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| Effects of C1q/TNF-related protein 3, matrix metalloproteinase 3, and matrix metalloproteinase 9 on bone mineral density in postmenopausal women |
| LU Xuechao1 XU Yuanyuan1▲ WEI Yingfeng1 REN Yali2 WANG Xia3 |
1.Department of Endocrinology, Nantong Third People’s Hospital Nantong Third Hospital Affiliated to Nantong University, Jiangsu Province, Nantong 226000, China;
2.Department of Medical Technology, Nantong Health Higher Vocational and Technical School, Jiangsu Province, Nantong 226000, China;
3.Department of Osteoporosis, Nantong Third People’s Hospital Nantong Third Hospital Affiliated to Nantong University, Jiangsu Province, Nantong 226000, China |
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Abstract Objective To investigate the effects of C1q/ TNF-related protein 3 (CTRP3), matrix metalloproteinase (MMP)-3, and MMP-9 on bone mineral density in postmenopausal women. Methods The clinical data of 92 women with natural men- opause who underwent physical examination in Nantong Third People’s Hospital of Jiangsu Province from June 2019 to June 2022 were retrospectively analyzed. They were divided into healthy group and osteoporosis group according to bone mineral density T score, osteoporosis was defined as bone mineral density T score≤-2.5 SD. The levels of CTRP3, MMP-3, and MMP-9 were compared between two groups. The correlation between CTRP3, MMP-3, and MMP-9 and bone mineral density was analyzed by Pearson correlation analysis, and the predictive value of CTRP3, MMP-3, and MMP-9 in osteoporosis was evaluated by receiver operation characteristic curve. Results Bone mineral density and bone mineral content of lumbar spine and femoral neck in osteoporosis group were lower than those in healthy group (P＜0.05). The level of CTRP3 in osteoporosis group was lower than that in healthy group, and the levels of MMP-3 and MMP-9 in osteoporosis group were higher than those in healthy group (P＜0.05). CTRP3 was positively correlated with bone mineral density of lumbar spine and femoral neck (r=0.451, 0.483, P＜0.05); MMP-3 was negatively correlated with bone mineral density of lumbar spine and femoral neck (r=-0.476, -0.439, P＜0.05); MMP-9 was negatively correlated with bone mineral density of lumbar spine and femoral neck (r=-0.508, -0.449, P＜0.05). The area under the curve predicted jointly by CTRP3, MMP-3, and MMP-9 was higher than that predicted by each index alone. Conclusion CTRP3, MMP-3, and MMP-9 levels are correlated with bone mineral density in postmenopausal women and can affect BMD levels, and the combined diagnosis of CTRP3, MMP-3, and MMP-9 has certain reference value for osteoporosis.
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[1] He J，Xu S，Zhang B，et al. Gut microbiota and metabolite alterations associated with reduced bone mineral density or bone metabolic indexes in postmenopausal osteoporosis [J]. Aging（Albany NY），2020，12（9）：8583-8604.
[2] 潘丽华，周凤，柯雁飞.子痫前期孕妇血清CTRP3、CTRP9水平与糖脂代谢的相关性[J].中国医师杂志，2020，22（2）：233-236，240.
[3] 张薇薇，华芳，梁超帅，等.促甲状腺激素通过抗炎蛋白CTRP3促进软骨细胞分化[J].山东大学学报（医学版），2022，60（10）：1-8，26.
[4] 李先耀，邹瑶，丁敬韬，等.血清MMP-3水平与类风湿关节炎骨侵蚀的相关性研究[J].中国医师杂志，2021，23（2）：227-230，235.
[5] 蒲沛东，马腾洋，周士平，等.ERK1/2信号蛋白和蛋白降解酶在骨关节炎患者软骨/软骨下骨中的表达及其意义[J].解放军医学杂志，2022，47（3）：277-285.
[6] 魏海英，宋立文.健脾益肾壮骨汤治疗原发性骨质疏松症的疗效及对血清IGF-1 MMP-9 ET-1水平的影响[J].河北医学，2021，27（12）：2101-2105.
[7] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊治指南（2011年）[J].中华骨质疏松和骨矿盐疾病杂志，2011，4（1）：2-17.
[8] 刘芳，王布，张长洪，等.CTRP3通过SIRT1/NF-κB信号通路改善脂多糖诱导的小鼠急性肺损伤[J].西部医学，2023，38（1）：28-33.
[9] 孙媛媛，余其贵，谢军.血清CTRP3、CTRP5、CTRP9水平与老年慢性心力衰竭的临床关系[J].中国老年学杂志，2021，41（17）：3633-3636.
[10] Demirtas D，Ac?覦bucu F，Baylan FA，et al. CTRP3 is Signi- ficantly Decreased in Patients with Primary Hyperparathyroidism and Closely Related with Osteoporosis [J]. Exp Clin Endocrinol Diabetes，2020，128（3）：152-157.
[11] 蒋晶，杨茜云，沈国强，等.基质金属蛋白酶3在类风湿关节炎患者中的临床意义[J].国际检验医学杂志，2022， 43（1）：73-77.
[12] 荆志慧，薛筱霏，方芷昱，等.脂肪因子Vaspin在骨代谢中的研究进展[J].中国骨质疏松杂志，2022，28（4）：596- 600.
[13] Xu ZH，Zhang X，Xie H，et al. Serum CTRP3 Level is Associated with Osteoporosis in Postmenopausal Women [J]. Exp Clin Endocrinol Diabetes，2018，126（9）：559-563.
[14] 余成帅，杜刚，庞慎宁，等.促炎脂肪因子Chemerin促进一氧化氮表达调节软骨细胞的增殖与代谢[J].中国组织工程研究，2021，25（2）：258-263.
[15] Zheng X，Zhang Y，Guo S，et al. Dynamic expression of matrix metalloproteinases 2，9 and 13 in ovariectomy-induced osteoporosis rats [J]. Exp Ther Med，2018，16（3）：1807- 1813.
[16] 冯刚，肖登，王翠婷，等.血清脂肪因子-CTRP 3水平与绝经后妇女骨密度相关性研究[J].中国骨质疏松杂志，2019，25（6）：789-792.
[17] 于静，梁丽萍，徐保群，等.MMP-3、CD10及Ki-67在三阴型乳腺癌组织中的表达及其意义[J].医学临床研究，2022，39（4）：484-487.
[18] 白晓亮.雌激素对去势雌兔腰椎间盘髓核中IL-20和MMP-3表达影响的实验研究[D].苏州：苏州大学，2010.
[19] Jehan F，Zarka M，de la Houssaye G，et al. New insights into the role of matrix metalloproteinase 3（MMP3）in bone [J]. FASEB Bioadv，2022，4（8）：524-538.
[20] Nagase Y，Nagashima M，Shimane K，et al. Effect of TNF inhibitors with bisphosphonates vs bisphosphonates alone on bone mineral density and bone and cartilage biomarkers at 1 year in patients with rheumatoid arthritis：A prospective study [J]. Mod Rheumatol，2022，32（3）：517-521.
[21] 张娴，王世军，周莲娥，等.不同剂量雌激素联合孕激素对围绝经期综合征患者性激素及骨密度的影响[J].中国病案，2022，23（8）：93-96.
[22] 方文焕，麦伟，颜志坚，等.绝经后骨质疏松性椎体压缩性骨折患者血清雌激素、前脂肪因子-1水平与骨代谢和骨密度相关性研究[J].中国骨质疏松杂志，2021，27（12）：1763-1766，1773.
[23] 谢春，李作瑞，史纲，等.高原藏族绝经后妇女不同部位骨密度的变化规律及其与生化指标的关联性[J].中国医疗设备，2022，37（7）：144-147.
[24] Sabry M，Mostafa S，Rashed L，et al. Matrix metalloproteinase 9 a potential major player connecting atherosclerosis and osteoporosis in high fat diet fed rats [J]. PLoS One，2021， 16（2）：e0244650.
[25] 杨荣，李跃红，张浩，等.血清MMP-9、TNF-α表达水平与膝骨关节炎严重程度及骨密度的相关性研究[J].现代实用医学，2019，31（8）：1048-1050. |
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