|
|
Professor Zhang Mianzhi’s clinical experience in treating proteinuria based on the theory of “kidney deficiency and blood stasis” |
CHEN Shu1 DONG Ao1 ZHANG Mianzhi2 |
1.The Second Clinical Medical College, Beijing University of Chinese Medicine, Beijing 100078, China; 2.Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China |
|
|
Abstract Proteinuria as one of the common clinical manifestations of chronic kidney disease, Chinese medicine treatment of proteinuria can avoid the western medicine treatment brought by the toxic side effects, unclear curative effect, and other problems. Based on this, Professor Zhang Mianzhi uses the theory of “kidney deficiency and blood stasis” to treat proteinuria. Professor Zhang Mianzhi believes that the etiology and pathogenesis of proteinuria are mainly classified as “kidney deficiency and blood stasis”, and spleen deficiency, dampness turbidity, wind evil, and heat toxicity are also key factors leading to the occurrence and development of the disease. Therefore, he advocates that the therapeutic principle of “tonifying kidney and promoting blood circulation” should be carried out in the whole process of disease treatment, and remarkable therapeutic effects have been achieved. Based on the theory of “kidney deficiency and blood stasis”, this article explains the clinical experience of Professor Mianzhi in the treatment of proteinuria, and provides a case for discussion.
|
|
|
|
|
[1] 王海燕.肾脏病学[M].北京:人民卫生出版社,2008. [2] 严瑞红,卢宏柱.微小病变病蛋白尿产生的机制研究进展[J].实用医学杂志,2018,34(22):3824-3827. [3] 邢蓓,王新玲.糖尿病肾病患者的尿微量白蛋白转归及其影响因素研究进展[J].新疆医学,2021,51(2):218-220, 225. [4] 孟加宁,姚源璋.高糖环境下糖尿病肾病蛋白尿的发病机制[J].中国中西医结合肾病杂志,2016,17(12):1121- 1123. [5] 陈孜瑾,陈晓农.血管紧张素Ⅱ受体拮抗剂降蛋白尿及肾脏保护研究进展[J].肾脏病与透析肾移植杂志,2017, 26(5):467-470. [6] Chang AM,Ohse T,Krofft RD,et al. Albumin-induced apopt- osis of glomerular parietal epithelial cells is modulated by extracellular signal-regulated kinase 1/2 [J]. Nephrol Dial Transplant,2012,27(4):1330-1343. [7] 王诗尧,王世东,傅强,等.国医大师吕仁和“微型癥瘕”病理假说的源流及发展[J].中华中医药杂志,2022,37(8): 4555-4559. [8] 董超,王子辰.基于吕仁和“肾络微型癥瘕”理论治疗糖尿病肾脏病体悟[J].中医药临床杂志,2022,34(9):1627- 1631. [9] 王立范,刘娜,吴宸广,等.国医大师张琪教授治疗肾性蛋白尿的回顾性研究[J].黑龙江中医药,2020,49(1):302-304. [10] 王宇光,张琪.国医大师张琪从脾肾论治肾病蛋白尿经验[J].湖南中医药大学学报,2017,37(9):925-927. [11] 黄飞,王小琴.肾藏象学说的现代研究及在慢性肾脏病中的运用[J].时珍国医国药,2014,25(1):189-192. [12] 吕琴,赵文晓,王世军,等.黄芪活血功效及现代药理学研究进展[J].中国实验方剂学杂志,2020,26(9):215- 224. [13] 姚红旗,侯雅竹,王贤良,等.黄芪心血管药理作用研究进展[J].河南中医,2019,39(2):302-306. [14] 马存,冼少华,相雨,等.肉豆蔻药理作用研究进展[J].中国现代中药,2017,19(8):1200-1206. [15] 徐荣佳,姜晨.基于网络药理学探析水陆二仙丹治疗糖尿病肾病蛋白尿的作用机制[J].湖南中医杂志,2021, 37(9):169-174,190. [16] 任秋月,常柏.水陆二仙丹合抵挡汤加减治疗早期糖尿病肾病的前瞻性研究[J].西部中医药,2021,34(7):9-12. [17] 梁正,徐强,张倩,等.五倍子化学成分和药理作用的研究进展[J].中草药,2022,53(18):5908-5919. [18] 高志华,贾彦诺,刘丽,等.肾病综合征并发血栓的危险因素、病理机制及预防[J].中国老年学杂志,2015,35(12):3460-3462. [19] 文辉,黄思芸,赖俊玉,等.鬼箭羽治疗糖尿病肾病探讨[J].实用中医药杂志,2022,38(10):1812-1814. [20] 郭延秀,席少阳,马毅,等.鬼箭羽化学成分及药理活性研究进展[J].中国现代应用药学,2021,38(18):2305- 2316. [21] 张晓娟,张燕丽,左冬冬.川芎的化学成分和药理作用研究进展[J].中医药信息,2020,37(6):128-133. [22] 葛亮,曹慧玲,张洁,等.川芎嗪对大鼠脑缺血再灌注损伤后氧化应激、Ca2+-ATP酶活性及炎症因子的影响[J].国际检验医学杂志,2021,42(5):517-520. [23] 汤迎湛,刘菊妍,江振洲,等.土茯苓总苷化学成分研究[J].中草药,2022,53(22):6977-6984. [24] 程双,彭财英,潘玲玲,等.中药土茯苓的现代研究进展[J].江西中医药,2021,52(3):69-76. [25] 孟然,薛志忠,鲁雪林,等.蒲公英的功效成分与药理作用研究进展[J].江苏农业科学,2021,49(9):36-43. [26] 段惠春,蒲华云.蒲公英赛醇保护胃上皮细胞及抗炎作用的研究进展[J].中国当代医药,2022,29(20):30-34. [27] 孙颖,王伟,陈翰翰.网络药理学及分子对接法分析蒲公英-夏枯草治疗肉芽肿性乳腺炎的作用机制[J].中国临床研究,2021,34(12):1620-1625. [28] 刘晓燕,龙凤,赵玉,等.蒲公英中有效成分抗肿瘤作用机制的研究进展[J].中草药,2023,54(10):3391-3400. |
|
|
|