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| Research progress on anticancer effect and mechanism of oleanolic acid |
| YUAN Bin1 WEI Yanfei1 ZHOU Fengling1 HUANG Delun2 |
1.College of Basic Medicine, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530200, China;
2.Key Laboratory of Traditional Chinese Medicine Pharmacology of Guangxi Education Department, Guangxi University of Chinese Medicine, Guangxi Zhuang Autonomous Region, Nanning 530200, China |
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Abstract The oleanolic acid (OA) is a natural pentacyclic triterpenoid acid, which has outstanding anticancer pharmacological effects, it has the advantages of broad antitumor spectrum, little side effects and abundant sources. Through the interaction with specific molecular targets, OA plays an anticarcinogenic role in inducing apoptosis, inhibiting proliferation, inhibiting invasion and metastasis, suppressing angiogenesis and so on. Its anti-tumor mechanism is diversified and involves a wide range of related pathway factors. Exploring the specific molecular mechanism of OA antitumor effect and developing higher activity and easy absorption OA derivatives will have important clinical significance on its application for carcinoma therapy.
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