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| Medication laws of patented Chinese medicine compound prescription in treating intracerebral hemorrhage |
| FANG Ziru1 XU Peng2 DING Xikang2 WANG Jian2 |
1.College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Jilin Province, Changchun 130117, China;
2.Department of Encephalopathy, Affiliated Hospital of Changchun University of Chinese Medicine, Jilin Province, Changchun 130021, China |
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Abstract Objective To explore the rule of using patented Chinese medicine compound prescription in treating cerebral hemorrhage, and to provide reference for developing new clinical prescription. Methods The data of the patented traditional Chinese medicine compound for the treatment of cerebral hemorrhage were retrieved from the database of China Patent Publication Network of the State Intellectual Property Office from October 2022. Microsoft Office Excel 2019 and IBM SPSS Statistics 20.0 software were used for drug and efficacy category frequency statistics and systematic cluster analysis. The tra- ditional Chinese medicine inheritance platform v2.5 was used to carry out the statistics of medicinal properties, medicinal tastes and menstrual conversion frequency. The Apriori association rule in IBM SPSS Modeler 18.0 software was used for modeling analysis. The complex core network of traditional Chinese medicine co-occurrence was constructed by Cytoscape 3.9 software, and the closely related traditional Chinese Medicine groups were extracted. Results A total of 85 traditional Chinese medicine compound prescription were included, involving 332 flavors. The high frequency traditional Chinese medicine included Floslarthami, Radix Angelicae Sinensis, Radix Astragaliseu Hedysari, etc. The main categories of Chinese medicine were activating blood circulation and removing blood stasis, calming liver, and calming wind, and tonifying deficiency. The taste of Chinese medicine was mainly warm and bitter, which belonged to liver channel. The commonly used pairs weree Rhizomu Gastrodiae-Ramulus Uncariae Cum Uncis, Rhizoma Ligustici Chuan Xiong-Semen Persicae, etc. Common drug groups included Floslarthami-Radix Angelicae Sinensis-Radix Astragaliseu Hedysari, Radix Angelicae Sinensis- Semen Persicae-Floslarthami, etc.; four new traditional Chinese medicine groups were obtained by systematic cluster analysis. Conclusion The main therapeutic methods of the patented Chinese medicine compound in the treatment of cerebral hemorrhage are promoting blood circulation and removing blood stasis, calming liver and calming wind, and tonifying qi and blood, which can be used as reference for further prescription medicine.
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