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| Analysis of Professor Liu Yanqiao’s medication rules in the treatment of polycystic ovary syndrome based on data mining |
| AN Qing1 LI Chang1 JIN Yi1 DANG Huimin2 LIU Yanqiao2 MU Siqi1 |
1.The First Clinical Medical College of Shaanxi University of Chinese Medicine, Shaanxi Province, Xianyang 712046, China;
2.Department of Traditional Chinese Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Shaanxi Province, Xi’an 710004, China |
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Abstract Objective To analyze Professor Liu Yanqiao’s prescription medication rules in the treatment of polycystic ovary syndrome (PCOS) based on data mining analysis. Methods The PCOS medical cases treated by Professor Liu Yanqiao from the Second Affiliated Hospital of Xi’an Jiaotong University from October 2019 to February 2023 were screened, and input into Excel to establish a database, prescription drug frequency, efficacy classification, flavor and meridian tropism were counted; R language and SPSS Statistics software were used for association rules and cluster analysis. Results A total of 131 prescriptions were collected, including 115 flavors of traditional Chinese medicine, and 20 flavors were used more than 40 times, the highest frequency was Shanyao and Xiangfu 90 times, most of which belonged to tonifying deficiency drugs and promoting blood circulation and removing blood stasis drugs, with sweet and bitter tastes, mainly warm and cold drugs, and most of them were attributed to liver (gallbladder) channel. Association rule analysis showed that there were 13 common drug pairs, and the support of angelica-Chuanxiong was the highest, and there were 13 kinds of three kinds of medicine combination, and the support of Xiangfu-angelica-Chuanxiong was the highest. Based on cluster analysis, three groups of cluster prescriptions were obtained, corresponding to kidney deficiency and blood stasis type, phlegm stasis block type, and spleen deficiency and phlegm dampness type respectively. Conclusion In the treatment of PCOS, Professor Liu Yanqiao combines with promoting blood circulation and resolving stasis, dispelling dampness and resolving phlegm, etc. on the basis of tonifying the kidney, strengthening the spleen, and soothing the liver, in order to comply with the physiological process of follicle growth, development, and excretion.
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