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| Effects of recombinant human interferon α2b combined with fructose 1，6-diphosphate on rotavirus enteritis in children and myocardial protection |
| HUA Jingming LI Yanling SUN Xiaobao ZHANG Wenhua▲ |
Department of Pediatrics, the First Affiliated Hospital of Anhui University of Science and Technology Huainan First People’s Hospital, Anhui Province, Huainan 232007, China
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Abstract Objective To explore the effects of recombinant human interferon α2b (RHIα2b) combined with fructose 1，6-diphosphate (FDP) on rotavirus enteritis (RVE) in children and myocardial protection. Methods A total of 78 children with RVE who admitted to Huainan First People’s Hospital from June 2019 to June 2022 were selected, they were divided into two groups, with 39 cases in each group. The control group was treated with RHIα2b, and the observation group was treated with RHIα2b combined with FDP. The clinical efficacy of two groups was evaluated after seven days of treatment, the immune function and myocardial enzyme levels were compared between two groups before and after treatment, the hospitalization time, antidiarrheal time, and dehydration correction time of two groups were compared, the occurrence of adverse reactions in two groups was observed. Results The clinical effect of observation group was better than that of control group (P＜0.05). After treatment, the levels of CD3+ and CD4+/CD8+ in observation group were higher than those before treatment, and observation group was higher than control group (P＜0.05). After treatment, the levels of creatine kinase, creatine kinase MB, and lactate dehydrogenase in two groups were lower than those before treatment, and observation group was lower than the control group (P＜0.05). The hospitalization time and antidiarrheal time in observation group were shorter than those in control group (P＜0.05); there was no significant difference in dehydration correction time between two groups (P＞0.05). No adverse reactions such as rash, fever, and palpitation were found in the two groups. Conclusion RHIα2b combined with FDP can improve the therapeutic effect of RVE in children, improve the immune function, play a certain protective effect on the heart muscle of children, accelerate the recovery of children, safe, and effective.
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[1] Posovszky C，Buderus S，Classen M，et al. Acute Infectious Gastroenteritis in Infancy and Childhood [J]. Dtsch Arztebl Int，2020，117（37）：615-624.
[2] Amimo JO，Raev SA，Chepngeno J，et al. Rotavirus Interactions With Host Intestinal Epithelial Cells [J]. Front Immunol，2021，12（22）：793841.
[3] 罗雪敏，黄东辉，邹晓惠. 馥感啉口服液联合重组人干扰素α1b治疗疱疹性咽峡炎的疗效及对患儿心肌酶谱和炎症因子的影响[J].海南医学，2022，33（10）：1290-1293.
[4] 蔡露良，林涛，钟广会，等.重组人干扰素α-1b用于小儿轮状病毒感染性肠炎对肠功能的保护作用[J].临床和实验医学杂志，2020，19（18）：1994-1998.
[5] 杜春燕，王春辉.不同剂量重组人干扰素α2b注射液雾化吸入治疗小儿呼吸道合胞病毒肺炎疗效比较[J].陕西医学杂志，2020，49（1）：105-108.
[6] 吴建刚，陈玉梅，陈美元，等.哮喘患儿呼吸道病毒感染特征及其与α-干扰素治疗前后Th1、Th2细胞因子平衡的相关性研究[J].中国免疫学杂志，2021，37（15）：1877- 1882.
[7] 彭程，黎金雨，赵云. 1，6-二磷酸果糖对小儿病毒性心肌炎心肌酶谱和心功能的影响[J].岭南心血管病杂志，2020，26（5）：585-588.
[8] 徐小玲，陈亚平，杨乐乐，等.儿童轮状病毒肠炎的临床特点以及危险因素分析[J].中华实验和临床病毒学杂志，2020，34（3）：280-283.
[9] 中华医学会儿科学分会消化学组，中华医学会儿科学分会感染学组，《中华儿科杂志》编辑委员会.儿童腹泻病诊断治疗原则的专家共识[J].中华儿科杂志，2009，47（8）：634-636.
[10] 杨严.腹泻儿童A群轮状病毒及粪便常规检测结果的分析[J].检验医学与临床，2020，17（18）：2704-2706.
[11] Wang X，Song L，Tan W，et al. Clinical efficacy of oral immunoglobulin Y in infant rotavirus enteritis：Systematic review and meta-analysis [J]. Medicine（Baltimore），2019，98（27）：e16100.
[12] 肖舒文，胡永红.果糖-1，6-二磷酸醛缩酶的研究进展[J].河北师范大学学报（自然科学版），2022，46（3）：297-303.
[13] 潘家华，羊礼荣，韩旻，等.口服重组人干扰素α2b治疗小儿轮状病毒肠炎的多中心随机双盲对照研究[J].儿科药学杂志，2019，25（1）：5-11.
[14] 王青伟，李悦，刘强，等.1，6-二磷酸果糖口服液对急性心肌梗死大鼠心肌细胞凋亡、氧化应激和能量代谢的影响及可能机制研究[J].实用心脑肺血管病杂志，2022， 30（5）：40-44.
[15] 李谨俐，庄小妮，郭伟，等.果糖二磷酸联合辅酶Q10对CVB3所致病毒感染性心肌炎血清MCP-1、sB-H4及MIP-1α影响[J].湖南师范大学学报（医学版），2020，17（1）：98-101.
[16] Liu P，Zou R，Zhao J，et al. Changes in humoral immunity，myocardial damage，trace elements，and inflammatory factor levels in children with rotavirus enteritis [J]. Am J Transl Res，2022，14（1）：452-459.
[17] 曹娟，管敏昌，娄召君，等.中药取穴贴敷并推拿治疗小儿病毒性肠炎疗效及对血液T细胞亚群水平的影响[J].中国卫生检验杂志，2021，31（15）：1850-1853.
[18] 曹阳，胡萍，田敏，等.6-磷酸果糖激酶-2/果糖-2，6-二磷酸酶3对人脐静脉内皮细胞管腔形成的影响[J].中国组织工程研究，2020，24（14）：2217-2222.
[19] 张雅宁，袁展望，郭亚鹏.辅酶Q10联合果糖二磷酸钠或磷酸肌酸钠治疗小儿病毒性心肌炎对心肌酶谱及免疫功能的影响[J].河北医学，2022（1）：168-173.
[20] 蔡昌君，黄惠敏，桂冬梅，等.磷酸肌酸钠联合果糖二磷酸钠通过miR-133b/ELAVL1分子轴缓解小儿病毒性心肌炎的机制研究[J].中国医院用药评价与分析，2022， 22（3）：313-318.
[21] 杨宜瑾，付冰，司丽.果糖二磷酸钠联合氯吡格雷治疗急性心肌梗死的临床研究[J].现代药物与临床，2021， 36（3）：547-550.
[22] 王应云，张利果.小儿双清颗粒联合重组人干扰素α2b治疗儿童手足口病的临床研究[J].现代药物与临床，2020， 35（7）：1438-1441.
[23] 黄春华，郭燕，郑钦亮，等.高压氧联合果糖二磷酸钠治疗急性一氧化碳中毒心肌损伤患儿的疗效观察[J].中华航海医学与高气压医学杂志，2020，27（6）：704-707.
[24] 刘振球，蔡亲武，梁安珊.果糖二磷酸钠联合辅酶Q10片治疗小儿病毒性心肌炎疗效分析[J].心脑血管病防治，2020，20（3）：305-307.
[25] 卢海景，粘少硕，王佳稳.注射果糖二磷酸钠致高磷血症1例[J].检验医学与临床，2020，17（21）：3229-3231. |
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