groups was eight weeks. Renal function (serum creatinine [Scr], urinary albumincreatinine ratio [UACR], microalbuminuria [MA], cystatin C [CysC]), alkaline phosphatase (ALP), blood pressure (diastolic blood pressure [DBP], systolic blood pressure [SBP]), blood glucose (fasting blood glucose [FBG], glycated hemoglobin [HbA1c]), NADPH Oxidase 4 (NOX4) of the two groups were compared before and after treatment, the efficacy and incidence of adverse reactions were compared between the two groups. Results After treatment, Scr, UACR, MA, CysC in both groups, and ALP in control group were lower than those before treatment, and Scr, UACR, MA, CysC in observation group were lower than those in control group (P＜0.05). The ALP in the observation group was higher than that before treatment, and the observation group was higher than that in the control group (P＜0.05). After treatment, SBP, DBP, FBG and HbA1c in both groups were decreased compared with those before treatment (P＜0.05), and there was no statistical significance between groups (P＞0.05). After treatment, urine NOX4 decreased in both groups compared with that before treatment, and the observation group was lower than the control group (P＜0.05). The efficacy of the observation group was better than that of the control group(P＞0.05). There was no significant difference in the total rate of adverse reactions between the two groups (P＞0.05). Conclusion Calcitriol in the treatment of early type 2 diabetic nephropathy patients can significantly reduce the renal function damage, the degree of interphase podocyte damage, and improve the efficacy.
		2023 Vol. 20 (33): 92-95 [Abstract] ( 19 ) HTML (1 KB) PDF (547 KB) ( 63 )

	96	Analysis of influencing factors of atherosclerosis in type 2 diabetes mellitus
		WU Li1 ZHU Hong1 CAO Changchun1 MA Jian2 LI Qian3 YE Meng3 ZHOU Wen1 WANG Shuang1
		DOI: 10.20047/j.issn1673-7210.2023.33.21
		Objective To explore the influencing factors of arteriosclerosis (AS) in type 2 diabetes mellitus (T2DM) patients. Methods A total of 120 patients with T2DM who were hospitalized in Department of Endocrinology, Nanjing Drum Tower Hospital Group Suqian Hospital from July 2019 to September 2021 were selected, and divided into arteriosclerosis group (60 cases) and non-atherosclerosis group (60 cases) according to the color doppler ultrasound results. The general clinical data of the two groups were compared; and the risk factors of AS were analyzed by logistic regression; receiver operating characteristic (ROC) curve was used to analyse the ability of visceral fat area (VFA) to predict AS risk. Results There were significant differences in age, systolic blood pressure, body mass index, VFA, total cholesterol, triglyceride, low density lipoprotein cholesterol, fasting blood glucose, steady-state model insulin resistance index, diabetic microanglopathy, and hypertension between the two groups (P＜0.05). Logistic regression analysis showed that VFA, age and triglyceride were independent risk factors for AS in T2DM patients (P＜0.05). ROC curve showed that the area under the curve of VFA in predicting AS in T2DM patients was 0.702, the critical value was 114.7 cm2, the sensitivity was 0.617, and the specificity was 0.733. Conclusion Increased VFA, especially VFA＞114.7 cm2 is closely related to the occurrence of AS in T2DM patients.
		2023 Vol. 20 (33): 96-99 [Abstract] ( 13 ) HTML (1 KB) PDF (574 KB) ( 72 )

	100	Relationship between visceral fat area and cardiovascular and cerebrovascular complications in type 2 diabetes mellitus patients with normal body mass index
		XIANG Xiaoyan1 YE Juan2▲
		DOI: 10.20047/j.issn1673-7210.2023.33.22
		Objective To investigate the relationship between visceral fat area and cardiovascular and cerebrovascular complications in type 2 diabetes mellitus patients with normal body mass index (BMI). Methods From January 2018 to May 2021, 44 patients with type 2 diabetes mellitus and cardiovascular and cerebrovascular complications （24 cases of combined coronary heart disease and 20 cases of cerebral infarction）with normal BMI who were treated in Suzhou Jiulong Hospital, School of Medicine, Shanghai Jiao Tong University were selected as the observation group, and 132 patients with simple type 2 diabetes mellitus with normal BMI were selected as the control group. The differences in visceral fat area, fasting glucose (FPG), fasting insulin (FINS), insulin resistance index (HOMA-IR), etc. between the two groups were compared, and the receiver operating characteristic (ROC) curve was drawn to analyze the diagnostic value of visceral fat area for type 2 diabetes mellitus patients with normal BMI complicated with cardiovascular and cerebrovascular diseases. Results There were significant differences in diabetes course, smoking proportion, visceral fat area, FPG, FINS and HOMA-IR between the two groups (P＜0.05). Logistic regression analysis showed that the course of diabetes (OR=2.440, 95%CI:1.483-4.014), smoking [OR=3.013, 95% CI:1.730-5.247), visceral fat area [OR=2.250, 95%CI:1.459-3.470) were the influencing factors of patients with cardiovascular and cerebrovascular complications (P＜0.05), the area under the ROC curve of this equation was 0.820 (95%CI:0.746-0.894, P＜0.05), sensitivity and specificity were 75.00% and 78.00%, respectively. Conclusion The visceral fat area of type 2 diabetes mellitus patients with normal BMI and cardiovascular and cerebrovascular complications increases, which has certain diagnostic value for the disease.
		2023 Vol. 20 (33): 100-103 [Abstract] ( 20 ) HTML (1 KB) PDF (586 KB) ( 7 )

	104	Influencing factors of postoperative complications in patients with radical hysterectomy for cervical cancer
		ZHANG Shanshan PENG Yan XIANG Rui WANG Jingyi
		DOI: 10.20047/j.issn1673-7210.2023.33.23
		Objective To analyze the influencing factors of postoperative complications in patients with radical hysterectomy for cervical cancer (CC). Methods The clinical data of 379 patients who received radical hysterectomy for CC in the Second Affiliated Hospital of Chengdu Medical College Nuclear Industry 416 Hospital from January 2020 to March 2023 were retrospectively collected. According to whether postoperative complications occurred, the patients were divided into complication group and non-complication group. The influencing factors of complications after radical hysterectomy for CC were analyzed. Results The complication rate of 379 patients after radical hysterectomy for CC was 20.32% (77/379). There were no significant differences in age, diabetes mellitus, hypertension, education background, family annual income, menopause, history of pelvic surgery, pathological classification, length of vaginal resection, length of principal ligament resection, and the levels of squamous cell carcinoma antigen and carbohydrate antigen 125 between two groups (P＞0.05); there were significant differences in body mass index (BMI), tumor diameter, clinical stage, lymph node metastasis, number of lymph node dissection, lymph vessel ligation, operation time, intraoperative blood loss, hemoglobin (Hb), serum albumin, C-reactive protein (CRP), and complement C3 between two groups (P＜0.05). BMI (OR=2.675), clinical stage (OR=3.350), lymph node metastasis (OR=3.010), number of lymph node dissection (OR=2.568), operation time (OR=2.442), and CRP (OR=3.093) were the risk factors for complications after radical hysterectomy for CC (P＜0.05); lymphatic vessel ligation was a protective factor for complications after radical hysterectomy for CC (OR=0.310, P＜0.05). Conclusion The main complications after radical hysterectomy for CC are urinary retention, ureteral fistula, and postoperative incision infection. BMI, clinical stage, lymph node metastasis, number of lymph node dissection, operation time, CRP are risk factors, lymph vessel ligation were protective factors. Therefore, clinical treatment or intervention can be given to reduce the risk of postoperative complications for patients.
		2023 Vol. 20 (33): 104-108 [Abstract] ( 12 ) HTML (1 KB) PDF (622 KB) ( 33 )

	109	Effects of C1q/TNF-related protein 3, matrix metalloproteinase 3, and matrix metalloproteinase 9 on bone mineral density in postmenopausal women
		LU Xuechao1 XU Yuanyuan1▲ WEI Yingfeng1 REN Yali2 WANG Xia3
		DOI: 10.20047/j.issn1673-7210.2023.33.24
		Objective To investigate the effects of C1q/ TNF-related protein 3 (CTRP3), matrix metalloproteinase (MMP)-3, and MMP-9 on bone mineral density in postmenopausal women. Methods The clinical data of 92 women with natural men- opause who underwent physical examination in Nantong Third People’s Hospital of Jiangsu Province from June 2019 to June 2022 were retrospectively analyzed. They were divided into healthy group and osteoporosis group according to bone mineral density T score, osteoporosis was defined as bone mineral density T score≤-2.5 SD. The levels of CTRP3, MMP-3, and MMP-9 were compared between two groups. The correlation between CTRP3, MMP-3, and MMP-9 and bone mineral density was analyzed by Pearson correlation analysis, and the predictive value of CTRP3, MMP-3, and MMP-9 in osteoporosis was evaluated by receiver operation characteristic curve. Results Bone mineral density and bone mineral content of lumbar spine and femoral neck in osteoporosis group were lower than those in healthy group (P＜0.05). The level of CTRP3 in osteoporosis group was lower than that in healthy group, and the levels of MMP-3 and MMP-9 in osteoporosis group were higher than those in healthy group (P＜0.05). CTRP3 was positively correlated with bone mineral density of lumbar spine and femoral neck (r=0.451, 0.483, P＜0.05); MMP-3 was negatively correlated with bone mineral density of lumbar spine and femoral neck (r=-0.476, -0.439, P＜0.05); MMP-9 was negatively correlated with bone mineral density of lumbar spine and femoral neck (r=-0.508, -0.449, P＜0.05). The area under the curve predicted jointly by CTRP3, MMP-3, and MMP-9 was higher than that predicted by each index alone. Conclusion CTRP3, MMP-3, and MMP-9 levels are correlated with bone mineral density in postmenopausal women and can affect BMD levels, and the combined diagnosis of CTRP3, MMP-3, and MMP-9 has certain reference value for osteoporosis.
		2023 Vol. 20 (33): 109-112 [Abstract] ( 17 ) HTML (1 KB) PDF (633 KB) ( 34 )

	113	Analysis of risk factors of venous thrombosis in critically ill children after peripherally inserted central catheter
		WANG Xiaojing
		DOI: 10.20047/j.issn1673-7210.2023.33.25
		Objective To analyze the risk factors of venous thrombosis after peripherally inserted central catheter (PICC) in critically ill children. Methods A total of 240 critically ill children with PICC admitted to Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January to June 2022 were selected as the study objects. According to the formation of venous thrombosis after PICC, the children were divided into thrombus group and non-thrombus group. The general and clinical data of the critically ill children were analyzed, and the risk factors of venous thrombosis after PICC in critically ill children were analyzed. Results Venous thrombosis was formed after PICC in 24 cases of critically ill children, the incidence was 10%. There were significant differences in age, type of catheterization, D-dimer, and fibrinogen (FIB) levels between two groups (P＜0.05). Age (OR=0.755), D-dimer (OR=9.490), and FIB (OR=4.106) were the influencing factors of venous thrombosis after PICC in critically ill children (P＜0.05). Conclusion Age, D-dimer, and FIB levels are the influencing factors of venous thrombosis in critically ill children after PICC, which can provide scientific reference for follow-up clinical monitoring, prevention of thrombosis and intervention treatment.
		2023 Vol. 20 (33): 113-116 [Abstract] ( 14 ) HTML (1 KB) PDF (538 KB) ( 29 )

	117	Clinical effect of self-made Ziyin Shugan Mingmu Prescription on patients with xerophthalmia with syndrome of yin deficiency of liver and kidney
		YANG Lei1 WU Xiaoyang1 LUO Jihong1 XUE Linping2 LI Dujun1
		DOI: 10.20047/j.issn1673-7210.2023.33.26
		Objective To observe the clinical effect of self-made Ziyin Shugan Mingmu Prescription on patients with xerophthalmia with syndrome of yin deficiency of liver and kidney. Methods A total of 65 patients with xerophthalmia with syndrome of yin deficiency of liver and kidney treated in the Department of Ophthalmology, Hubei Provincial Hospital of Traditional Chinese Medicine from May 2019 to April 2021 were divided into control group (32 cases) and combination group (33 cases) according to random number table method. The control group was treated with Sodium Hyaluronate Eye Drops combined with acupuncture, and the combined group was treated with self-made Ziyin Shugan Mingmu Prescription on the basis of the treatment of control group. Ten days was taken as a course of treatment, and after two courses of treatment, the clinical efficacy of the two groups was compared. The changes of traditional Chinese medicine symptom score, breakup time of tear film (BUT), tear secretion, and corneal fluorescein staining (FL) scores before and after treatment were compared between the two groups. Results The clinical effect of the combined group was better than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, the traditional Chinese medicine symptom scores and FL scores of the two groups were lower than those before treatment, and those of combined group were lower than those of control group, the differences were statistically significant (P＜0.05). After treatment, the BUT in both groups were longer than those before treatment, and the tear secretion were higher than those before treatment, and the BUT in the combined group was longer than that in the control group, and the tear secretion was higher than that in the control group, the differences were statistically significant (P＜0.05). Conclusion On the basis of Sodium Hyaluronate Eye Drops combined with acupuncture, the self-made Ziyin Shugan Mingmu Prescription has therapeutic effect on the clinical symptoms and indicators of patients with xerophthalmia with syndrome of yin deficiency of liver and kidney, highlighting the advantages of acupuncture and medicine in the treatment of eye diseases, worthy of further promotion and application.
		2023 Vol. 20 (33): 117-121 [Abstract] ( 14 ) HTML (1 KB) PDF (732 KB) ( 18 )

	122	Comparison of the effect and safety of double over and out orbicularis oculi muscle flap eye bag excision and four-step plastic surgery on the removal of eye bags
		ZHANG Zheng1 ZHENG Botao2 LI Chao1▲
		DOI: 10.20047/j.issn1673-7210.2023.33.27
		Objective To compare the effect and safety of double over and out orbicularis oculi muscle flap eye bag excision and four-step plastic surgery on the removal of eye bags. Methods A total of 89 patients admitted to Suzhou Jiulong Hospital, School of Medicine, Shanghai Jiao Tong University from September 2019 to August 2021 were going to receive cosmetic plastic surgery for eye bags, and they were selected and divided into the orbicularis oculi muscle flap group (48 cases with double over and out orbicularis oculi muscle flap eye bag excision) and the four-step plastic surgery group (41 cases with four-step plastic surgery) according to the ball-touching method. The time of ocular appearance return to normal, the effect of eye bag removal and the improvement of lacrimal furrow were compared between the two groups. The complications were recorded after one year of postoperative follow-up. Results There was no significant difference in the recovery time of ocular appearance between the two groups (P＞0.05). The removal of bags in orbicularis oculi muscle flap group was better than that in four-step plastic surgery group, and the difference was statistically significant (P＜0.05). After surgery, Barton grading in both groups was better than that before surgery, and that of orbicularis oculi muscle flap group was better than that of four-step plastic surgery group, the differences were statistically significant (P＜0.05). The incidence of complications orbicularis oculi muscle flap group was lower than that in four-step plastic surgery group, and the difference was statistically significant (P＜0.05). Conclusion Compared with the four-step plastic surgery, the double over and out orbicularis oculi muscle flap eye bag excision can improve the effect of removing bags, improve lacrimal furrow, and reduce the incidence of postoperative complications.
		2023 Vol. 20 (33): 122-125 [Abstract] ( 12 ) HTML (1 KB) PDF (574 KB) ( 13 )

	126	Comparison of the application effect of iRoot SP and AH Plus root canal sealer in the root canal treatment of refractory anterior periapical disease
		LIU Man YU Ling GAO Yaojie CHANG E DONG Kaili
		DOI: 10.20047/j.issn1673-7210.2023.33.28
		Objective To compare the application of iRoot SP and AH Plus root canal sealer in the root canal treatment of refractory anterior periapical disease. Methods A total of 112 patients with refractory anterior periapical disease (single affected tooth) who received root canal treatment in the Department of Stomatology, Changzhou Hospital of Traditional Chinese Medicine, Jiangsu Province from February 2021 to February 2022 were selected and they were divided into iRoot SP group (56 cases) and AH Plus group (56 cases) according to random number table method. iRoot SP group was treated with iRoot SP root canal sealer, and AH Plus group was treated with AH Plus root canal sealer. The quality of root canal filling was compared between the two groups, the visual analogue scale (VAS) scores were compared between the two groups before treatment and one week after treatment, and the periapical index (PAI) was compared between the two groups before treatment and six months after treatment, and the efficacy of the two groups was evaluated. Results The filling rate of iRoot SP group was higher than that of AH Plus group, and the difference was statistically significant (P＜0.05). One week after treatment, VAS scores of the two groups were lower than those before treatment, and those of iRoot SP group were lower than those of AH Plus group, the differences were statistically significant (P＜0.05). At six months after treatment, PAI in two groups was lower than those before treatment, and those of iRoot SP group were lower than those of AH Plus group, the differences were statistically significant (P＜0.05). The curative effect of iRoot SP group was better than that of AH Plus group, and the difference was statistically significant (P＜0.05). Conclusion Compared with AH Plus root canal sealer, iRoot SP root canal sealer can improve the quality of root canal filling, relieve pain, promote disease recovery, and improve the therapeutic effect when applied in the root canal treatment of refractory anterior periapical disease.
		2023 Vol. 20 (33): 126-129 [Abstract] ( 17 ) HTML (1 KB) PDF (550 KB) ( 7 )

	130	Professor Zhang Mianzhi’s clinical experience in treating proteinuria based on the theory of “kidney deficiency and blood stasis”
		CHEN Shu1 DONG Ao1 ZHANG Mianzhi2
		DOI: 10.20047/j.issn1673-7210.2023.33.29
		Proteinuria as one of the common clinical manifestations of chronic kidney disease, Chinese medicine treatment of proteinuria can avoid the western medicine treatment brought by the toxic side effects, unclear curative effect, and other problems. Based on this, Professor Zhang Mianzhi uses the theory of “kidney deficiency and blood stasis” to treat proteinuria. Professor Zhang Mianzhi believes that the etiology and pathogenesis of proteinuria are mainly classified as “kidney deficiency and blood stasis”, and spleen deficiency, dampness turbidity, wind evil, and heat toxicity are also key factors leading to the occurrence and development of the disease. Therefore, he advocates that the therapeutic principle of “tonifying kidney and promoting blood circulation” should be carried out in the whole process of disease treatment, and remarkable therapeutic effects have been achieved. Based on the theory of “kidney deficiency and blood stasis”, this article explains the clinical experience of Professor Mianzhi in the treatment of proteinuria, and provides a case for discussion.
		2023 Vol. 20 (33): 130-133,142 [Abstract] ( 47 ) HTML (1 KB) PDF (788 KB) ( 13 )

	134	Discussion on prescription theory of ancient classical prescription of Kaixin Powder and its related prescriptions
		YIN Junmei1 WANG Cai1 DING Kan2 GAO Ya2
		DOI: 10.20047/j.issn1673-7210.2023.33.30
		Kaixin Powder is in the first batch of ancient classical prescription published by National Administration of Traditional Chinese Medicine. Kaixin Powder is a commonly used prescription for traditional Chinese Medicine clinial treatment of “forgettery”. In the process of application by later clinical practitioners, related prescriptions had been evolved. Compared with Kaixin Powder, the theory of related prescriptions are both “righteous” and “innovative”. The article inspects the name of Kaixin Powder and the source of it, discusses the feature of Kaixin Powder and its related prescriptions, and clarifies the change of the treatment scope. As a result, Kaixin Powder comes from the book of Jiyan Fang wrote by an ancient doctor named Yao Sengyuan. It is believed that the name of Kaixin Powder indicates the functional regulation of opening the heart and regulating the kidney. In the process of spreading, this formula has derived seven main types of prescriptions, including Dingzhi Pills, Lingren Buwang Fang, Yuanzhi Powder, Xiaodingzhi Pills, Yuanzhi Pills, Jiawei Dingzhi Pills, and Changpu Yizhi Pills. Kaixin Powder and its related prescriptions follow the theory of compatibility of sweet, bitter, and pungent, and determine the dosage of the main medicine according to the characteristics of the syndrome, and the method of administration according to the characteristics of the dosage form. According to the theory of this group of prescription, the main treatment syndromes of Kaixin Powder and its related prescriptions have gone through a process from simple “forgettery” to abnormal mental state, and then to psychosomatic diseases, which has an enlightening effect on exploring and expanding the clinical application scope of Kaixin Powder.
		2023 Vol. 20 (33): 134-137 [Abstract] ( 15 ) HTML (1 KB) PDF (621 KB) ( 12 )

	138	Professor Chang Jingling’s experience in the treatment of post-stroke aphasia based on the theory of “brain-kidney-marrow”
		WANG Haifang XU Minjie CHANG Jingling
		DOI: 10.20047/j.issn1673-7210.2023.33.31
		Post-stroke aphasia is one of the most common complications of stroke, and one of the causes of long-term deficits in speech disorders, which seriously affects patients’ quality of daily life. At present, it is mainly treated with speech rehabilitation therapy combined with conventional western medicine treatment in stroke medicine, which the clinical efficacy varies greatly among individuals. Through years of clinical observation and practice, Professor Chang Jingling concluded that post-stroke aphasia should be treated with “brain-kidney-marrow” as the main line of syndrome differentiation and treatment, and overall syndrome differentiation and treatment of pathological factors such as wind, fire, and phlegm. The theory is based on strengthening vital qi and dispersing blood stasis. The syndrome differentiation adopts the methods of clearing heat and promoting blood circulation, soothing the liver and extinguishing wind, resolving phlegm and unblocking collaterals, awakening the spirit and opening the body, and treating both the tip and root, combining tonifying and supplementing, demonstrating the dialectical thinking advantages of “integration of body and spirit” for traditional Chinese medicine.
		2023 Vol. 20 (33): 138-142 [Abstract] ( 14 ) HTML (1 KB) PDF (845 KB) ( 101 )

	143	Clinical effect on the treatment of diplopia after stroke of liver and kidney deficiency type with the combination of modified Yiqi Congming Decoction and weijin intersection acupuncture method
		WANG Yue1 SHAO Yue2 WU Songbai1 LIU Yulan1 SONG Chunxia1 QUAN Xingmiao1 LI Ying1
		DOI: 10.20047/j.issn1673-7210.2023.33.32
		Objective To explore the clinical efficacy of Yiqi Congming Decoction combined with weijin intersection acu- puncture in the treatment of diplopia after stroke of liver and kidney deficiency type. Methods A total of 90 patients with post stroke diplopia admitted to Affiliated Hospital of Chengde Medical College from January 2021 to January 2023 were selected as the subjects, and they were divide into three groups by random number table method, with 30 cases in each group. Control group 1 received conventional treatment+modified treatment with Yiqi Congming Decoction; control group 2 received conventional treatment+acupuncture treatment; combined group received conventional treatment+modified Yiqi Congming Decoction +acupuncture treatment. Ten days was one course of treatment. After three courses of treatment, the clinical efficacy, symptom score, ocular function index, and treatment safety of the three groups were evaluated. Results The effective rate of the combined group was higher than that of control group 1 and control group 2 (P＜0.05). After treatment, diplopia, oblique eye, dizziness, nausea， and compensatory head position scores in the three groups were lower than before treatment, and the combined group was significantly lower than control group 1 and control group 2 (P＜0.05). After treatment, the diplopia image distance and pupil diameter of the three groups were smaller than before treatment, and the eye cleft width was larger than before treatment, and the combined group’ diplopia image distance and pupil diameter were smaller than control group 1 and control group 2, and the eye cleft width was larger than control group 1 and control group 2 (P＜0.05). There was no significant difference in the incidence of adverse reactions between the combined group and control group 1 and control group 2 (P＞0.05). Conclusion The clinical efficacy of modified Yiqi Congming Decoction combined with acupuncture in the treatment of post stroke diplopia is significant, which can improve the patients’ traditional symptom and symptom scores.
		2023 Vol. 20 (33): 143-147 [Abstract] ( 13 ) HTML (1 KB) PDF (725 KB) ( 13 )

	148	Study on diagnosis and treatment rule of modern clinical application of Chaihu Guizhi Ganjiang Decoction
		WANG Yichen1 XU Zhengyu1 WANG Han1 ZHANG Qingqing1 REN Lijiang1 WANG Ping2
		DOI: 10.20047/j.issn1673-7210.2023.33.33
		Objective To analyze the diagnosis and treatment rule of modern clinical application of Chaihu Guizhi Ganjiang Decoction based on the case literature, and to provide reference for its clinical use and scientific research. Methods The case literatures on “Chaihu Guizhi Ganjiang Decoction” and “Chaihu Jianggui Decoction” published from January 2000 to December 2021 were searched on CNKI and Wanfang Data, and were input into the database after literature screening, nomenclature specification and data extraction. Syndrome elements, symptoms, tongue and pulse distribution, and drug use were described by frequency analysis, and drugs and pathogenesis rules were analyzed by cluster analysis. Results Finally, a total of 83 literatures were included, and a total of 118 cases met the requirements. The treatment of diseases involves 51 kinds of western diseases and 38 kinds of traditional Chinese diseases. A total of 57 symptoms were involved in 118 cases, the common symptoms were mainly loose or diarrhea, bitter mouth, thirst/dry oropharynx. The frequency of tongue quality was the highest in red tongue, the frequency of tongue coating was the highest in white tongue, and the pulse image was the highest in string pulse. Symptoms tongue and pulse with frequency ＞ 20%, could be grouped into four categories by systematic clustering analysis. Among the 118 cases, 87 cases were treated with zang-fu syndrome differentiation and 31 cases with six channels differentiation. By dividing the complex syndromes in the original medical records, a total of 118 main syndromes and 49 concurrent syndromes were obtained. A total of 98 kinds of drugs were used in 118 cases, and 14 kinds of common flavored drugs were used. By cluster analysis of the original prescription drugs and commonly used flavoring drugs, five groups of drug combinations were obtained. The original prescription drugs and five groups of flavoring drugs were combined respectively, and the similar prescriptions of Chaihu Longgu Muli Decoction, Xiao Chaihu Decoction, Tongxieyao Prescription, Danggui Buxue Decoction were extracted. Conclusion The modern clinical application of Chaihu Guizhi Ganjiang Decoction has the following rules: the disease is in Shaoyang, good at treating diseases with mixed characteristics of cold and heat. It can be widely used in the treatment of digestive system diseases, and spleen deficiency syndrome is common in patients. It can sooth the liver and relieve depression, treat insomnia, anxiety, depression, and other emotional symptoms.
		2023 Vol. 20 (33): 148-152 [Abstract] ( 17 ) HTML (1 KB) PDF (1179 KB) ( 10 )

	153	Professor Yuan Bin’s experience in treating childrens’ new-long cough from“wind-phlegm”
		CAO Bingxue1 YUAN Bin2
		DOI: 10.20047/j.issn1673-7210.2023.33.34
		Professor Yuan Bin inherited the teacher’s theory and made some innovations, on the basis of Professor Wang Shouchuan’s theory of hidden wind, the concept of wind-phlegm cough is put forward. Professor Yuan describes the specific symptoms of this cough. He believes that the key to the pathogenesis is the retention of wind-phlegm in the lung and the imbalance in lung qi. More phlegm and blood in the stasis mutual knot day after day. After consulting ancient and modern literature, Professor Yuan wrote new prescriptions to restore lung qi by reducing phlegm and wind with ephedra and pinellia tuber. Treatment is supplemented with activating the spleen and regulating the liver to coordinate the five internal organs and improve the condition. He attached great importance to the relationship between the lung and the orifices. A distinction between the nose and pharynx should be made, and treatment of organs and orifices should be performed at the same time for internal and external patency. He is skilled in flexible methods with a combination of traditional Chinese medicine and western medicine, though mainly in traditional Chinese medicine. Diagnosis and treatment involve both Chinese and western methods. Professor Yuan bin often attaches importance to the supplementary examination of modern medicine and often combines syndrome differentiation with disease differentiation when diagnosing disease. Professor Yuan Bin’s treatment of the disease is mainly based on traditional Chinese medicine, supplemented by western medicine, and has repeatedly achieved good results.
		2023 Vol. 20 (33): 153-156,161 [Abstract] ( 16 ) HTML (1 KB) PDF (890 KB) ( 48 )

	157	Application effect of individualized diet intervention program in elderly patients with dysphagia after stroke
		SUN Feng1 ZHANG Tao2 WANG Fang2 TANG Xianping1
		DOI: 10.20047/j.issn1673-7210.2023.33.35
		Objective To explore application effect of individualized diet intervention program in elderly patients with dysphagia after stroke. Methods A total of 100 elderly stroke patients with dysphagia who were hospitalized in the Nanjing Drum Tower Hospital Group Suqian Hospital, from November 2021 to July 2022 were selected as the study objects, according to the random number table method, they were divided into control group and experimental group, with 50 cases in each group. The control group was given routine diet nursing, and the experimental group was given individualized dietary intervention program. The frequency of symptoms related to the swallowing safety and swallowing of ficacy during three meals a day was compared between the two groups. Results The incidence of coughing, abnormal pronunciation, and decrease of blood oxygen saturation of more than 3% in experimental group was lower than that in control group, and the differences were statistically significant (P＜0.05). The incidence of oral food residue and fluid outflow in experimental group was lower than that in control group, and the difference was statistically significant (P＜0.05). Conclusion Individualized dietary intervention program can improve the clinical symptoms of swallowing disorder in elderly stroke patients, effectively reduce the incidence of aspiration, oral food residue, and fluid outflow, and improve the swallowing safety and swallowing efficacy in patients.
		2023 Vol. 20 (33): 157-161 [Abstract] ( 15 ) HTML (1 KB) PDF (975 KB) ( 53 )

	162	Effect of semiconductor laser therapy combined with auricular pressure beans on postoperative pain and limb movement in patients with lumbar disc herniation undergoing low-temperature plasma radiofrequency ablation
		LIU Hui WANG Shasha▲ ZHU Yuqi ZHAO Yingjun
		DOI: 10.20047/j.issn1673-7210.2023.33.36
		Objective To explore the effect of semiconductor laser therapy combined with auricular pressure beans on postoperative pain and limb movement in patients with lumbar disc herniation undergoing low-temperature plasma radiofrequency ablation. Methods A total of 100 patients with lumbar disc herniation undergoing low-temperature plasma radiofrepuency ablation admitted to the orthopedic ward of the Eye Hospital China Academy of Chinese Medical Sciences from January 2021 to January 2022 were included, according to the random number table method, the patients were divided into control group and study group, with 50 cases in each group. The control group was treated with routine care and semiconductor laser therapy. The study group was treated with auricular pressure beans therapy on the basis of the control group. Postoperative visual analogue scale (VAS) score, Japanese Orthopaedic Association (JOA) score, Oswestry Disability Index (ODI) score, and length of hospital stay, and clinical efficacy were compared between the two groups. Results Overall analysis found that there were significant differences in VAS, JOA and ODI scores, inter-group and interaction between the two groups (P＜0.05). Intra-group comparison, VAS, JOA scores, and ODI scores of the two groups were compared at each time point after surgery, and the differences were statistically significant (P＜0.05). Compared between groups, VAS and ODI scores of the study group were lower than those of the control group at one, three and five days after surgery, JOA score was higher than that of the control group, and the differences were statistically significant (P＜0.05). The postoperative hospitalization time of the study group was shorter than that of the control group, and the difference was statistically significant (P＜0.05). The clinical effect of the study group was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The implementation of semiconductor laser therapy combined with auricular pressure beans for patients after lumbar low-temperature plasma radiofrequency ablation is conducive to early relief of pain, recovery of limb motion, promoting postoperative recovery of patients, and shortening hospital stay.
		2023 Vol. 20 (33): 162-165 [Abstract] ( 15 ) HTML (1 KB) PDF (777 KB) ( 48 )

	166	Clinical study of group-based recreation activities on the improvement of post-stroke cognitive impairment patients with group-based recreation activities
		ZHANG Jie WANG Weiwei ZHU Mingjin
		DOI: 10.20047/j.issn1673-7210.2023.33.37
		Objective To explore the effects of group-based recreation activities on the improvement of cognitive function, daily living ability, and quality of life in patients with post-stroke cognitive impairment (PSCI). Methods A total of 80 subjects meeting PSCI standards in Rehabilitation Center of Tongde Hospital of Zhejiang Province from June 2021 to May 2023 were selected, and the group was divided into control group and treatment group with 40 cases in each group according to the ratio of 1∶1 by block randomization. The control group received traditional cognitive rehabilitation training, and the treatment group received group-based recreation activities training on the basis of the control group. They were assessed by the mini mental state examination (MMSE), the Montreal cognitive assessment (MoCA), the Barther index (BI) and the World Health Organization quality of life scale (WHO-QoL) before treatment, the occurrence of adverse events in the two groups during the intervention period was analyzed. Results The overall analysis found that there were statistically significant differences in time and interaction between the two groups (P＜0.05). In intra-group comparison, MMSE and MoCA scores were compared between the two groups at each time point, and the differences were statistically significant (P＜0.05). Before treatment, there were no significant differences in MMSE and MoCA scores between the two groups (P＞0.05). After treatment and at follow-up, MMSE scores in the treatment group were higher than those in the control group, and the differences were statistically significant (P＜0.05). Overall analysis found that there were statistically significant differences in the comparison of inter-group, time and interaction between the two groups (P＜0.05). Intra-group comparison and comparison of BI and WHOQoL scores at each time point between the two groups showed statistically significant differences (P＜0.05). Before treatment, there were no significant differences in BI and WHO-QoL scores between the two groups (P＞0.05). After treatment and at follow-up, BI and WHOQoL-BREF scores in the treatment group were higher than those in the control group (P＜0.05). No adverse events were reported during the study period in either group. Conclusion Group-based recreation activities can effectively improve cognitive function, daily activity ability, and quality of life in PSCI patients.
		2023 Vol. 20 (33): 166-170 [Abstract] ( 13 ) HTML (1 KB) PDF (676 KB) ( 7 )

	171	Clinical value of standardized nutrition process nursing in patients with pancreatitis
		WU Li QU Fang FAN Qian MA Li▲
		DOI: 10.20047/j.issn1673-7210.2023.33.38
		Objective To explore the clinical value of standardized nutrition process nursing in patients with pancreatitis. Methods A total of 100 patients with pancreatitis admitted to the gastroenterology department of the Second People’s Hospital of Nantong, Jiangsu Province from January 2020 to April 2022 were selected, random number table method was used to divide the patients into reference group and intervention group, with 50 cases in each group. The reference group implemented routine nutrition nursing intervention, and the intervention group implemented standardized nutrition nursing intervention. One day after admission and 14 days after intervention, abdominal distension, body temperature, blood amylase, urine amylase, body mass index (BMI), plasma albumin (ALB), total protein (TP), vomiting, abdominal distension, constipation, gastric retention, and other nutritional intolerance were observed and analyzed in the two groups. Results The time of abdominal distension relief, normal body temperature, blood amylase recovery and urine amylase recovery in the intervention group were shorter than those in the reference group, and the differences were statistically significant (P＜0.05); after 14 days of intervention, the levels of BMI, ALB, and TP of the two groups were higher than those of the one day after admission, and the intervention group was higher than the reference group, the differences were statistically significant (P＜0.05); the total incidence of nutritional intolerance such as vomiting, bloating, constipation and gastric retention in the intervention group was lower than that in the reference group, and the difference was statistically significant (P＜0.05). Conclusion The implementation of standardized nutrition process nursing intervention in patients with pancreatitis is conducive to improving the clinical rehabilitation indicators of patients, improving the nutritional status of the body, and reducing the incidence of nutritional intolerance.
		2023 Vol. 20 (33): 171-174 [Abstract] ( 14 ) HTML (1 KB) PDF (623 KB) ( 12 )

	175	Effect of different length indentation of gastric tube on dysphagia in stroke patients
		ZHOU Chang LI Tian LIU Aidi LIN Suhan
		DOI: 10.20047/j.issn1673-7210.2023.33.39
		Objective To investigate the effect of different length indentation of gastric tube on stroke patients with dysphagia. Methods A total of 100 patients with stroke complicated with dysphagia requiring gastric catheterization admitted to Wenzhou Central Hospital of Zhejiang Province from February 2021 to February 2023 were selected as the study objects, and they were divided into control group and observation group by random number table method, with 50 cases in each group. The control group was placed according to the traditional measuring method, and the observation group was increased by 10 cm on the basis of the traditional catheterization. The changes of heart rate (HR), respiration (R), percutaneous arterial oxygen saturation (SpO2), and mean arterial blood pressure (MAP) before and after catheterization were compared between the two groups, and the success rate of one-time catheterization, incidence of adverse reactions, and aspiration times were compared between the two groups. Results After catheterization, there were no significant differences in HR and R between the two groups (P＞0.05). After catheterization, SpO2 and MAP were higher than those before treatment, and those of observation group were higher than those of control group, the differences were statistically significant (P＜0.05). There was no significant difference in the success rate of one-time catheterization, the incidence of adverse reactions, and the proportion of patients with different aspiration times between the two groups (P＞0.05). Conclusion In patients with stroke complicated with dysphagia, an increase of 10 cm on the basis of traditional indenture gastric tube length has no effect on the success rate of one-time catheterization and other indicators, and is beneficial to the recovery of SpO2 and MAP indicators of patients.
		2023 Vol. 20 (33): 175-178 [Abstract] ( 14 ) HTML (1 KB) PDF (541 KB) ( 31 )

	179	Effect of PDCA circulation intervention in patients with advanced liver cancer after peripherally inserted central venous catheter
		LYU Yuan1 LI Naxin2▲
		DOI: 10.20047/j.issn1673-7210.2023.33.40
		Objective To investigate the effect of PDCA circulation intervention mode in patients with advanced liver cancer undergoing peripherally inserted central venous catheter (PICC). Methods A total of 82 patients with advanced liver cancer who received PICC catheterization from January 2020 to January 2022 in Beijing You’an Hospital, Capital Medical University were selected and divided into control group and intervention group by random number table method, with 41 cases in each group. The control group received routine nursing, and the intervention group received PDCA circulation intervention on the basis of the control group. Both groups were treated for one month and followed up for two months. The adherence to PICC catheterization, self-care ability, catheter adverse events, and complications were observed in both groups. Results The compliance of PICC catheterization in intervention group was better than that in control group, and the difference was statistically significant (P＜0.05). After two months of follow-up, the scores of exercise of self-care agency scale in both groups were higher than those before intervention, and those of intervention group were higher than those of control group, the differences were statistically significant (P＜0.05). The total incidence of catheter adverse events and total incidence of complications in the intervention group were lower than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion PDCA circulation intervention can improve catheterization compliance and self-care ability of patients with advanced liver cancer receiving PICC catheterization, and reduce catheter adverse events and complications.
		2023 Vol. 20 (33): 179-183 [Abstract] ( 14 ) HTML (1 KB) PDF (737 KB) ( 10 )

	184	One case of high complexity anal fistula complicated with female presacral cyst and literature review
		YUAN Run ZHANG Zhuhui TIAN Rui JIANG Yun LEI Li LI Huashan
		DOI: 10.20047/j.issn1673-7210.2023.33.41
		For a long time, high complexity anal fistula has been recognized as a difficult disease in proctology department, while the incidence of presacral cyst is low, the understanding is still shallow, and the operation is difficult, which also poses no small problem for anorectal medical workers. Presacral cyst is often misdiagnosed as anal fistulas, and their pathogenesis and differential diagnosis remain to be further understood. In this paper, a female patient with recurrent high complexity anal fistula was found to have missed presacral cyst. Considering the close relationship between the cyst and the incidence of high complexity anal fistula, the incision was lengthened and the sinuses were removed completely and the mass was completely removed. Through the review and analysis of the diagnosis and treatment process and frontier progress, in order to provide reference for clinical diagnosis and treatment.
		2023 Vol. 20 (33): 184-187 [Abstract] ( 17 ) HTML (1 KB) PDF (1039 KB) ( 148 )

	188	Management and intervention strategies of pulmonary nodules with traditional Chinese medicine
		LI Yue1 LIU Rui2 HUA Baojin2
		DOI: 10.20047/j.issn1673-7210.2023.33.42
		Pulmonary nodules are the main manifestation of early lung cancer, and modern medicine has formed its standardized management and intervention system, but there are still problems such as lack of intervention measures during the follow-up period. Traditional Chinese medicine has advantages in the diagnosis and treatment of pulmonary nodules. This paper proposes to establish a management and intervention system for pulmonary nodules with Traditional Chinese medicine characteristics, apply traditional Chinese medicine to the entire diagnosis and treatment of pulmonary nodules, form a screening model combining imaging and constitution, construct a malignant risk prediction model with the participation of traditional Chinese medicine syndromes, adopt interventions combining the identification of constitution and syndromes as well as the internal and external treatments in the follow-up period, and set up a comprehensive platform for the networked management and intervention of traditional Chinese medicine in pulmonary nodules. Also, limitations such as the lack of standardization of the traditional Chinese medicine management and intervention protocol in pulmonary nodules, the gaps in the study of the time-pharmacodynamic effect, and the imperfect evaluation of the therapeutic efficacy are discussed.
		2023 Vol. 20 (33): 188-191 [Abstract] ( 11 ) HTML (1 KB) PDF (589 KB) ( 17 )

	192	Construction and management of women and children biobank in Fujian Province
		LIN Aizhu1 WU Yuping1 ZHU Yibing2 CAO Hua1 WANG Xinrui1
		DOI: 10.20047/j.issn1673-7210.2023.33.43
		The construction of women and children biobank has a great significance to the analysis and research of women and child-related diseases. The biobank of Fujian Maternity and Child Health Hospital combined with the development characteristics of the hospital, reference to the construction experience of international large-scale biobanks, and the standardization ideas of International Organizations for Standardization and other organizations, from the aspects of infrastructure construction, organizational framework, ethics, personnel, equipment, and process management. Additionally, this biobank is a provincial biobank that covers the full life cycle from pregnancy to life development (infants, children, and adolescents) to adulthood in Fujian Province, in order to attract more exchanges and cooperation between units, and jointly contribute to the prevention and treatment of women and children-related diseases, especially major characteristic diseases.
		2023 Vol. 20 (33): 192-封三 [Abstract] ( 19 ) HTML (1 KB) PDF (2134 KB) ( 12 )

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