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| Study on diagnosis and treatment rule of modern clinical application of Chaihu Guizhi Ganjiang Decoction |
| WANG Yichen1 XU Zhengyu1 WANG Han1 ZHANG Qingqing1 REN Lijiang1 WANG Ping2 |
1.Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;
2.Department of Gastroenterology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China |
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Abstract Objective To analyze the diagnosis and treatment rule of modern clinical application of Chaihu Guizhi Ganjiang Decoction based on the case literature, and to provide reference for its clinical use and scientific research. Methods The case literatures on “Chaihu Guizhi Ganjiang Decoction” and “Chaihu Jianggui Decoction” published from January 2000 to December 2021 were searched on CNKI and Wanfang Data, and were input into the database after literature screening, nomenclature specification and data extraction. Syndrome elements, symptoms, tongue and pulse distribution, and drug use were described by frequency analysis, and drugs and pathogenesis rules were analyzed by cluster analysis. Results Finally, a total of 83 literatures were included, and a total of 118 cases met the requirements. The treatment of diseases involves 51 kinds of western diseases and 38 kinds of traditional Chinese diseases. A total of 57 symptoms were involved in 118 cases, the common symptoms were mainly loose or diarrhea, bitter mouth, thirst/dry oropharynx. The frequency of tongue quality was the highest in red tongue, the frequency of tongue coating was the highest in white tongue, and the pulse image was the highest in string pulse. Symptoms tongue and pulse with frequency ＞ 20%, could be grouped into four categories by systematic clustering analysis. Among the 118 cases, 87 cases were treated with zang-fu syndrome differentiation and 31 cases with six channels differentiation. By dividing the complex syndromes in the original medical records, a total of 118 main syndromes and 49 concurrent syndromes were obtained. A total of 98 kinds of drugs were used in 118 cases, and 14 kinds of common flavored drugs were used. By cluster analysis of the original prescription drugs and commonly used flavoring drugs, five groups of drug combinations were obtained. The original prescription drugs and five groups of flavoring drugs were combined respectively, and the similar prescriptions of Chaihu Longgu Muli Decoction, Xiao Chaihu Decoction, Tongxieyao Prescription, Danggui Buxue Decoction were extracted. Conclusion The modern clinical application of Chaihu Guizhi Ganjiang Decoction has the following rules: the disease is in Shaoyang, good at treating diseases with mixed characteristics of cold and heat. It can be widely used in the treatment of digestive system diseases, and spleen deficiency syndrome is common in patients. It can sooth the liver and relieve depression, treat insomnia, anxiety, depression, and other emotional symptoms.
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