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2023 Vol. 20, No. 20 Published: 2023-07-15

	4	Construction of apoptosis-related lncRNA-mRNA network in ischemic stroke and prediction of hub genes
		GU Lian1 YANG Yibing2 YAN Yan1 HUANG Xianli2 SU Li3 LIANG Baoyun1
		DOI: 10.20047/j.issn1673-7210.2023.20.01
		Objective To explore the apoptosis-related long non-coding RNA(lncRNA)-mRNA network in ischemic stroke (IS) and predict the hub genes. Methods A total of 10 patients with IS admitted to the First Affiliated Hospital of Guangxi University of Chinese Medicine (“our hospital” for short) from January 2016 to June 2017, and 10 healthy controls from community health examination center of our hospital during the same period were selected as the research objects. Differential analysis of microarray expression profiles was performed, weighted gene co-expression network analysis was used to screen out genes in the target module, and the intersection with apoptotic genes was taken. Top 10 differentially mRNAs (DEMs) were selected using the STRING website and Cytoscape software, and lncRNA-mRNA co-expression network was constructed between DEMs and differentially lncRNAs (DELs). Finally, hub genes were obtained. Results A total of 3 930 DEMs were obtained, and 553 apoptosis-related IS genes were obtained after intersection of module genes and apoptosis genes. The lncRNA-mRNA co-expression network consisted of 9 DEMs and 277 DELs. Finally, 7 hub genes G015366, G068382, PIK3CB, BPTF, NR3C1, Akt2, and INS were obtained. Conclusion G015366, G068382, PIK3CB, BPTF, NR3C1, Akt2, and INS are related to the occurrence and development of IS, and may become diagnostic markers of IS.
		2023 Vol. 20 (20): 4-9 [Abstract] ( 10 ) HTML (1 KB) PDF (2070 KB) ( 19 )

	10	Effect of HIF2α knockdown in the neurons of mediobasal hypothalamus on body weight and energy metabolism in mice
		Dilihumaier Duolikun1 Aizimaiti Rouzijiang1 MA Lijuan1 GUO Hai2 YAO Qiaoling1
		DOI: 10.20047/j.issn1673-7210.2023.20.02
		Objective To investigate the effects of hypoxia-inducible factor 2α (HIF2α) knockdown in the neurons of the mediobasal hypothalamus on body weight, food intake and energy metabolism in mice. Methods Sixteen HIF2αflox/flox transgenic male mice were selected and they were divided into control group injected with AAV-hSyn-GFP virus at the mediobasal of the hypothalamus (n=8) and HIF2α knockdown group injected with AAV-hSyn-cre-GFP virus groups of mice were fed with normal chow and their body weight and food intake were weighed every three days. After four weeks, the body composition and energy metabolic rate of mice were measured by nuclear magnetic resonance analyzer and metabolic cage. Results The body weight of mice in the control group on days 18 to 30 was higher than that on days 3, the difference was statistically significant (P＜0.05). The body weight of mice in HIF2α knockout group on days 9 to 30 was higher than that on days 3, the difference was statistically significant (P＜0.05); the body weight of mice in HIF2α knockdown group was higher than that in control group on the 15th to 30th day, and the difference was statistically significant (P＜0.05). The food intake of mice in the control group on the 12th to 30th day was significantly different from that on the 3rd day (P＜0.05). The food intake of mice in HIF2α knockout group on days 9 to 30 was higher than that on days 3, and the difference was statistically significant (P＜0.05). The food intake of mice in HIF2α knock-down group was higher than that in control group from 9 to 30 days, and the difference was statistically significant (P＜0.05). Body fat weight, body fluid weight and lean body mass in HIF2α knockout group were higher than those in control group (P＜0.01). The oxygen consumption (VO2) during the day and night in the knockdown group was lower than that in the control group (P＜0.05 or P < 0.01); in control group, VO2 at night was higher than that at day (P＜0.05). There was no significant difference in VO2 between HIF2α knockdown group at night and daytime (P＞0.05). The carbon dioxide production (VCO2) in the HIF2α knockdown group at night was lower than that in the control group (P＜0.05), and there was no statistical significance in the daytime VCO2 between the two groups (P＞0.05). In control group, VCO2 at night was higher than that at day (P＜0.05). There was no significant difference in VCO2 between night and day in HIF2α knockdown group (P＞0.05). The daytime respiratory entropy (RER) in HIF2α knockdown group was higher than that in control group (P＜0.05). There was no significant difference between night and day RER between the two groups (P＞ 0.05). The energy expenditure (EE) in HIF2α knockdown group was lower than that in control group during the day and night (P＜0.05 or P＜0.01). In the control group, EE at night was higher than that at day, and the difference was statistically significant (P＜0.05). There was no significant difference in EE between HIF2α knockdown group at night and daytime (P＞0.05). The night activity of HIF2α knockdown group was lower than that of control group (P＜0.05), but there was no significant difference between the two groups in daytime activity (P＞0.05). The activity level of the control group at night was higher than that at day (P＜0.05). There was no significant difference in activity level between HIF2α knockdown group at night and daytime (P＞0.05). The food intake of HIF2α knockdown group during the day was higher than that of control group (P＜0.05), and there was no statistical significance in food intake at night between the two groups (P＞0.05). The food intake in the control group was higher at night than at day (P＜0.01). There was no significant difference in food intake between HIF2α knockdown group at night and day (P＞0.05). Conclusion Under normal chow-diet feeding, knockdown of HIF2α in the mediobasal hypothalamus may lead to an increase in body weight in mice. The underlying mechanisms may involve increased food intake, decreased energy expenditure, and disordered circadian rhythms.
		2023 Vol. 20 (20): 10-16,22 [Abstract] ( 12 ) HTML (1 KB) PDF (1688 KB) ( 29 )

	17	Visual analysis of knowledge map correlation between cirrhosis and gut microbiota
		YAO Yiqi1 YANG Yaxin2 CHEN Xuanrui1 CHEN Daman3 HOU Zhengkun4
		DOI: 10.20047/j.issn1673-7210.2023.20.03
		Objective To analyze the relationship of cirrhosis and gut microbiota by text network analysis. Methods By using VOSviewer and CiteSpace, the author and institutional cooperation network, keywords and breakout words of the literatures collected by CNKI and WOS from January 1992 to June 2022 were analyzed. Results A total of 1 000 articles were included. The Chinese author had five cooperative groups, and the English author was mainly Jasmohan S Bajaj team. Research institutions were concentrated in universities and affiliated hospitals; the high-frequency keywords were probiotics, endotoxins, etc., and the research focused on intestinal bacterial translocation and microecological preparations. Conclusion The knowledge map shows the research progress of liver cirrhosis and intestinal flora, focusing on the relationship between microbial preparations, microbial metabolites and liver cirrhosis. Future hotspots may be related to preventing gut microbiota imbalance and exploring the mechanism of bacterial flora transplantation.
		2023 Vol. 20 (20): 17-22 [Abstract] ( 16 ) HTML (1 KB) PDF (2007 KB) ( 24 )

	23	Analysis of Professor Wang Jing’s medication rules in the treatment of chronic heart failure based on data mining
		MIAO Wenxiong SHAN Yajuan CHEN Yang WANG Jing
		DOI: 10.20047/j.issn1673-7210.2023.20.04
		Objective To analyze the medication rules of Professor Wang Jing in the treatment of chronic heart failure (CHF) based on data mining. Methods A total of 124 patients with CHF admitted to Professor Wang Jing’s clinic in Taizhou Hospital of Traditional Chinese Medicine of Jiangsu Province from January 2018 to June 2020 were selected as the research objects. The data in the medical records were sorted out and the symptoms, pulse signs, and traditional Chinese medicine syndrome types of the patients were counted. The methods of frequency distribution, cluster analysis, association rule analysis, and complex network analysis were used to analyze the drugs frequently, drug attribute distribution (four nature, five flavours, channel tropism, and efficacy), core drugs, and their combinations used in medical records. Results The most common symptoms of the 124 patients were oppression in chest, panting, and weakness. The main syndrome type was blood stasis due to qi deficiency combined with yang deficiency, and the main pulse pattern was deep, stringy, thready pulse. A total of 638 prescriptions were included in this study, involving 175 drugs, and the total frequency of drug use was 1 700 times. Among them, tonifying deficiency drugs, promoting blood circulation for removing blood stasis drugs, diuresis and diffusing dampness drugs were common. The four natures were mainly warm, cold, and flat, and the five flavours were mainly sweet and bitter, mostly returning to the spleen, lung, and liver channels. There were 27 drugs with frequency ≥20 times, which could be divided into three categories by cluster analysis. Twenty-three drug association rules were obtained by association analysis. Complex network analysis found that Astragali Radix, Angelicae Sinensis Radix, Chuanxiong Rhizoma, Rhodiolae Crenulatae Radix Et Rhizoma and so on were the core drugs for the treatment of CHF. Conclusion Professor Wang Jing’s treatment of CHF is based on tonifying deficiency, and drugs mainly include tonifying deficiency, promoting blood circulation for removing blood stasis, and diuresis and diffusing dampness.
		2023 Vol. 20 (20): 23-28 [Abstract] ( 21 ) HTML (1 KB) PDF (1608 KB) ( 27 )

	29	Visual analysis of music therapy for post-stroke depression based on CiteSpace
		LIANG Fengjiao1 ZHOU Xia2 WANG Lei1 WANG Xiangyu1 ZHANG Jiale1
		DOI: 10.20047/j.issn1673-7210.2023.20.05
		Objective To visual analysis of music therapy for post-stroke depression based on CiteSpace. Methods Based on the search terms “stroke”, “depression”, and “music”, the relevant literature on the use of music therapy in the treatment of post-stroke depression was searched from January 2001 to October 2022 in CNKI, WIP, Wanfang Data, and Web of Science. Using CiteSpace software, the author, institution, country, and key words of the included literature were analyzed by visual knowledge graph. Results The study included 180 Chinese literatures and five foreign literatures; a total of 213 domestic authors and 38 international authors were involved; a total of 146 institutions were involved in the study; the study involved six countries; 161 keywords were included in Chinese literatures, and 12 cluster labels were obtained by keyword clustering analysis. Conclusion The clinical research of music therapy for post-stroke depression mainly focuses on the exploration of different music therapy schemes, and the effective application of music therapy in the rehabilitation of patients with post-stroke depression. Nowadays, the research focus and frontier is mainly five-tone therapy, which mainly focuses on the angle modulation in the five-tone.
		2023 Vol. 20 (20): 29-33,47 [Abstract] ( 22 ) HTML (1 KB) PDF (1925 KB) ( 58 )

	34	Mining medication law of traditional Chinese medicine treatment of osteoporotic fracture under the guidance of three-stage syndrome differentiation based on traditional Chinese medicine inheritance support system
		DU Mengfan1 CHEN Can1 CHEN Yiren1 GUO Shuang1 ZHAO Yu1 ZHANG Yan2 LIU Junning2 NIU Susheng2
		DOI: 10.20047/j.issn1673-7210.2023.20.06
		Objective To explore the medication rule of traditional Chinese medicine for osteoporotic fracture under the theory of three-stage syndrome differentiation, and to provide reference for clinical treatment of osteoporotic fracture. Methods Through CNKI, Wanfang Data, and VIP, literatures related to the use of traditional Chinese medicine prescriptions in the treatment of osteoporotic fractures from inception to May 2022 was collected, prescription data were screened and sorted out, and standardized processing was carried out. The traditional Chinese medicine inheritance support system system (V 2.5) was used to conduct drug classification, normalization of nature and flavour, formula composition rule, and entropy cluster analysis. Results After retrieval and removal, 2 009 articles were included, including 100 prescriptions in the early stage, 95 in the middle stage, and 95 in the late stage. In the early stage of osteoporotic fracture, the most frequently used drug was Fos Carthami, and the most frequently used drugs were Radix Angelicae Sinensis and Cortex Eucommiae in the middle and late stage. In three-stage, the four nature of drugs were mainly warm, cold, clam, and the five flavour of drugs were mainly sweet, bitter, and pungent. Liver, kidney, spleen, and heart channels with high frequency of meridian conversion were developed, and six common drug pairs and three new prescriptions were obtained. Conclusion Clinical treatment of osteoporotic fracture can be based on the three-stage syndrome differentiation, flexible use the drugs of promoting blood circulation for removing blood stasis, relieving pain and harmonizing ying, nourishing liver and kidney, replenishing qi and blood, improve the effect of Chinese medicine treatment.
		2023 Vol. 20 (20): 34-38 [Abstract] ( 20 ) HTML (1 KB) PDF (1072 KB) ( 25 )

	39	Research progress on the correlation between irritable bowel syndrome with diarrhea and inflammatory immunity
		WANG Xuejiao1 SUN Zhangyin2 JI Changchun3
		DOI: 10.20047/j.issn1673-7210.2023.20.07
		Irritable bowel syndrome with diarrhea (IBS-D) is a functional intestinal disorder with recurrent abdominal pain, bloating, diarrhea, and a series of other gastrointestinal symptoms, which seriously affects the normal social life of patients, and causes serious psychological burden. The relationship between IBS-D and the immune system is complex, as IBS-D can affect the function of the immune system, and immune dysfunction can in turn affect the occurrence of IBS-D. This article reviews the alterations of the immune system in IBS-D patients and the effects of immune system disorders on IBS-D. We review the progress of research on the correlation between IBS-D and immune function from four perspectives: immune cells, immune factors, intestinal mucosal immunity, and immune homeostasis.
		2023 Vol. 20 (20): 39-42,64 [Abstract] ( 19 ) HTML (1 KB) PDF (654 KB) ( 310 )

	43	Research progress of Radix et Rhizoma Rhei improving microinflammatory state of chronic kidney disease by promoting autophagy
		WU Xinye1 BAI Tianli2 ZHU Bingbing2 MENG Sixuan1 WANG Yunman2
		DOI: 10.20047/j.issn1673-7210.2023.20.08
		In recent years, the incidence of chronic kidney disease has been increasing, and the onset of chronic kidney disease is becoming younger, which has caused serious harm to human life and health. Microinflammatory state is one of the common pathological changes of chronic kidney disease and an important factor leading to the occurrence and development of chronic kidney disease. Studies have shown that autophagy is involved in the occurrence and development of chronic kidney disease and promoting autophagy can improve the microinflammatory state of chronic kidney disease. Based on the new target of autophagy treatment, the application of traditional Chinese medicine to promote autophagy has obvious advantages in improving the microinflammatory state of chronic kidney disease. The monomeric components of Radix et Rhizoma Rhei in Chinese herbal medicine and its composition of drug pairs and compounds can play the role of anti-inflammation, anti-oxidative stress, anti-apoptosis, and anti-fibrosis by promoting autophagy, which is of great significance in delaying the progression of chronic kidney disease, and is expected to become one of the effective treatment methods for chronic kidney disease and its complications.
		2023 Vol. 20 (20): 43-47 [Abstract] ( 24 ) HTML (1 KB) PDF (804 KB) ( 127 )

	48	Research progress of Chinese and western medicine in pulmonary rehabilitation of idiopathic pulmonary fibrosis
		LIN Qingqing1 LI Zhihui1 HONG Yunzhe1 YANG Shuguang2 YU Xueqing2▲
		DOI: 10.20047/j.issn1673-7210.2023.20.09
		Idiopathic pulmonary fibrosis (IPF) is a refractory pulmonary disease. With the progress of the disease, the pulmonary function of the patients decreases progressively, which seriously affects the quality of life. Drug treatment has delayed the disease progression to a certain extent, and won more conditions and time windows for pulmonary rehabilitation treatment. Traditional Chinese and western medicine in pulmonary rehabilitation strategies such as exercise training, respiratory training, oxygen therapy, disease self-management, external treatment of traditional Chinese medicine and traditional Chinese medicine functional exercise can improve the exercise endurance, quality of life and reduce the risk after lung transplantation of IPF patients. However, there are still many problems to be further studied in IPF pulmonary rehabilitation. The article reviews the latest research progress of pulmonary rehabilitation in patients with IPF around the training methods and effect evaluation of pulmonary rehabilitation.
		2023 Vol. 20 (20): 48-51 [Abstract] ( 11 ) HTML (1 KB) PDF (553 KB) ( 107 )

	52	Research progress of the osteocyte-related biomarkers in predicting osteoporosis and fragility fractures
		LI Shiwei1 WANG Boling2 SHI Cheng2 SUN Zhongyang3
		DOI: 10.20047/j.issn1673-7210.2023.20.10
		The traditional bone turnover markers derived from osteoblasts and osteoclasts are useful in the diagnosis and treatment of osteoporosis. However, the usefulness of bone turnover markers in predicting osteoporosis and fragility fractures remains elusive. As the most abundant cell in bone tissue, osteocytes play a central role in regulating bone turnover. Recent research shows that bone turnover markers secreted by osteocytes, such as sclerostin, DKK1, and fibroblast growth factor 23 could be a new type of bone turnover markers for osteoporosis and fragility fracture prediction. This paper will briefly summarize the new research progress of the osteocyte related biomarkers with clinical application prospects in the prediction of osteoporosis and fragility fracture, in order to provide theoretical basis for the diagnosis and evaluation of osteoporosis and fragility fractures.
		2023 Vol. 20 (20): 52-55 [Abstract] ( 10 ) HTML (1 KB) PDF (426 KB) ( 81 )

	56	Research progress in the application of ketogenic diet in nervous system diseases
		ZHU Jinyi1 YIN Jiantao1 ZHANG Miao2
		DOI: 10.20047/j.issn1673-7210.2023.20.11
		The pathogenesis of nervous system diseases is complex, and the clinical symptoms are lingering and difficult to cure, which seriously affect the quality of life of patients. At present, the treatment of nervous system diseases by changing dietary habits is an important intervention route. As an effective diet, ketogenic diet is first used in the control of refractory epilepsy and gradually extended to other neurological diseases. This paper reviews the research progress of ketogenic diet in the treatment of epilepsy, Alzheimer’s disease, Parkinson disease, migraine, multiple sclerosis, amyotrophic lateral sclerosis, and other neurological diseases, summarize the mechanism of action and analyze the application status, in order to provide new ideas for the optimization of keto genic diet and the treatment of nervous system diseases.
		2023 Vol. 20 (20): 56-59 [Abstract] ( 17 ) HTML (1 KB) PDF (570 KB) ( 63 )

	60	Research progress of common muscle factors in non-alcoholic fatty liver disease
		ZHANG Xin1　ZHAO Xinyan1　YANG Fan1　WEI Xiaoguo2
		DOI: 10.20047/j.issn1673-7210.2023.20.12
		Non-alcoholic fatty liver disease is one of the common chronic liver diseases in the world, and its incidence is on the rise in China. At present, its pathogenesis is not clear, but it is widely involved in liver glucose, lipid metabolism, insulin resistance, oxidative stress, and so on. Recent studies have found that skeletal muscle can affect non-alcoholic fatty liver disease by releasing muscle factors such as irisin, fibroblast growth factor-21, insulin-like growth factor-1, interleukin-6, tumor necrosis factor-α, and vascular endothelial growth factor B. In this paper, the correlation between some common muscle factors and non-alcoholic fatty liver disease and the possible mechanism of action in this disease are reviewed in order to provide a new perspective and thinking for the prevention and treatment of non-alcoholic liver disease.
		2023 Vol. 20 (20): 60-64 [Abstract] ( 19 ) HTML (1 KB) PDF (597 KB) ( 21 )

	65	Research progress on perioperative cough in patients undergoing lung surgery
		YAN Tingzhi1 WU Di1 LIU Hongyu2 CHEN Jun1
		DOI: 10.20047/j.issn1673-7210.2023.20.13
		Cough is one of the common symptoms and complications of patients undergoing lung surgery, which often has a great impact on the recovery process and quality of life of patients after surgery. Early identification and management of the risk factors of perioperative cough in patients undergoing lung surgery are the basis of effective intervention strategies. At present, many clinical and basic studies at home and abroad have tried to put forward a systematic management plan for patients with cough during perioperative period, but the results are not satisfactory. Through searching the relevant literature reports of cough symptoms during the perioperative period of lung surgery in recent years, this article found that women, right lung cancer, difficult airway, acute cough, history of chronic obstructive pulmonary disease, mediastinal lymph node dissection, length of bronchial stump, anesthesia, postoperative pleural effusion, and bronchial kink are all related to the perioperative cough of lung surgery, and the conversion receptor potential cation channel subfamily V member 1 pathway may be its potential molecular mechanism. The management of perioperative cough during lung surgery includes drug treatment, lymph node residual cavity filling, intraoperative nerve monitoring, bronchial prosthesis placement, acupuncture, postoperative respiratory exercise, etc. These findings can provide reference for clinical early identification of high-risk patients with cough during the perioperative period of lung surgery, as well as the prevention and management of cough symptoms, and provide direction for further research.
		2023 Vol. 20 (20): 65-68,76 [Abstract] ( 20 ) HTML (1 KB) PDF (686 KB) ( 38 )

	69	Research progress in rat and mouse animal models of rheumatoid arthritis
		WuRiliga WuLanqiqige HuRilebagen LIAN Hua HuHemuren BAI Long
		DOI: 10.20047/j.issn1673-7210.2023.20.14
		Rheumatoid arthritis is a chronic, systemic immune disease mainly characterized by synovitis, with a high disability rate and an unclear pathogenesis. Therefore, finding animal models similar to human arthritis is crucial for studying the pathogenesis and treatment of the disease. There are many different models of rheumatoid arthritis in mice and rats, although they are well established, and there are advantages and disadvantages. Finding suitable models according to the situation can facilitate the establishment of animal models and improve the success rate. This article introduces several common models, adjuvant induced arthritis models and collagen-induced arthritis models are most commonly used. In addition, there are models of collagen antibodies induced arthritis, pristane induced arthritis, cartilage oligomeric matrix protein induced arthritis, streptococcal cell wall induced arthritis, and genetically engineered rheumatoid arthritis, in order to provide useful references for experiments related to rheumatoid arthritis.
		2023 Vol. 20 (20): 69-72 [Abstract] ( 16 ) HTML (1 KB) PDF (571 KB) ( 92 )

	73	Study on the correlation between post-traumatic growth and self-disclosure and psychological resilience in patients with unwanted pregnancy after induced abortion
		LYU Qin1 CHEN Xiaoli1 CHEN Songyan2
		DOI: 10.20047/j.issn1673-7210.2023.20.15
		Objective To explore the relationship between post-traumatic growth and self-disclosure and psychological resilience in patients with unwanted pregnancy after induced abortion. Methods A total of 254 induced abortion patients in the Department of Gynecology, Wuhan Third Hospital from September to November 2022 were selected by convenience sampling method. General data questionnaire, post-traumatic growth scale (PTGI), self-disclosure scale [distfess self-disclosure scale (DDI)], and mental resilience scale (CD-RISC) were used to investigate the current situation. Results A total of 254 questionnaires were sent out, and 250 were valid, with an effective recovery rate of 98.4%. The total score of the 250 patients was (66.58±13.96) points, mental toughness total score was (87.19±15.10) points, and total self-disclosure score was (37.75±7.00) points, respectively. The total score of PTGI scale of patients with different education levels was compared, and the difference was statistically significant (P＜0.05). The total score and dimensions of the post-traumatic growth scale of 250 patients after abortion were positively correlated with the total score and dimensions of the mental toughness scale and the total score of the self-disclosure scale (P＜0.01). Conclusion The post-traumatic growth of patients with unwanted pregnancy after induced abortion is at a moderate level, which is positively correlated with mental toughness and self-disclosure.
		2023 Vol. 20 (20): 73-76 [Abstract] ( 15 ) HTML (1 KB) PDF (599 KB) ( 230 )

	77	Preparation and validity of the willingness scale to assess maternal psychological trauma during childbirth
		RAN Ying1 ZHANG Silian1 LI Yufeng1 BAI Aoshuang1 JIANG Yifei1 LI Fengling1,2 HOU Hailong3 OUYANG Tianrui2
		DOI: 10.20047/j.issn1673-7210.2023.20.16
		Objective To develop a scale of maternal willingness to assess psychological trauma during childbirth and test its reliability and validity. Methods By means of qualitative research, expert letter consultation, pre-experiment, and large sample survey, objective sampling method was adopted to conduct qualitative interviews and construct questionnaire item pool among 22 pregnant women from five first-class hospitals in Sichuan Province from November 2021 to January 2022, and then construct the draft scale based on the results of expert letter consultation. From February to June 2022, a total of 171 pregnant women were selected for pre-experiment, items of the scale were optimized through item analysis, exploratory factor analysis was carried out, and a large sample of 264 pregnant women were investigated to measure the reliability and validity of the scale. Results The final scale consisted of one dimension and 15 items. Exploratory factor analysis extracted one common factor and the cumulative variance contribution rate was 80.890%. The confirmatory factor analysis showed that the model fit of the scale was good (χ2/df=2.386，RMSEA=0.069，GFI=0.94，CFI=0.964，RMR=0.032，NFI=0.94，NNFI= 0.958). The I-CVI was 0.800-1.000 and the S-CVI was 0.860. The Cronbach’s α was 0.993. The half-reliability was 0.918, and the retest reliability was 0.885. Conclusion The willingness scale to assess maternal psychological trauma during childbirth has good reliability and validity.
		2023 Vol. 20 (20): 77-80,90 [Abstract] ( 16 ) HTML (1 KB) PDF (693 KB) ( 118 )

	81	Meta analysis and GRADE quality evaluation of 1, 6-diphosphate fructose combined with western medicine in improving cardiac function of patients with chronic heart failure
		ZHA Yuling1　LI Jun2
		DOI: 10.20047/j.issn1673-7210.2023.20.17
		Objective To systematically evaluate the effect and evidence level of 1, 6-diphosphate fructose combined with western medicine on improving cardiac function in patients with chronic heart failure (CHF). Methods Randomized controlled trials on the use of 1, 6-diphosphate fructose in treating patients with CHF were searched through CNKI, Wanfang Data, VIP, China Biomedical Literature Service System, PubMed, and Web of Science from inception to November 2022. Literatures management, meta analysis, and outcome indicators were evaluated by Endnote 20.0, Review Manager 5.4.1, and GRADE profiler. Results A total of nine literatures were included, involving 771 subjects, including 388 in the experimental group and 383 in the control group. The results of meta analysis showed that left ventricular ejection fraction [MD=5.00, 95%CI: 4.91-5.09, P=0.000 01], E/A[MD=0.10, 95%CI: 0.04-0.16, P=0.000 08], cardiac output index [MD=0.61, 95%CI: 0.38-0.83), P=0.000 01], cardiac output [MD=0.73, 95%CI: 0.36-1.10, P=0.000 1] of experimental group were higher than those of control group. GRADE quality evaluation suggested that the evidence levels of the included literatures were low. Conclusion 1, 6-diphosphate fructose combined with western drugs can improve cardiac function in patients with CHF, but high-level evidence is still needed.
		2023 Vol. 20 (20): 81-85 [Abstract] ( 15 ) HTML (1 KB) PDF (1564 KB) ( 11 )

	86	Influencing factors of prognosis of young patients with myocardial infarction
		DONG Ningchao　WANG Wenbin　CHENG Guojie▲
		DOI: 10.20047/j.issn1673-7210.2023.20.18
		Objective To explore the influencing factors of prognosis of young patients with myocardial infarction. Methods A retrospective analysis was performed on 360 young patients with myocardial infarction who received treatment in Beijing Daxing District People’s Hospital from January 2020 to May 2022. All patients were followed up until November 2022. According to the occurrence of cardiogenic shock, heart failure, arrhythmia, angina pectoris after infarction, and death, the patients were divided into poor prognosis group (116 cases) and good prognosis group (244 cases). The clinical data of the two groups were compared. Logistic regression model was used to analyze the influnencing factors of prognosis of young patients with myocardial infarction. Results The heart rate, drinking proportion, Killip grade Ⅳ proportion, C-reactive protein, red cell volume distribution width, creatine kinase isozyme hybrid type, fibrinogen, myocardial troponin, and N-terminal brain natriuretic peptide precursor levels in the poor prognosis group were higher than those in the good prognosis group, and ejection fraction was lower than that in the good prognosis group, the differences were statistically significant (P＜0.05). The results of multivariate analysis showed that Killip grading (OR=1.672, 95%CI: 1.123-2.489), red cell volume distribution width (OR=2.319, 95%CI: 1.500-3.586), fibrinogen (OR=3.422, 95%CI: 1.123-2.489) were the influencing factors of poor prognosis in young patients with myocardial infarction (P＜0.05). Conclusion Killip grading, red blood cell volume distribution width, and fibrinogen are risk factors for poor prognosis in young patients with myocardial infarction, and patients with abnormal indexes should be closely monitored in clinical treatment.
		2023 Vol. 20 (20): 86-90 [Abstract] ( 17 ) HTML (1 KB) PDF (620 KB) ( 15 )

	91	Hotspots and trends in visual analysis of atrial fibrillation and electrical remodeling based on CiteSpace and VOSviewer
		LIU Yuxuan1 SHI Dazhuo2 GAO Zhuye2 JI Xinke1 LI Ping3
		DOI: 10.20047/j.issn1673-7210.2023.20.19
		Objective To discuss the hotspots and trends of atrial fibrillation（AF） and electrical remodeling based on CiteSpace and VOSviewer. Methods The literatures on AF and electrical remodeling were searched from the Web of Science database From January 2004 to December 2021, CiteSpace 5.8.R3 and VOSviewer 1.6.16 were used to draw visual maps of countries, institutions, authors, and keywords. Results A total of 1 178 articles were included, and the number of published articles was on the rise. The most productive country was the United States, the University of Montreal was the most influential scientific research institution, and Nattle S was the most prolific author. Atrial remodeling, electrical remodeling, mechanism, risk, and so on were the high frequency and medium central keywords in this field. Fibrosis was the key word with the strongest burst intensity. Conclusion The research interest in the field of AF and electrical remodeling continues to rise. The main research focuses on the mechanism of electrical remodeling, the change of ion channels, the treatment of AF and the prevention of risk factors. Fibrosis is the trend of future research.
		2023 Vol. 20 (20): 91-96 [Abstract] ( 20 ) HTML (1 KB) PDF (2462 KB) ( 57 )

	97	Genotype and phenotype analysis of 15 rare β-thalassemia carriers in Guizhou Province
		WU Peng1 XIE Dan2 WU Jiangfen2 WANG Lei2 LI Di3 HUANG Shengwen1
		DOI: 10.20047/j.issn1673-7210.2023.20.20
		Objective To identify the β-globin gene sequence of suspected cases of β-thalassemia (“β-thalassemia” for short”), the rare mutation site identified and the clinical phenotype were analyzed. Methods From January 2020 to March 2022, 20 suspected β-thalassemia carriers with hematologic phenotype but no related β-thalassemia gene test results were negative in Guizhou Provincial People’s Hospital. The full length of β-globin gene was amplified by PCR, The amplification products were sequenced bidirectionally by Sanger sequencing technique. The sequencing results were compared with the β-globin gene reference sequence to find out whether there were rare mutations. Results Among 20 Carriers with suspected β-thalassaemia, 15 were found to carry rare β-globin gene mutations, with a total of six mutation types: CD53(-T), CD5(-CT), CD8(-AA), -88(C＞A), Cap+22(G＞A) and -50(G＞A). Except for one case of -50(G＞A) carrier, the other 14 cases showed the clinical phenotype of β-thalassaemia minor. Conclusion Rare β-globin gene analysis in suspected carriers whose phenotypes were not consistent with their genotypes plays an important role in guiding β-thalassemia genetic counseling, prenatal diagnosis and reducing the birth of children with moderate and severe β-thalassaemia. The results of this study broaden the mutation spectrum of β-globin gene in Chinese population and Guizhou region.
		2023 Vol. 20 (20): 97-100,138 [Abstract] ( 20 ) HTML (1 KB) PDF (820 KB) ( 12 )

	101	Correlation analysis of carotid plaques with fibrinogen, cystatin C, and oxidized low-density lipoprotein in patients with acute cerebral infarction
		SHI Yuxi1，2 DING Hongmei3 GENG Deqin3▲
		DOI: 10.20047/j.issn1673-7210.2023.20.21
		Objective To analyze the correlation of carotid plaques with fibrinogen (FIB), cystatin C (Cys-C), and oxidized low-density lipoprotein (ox-LDL) in patients with acute cerebral infarction. Methods The clinical data of 97 patients with acute cerebral infarction admitted to Suqian Zhongwu Hospital from May 2020 to April 2021 were retrospectively analyzed. According to the presence or absence of carotid plaque formation, they were divided into the non-plaque group (46 cases) and the plaque group (51 cases). The clinical data of the two groups were compared, and the risk factors of carotid plaque formation in patients with acute cerebral infarction were analyzed by multivariate logistic regression analysis. The receiver operating characteristic (ROC) curve was made, and the area under the curve (AUC) was used to analyze the predictive value of serum FIB, Cys-C, ox-LDL and their combination on carotid plaque formation in patients with acute cerebral infarction. Results The proportion of hyperlipidemia and hypertension, and the levels of total cholesterol, serum FIB, Cys-C， and ox-LDL at admission in the plaque group were higher than those in the non-plaque group (P＜0.05). Multivariate logistic regression analysis showed that hyperlipidemia and high serum FIB, Cys-C, and ox-LDL levels on admission were risk factors for carotid plaque formation in patients with acute cerebral infarction (OR＞1，P＜0.05). ROC results showed that, the AUC value of combined prediction of carotid plaque formation in patients with acute cerebral infarction was higher than that of single prediction (P＜0.05). Conclusion Serum levels of FIB, Cys-C and ox-LDL have important value in predicting carotid plaque formation in patients with acute cerebral infarction, and the combination of the three has a higher predictive value.
		2023 Vol. 20 (20): 101-104 [Abstract] ( 19 ) HTML (1 KB) PDF (623 KB) ( 22 )

	105	Clinical effect of Duloxetine on fatigue in patients with Parkinson disease
		WANG Shen HOU Qing SHAO Qiuying ZHANG Lian GONG Yuanyuan LYU Haixia YANG Ting YUE Shumin▲
		DOI: 10.20047/j.issn1673-7210.2023.20.22
		Objective To observe the clinical effect of Duloxetine in treating Parkinson disease fatigue. Methods From July 2020 to March 2022, 58 patients with Parkinson disease fatigue who were treated and followed up in the Department of Neurology of the First Hospital of Zhangjiakou they were divided into intervention group 1 and intervention group 2 by random number table method, with 29 patients in each group. Intervention group 1 was treated with parkinson’s drugs, and intervention group 2 was treated with Duloxetine on this basis. Fatigue scores, depression scores and serum levels of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) before and after treatment were compared between the two groups. Results The overall analysis showed that there were significant differences between groups, time point comparison and interaction (P＜0.05). Intra-group comparison: the FS-14 score and depression score between the two groups at each time point and the differences were statistically significant (P＜0.05). Inter-group comparison: the FS-14 score and depression score of intervention group 2 were lower than those of intervention group 1 at each time point after treatment, and the differences were statistically significant (P＜0.05). The fatigue control effect of intervention group 2 was better than that of intervention group 1, the difference was statistically significant (P＜0.05). Intra-group comparison: the 5-HT and NE levels between the two groups at each time point and the differences were statistically significant (P＜0.05). Inter-group comparison: After treatment, the levels of 5-HT and NE in intervention group 2 were higher than those in intervention group 1 at each time point, and the differences were statistically significant (P＜0.05). Conclusion On the basis of optimizing Parkinson’s drug, Duloxetine can improve fatigue control effect by regulating serum 5-HT and NE levels, and its effect on fatigue improvement is not dependent on improving depressive symptoms.
		2023 Vol. 20 (20): 105-108 [Abstract] ( 16 ) HTML (1 KB) PDF (588 KB) ( 68 )

	109	Analysis of risk factors for early neurological deterioration in patients with isolated subcortical infarction
		LI Qian QU Mingwei WANG Ningning WANG Limin FAN Guimei YANG Chaoping
		DOI: 10.20047/j.issn1673-7210.2023.20.23
		Objective To analyze the risk factors for early neurological deterioration (END) in patients with isolated subcortical infarction. Methods A total of 422 patients who were hospitalized in the Department of Neurology of Cangzhou Central Hospital from January 2021 to March 2022 and diagnosed as isolated subcortical infarction by MRI were selected as the research objects. National Institutes of Health stroke scale (NIHSS) score was used to assess the degree of neurological impairment of all patients on the day of admission and within three days after admission. If the NIHSS score increased ≥2 points within 72 hours after admission, it was considered that END had occurred. Then, patients were divided into the END group (81 cases) and the non-END group (341 cases) according to whether END occurred. Baseline data and risk factors of the two groups were compared, and the independent risk factors for predicting END were screened out. Results There were significant differences in age, male ratio, stroke history, lesion diameter, and carrier artery stenosis between the two groups （P＜0.05）. Logistic regression analysis showed that male (OR=3.084, 95%CI:1.500-6.340, P=0.002), stroke history (OR=2.391, 95%CI:1.158-4.937, P=0.018), lesion diameter ＞2 cm (OR=3.038, 95%CI:1.434-6.436, P=0.004) and carrier artery stenosis (OR=14.157, 95%CI: 7.602-26.363, P＜0.001) were independent risk factors for END in patients with acute isolated subcortical infarction. Conclusion Isolated subcortical infarction patients with male, stroke history, lesion diameter＞2.0 cm, and carrier artery stenosis are more likely to develop END, which should arouse clinical attention.
		2023 Vol. 20 (20): 109-112 [Abstract] ( 26 ) HTML (1 KB) PDF (513 KB) ( 24 )

	113	Relationship between serum lncRNA MEG3 expression and Th17/Treg balance in children with allergic asthma
		WANG Xing1 LI Ruiting2 MA Xiaomiao3▲
		DOI: 10.20047/j.issn1673-7210.2023.20.24
		Objective To investigate the relationship between maternal long chain non-coding ribonucleic acid maternally expressed gene 3 (lncRNA MEG3) expression and T helper cell (Th) 17/ regulatory T cell (Treg) imbalance in children with allergic asthma. Methods A total of 75 children with allergic asthma admitted to the First Affiliated Hospital of Xi’an Jiaotong University (hereinafter referred to as “our hospital”) from January 2018 to January 2022 were selected as asthma group, and 49 healthy children from the Children’s health clinic of our hospital were selected as control group. The percentage of Th17 cells, the percentage of Treg cells, Th17/Treg ratio, lncRNA MEG3 expression, interleukin (IL)-17, IL-22，IL-10，transforming growth factor-β (TGF-β) levels, and forced expiratory volume in one second (FEV1) were detected, the ratio of FEV1 to forced vital capacity (FEV1/FVC), and the percentage of FEV1 to predicted value (FEV1%pred) were calculated. The correlation between lncRNA MEG3 expression and Th17/Treg and its cytokines, and lung function were analyzed. Results The expression of lncRNA MEG3, the percentage of Treg cells in asthma group were lower than those in control group, while the percentage of Th17 cells, Th17/Treg were higher than those in control group (P＜0.05). The levels of IL-17 and IL-22 in asthma group were higher than those in control group, while the levels of TGF-β and IL-10 were lower than those in control group (P＜0.05). The FEV1, FEV1/FVC, and FEV1%pred in asthma group were lower than those of control group (P＜0.05). The expression of lncRNA MEG3 in children with asthma was positively correlated with the percentage of Treg cells, IL-10, TGF-β, FEV1, FEV1/FVC, and FEV1%pred (r=0.502, 0.415, 0.491, 0.493, 0.428, 0.497, P＜0.05), and the percentage of Th17 cells, Th17/Treg, IL-17, and IL-22 were negatively correlated (r=-0.501, -0.727, -0.631, -0.452, P＜0.05). Conclusion The expression of lncRNA MEG3 in peripheral blood of patients with allergic asthma is decreased, which is related to Th17/Treg imbalance and low lung function.
		2023 Vol. 20 (20): 113-116 [Abstract] ( 17 ) HTML (1 KB) PDF (565 KB) ( 23 )

	117	Effects of recombinant human interferon α2b combined with fructose 1，6-diphosphate on rotavirus enteritis in children and myocardial protection
		HUA Jingming LI Yanling SUN Xiaobao ZHANG Wenhua▲
		DOI: 10.20047/j.issn1673-7210.2023.20.25
		Objective To explore the effects of recombinant human interferon α2b (RHIα2b) combined with fructose 1，6-diphosphate (FDP) on rotavirus enteritis (RVE) in children and myocardial protection. Methods A total of 78 children with RVE who admitted to Huainan First People’s Hospital from June 2019 to June 2022 were selected, they were divided into two groups, with 39 cases in each group. The control group was treated with RHIα2b, and the observation group was treated with RHIα2b combined with FDP. The clinical efficacy of two groups was evaluated after seven days of treatment, the immune function and myocardial enzyme levels were compared between two groups before and after treatment, the hospitalization time, antidiarrheal time, and dehydration correction time of two groups were compared, the occurrence of adverse reactions in two groups was observed. Results The clinical effect of observation group was better than that of control group (P＜0.05). After treatment, the levels of CD3+ and CD4+/CD8+ in observation group were higher than those before treatment, and observation group was higher than control group (P＜0.05). After treatment, the levels of creatine kinase, creatine kinase MB, and lactate dehydrogenase in two groups were lower than those before treatment, and observation group was lower than the control group (P＜0.05). The hospitalization time and antidiarrheal time in observation group were shorter than those in control group (P＜0.05); there was no significant difference in dehydration correction time between two groups (P＞0.05). No adverse reactions such as rash, fever, and palpitation were found in the two groups. Conclusion RHIα2b combined with FDP can improve the therapeutic effect of RVE in children, improve the immune function, play a certain protective effect on the heart muscle of children, accelerate the recovery of children, safe, and effective.
		2023 Vol. 20 (20): 117-120 [Abstract] ( 18 ) HTML (1 KB) PDF (576 KB) ( 28 )

	121	Correlation analysis of traditional Chinese medicine syndrome type, lymphocyte subsets, and biochemical indexes of stage Ⅲ/Ⅳ non-small cell lung cancer
		WANG Fei1　LIU Qiongni1　WANG Jing2　YANG Li1　HU Kaiwen2　ZHOU Tian2
		DOI: 10.20047/j.issn1673-7210.2023.20.26
		Objective To explore the correlation between traditional Chinese medicine syndrome type, lymphocyte subsets, and biochemical indexes in patients with stage Ⅲ/Ⅳ non-small cell lung cancer (NSCLC). Methods From November 2020 to February 2022, 153 patients with stage Ⅲ/Ⅳ NSCLC admitted to Dongfang Hospital, Beijing University of Chinese Medicine were selected, including 45 patients with spleen-lung qi deficiency pattern, 33 patients with syndrome of deficiency of lung yin, and 75 patients with syndrome of intermin-gled phlegm and blood stasis. The differences of lymphocyte subsets and biochemical indexes in patients with different traditional Chinese medicine syndrome types were compared. Multiple logistic regression model was used to analyze the correlation between traditional Chinese medicine syndrome types, lymphocyte subsets, and biochemical indexes. Results There were significant differences in CD4+, CD8+, CD4+/CD8+, natural killer cells, total bilirubin, creatinine, and low density lipoprotein-cholesterol among patients with different traditional Chinese medicine syndrome types in stage Ⅲ/Ⅳ NSCLC (P＜0.05). The results of multiple logistic regression model analysis showed that stage Ⅲ/Ⅳ NSCLC patients with spleen-lung qi deficiency pattern compared with syndrome of intermin-gled phlegm and blood stasis, the lower CD4+(OR=0.885, 95%CI: 0.808-0.970), natural killer cells (OR=0.918, 95%CI: 0.850-0.991), and total bilirubin (OR=0.885, 95%CI: 0.814-0.962), the more likely it was spleen-lung qi deficiency pattern (P＜0.05). In stage Ⅲ/Ⅳ NSCLC patients with syndrome of deficiency of lung yin compared with syndrome of intermin-gled phlegm and blood stasis, the lower CD4+ (OR=0.824, 95%CI: 0.733-0.925), the more likely it was syndrome of deficiency of lung yin (P＜0.05). Conclusion The levels of CD4+, natural killer cells, and total bilirubin in patients with stage Ⅱ/Ⅳ NSCLC are related to traditional Chinese medicine syndrome types, which can be used to assist syndrome differentiation.
		2023 Vol. 20 (20): 121-124 [Abstract] ( 19 ) HTML (1 KB) PDF (557 KB) ( 28 )

	125	Clinical dosimetry evaluation of linear accelerator intensity-modulated radiation therapy for esophageal cancer at different sites
		LU Dongyun　YANG Jian　SUN Jinyi　ZHOU Jianjun　YANG Jun▲
		DOI: 10.20047/j.issn1673-7210.2023.20.27
		Objective To evaluate the clinical dosimetry characteristics of linear accelerator intensity-modulated radiation therapy (IMRT) for esophageal cancer at different pathological sites. Methods The clinical data of 132 patients with esophageal cancer admitted to Haian Traditional Chinese Medicine Hospital of Jiangsu Province from November 2019 to October 2021 were retrospectively analyzed, including 33 patients with cervical and upper, middle, and lower thoracic esophageal cancer. The difference of planned target dose, the dosimetric index of sketched organs at risk, machine hops, dose-validation pass rate, and treatment time of linear accelerator IMRT in patients with esophageal cancer at different sites was compared. Results The 2% of target volume exposure dose (D2), D50, D98, and mean dose (Dmean) in patients with upper and middle thoracic esophageal cancer were higher than those in cervical patients, and the treatment time was longer than that in cervical patients; target dose homogeneity index (HI) in patients with middle thoracic esophageal cancer was higher than that in cervical patients; the volume receiving a radiation dose of 25 Gy (V25), Dmean of the heart and V5, V20, V30 of both lungs in patients with upper, middle, and lower thoracic esophageal cancer were higher than those in cervical patients; the dose-validation pass rate in patients with upper and lower thoracic esophageal cancer were higher than those of cervical patients (P＜0.05). D2, HI, V25 of heart, Dmean of heart, and V5, V20, V30 of both lungs in patients middle thoracic esophageal cancer were higher than those in upper thoracic patients, and the dose-validation pass rate was lower than that in upper thoracic patients; the machine hops in patients with lower thoracic esophageal cancer were lower than those in upper thoracic patients, the treatment time was shorter than that in upper thoracic patients (P＜0.05). D2, D50, D98, Dmean, HI, and machine hops in patients with lower thoracic esophageal cancer were lower than those in middle thoracic patients, and V25, Dmean of heart, and dose-validation pass rate were higher than those in middle thoracic patients, and the treatment time was shorter than that in middle thoracic patients (P＜0.05). Conclusion The clinical dose of linear accelerator IMRT in different pathological sites of esophageal cancer is different, which should be paid attention to in clinic.
		2023 Vol. 20 (20): 125-128 [Abstract] ( 18 ) HTML (1 KB) PDF (531 KB) ( 26 )

	129	Analysis of influencing factors of 3.70 GBq 131I treatment after total rese-ction of differentiated thyroid carcinoma based on logistic regression ana- lysis
		WANG Ziyan　YANG Shijian▲　LI Guangming　XU Miaoyu
		DOI: 10.20047/j.issn1673-7210.2023.20.28
		Objective To investigate the factors influencing the therapeutic effect of 3.70 GBq 131I after total resection of differentiated thyroid carcinoma. Methods A total of 151 patients with differentiated thyroid carcinoma who received initial 131I treatment (dose 3.70 GBq) at the Department of Nuclear Medicine of Qingyuan People’s Hospital, Guangdong Province from July 2018 to May 2022 were collected. According to the results 6-12 months after discharge, they were divided into excellent response (ER) group (70 cases) and non-ER (NER) group (81 cases). Gender, age, pathological type, T stage, N stage, positive rate of static thyroid imaging, thyroid stimulating hormone (TSH), postoperative interval, 24 h radioactive iodine uptake (24h-RAIU), and serum stimulating thyroglobulin (sTg) were collected and compared between the two groups. Multivariate logistic regression model was used to analyze the factors affecting the effect of 3.70 GBq 131I treatment after total resection of differentiated thyroid carcinoma. Results The static thyroid imaging positive rate and sTg in NER group were higher than those in ER group, and the postoperative interval was shorter than that in ER group (P＜0.05). The results of multivariate analysis showed that thyroid static imaging status (OR=3.470, 95%CI: 1.559-7.725), postoperative interval (OR=0.667, 95%CI: 0.549-0.811), sTg (OR=1.092, 95%CI: 1.046-1.141) were the independent influencing factors of 3.70 GBq 131I treatment after total resection of differentiated thyroid carcinoma (P＜0.05). Conclusion Static thyroid imaging, postoperative interval, and sTg level are related to the effect of 3.70 GBq 131I treatment in patients with differentiated thyroid carcinoma after total resection. Attention should be paid to patients with abnormal three indicators.
		2023 Vol. 20 (20): 129-133 [Abstract] ( 17 ) HTML (1 KB) PDF (687 KB) ( 19 )

	134	Effect of different concentrations of Desflurane combined with intravenous anesthesia on intraoperative cerebral oxygen metabolism and postoperative delirium in elderly hip fracture patients with mild cognitive impairment
		WU Zhenpang WANG Lixia ZUO Wenjie NIE Guangchen ZHEN Xingang JU Ying XIAO Jingkuan CHEN Ning
		DOI: 10.20047/j.issn1673-7210.2023.20.29
		Objective To observe the effect of different concentrations of Desflurane combined with intravenous anesthesia on intraoperative cerebral oxygen metabolism and postoperative delirium in elderly hip fracture patients with mild cognitive impairment (MCI). Methods A total of 90 elderly hip fracture patients with MCI admitted to the Department of Orthopedics, the Fifth Hospital of Harbin City from January to October 2022 were selected. They were divided into 1% Desflurane group (group D1), 3% Desflurane group (group D2), and 5% Desflurane group (group D3) by random number table method, with 30 cases in each group. All patients underwent robot-assisted proximal femoral intramedullary nail fixation under general anesthesia. The awakening time, extubation time, postanesthesia care unit (PACU) residence time, Propofol dosage, and the number of vasoactive drug users among three groups were compared; the cerebral blood flow/cerebral metabolic rate of oxygen (CBF/CMRO2) and jugular venous oxygen saturation (SjvO2) among three groups were compared immediately after induction (T1) and at suture (T2); the incidence of postoperative delirium among three groups within three days after operation was compared. Results There were statistically significant differences in awakening time, extubation time, PACU residence time, and Propofol dosage among three groups (P＜0.05); the recovery time, extubation time, and PACU residence time in group D3 were shorter than those in group D1, and longer than those in group D2; and Propofol dosage was lower than those in group D1 and D2, and the differences were statistically significant (P＜0.05). The recovery time, extubation time, and PACU residence time in group D2 were shorter than those in group D1, and Propofol dosage was lower than that in group D1, and the differences were statistically significant (P＜0.05). At T1, there were no significant differences in CBF/CMRO2 and SjvO2 among three groups (P＞0.05); at T2, there were significant differences in CBF/CMRO2 and SjvO2 among three groups (P＜0.05); the CBF/CMRO2 and SjvO2 in group D3 were higher than those in group D1 and D2, and the CBF/CMRO2 and SjvO2 in group D2 were higher than those in group D1, and the differences were statistically significant (P＜0.05). There was statistical significance in the number of postoperative delirium among three groups (P＜0.05). Conclusion 3% Desflurane combined intravenous anesthesia can reduce the intraoperative brain metabolism in elderly hip fracture patients with MCI, which is conducive to early postoperative recovery and reduce the occurrence of postoperative delirium, and is worthy of clinical promotion.
		2023 Vol. 20 (20): 134-137,145 [Abstract] ( 11 ) HTML (1 KB) PDF (767 KB) ( 88 )

	138	Correlation analysis of pulmonary function indicators and inflammatory indicators in patients with acute exacerbation of chronic obstructive pulmonary disease
		CAO Haiyan1 CHEN Long2 CHU Xiangjian3
		DOI: 10.20047/j.issn1673-7210.2023.20.30
		Objective To explore the correlation between pulmonary function indicators and inflammatory indicators in patients with chronic obstructive pulmonary disease. Methods From March to August 2022, 68 patients with chronic obstructive pulmonary disease admitted to the Department of Respiratory Medicine, Rugao People’s Hospital, Jiangsu Province were selected. They were divided into stable group (31 cases) and acute exacerbation group (37 cases) according to the disease status. Serum interleukin-33 (IL-33), C-reactive protein (CRP), tumor necrosis factor (TNF-α）, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), red blood cell distribution width (RDW), forced vital capacity (FVC), peak expiratory flow (PEF), forced expiratory volume in one second/forced vital capacity (FEV1/FVC) between two groups were compared; the correlation of lung function indicators and inflammatory factors indicators were analyzed. Results FVC, PEF, and FEV1/FVC in acute exacerbation group were lower than those in stable group, IL-33, CRP, TNF-α, NLR, PLR, and RDW were higher than those in stable group (P＜0.05). In acute exacerbation patients, FVC was negatively correlated with IL-33, CRP, and PLR; PEF was negatively correlated with IL-33 and TNF-α, NLR, and PLR; FEV1/FVC was negatively correlated with IL-33 and TNF-α, NLR, and RDW (r＜0, P＜0.05). Conclusion Factors such as CRP, NLR, PLR, and RDW are correlated with pulmonary function indicators of patients with chronic obstructive pulmonary disease, which can be used to assist in assessing the disease changes in patients with chronic obstructive pulmonary disease.
		2023 Vol. 20 (20): 138-141 [Abstract] ( 14 ) HTML (1 KB) PDF (526 KB) ( 133 )

	142	Effect of Lifei Decoction on respiratory function and activities of daily living in patients with acute exacerbation of chronic obstructive pulmonary disease of phlegm dampness accumulating in the lung type
		ZHANG Ying1 TANG Haihong1 ZHANG Ming2▲
		DOI: 10.20047/j.issn1673-7210.2023.20.31
		Objective To investigate the effect of Lifei Decoction on respiratory function and ability of daily living (ADL) in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Eighty patients with AECOPD admitted to Shuyang Hospital Affiliated to Xuzhou Medical University from June 2019 to December 2021 were selected, and they were divided into observation group and control group, with 40 patients in each group. the control group received conventional symptomatic treatment. The observation group added Lifei Decoction on the basis of the control group. The symptom score, clinical efficacy, ADL score, and adverse reaction rate during treatment were compared before and after treatment. Results After treatment, the two traditional Chinese medicine syndrome scores were lower than before treatment, and the observation group was lower than the control group (P＜0.05). The clinical effect of the observation group was better than that of the control group (P＜0.05). After treatment, the ADL score of the two groups was higher than those before treatment, and that of the observation group was higher than that of the control group (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion Lifei Decoction has a good effect, and it can significantly improve the symptoms and daily living ability of AECOPD patients.
		2023 Vol. 20 (20): 142-145 [Abstract] ( 22 ) HTML (1 KB) PDF (601 KB) ( 13 )

	146	Relationship between blood pressure level before and after tooth extraction and wound healing effect in elderly patients with hypertensive
		LI Jingrong1 XING Yujing2 ZENG Wenjun3
		DOI: 10.20047/j.issn1673-7210.2023.20.32
		Objective To investigate the relationship between blood pressure level before and after tooth extraction and wound healing in elderly patients with hypertension. Methods A total of 115 elderly patients with hypertension admitted to Beijing Puren Hospital from January 2019 to December 2021 were selected as the study objects, and all patients were treated with tooth extraction. The wound healing of patients one week after tooth extraction was counted, and they were divided into poor healing group and good healing group according to the wound healing condition. The clinical data and the difference of systolic blood pressure and diastolic blood pressure before and after tooth extraction between two groups were compared; the influencing factors of wound healing effect in elderly hypertension patients were analyzed; the predictive value of blood pressure level before and after tooth extraction for wound healing was evaluated. Results There were 94 cases of good wound healing and 21 cases of bad wound healing in 115 elderly patients with hypertension. The level of serum interleukin-6 (IL-6) and the difference of systolic blood pressure and diastolic blood pressure before and after extraction in poor healing group were higher than those in good healing group (P＜0.05). IL-6, the difference of systolic blood pressure and diastolic blood pressure before and after tooth extraction were risk factors for poor wound healing in elderly patients with hypertension (OR=3.080, 2.954, 3.350, P＜0.05). The area under the curve of combined systolic blood pressure and diastolic blood pressure before and after tooth extraction was higher than that of each single prediction (P＜0.05). Conclusion The blood pressure level before and after tooth extraction is related to the wound healing effect in elderly patients with hypertension, and the combined measurement of the difference of systolic blood pressure and diastolic blood pressure before and after tooth extraction can predict the wound healing effect in elderly patients with hypertension.
		2023 Vol. 20 (20): 146-149 [Abstract] ( 16 ) HTML (1 KB) PDF (604 KB) ( 17 )

	150	Effect of Huoxue Huayu Yangxin Decoction combined with auricular point sticking and pressing on unstable angina pectoris after coronary stenting with qi deficiency and blood stasis syndrome
		DAI Yu YANG Jing LEI Dongxue LIU Huaying
		DOI: 10.20047/j.issn1673-7210.2023.20.33
		Objective To investigate the effect of Huoxue Huayu Yangxin Decoction combined with auricular point sticking and pressing on unstable angina pectoris after coronary stenting with qi deficiency and blood stasis syndrome. Methods A total of 122 patients with unstable angina pectoris after coronary stenting treated in Tangshan Traditional Chinese Medicine Hospital of Hebei Province from May 2020 to May 2022 were selected as the study objects, and they were divided into the control group (61 cases with oral conventional western medicine) and the experimental group (61 cases with Huoxue Huayu Yangxin Decoction combined with auricular point sticking and pressing treatment on the basis of the control group) by random number table method. Seven days for one course of treatment, both groups were treated for four courses. The traditional Chinese medicine syndrome score, clinical efficacy, coronary hemodynamics, and treatment safety were compared between the two groups. Results After treatment, the traditional Chinese medicine syndrome scores of both groups were lower than before treatment, and those of the experimental group were lower than those of the control group, the differences were statistically significant (P＜0.05). The clinical efficacy of the experimental group was better than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, the peak systolic velocity (PSV), end diastolic velocity (EDV), and pulsatility index (PI) of the two groups were higher than before treatment, and the PSV, EDV, and PI of the experimental group were higher than those of the control group, the differences were statistically significant (P＜0.05). The resistance index (RI) of the two groups was lower than before treatment, and the RI of the experimental group was lower than that of the control group, the differences were statistically significant (P＜0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P＞0.05). Conclusion The effect of Huoxue Huayu Yangxin Decoction combined with auricular point sticking and pressing on unstable angina pectoris after coronary stenting is remarkable, which can improve the symptoms and coronary hemodynamics of patients with good safety.
		2023 Vol. 20 (20): 150-153 [Abstract] ( 25 ) HTML (1 KB) PDF (640 KB) ( 32 )

	154	Huang Yuanyu’s experience in treating insomnia with phlegm-fire disturbing heart type based on the theory of “cycle flow of one qi”
		XING Yadan1 CAO Muyuan2 WEN Qianqian3 DU Caifeng1
		DOI: 10.20047/j.issn1673-7210.2023.20.34
		Insomnia, is due to emotion, diet, internal injury, and many other causes, often can not get normal sleep as a kind of disease syndrome, of which phlegm-fire disturbing heart type is quite common in clinical. Huang Yuanyu, a doctor in the Qing Dynasty, held the idea of “cycle flow of one qi”, from the point of view of qi of spleen and stomach as the basis hub to transfer the other four of the five elements, names wood, fire, gold, and water, to explore the etiology, pathogenesis, syndrome, and treatment of the disease. He believes that the basic pathogenesis of insomnia with phlegm-fire disturbing heart type is the decay of spleen and stomach, phlegm-turbidity disturbing clear orifices, and ministerial fire growth. Based on this, a distinctive treatment method is formed, that is banking up earth to control water, diving ministerial fire and eliminating phlegm-turbidity. In the course of treatment, the application of Huangya Decoction and Jinding Decoction is mostly based on addition and subtraction, in order to the spleen and stomach and make the movement of qi rise and fall harmoniously, to achieve the purpose of phlegm fire not produce and sleep orderly.
		2023 Vol. 20 (20): 154-157 [Abstract] ( 15 ) HTML (1 KB) PDF (667 KB) ( 17 )

	158	Clinical effect of Qingfei Huatan Decoction in treating infantile Mycoplasmal pneumoniae pneumonia with wind-phlegm obstruction of lung syndrome
		XU Yuanyuan ZHANG Xiaodong QIU Zhinan
		DOI: 10.20047/j.issn1673-7210.2023.20.35
		Objective To explore the clinical effect of Qingfei Huatan Decoction in treating infantile Mycoplasmal pneumoniae pneumonia with wind-phlegm obstruction of lung syndrome. Methods Eighty-four cases of infantile Mycoplasma pneumoniae pneumonia with wind-phlegm obstruction of lung syndrome admitted to Rugao Traditional Chinese Medicine Hospital in Jiangsu Province from June 2017 to June 2022 were selected as the research objects. They were divided into the control group and the study group by random number table method, with 42 cases in each group. The control group was treated with acupoint application of traditional Chinese medicine on the basis of basic treatment, and the study group was treated with Qingfei Huatan Decoction on the basis of control group. After two weeks of treatment, traditional Chinese medicine syndrome scores, efficacy, serum levels of interleukin-6 (IL-6), hypersensitive C-reactive protein (hs-CRP), and immunoglobulin (Ig) A, IgM were compared between the two groups. Results After treatment, the scores of principal syndrome and secondary syndrome in both groups were lower than before treatment, and those in the study group were lower than those in the control group (P＜0.05). Serum levels of IL-6 and hs-CRP in two groups after treatment were lower than before treatment, and those in the study group were lower than those in the control group (P＜0.05). The serum IgA and IgM levels of the two groups were higher after treatment than before, and those of the study group were higher than those of the control group (P＜0.05). The clinical efficacy of the study group was better than that of the control group (P＜0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P＞0.05). Conclusion Qingfei Huatan Decoction in the treatment of infantile Mycoplasmal pneumoniae pneumonia with wind-phlegm obstruction of lung syndrome is helpful to improve the therapeutic effect and good safety.
		2023 Vol. 20 (20): 158-161 [Abstract] ( 15 ) HTML (1 KB) PDF (606 KB) ( 48 )

	162	Clinical effect of specific electromagnetic spectrum combined with Guizhi Fuling Capsules on sequelae of cold-damp and dampness stasis type pelvic inflammatory disease
		ZHANG Yanming1 LUO Lihua2▲ WANG Huige3 DONG Jige2 WANG Yusheng2
		DOI: 10.20047/j.issn1673-7210.2023.20.36
		Objective To observe the efficacy of specific electromagnetic spectrum (TDP) irradiation combined with Guizhi Fuling Capsules for patients with sequelae of cold-damp and dampness stasis type pelvic inflammatory disease in the elderly. Methods A total of 64 elderly patients with the sequelae of cold-damp and dampness stasis type pelvic inflammatory disease treated in Wangjing Hospital of China Academy of Chinese Medical Sciences from September 2019 to September 2022 were selected and they were divided into control group and experimental group according to random number table method, with 32 cases in each group. The control group was treated with oral Guizhi Fuling Capsules, and the experimental groups were treated with combined TDP irradiation of b?觀li?觃o point on the basis of the control group. The treatment cycle was four weeks. Before treatment and after four weeks of treatment, the symptom grading, local sign grading, visual analogue scales(VAS) score and therapeutic effect of all patients were compared. Results After treatment, symptom grading quantification score, local signs severity grading score and VAS score were decreased in both groups, and the experimental group was lower than the control group, the differences were statistically significant (P＜0.05). The clinical efficacy of experimental group was better than that of control group, and the difference was statistically significant (P＜0.05). Conclusion TDP irradiation combined with Guizhi Fuling Capsules could can not only effectively improve the clinical symptoms and related physical signs of elderly patients with cold-damp and dampness stasis type sequelae of pelvic in- flammatory disease in higher clinical efficiency, which is worthy of clinical application.
		2023 Vol. 20 (20): 162-165 [Abstract] ( 21 ) HTML (1 KB) PDF (632 KB) ( 35 )

	166	Clinical comprehensive evaluation of Fengliao Changweikang Granules
		GUO Yuanyuan1 MA Lina1 MAO Liuying1 HE Ting1 GU Yuanyuan1 ZHAO Wei1 CAO Junling2
		DOI: 10.20047/j.issn1673-7210.2023.20.37
		The clinical comprehensive evaluation of Fengliao Changweikang Granules is carried out to provide reference for clinical rational drug use and basic drug management. Through the comprehensive collection of safety, effectiveness, economy, innovation, suitability, and accessibility of Fengliao Changweikang Granules, and the theories of pharmacology, toxicology, evidence-based medicine, evidence-based pharmacy, clinical epidemiology, pharmacoeconomics, medical statistics, and health technology evaluation and other theories are used to evaluate Fengyao Weichangkang Granules. Compared with conventional chemical drugs, Fengliao Changweikang Granules have higher safety, better clinical efficacy, and certain economy. The drug labeling is in line with the current regulations, and tablets, capsules, dripping pills, and other dosage forms have been prepared, and sugar-free granules have been developed. Drug sales throughout a number of provinces and cities, high accessibility. However, there are few clinical studies, pharmacological and toxicological research, and economic research, so it is suggested to carry out related studies in the future.
		2023 Vol. 20 (20): 166-169 [Abstract] ( 66 ) HTML (1 KB) PDF (604 KB) ( 27 )

	170	Effect of family members’ comprehensive enabling health education on anaphylactoid purpura in preschool
		CHEN Xi SUN Juan LI Hui
		DOI: 10.20047/j.issn1673-7210.2023.20.38
		Objective To analyze the effect of family members’ comprehensive enabling health education on anaphylactoid purpura in preschool. Methods A total of 145 preschool children with anaphylactoid purpura and their parents admitted to the Department of Pediatrics, Fuyang People’s Hospital from January 2020 to December 2022 were selected by convenience sampling method, and they were divided into control group (73 cases) and observation group (72 cases) by random number table method. The control group carried out routine health education, and the observation group carried out comprehensive empowering health education for family members. The parents’ compliance behavior, the time of social function, clinical symptoms, and hospital stay were compared between the two groups. Results The rates of correct medication, scientific diet, good habits, timely review, prevention of incentives, and compliance behavior of parents in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05); after intervention, the Weiss functional impairment rating scale of parent scale in the two groups was lower than those of before intervention, and the observation group was lower than the control group, and the differences were statistically significant (P＜0.05). The time of joint symptom disappearance, gastrointestinal healing, skin symptom disappearance, and hospitalization in the observation group were shorter than those in the control group, and the differences were statistically significant (P＜0.05). Conclusion Family empowering health education for preschool children with anaphylactoid purpura can effectively alleviate anxiety, shorten hospital stay, and enhance social function.
		2023 Vol. 20 (20): 170-173 [Abstract] ( 14 ) HTML (1 KB) PDF (655 KB) ( 30 )

	174	Effect of personalized comprehensive care on elderly patients with frailty and swallowing disorders
		LIU Shaoni LI Xuejiao ZUO Jing
		DOI: 10.20047/j.issn1673-7210.2023.20.39
		Objective To explore the effect of personalized comprehensive care on elderly patients with frailty and swallowing disorders. Methods A total of 96 elderly patients with frailty and swallowing disorders who were treated in the Chinese People’s Liberation Army General Hospital from June 2016 to December 2020 were selected, they were divided into control group and experimental group by random number table method, with 48 cases in each group. The control group received routine care for dysphagia, and the experimental group received individualized comprehensive care. The recovery of dysphagia (Kutoba drinking water test), the incidence of complications (aspiration pneumonia) and body mass index were observed. Results The improvement of swallowing function in experimental group was better than that in control group (P＜0.05), the complication rate of experimental group was lower than that of control group (P＜0.05), the body mass index of experimental group was higher than that before intervention and the control group ( P＜0.05). Conclusion For patients with dysphagia complicated with senile as asthenia, giving the best care for the symptoms, personalized formulation of chewing muscle exercise, whole body muscle exercise program, management of multiple drugs and nutritional care can effectively improve the swallowing function and nutritional status of patients, reduce the incidence of aspiration pneumonia, and help patients recover in the future.
		2023 Vol. 20 (20): 174-176,185 [Abstract] ( 18 ) HTML (1 KB) PDF (667 KB) ( 39 )

	177	Anesthetic management of a patient with ankylosing spondylitis and massive cerebral infarction undergoing transurethral resection of prostate and literatures review
		LI Huibo1 SU Yuqi2 TAO Ruijiao2 LIANG Zhuofeng2 WU Hua2 CHEN Hanwen2 ZHANG Yiwen1
		DOI: 10.20047/j.issn1673-7210.2023.20.40
		Patients with ankylosing spondylitis (AS) with severe cardiovascular and cerebrovascular diseases have a high risk of emergency airway, cardiovascular and cerebrovascular accidents during perioperative period, anesthesia management is difficult, but it is not well understood in clinical practice, and no related cases have been reported. This paper reports a case of AS complicated with massive cerebral infarction. The admitting diagnosis includes: Prostatic hyperplasia; Ankylosing spondylitis; Sequelae of cerebral infarction. Transurethral electrified resection of the prostate was performed under general anesthesia. Through perfect preoperative preparation, individual management of difficult airway and perioperative stroke prevention. The patient finally passed the perioperative period smoothly and was discharged successfully, and no new neurological dysfunction was found within 30 days of follow-up. Through the retrospective analysis of the case and literature review, this paper provides clinical reference.
		2023 Vol. 20 (20): 177-180 [Abstract] ( 14 ) HTML (1 KB) PDF (963 KB) ( 34 )

	181	Problems and solution ideas of undergraduate scientific research ability training in newly-built medical colleges and universities
		WU Weijing TAN Qianglai WU Lanlan
		DOI: 10.20047/j.issn1673-7210.2023.20.41
		Due to the lack of a joint talent development system of undergraduate, master， and doctor in newly-built medical colleges and universities, the current situation of undergraduate scientific research ability training system in newly-built medical colleges and universities is different from that of research-oriented universities. Firstly, this article analyzes the problems of undergraduate scientific research ability training system in newly-built medical colleges and universities from the two perspectives of students and teachers. Secondly, the progressive evaluation system of undergraduate scientific research ability is constructed, including six dimensional indicators and five levels of assessment. This system aims at turning the target of improving undergraduate scientific research ability into concrete action. Finally, learned from the method of organizational process asset management, the technology and experience from orderly scientific research projects can guide new projects, improve the efficiency of new projects, and promote the whole process management of new projects. It not only provides a guarantee for the well processing of the teacher’s projects, but also effectively improves the undergraduate scientific research ability.
		2023 Vol. 20 (20): 181-185 [Abstract] ( 18 ) HTML (1 KB) PDF (774 KB) ( 130 )

	186	Design and implementation of listening and interpreting robot in consulting room based on artificial intelligence
		LIAO Cong1 YUAN Fang2 ZHAO Meng1 CHEN Ting1 SHI Xinxin1 REN Hailing2▲
		DOI: 10.20047/j.issn1673-7210.2023.20.42
		In response to the current problems of large number of outpatients and time constraints, which make it difficult for doctors to balance doctor-patient communication and medical record writing quality, this study designs an intelligent consultation room listening and interpreting robot based on dialogue understanding, natural language processing and expertise mapping technologies. The system includes three ports: machine side, doctor side and patient side, which can realize seamless communication before, during， and after consultation. The robot listens to the doctor-patient dialogue without disturbance throughout the consultation to automatically generate medical records and provide patients with services such as medication guidance, special disease management， and online follow-up. The practice shows that the intelligent consultation room listening and interpreting robot has high recognition speed, high accuracy rate and low secondary revision rate of medical records, which significantly improves the efficiency of doctors' treatment, treatment safety， and patients’ medical experience.
		2023 Vol. 20 (20): 186-190 [Abstract] ( 18 ) HTML (1 KB) PDF (1779 KB) ( 211 )

	191	Quantitative analysis of the intersection of media and psychology based on VOSviewer
		ZHOU Yinchou
		DOI: 10.20047/j.issn1673-7210.2023.20.43
		Objective To conduct an econometric analysis of the current research progress at the intersection of media and psychology. Methods All literatures in the cross-field of media and psychology from January 2018 to June 2022 were collected on Scopus. After screening, VOSviewer was used to conduct a quantitative analysis in terms of connection strength, time, word agglomeration, and other dimensions from the perspectives of author and keywords. Results A total of 3 233 literatures were selected, and it was found that the research subject in February 2022 was Griffiths MD. The scholars group with the core of Li was transferred to the Chinese scholars group with the core of Li. The overall number of connections among Chinese scholars was large, but the individual connection strength was weak. The total number of published papers was large, but the number of citations per paper was low. 40% of the authors’ keywords focused on the public mental health state influenced by the media; there were word agglomerates named after gender and age stage. Information epidemiology was widely mentioned. Conclusion The research foundation of domestic academic circles in this field is large, but the influence needs to be improved. Depression and anxiety caused by the influence of media and their mental health categories are the mainstream research directions at present. Dichotomy of gender and age are the main research method of population classification. Information epidemiology has the potential to develop further as a new discipline.
		2023 Vol. 20 (20): 191-196 [Abstract] ( 36 ) HTML (1 KB) PDF (1375 KB) ( 131 )

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