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2023 Vol. 20, No. 13
Published: 2023-05-05
4
Anatomic study of ultrasound-guided acupotomy release of rabbits lumbar ligamentum flavum
ZHAO Yu1 GUO Shuang1 CHEN Can1 CHEN Yiren1 DU Mengfan1 NIU Susheng2 LIU Jing3 ZHANG Yan1
DOI: 10.20047/j.issn1673-7210.2023.13.01
Objective To explore the approach of acupotomy release rabbit lumbar ligamentum flavum under ultrasound guidance, according to the anatomical structure of the rabbit lumbar spine and the shape of the ligamentum flavum. Methods The height of spinous process, mastoid process, length, and width of lamina space of L5, L6, and L7 vertebrae in six male New Zealand rabbits aged three months were measured; the six 3-month-old male New Zealand rabbits were measured with the ultrasound probe vertical. The lateral axis of the posterior midline was placed, and the angle between the spinous process and the mastoid process was measured under ultrasound. The longitudinal axis of the ultrasonic probe was placed beside the spinous process to release the ligamentum flavum on both sides of L4/5, L5/6, and L6/7 segments in a plane way the acupotomy insertion depth, insertion angle, the vertical distance from the insertion point to the posterior midline and the vertical distance from the horizontal line of the sacral angle were measured, after the measurement, the data was analyzed and the anatomical structure of acupotomy path was observed. Results There was no significant difference in mastoid hight and spinous process height among L5, L6, and L7 vertebrae (P＞0.05). The length and width of the L5-L7 intervertebral space gradually increased, and the middle part of the yellow ligament was thicker, followed by the medial part, and the lateral part was thinner. There was no significant difference in the angle between spinous process and mastoid process on both sides of L5, L6 and L7 vertebrae measured by ultrasonic transverse axis (P＞0.05). After the longitudinal approach of the needle knife arrived at the yellow ligament under ultrasound guidance, there was no statistical significance in the vertical distance between the insertion points of the left and right sides of the L4/5, L5/6 and L6/7 segments measured after needle retention, the insertion depth of the needle knife, the angle between the needle knife and the horizontal line, namely the insertion angle of the needle knife (P＞0.05). The vertical distance of the horizontal line of the sacral angle at the left and right needle insertion points of L6/7 was shorter than L4/5 and L5/6, and the vertical distance of the horizontal line of the sacral angle at the left and right needle insertion points of L5/6 was shorter than L4/5, the differences were statistically significant (P＜0.05). No obvious blood vessels and nerves were observed in the puncture path, and the dura was intact. Conclusion It is a safe approach to release the rabbit ligamentum flavum with acupotomy when the ultrasound probe is placed parallel to the longitudinal axis. The needle insertion angle should be adjusted according to the anatomical differences of L4/5, L5/6, and L6/7 segments.
2023 Vol. 20 (13): 4-8 [
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Mechanism study of sevoflurane on proliferation and apoptosis of colorectal cancer cells by regulating miR-221
XU Jie MIAO Xiaolei WANG Hui ZHANG Jian
DOI: 10.20047/j.issn1673-7210.2023.13.02
Objective To investigate the effect of sevoflurane on proliferation and apoptosis of colorectal cancer cells through regulation of miR-221. Methods HCT116 cells were treated with low (1.7%), medium (3.4%) and high (5.1%) doses of sevoflurane for 6 h, respectively, and cells were stimulated with high doses of sevoflurane after transfection as required. CCK-8, clone formation assay and flow cytometry were used to detect cell proliferation and apoptosis. Results The cell OD values at all time points in the medium and high dose groups were lower than those in the low dose group; the cell OD values at all time points in the high dose group were lower than those in the medium dose group (P＜0.05). The clone formation rates of the low, medium, and high dose sevoflurane-treated groups were lower than those of the control group; the cell clone formation rates of the medium and high dose groups were lower than those of the low dose group; the cell clone formation rates of the high dose group were lower than those of the medium dose group (P＜0.05). The apoptosis rate in the low, medium, and high dose sevoflurane-treated groups were higher than that in the control group; the apoptosis rate in the medium and high dose groups were higher than that in the low dose group, and the apoptosis rate in the high dose group was higher than that in the medium dose group (P＜0.05). The miR-221 expression levels in HCT116 cells in the low, medium, and high dose sevoflurane-treated groups were lower than those in the control group, miR-221 expression levels in HCT116 cells in the medium and high dose groups were lower than those in the low dose group, and miR-221 expression levels in HCT116 cells in the high dose group were lower than those in the medium dose group (P＜0.05). The cell OD values at all time points in the anti-miR-221 group were lower than those in the anti-miR-NC group (P＜0.01). The clone formation rate of HCT116 cells in the anti-miR-221 group was lower than that in the anti-miR-NC group, and the apoptosis rate was higher than that in the anti-miR-NC group (P＜0.01). The cell OD values were higher in the miR-221 group than in the miR-NC group at each time point (P＜0.05). The cell clone formation rate in the miR-221 group was higher than that in the miR-NC group, and the apoptosis rate was lower than that in the miR-NC group (P＜0.01). The cell OD values of miR-221+sevoflurane were higher than those of miR-NC+sevoflurane group at each time point (P＜0.01). The cell clone formation rate of miR-221+sevoflurane group was higher than that of miR-NC+sevoflurane group and the apoptosis rate was lower than that of miR-NC+sevoflurane group (P＜0.05). Sevoflurane inhibits colorectal cancer cell proliferation and promotes apoptosis by suppressing miR-221 expression. Conclusion Sevoflurane inhibits the proliferation and promotes apoptosis of CRC cells by down-regulating miR-221.
2023 Vol. 20 (13): 9-12,28 [
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Analysis of effects of miR-143 regulation of TLR2 signaling pathway on ulcerative colitis based on bioinformatics
HAN Ling1 CHEN Qin2 XIE Changying3 HUANG Xueyun4 WU Na4
DOI: 10.20047/j.issn1673-7210.2023.13.03
Objective To explore the effects of miR-143 regulation of Toll-like receptor 2 (TLR2) signaling pathway on ulcerative colitis (UC) based on bioinformatics. Methods Gene data sets GSE75214, GSE53306, GSE48958 and miRNA data set GSE68306 were downloaded from GEO database for analysis. The target genes of the differential miRNAs meeting the criteria were predicted by miRDB software, and mapped with the screened differential genes, and the key miRNA in UC were selected for experiments. According to random number table method, 20 mice were divided into normal group and UC group, with 10 mice in each group. Sodium gluconosulfate was used for modeling. The pathological changes were observed by hematoxylin-eosin staining staining. The contents of tumor necrosis factor-α(TNF-α) were detected by ELISA, and the contents of TLR2 and interleukin-1β (IL-1β) in colon were detected by Western blot. The contents of miR-143, nuclear transcription factor-κB (NF-κB), and myeloid differentiation factor (MyD88) in colon tissue were determined by real-time quantitative PCR. Results There were 85 DEMs, including 34 DEMs were downregulated and 51 DEMS were up-regulated, and 19 DEMS (5 DEMS were highly expressed, and 14 DEMS were underexpressed), with miR-143 being the key miRNA. The results showed that compared with normal group, the serum TNF-α content in UC group was significantly increased, the expression of miR-143 in colon tissue was significantly decreased (P＜0.05), the protein expressions of TLR2 and IL-1β were significantly increased, and the mRNA contents of NF-κB and MyD88 were significantly increased (P＜0.05). Conclusion miR-143 is an important miRNA in ulcerative colitis, which may affect the development of UC through regulation of TLR2 pathway.
2023 Vol. 20 (13): 13-17 [
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Pharmacogenetic components detection of Polygonati Rhizoma Coll. et Hemsl in the liver mitochondria of metabolic associated fatty liver disease by Semi-Pre-HPLC combined with HPLC-MS of two-dimensional chromatographic analysis system
SHI Tingting1* LI Yanjuan2* YANG Ai2 WANG Tao2 SONG Chengzhu2 XI Jianjun1 JIANG Xiaojie1 YANG Xingxin2▲
DOI: 10.20047/j.issn1673-7210.2023.13.04
Objective To detect the pharmacogenetic components of Polygonati Rhizoma Coll. et Hemsl in liver mitochondria of metabolic associated fatty liver disease (MAFLD). Methods Twenty-four 6-week-old male SD rats were divided into normal group, model group, and Polygonati Rhizoma Coll. et Hemsl water extract group by random number table method, with eight rats in each group. The normal group was fed ordinary diet, and the other groups were fed with high fat diet. At the same time, the Polygonati Rhizoma Coll. et Hemsl water extract group was intragastric with Polygonati Rhizoma Coll. et Hemsl water extract at 8 g/(kg·d), and the normal group and model group were given with normal saline at the same volume for 14 weeks. One hour after the last administration, mitochondria were isolated from liver tissues of rats in each group, and the pharmacogenetic components of liver mitochondria of each group were analyzed by Semi-Pre-HPLC combined with HPLC-MS of two-dimensional chromatography analysis system. Results A total of ten pharmacogenetic components were detected in the liver mitochondria of MAFLD rats. Seven of them, diosgenin, dioscin, Smilax saponin, Pratioside D1, isoglycyrrhizin, β-sitosterol, and ivy saponin had been reported to regulate lipid metabolism. Conclusion A total of ten pharmacogenetic components detected may be the main active substances of polygonatum yunnanensis in regulating mitochondria to alleviate MAFLD.
2023 Vol. 20 (13): 18-22 [
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Expression of SOX4 in colorectal cancer and its effect on biological behavior
ZHANG Gang1 WANG Guoqiang1 WANG Wei1 WU Xueliang2 ZHENG Haiping1 LIU Nan3 ZHANG Yuguo1
DOI: 10.20047/j.issn1673-7210.2023.13.05
Objective To investigate the expression of sex-determining region Y-box 4 (SOX4) in colorectal cancer tissues, and to study the effects of SOX4 on the proliferation, migration, and invasion of human colorectal cancer SW480 cells. Methods A total of 40 specimens with pathologically confirmed colorectal cancer removed during surgical treatment in the First Affiliated Hospital of Hebei North University from January 2018 to January 2019 were collected. The mRNA and protein expression levels of SOX4 in tissues were analyzed by reverse transcription quantitative polymerase chain reaction (RT-qPCR) and Western blot. Human colorectal cancer SW480 cells were cultured and transfected with negative control plasmid (siRNA-NC group) and interference plasmid (siRNA-SOX4 transfection group) using lentivirus transfection technique, and blank group was set up. Cell proliferation, migration, and invasion were detected by CCK-8 assay, cell scratch assay, and Transwell assay. Results Compared with paracancer normal tissue, the mRNA and protein expression levels of SOX4 in colorectal cancer tissue were increased. There was no significant difference in the mRNA expression level of SOX4, the protein expression level of SOX4, the proliferation ability of SW480 cells, the scratch healing rate of SW480 cells, and the invasion ability of SW480 cells between blank group and siRNA-NC group (P＞0.05). Compared with siRNA-NC group, the mRNA expression level of SOX4, the protein expression level of SOX4, the proliferation ability of SW480 cells, the scratch healing rate of SW480 cells, and the invasion ability of SW480 cells were decreased in siRNA-SOX4 transfection group (P＜ 0.05). Conclusion The expression of SOX4 is up-regulated in colorectal cancer tissues, and the down-regulation of SOX4 expression in SW480 cells can significantly inhibit the proliferation, migration, and invasion of colorectal cancer cells.
2023 Vol. 20 (13): 23-28 [
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Discussion of molecular mechanism and experimental verification of Radix Astragali seu Hedysari in the treatment of osteoporosis based on network pharmacology and molecular docking
LI Yuanmei1 GUO Shuai1 ZHANG Xinyi1 HUA Maoqi2 LIU Xifang3
DOI: 10.20047/j.issn1673-7210.2023.13.06
Objective To explore the pharmacological mechanism of Radix Astragali seu Hedysari in the treatment of osteoporosis based on network pharmacology and molecular docking, and to verify by in vitro experiment. Methods The active ingredients and drug targets of Radix Astragali seu Hedysari were obtained through Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. GeneCard, OMIM, PharmGkb, TTD, and DrugBank databases were used to screen the genes related to osteoporosis, and the intersection of targets and genes was established to construct the drug-compotion-disease-target regulatory network. Enrichment analysis of KEGG pathway was performed, and finally molecular docking and cell experiments were performed. Pre-osteoblast cell line MC3T3-E1 was selected and divided into 10, 20, 30 μmol/L groups (adding 10, 20, 30 μmol/L isorhamnosin solution), and blank group (equal volume medium). The cell proliferation of the four groups cultured for 0, 24, 48, 72 h was detected by CCK8 method. Results A total of 20 active components, 1 290 osteoporosis related genes, and 78 associated gene intersections were obtained. There were six core targets of Radix Astragali seu Hedysari against osteoporosis, and the enrichment analysis of core gene KEGG pathway showed lipid and atherosclerosis pathway, MAPK signaling pathway, etc. Molecular docking results showed that the key target of Radix Astragali seu Hedysari membranaceus had higher binding activity with active components. The main active component isorhamnetin of Radix Astragali seu Hedysari was selected for cell experiment, experiment results showed that the cell optical density values of 10, 20, and 30 μmol/L groups at 24, 48, 72 h culture were higher than those of the blank group at the same time point, the 20 and 30 μmol/L groups were higher than those of the 10 μmol/L group at the same time point, and the 30 μmol/L group was higher than those of the 20 μmol/L group at the same time point, the differences were statistically significant (P＜0.05). Conclusion The effective component of Radix Astragali seu Hedysari in the treatment of osteoporosis is isorhamnetin, Radix Astragali seu Hedysari may play a role in regulating bone metabolism and promoting osteoblast proliferation through multiple targets participating in specific signaling pathways.
2023 Vol. 20 (13): 29-32 [
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Data mining analysis of mice model of allergic rhinitis induced by ovalbumin
YAN Jiaxin1 JIA Mingyue2 XIAO Siyao2 FAN Jiajia1 LUO Xue1 ZHANG Shunan2
DOI: 10.20047/j.issn1673-7210.2023.13.07
Objective To analyze the mice model of allergic rhinitis (AR) induced by ovalbumin (OVA). Methods Animal experimental literatures on mice model of AR induced by OVA published from July 2017 to June 2022 were retrieved from PubMed, and a database was constructed with animal species, sex, positive drugs, modeling methods, sensitizing drugs, administration dose, and behavioral evaluation as items, and data mining was carried out. The modeling elements, materials, and behavioral evaluation methods of mice model of AR induced by OVA were analyzed. Results A total of 156 literatures were selected, among which the most used were BALB/c female mice, most of which did not have a positive control group. Among the literatures with a positive control group, glucocorticoid was the most used, and the most commonly used modeling method was intraperitoneal injection based sensitization + local excitation. OVA manufacturers’ choice was mainly American Sigma-Aldrich, sensitizing adjuvant was mainly Al(OH)3. The most commonly used doses in the basal sensitization phase were 50 μg OVA and 1 mg Al (OH)3, and the volume of the solution was 200 μl for a single intraperitoneal injection. The most frequently used doses were given once every one week, for a total of three times. The most commonly used local excitation dose was single OVA of 500 μg, single nasal drip solution volume of 20 μl, and the most commonly used frequency was six days of continuous nasal drip. Nasal mucosa was the most sampled item, followed by blood. The most frequently observed behavior evaluation is sneezing + nose scratching, and the observation time is mostly ten minutes. Conclusion The specific conditions of mice model of AR induced by OVA are complex and the options are diverse, so researchers should combine the literature and research obj- ectives to select.
2023 Vol. 20 (13): 33-36,45 [
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Application of whole exon sequencing in diabetic kidney disease
LIU Zehui YANG Mengru MA Sha MA Qiang HAN Rui
DOI: 10.20047/j.issn1673-7210.2023.13.08
Diabetic kidney disease (DKD), as one of the most common complications of diabetes mellitus, which is characterized by microvascular damage of renal dysfunction. DKD is the first cause of end stage renal failure, but its specific occurrence and development mechanism is complex. Clinical and epidemiological evidence shows that DKD has familial aggregation in different ethnic groups, suggesting that genetic factors are involved in the progression of the disease. Whole exon sequencing (WES) includes the capture, sequencing, and analysis of all exons in the human genome. This paper aims to summarize the latest progress of WES in DKD, hoping to develop new targets for future clinical diagnosis and treatment.
2023 Vol. 20 (13): 37-40 [
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Research progress on tongue image of traumatic blood stasis syndrome
KONG Jiaxing DENG Rongrong XU Xidong ZHAO Xu KANG Ran
DOI: 10.20047/j.issn1673-7210.2023.13.09
The etiology and pathogenesis of traumatic blood stasis syndrome is clear, and there is no cold and heat and yin and yang bias in the early onset, which is more conducive to the objective study of tongue symptoms of blood stasis syndrome. The analysis of the characteristics of the tongue image mainly focuses on three aspects: ecchymosis (petechia), (blue) purple tongue, and sublingual collaterals, with the highest diagnostic weight, which can indicate the severity of blood stasis syndrome and help to judge the occurrence and development of the disease. At the same time, some results have been achieved in the objective analysis of tongue characteristics of traumatic blood stasis syndrome, but the image definition of ecchymosis (petechia) on the tongue, the chromaticity value range of (blue) purple tongue, and the sublingual collaterals in terms of segmentation and extraction, there are problems such as inconsistent standards, unsatisfactory accuracy, and stability. In addition, the tongue characteristics of traumatic blood stasis syndrome are closely related to blood indicators and immune indicators, which can reflect blood stasis and hypercoagulability, and have broad application prospects in clinical diagnosis and treatment of diseases.
2023 Vol. 20 (13): 41-45 [
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Research progress of characteristic rehabilitation therapy of traditional Chinese medicine for shoulder subluxation after stroke
LIU Yuhan1 GE Xingchen1 WANG Hui1 WEI Jiaying1 ZHANG Zhenwei2
DOI: 10.20047/j.issn1673-7210.2023.13.10
Shoulder subluxation is a common complication of stroke, which can lead to a slow recovery of the upper limb and seriously affect the recovery confidence of patients. Traditional Chinese medicine rehabilitation therapy has obvious effect, high safety factor, good patient compliance, and other advantages, can promote blood circulation, reduce inflammatory response, regulate peripheral nerve function, reconstruction peripheral nerve innervation, and other aspects of the patients with shoulder subluxation after stroke, in order to relieve pain, improve muscle strength, balance muscle tension, and finally promote shoulder joint reset. This article reviews three aspects of characteristic acupuncture, characteristic massage, and special external use of traditional Chinese medicine to provide reference for clinical treatment and further research of the disease.
2023 Vol. 20 (13): 46-49 [
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Research status of epidemiology and risk factors of chronic kidney disease
GUO Jiaheng1 ZHANG Geng2 YAN Fengqi3 WANG Dongsheng1 DUAN Yongfei4 WU Guojun5
DOI: 10.20047/j.issn1673-7210.2023.13.11
Chronic kidney disease (CKD) is one of the major public health problems in the world. The etiology and pathogenesis of CKD are still unclear, and there are obvious geographical and ethnic differences. Because of the hidden onset of CKD, it is easy to be ignored, which brings certain difficulties to the prevention and treatment. China is a high incidence area of CKD, which is one of the major diseases endangering the health of Chinese residents and a major public health problem that needs to be solved urgently. Epidemiological studies have shown that CKD is the result of multiple factors. This article reviews the research results of the epidemiology and related risk factors of CKD, in order to provide help for the future research.
2023 Vol. 20 (13): 50-53 [
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Research advances in the treatment of Crohn’s disease with mesenchymal stem cells
WU Xiaojia1 CHEN Jinyang1 ZHUANG Pan1 LIU Junquan2▲
DOI: 10.20047/j.issn1673-7210.2023.13.12
Crohn’s disease (CD) is a chronic inflammatory bowel disease that is prone to relapse and has various symptoms. Currently, there is no effective treatment. Mesenchymal stem cells (MSCs) have the potential of anti-inflammatory, immune regulation, tissue repair, etc. In recent years, there have been many clinical studies on the application of MSCs in the treatment of CD at home and abroad. This article reviews the related reports on the use of bone marrow-derived MSCs and adipose-derived MSCs in the treatment of CD. In terms of the immune regulation mechanism of natural killer cells, dendritic cells, macrophages, neutrophils, and regulatory T cells and the tissue repair ability of MSCs, the mechanism, efficacy and safety of MSCs in the treatment of CD are described, in order to provide new ideas and methods for the clinical treatment of CD in the future.
2023 Vol. 20 (13): 54-57 [
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Study of correlation between intestinal flora and preeclampsia
ZHANG Jiwei1 JIA Sihui1 QIAO Jing1 WANG Cuixiu2
DOI: 10.20047/j.issn1673-7210.2023.13.13
Preeclampsia is a unique complication during pregnancy, which seriously threatens the health of mothers and fetuses. Up to now, the etiology and pathogenesis have not been fully elucidated, but a large number of studies have shown that the pathogenesis may be related to inflammatory immune overactivation, abnormal glucose and lipid metabolism, oxidative stress, and other abnormalities. With the in-depth study of intestinal flora, studies have found that intestinal flora can affect the over-activation of inflammatory immunity by regulating inflammatory factors, cytokines, and the proliferation and differentiation of T cells. When intestinal flora is disturbed, short-chain fatty acids produced by metabolism are reduced, which affects glucose and lipid metabolism and jointly participate in the occurrence and development of preeclampsia. In addition, placental microecology can be a new entry point to explore the pathogenesis of preeclampsia. This provides new ideas for revealing the pathogenesis of preeclampsia and exploring the prevention and treatment of preeclampsia. This article reviews the current research on the correlation between intestinal flora and preeclampsia.
2023 Vol. 20 (13): 58-62 [
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Research progress on natural medicine in preventing dental caries
GUO Xueqiang1 LIU Xinqiang2 ZHANG Jiarui1 QIN Qi1 GAO Yang3
DOI: 10.20047/j.issn1673-7210.2023.13.14
Dental Caries is a multifactorial disease, which is the result of the interaction of the three pathogenic factors of host, microorganism, and diet in a sufficient period of time, and it is one of the main causes of tooth loss, and it is necessary to carry out policy of prevention in the first place and integrating prevention with control. With the emergence of many adverse reactions and drug resistance of western medicine, traditional Chinese medicine has a unique advantage in caries prevention and bacteriostasis due to its characteristics of “natural medicine”, and can inhibit and kill a variety of oral pathogens. With little side effects, wide range of materials and remarkable curative effect, Chinese medicine has scientific theoretical basis and broad market prospect in preventing caries and oral care. The article summarizes a variety of natural medicines for active ingredients, anti-caries mechanism and application prospects such as officinal magnolia bark, Chinese gall, tea, propolis, geranium strictipes, lemon， and other drugs.
2023 Vol. 20 (13): 63-66 [
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Research progress on influencing factors of grip strength and pinch strength after hand trauma
JIA Xinwei1 WANG Hui2 WANG Hongtao1 GUO Chong1 ZHAO Xingwang1 WANG Zhiqiang1
DOI: 10.20047/j.issn1673-7210.2023.13.15
The activities of gripping and pinching are the basis of people’s daily life and fine movement. And stable grip and pinch strength is a good indication of upper body strength and function. With the increase of social labor, more and more hand trauma events occur. Recovery of grip and pinch strength after hand injury is an important part of hand function reconstruction. This paper summarizes and analyzes the effects of measuring tools and methods, anthropometric changes, tendon injury, collateral ligament injury, finger amputation, internal and external muscles of the hand, postoperative pain and psychological factors, flap repair, rehabilitation training on hand pinch and grip strength after trauma surgery, hoping to provide a certain reference for future clinical research and rehabilitation of hand trauma surgery.
2023 Vol. 20 (13): 67-70 [
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Application value of peer mentors model in the training of junior nurses
JIN Lan1 XU Yan2 TIAN Yali3 CHENG Jingjuan4 CAI Yu5▲
DOI: 10.20047/j.issn1673-7210.2023.13.16
Objective To explore the value of the peer mentors model in the training of junior nurses. Methods Eighty-nine Junior nurses with low seniority from January 2020 to December 2021 in Suzhou Science and Technology City Hospital were selected and divided into two groups according to their on-the-job training years. Forty-five nurses in the control group were taught in the conventional shadowing mode, while 44 nurses in the observation group were taught in the peer mentor mode. The comprehensive ability and professional identity of the two groups were observed before and after the training. Results After the training, the theoretical knowledge and practical operation assessment scores of junior nurses of the two groups were higher than those before the training, while those of the observation group were higher than those of the control group, and the differences were statistically significant (P＜0.05). After the training, the total scores of the professional identity scale for junior nurses of the two groups were higher than those before the training, while that of the observation group was higher than that of the control group, and the differences were statistically significant (P＜0.05). Conclusion The peer mentors model can effectively improve the theoretical knowledge base and practical operation ability of junior nurses, and has positive significance for enhancing their professional identity.
2023 Vol. 20 (13): 71-75 [
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Application of combined teaching model of BOPPPS and problem-based learning in pharmacology teaching
YANG Le DANG Xueliang YANG Qi
DOI: 10.20047/j.issn1673-7210.2023.13.17
Objective To discuss the application effect of combined teaching mode of bridge-in, objective, pre-assessment, participatory learning, post-assessment，summary (BOPPPS) and problem-based learning (PBL) in pharmacology teaching. Methods Twenty pharmacy students from the 2017 class of Air Force Medical University were selected as the control group to implement the traditional teaching model, and 20 pharmacy students from the 2018 class were selected as the study group to implement the BOPPPS + PBL teaching model. The self-assessed classroom effects and post-class theory test scores of students in the two groups were compared. Results The classroom atmosphere, perceived degree of key content, self-confidence in learning, and classroom attention scores of study group were higher than those of the control group, and the differences were statistically significant (P＜0.05). The difference was not statistically significant when comparing the time rationalization scores of the two groups (P＞0.05). The score of study group after-school theory test was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion The application of combined teaching mode of BOPPPS and PBL in pharmacology teaching can significantly improve the classroom effect and enhance the quality of teaching.
2023 Vol. 20 (13): 76-78,82 [
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Construction of laparoscopic operation skill training system for clinical medical students in China
QI Shuo DING Chengming LI Xiaoyan WANG Huiqing CHEN Guodong
DOI: 10.20047/j.issn1673-7210.2023.13.18
With the development of precision, minimally invasive and intelligent of medicine, minimally operation skill technology is required for minimally invasive surgery to routinely learn and master basic laparoscopic operation skills. Foreign countries have formed a multi-dimensional skill training system with comprehensive curriculum model, standardized training model, diversified training content, visualization of training results, and standardized assessment model, while domestic medical colleges put most of their energy into the operation training of skill assessment while ignoring the systematic training of laparoscopic skill. As a result, there is a big gap between the training mode and effectiveness of laparoscopy skill at home and abroad. In this paper, the reform of laparoscopic operation skill training mode is carried out through five aspects, including the reform of curriculum mode, the reform of training mode, the reform of enriching training content, the reform of visual training process, and the reform of comprehensive examination mode, so as to construct a “multidimensional and progressive” laparoscopic skill training system suitable for Chinese clinical medical students. In order to cultivate all-round medical talents with excellent medical literacy and solid operational basic skills.
2023 Vol. 20 (13): 79-82 [
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CiteSpace analysis of hot spots and trends in the quality of life of domestic acne patients
ZHANG Rui1 ZHOU Lanhua2 ZHANG Hui1 JIANG Yanxin1 LI Yipeng1 WANG Xu1 FENG Lili1 ZHANG Jianjun1
DOI: 10.20047/j.issn1673-7210.2023.13.19
Objective To analyze the current status of domestic acne patients’ quality of life studies in the past ten years and predict their future trends. Methods Using China National Knowledge Infrastructure, Wanfang, and VIP as data sources, the literature related to acne quality of life was searched from January 2012 to July 2022, and statistical analysis was performed on the number of journal articles, impact factors, research institutions, authors, keywords, treatment modalities, and use of scales. Results A total of 732 publications were included. Chinese Aesthetic Medicine was the journal that included the most studies in this category; Wang Li of Henan Provincial Hospital of Traditional Chinese Medicine was the author with the most publications in this field in the past ten years; Guangzhou University of Chinese Medicine was the institution with the highest number of studies; in addition to acne and quality of life, acne vulgaris was the most used keyword, herbal compound, Chinese medicine, and acupuncture were the main treatments for acne, and Adapalene Gel and Minocycline Hydrochloride Capsules were the main western drugs applied for acne; Dermatology Life Quality Index was the most used scale. Conclusion Acne scarring, safety and anxiety have become research hotspots and trends in the field of acne quality of life. Chinese medicine therapy has obvious advantages in enhancing the quality of life of acne patients, but the number of Chinese scales used in China for acne is limited and not standardized, and there is an urgent need to standardize their use.
2023 Vol. 20 (13): 83-87,117 [
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Clinical effect of Kaiqiao Xinshen Acupuncture Method in the treatment of post-stroke motor aphasia
SUN Jiabao1 YAN Huixin1 WANG Gaofeng1 CHEN Lili1 WU Xingquan2 SONG Bailin1
DOI: 10.20047/j.issn1673-7210.2023.13.20
Objective To explore the clinical effect of Kaiqiao Xinshen Acupuncture Method in the treatment of post-stroke motor aphasia (PSMA). Methods A total of 80 patients with PSMA admitted to the Affiliated Hospital of Changchun University of Chinese Medicine from January 2021 to June 2022 were selected and divided into control group and observation group according to random number table method, with 40 cases in each group. The control group received routine speech rehabilitation training and transcranial direct current stimulation treatment, and the observation group received Kaiqiao Xinshen Acupuncture Method on the basis of the control group. Both groups were treated for six weeks. The clinical efficacy were compared, and the scores of China Rehabilitation Research Center Chinese standard aphasia examination (CRRCAE), National Institutes of Health stroke scale (NIHSS), and the stroke and aphasia quality of life scale-39 (SAQOL-39) before and after treatment were compared between the two groups, and the safety was also observed. Results The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). After treatment, spontaneous speech, listening comprehension, retelling, naming, aphasia quotient scores of CRRCAE, and SAQOL-39 scores in both groups were higher than those before treatment, and the NIHSS scores of the both groups were lower than those before the treatment, and the CRRCAE scores and SAQOL-39 scores of the observation group were higher than those in the control group, and the NIHSS scores were lower than those in the control group, the differences were statistically significant (P＜0.05). There were no obvious adverse reactions during the treatment in both groups. Conclusion The treatment of PSMA with Kaiqiao Xinshen Acupuncture Method has a remarkable effect, which can effectively improve the aphasia symptoms and quality of life of patients.
2023 Vol. 20 (13): 88-91 [
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Clinical effect evaluation of closed lateral internal sphincterotomy through intersphincteric approach in patients with chronic anal fissure and its pathogenic characteristics
QIN Qin1 DONG Qingjun2 WANG Chen2
DOI: 10.20047/j.issn1673-7210.2023.13.21
Objective To evaluate the clinical effect of closed internal sphincter sphincterotomy through intersphincter approach for the treatment of old anal fissure and its pathogenic characteristics. Methods Eighty-three patients with old anal fissure admitted to the Department of Anorectal, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January to December 2020 were selected and divided into treatment group (34 cases) and control group (49 cases) according to the surgical methods. The treatment group was treated with closed internal sphincterotomy through intersphincteric approach, while the control group was treated with anal fissure incision and expansion. The clinical effect, healing time, pain and bleeding at the third day after surgery, intraoperative blood loss, operation time, hospitalization cost, hospitalization time, and abnormal anal function and recurrence at three months after discharge of the two groups were analyzed, and the pathogenic characteristics of old anal fissure were summarized. Results The results of this study showed that most of the old anal fissure consisted of single fissure, which was mainly located at the six o’clock position. Most of the clinical symptoms were pain and bleeding, and most of the complications were sentinel hemorrhoids. Both groups were cured, and there was no abnormal anal function or recurrence at three months after operation. There were no significant differences in intraoperative blood lose, hospitalization cost, and hospitalization time between the two groups (P＞0.05). The pain and bleeding at the third day after surgery in the treatment group were less than those in the control group, the healing time was shorter than that in the control group, and the operation time was longer than that in the control group, the differences were statistically significant (P＜0.05). Conclusion Closed internal sphincterotomy through intersphincter approach for the treatment of patients with old anal fissure is effective, can accelerate postoperative rehabilitation, worthy of application and promotion.
2023 Vol. 20 (13): 92-95 [
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Study of correlation between endogenous sex hormone levels and left ventricular ejection fraction in postmenopausal patients with chronic heart failure
ZHANG Haiyang1 FENG Jingru2 LI Fan3 WANG Jing1 ZHAO Na1 BI Shengli2 LI Xinjun1
DOI: 10.20047/j.issn1673-7210.2023.13.22
Objective To investigate and analyze the correlation between endogenous sex hormone levels and left ventricular ejection fraction (LVEF) in postmenopausal patients with chronic heart failure. Methods A total of 125 postmenopausal inpatients diagnosed with chronic heart failure in the Second Affiliated Hospital of Hebei North University (hereinafter referred to as “our hospital”) from March 2019 to October 2021 were selected as the study objects. According to the New York Heart Association cardiology grading scheme, they were divided into cardiac functionⅡ (34 cases), Ⅲ (42 cases), Ⅳ (49 cases) groups. At the same time, 30 menopausal patients without heart failure admitted to our hospital were selected as the non-heart failure group. Testosterone (T), estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), progesterone (PROG), and LVEF in the four groups were collected and compared. Spearman correlation coefficient was further used to analyze the correlation between endogenous sex hormone levels and LVEF in postmenopausal patients with chronic heart failure. Results E2 and LVEF of cardiac function Ⅱ, Ⅲ, and Ⅳ groups were lower than those of non-heart failure group, while PRL was higher than that of the non-heart failure group, E2 and LVEF in cardiac function Ⅲ and Ⅳ groups were lower than those in cardiac function Ⅱ group, while PRL was higher than those in cardiac function Ⅱ group, E2 and LVEF in cardiac function Ⅳ group were lower than those in cardiac function Ⅲ group, and PRL was higher than those in cardiac function Ⅲ group, the differences were statistically significant (P＜0.05). Correlation analysis showed that E2 was positively correlated with LVEF in postmenopausal patients with chronic heart failure (rs＞0, P＜0.05), while PRL was negatively correlated with LVEF (rs＜0, P＜0.05). Conclusion There is a close correlation between E2, PRL levels, and LVEF in postmenopausal patients with chronic heart failure. Monitoring the above indexes can provide a reference for the evaluation and judgment of cardiac function in postmenopausal patients with chronic heart failure.
2023 Vol. 20 (13): 96-99 [
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Clinical effects of self-made Qingyu Hejiang Decoction in treating patients with liver and stomach stagnation-heat type of reflux esophagitis
LIU Jie ZHU Qi CHEN Xin BAI Shaoyu REN Dengjie
DOI: 10.20047/j.issn1673-7210.2023.13.23
Objective To investigate the clinical effects of self-made Qingyu Hejiang Decoction Tang in treating patients with liver and stomach stagnation-heat type of reflux esophagitis (RE). Methods Ninety-eight cases of RE patients admitted to Zigong First People’s Hospital, Sichuan Province from January 2021 to April 2022 were selected and divided into control and observation groups using the random number table method, with 49 cases in each group. The control group was treated with conventional western medicine, while the observation group was treated with the addition of self-made Qing Yu and Hejiang Decoction. Both groups were treated with 14 d as a course of treatment, and a total of three courses of treatment were given. The efficacy of the two groups was compared, the traditional Chinese medicine symptom score and esophageal kinetics before and after treatment in both groups, and the occurrence of adverse reactions was recorded. Results After the treatment, the points of acid reflux and heartburn, abdominal distension and fullness, belching and early satiety, loss of appetite, and red tongue with yellow coating in both groups were lower than those before treatment, while those in the observation group were lower than those in the control group， and the differences were statistically significant (P＜0.05). After treatment, the esophageal sphincter pressure, lower esophageal sphincter pressure, and distal esophageal contraction points in both groups were higher than before treatment, while those in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05). The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). The difference was not statistically significant when comparing the total incidence rate during treatment between the two groups (P＞0.05). Conclusion The self-made Qingyu Hejiang Decoction is effective in treating RE with liver and stomach stagnation and heat, and can effectively improve clinical symptoms and esophageal dynamics with high safety.
2023 Vol. 20 (13): 100-103 [
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Application effect of non-inflated transaxillary approach versus thoracic breast approach lumpectomy in unilateral thyroid lobectomy
LI Yayun HUA Shenghe WANG Menglong YANG Wei▲
DOI: 10.20047/j.issn1673-7210.2023.13.24
Objective To analyze the application effect of non-inflated transaxillary approach lumpectomy versus thoracic breast approach in unilateral thyroid lobectomy. Methods Ninety-eight patients with unilateral thyroid nodules admitted to Shuyang Affiliated Hospital, Nanjing University of Chinese Medicine from May 2020 to May 2022 were selected and divided into control group (49 patients with unilateral thyroid lobectomy by lumpectomy through the thoracic breast approach) and observation group (49 patients with uninflatable unilateral thyroid lobectomy by lumpectomy through the axillary approach) by the random number table method. The surgery-related indicators, immune function, cosmetic satisfaction, and complications between the two groups were compared. Results There was no statistically significant difference in the operative time between the two groups (P＞0.05). The postoperative drainage and intraoperative bleeding in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05); the postoperative hospital stay in the observation group was shorter than that in the control group, and the difference was statistically significant (P＜0.05). The levels of CD3+ and CD4+ in the two groups one day after surgery were lower than those before surgery, while those in the observation group were higher than those in the control group, and the differences were statistically significant (P＜0.05); the levels of CD8+ in the two groups one day after surgery were higher than those before surgery, while those in the observation group were lower than those in the control group, and the differences were statistically significant (P＜0.05). The satisfaction of the cosmetic effect in the observation group was better than that in the control group, and the difference was statistically significant (P＜0.05). There was no statistically significant difference in the total incidence of complications between the two groups (P＞0.05). Conclusion Compared with unilateral thyroid lobectomy by trans-thoracic breast approach lumpectomy, non-inflated transaxillary approach lumpectomy is more effective in patients with unilateral thyroid nodules, which can reduce surgical trauma, promote patient recovery, enhance satisfaction with cosmetic results, and have less impact on patient immune function, and is safe and reliable.
2023 Vol. 20 (13): 104-107 [
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Effects of different routes of Dexamethasone on inflammatory factors, intrapartum fever, and pregnancy outcome after epidural labor analgesia
HOU Zhenhuan1 ZHANG Qinglin2
DOI: 10.20047/j.issn1673-7210.2023.13.25
Objective To investigate the effects of different routes of Dexamethasone on inflammatory factors, intrapartum fever, and pregnancy outcome after epidural labor analgesia. Methods A total of 120 primiparas who voluntarily underwent epidural labor analgesia and had a healthy term from Beijing Tongzhou District Maternal and Child Health Hospital and Beijing Obstetrics and Gynecology Hospital, Capital Medical University from September to December 2020 were selected as the research objects. They were divided into epidural group and intravenous group by random number table method, with 60 cases in each group. In the epidural group, 1% Lidocaine Hydrochloride 7-10 ml combined with Dexamethasone 5 mg was pushed into the epidural space, and in intravenous group, 1% Lidocaine Hydrochloride 7-10 ml was pushed into the epidural space and Dexamethasone 5 mg was put into the intravenous pot. The epidural catheter was connected to an electronic pump to adopt patient controlled analgesia model. The levels of interleukin (IL)-6, IL-10, and tumor necrosis factor-α (TNF-α) were compared between two groups before analgesia and 30, 60 min and 24 h after analgesia; intrapartum fever rate, cesarean section rate, and forceps rate were compared between two groups; Apgar scores 1, 5 and 10 min after delivery were compared between two groups. Results Because of failed anesthetic analgesia and immediate cesarean delivery, eight cases were excluded from the epidural group, nine cases were excluded from intravenous group. At 30 and 60 min after analgesia, the levels of IL-6, IL-10, and TNF-α in epidural group were higher than those before analgesia; 24 h after analgesia, the levels of IL-6, IL-10, and TNF-α in epidural group were lower than those at 30 and 60 min after analgesia, and the differences were statistically significant (P＜0.05). At 30 min after analgesia, the levels of IL-6, IL-10, and TNF-α in intravenous group were higher than those before analgesia; at 60 min and 24 h after analgesia, the levels of IL-6, IL-10, and TNF-α in intravenous group were lower than those at 30 min after analgesia, and the differences were statistically significant (P＜0.05). At 30 and 60 min after analgesia, the levels of IL-6, IL-10, and TNF-α in intravenous group were lower than those in epidural group, and the differences were statistically significant (P＜0.05). At 24 h after analgesia, there were no significant differences in the levels of IL-6, IL-10, and TNF-α between two groups (P＞0.05). The intrapartum fever rate in intravenous group was lower than that in epidural group, and the difference was statistically significant (P＜0.05); there was no significant difference in cesarean section rate and forceps delivery rate between two groups (P＞0.05). There were no significant differences in apgar score time, inter-group, and interaction between two groups (P＞0.05). Conclusion Intravenous application of Dexamethasone can effectively reduce the incidence of epidural related labor fever.
2023 Vol. 20 (13): 108-112 [
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Effect of press needle on rehabilitation of patients after total knee arthroplasty
LI Jinhu1 CHEN Xiaoxi1 GU Fang1 HE Jinliang1 YANG Liqiang2
DOI: 10.20047/j.issn1673-7210.2023.13.26
Objective To investigate the effect of press needle on rehabilitation of patients after knee arthroplasty. Methods Seventy patients who received unilateral total knee arthroplasty in Beijing Daxing District Hospital of Integrated Chinese and Western Medicine from October 2020 to March 2022 were selected as study objects, and they were divided into observation group and control group according to random number table method, with 35 cases in each group. The control group received continuous adductor canal block (ABC) analgesia under the guidance of ultrasound after surgery, and observation group was combined with press needle on the basis of control group. Visual analog scale (VAS) scores at resting and passive functional exercise and knee movement angles were compared between two groups at 24, 48, 72, 96 h, and 120 h after surgery; the recovery rate of oral analgesic drugs after surgery, length of hospitalization, and satisfaction score were compared between two groups; the occurrence of complications in two groups was observed. Results VAS scores at resting and passive functional exercise and knee movement angles at different time points in two groups were statistically significant (P＜0.05); 24, 48, 72, 96 h, and 120 h after surgery, VAS scores at resting and passive functional exercise in observation group were lower than those in control group, and knee movement angles were higher than those in control group, and the differences were statistically significant (P＜0.05). The recovery rate of oral analgesic drugs after surgery in observation group was lower than that in control group, the length of hospitalization was shorter than that in control group, and the satisfaction score was higher than that in control group, and the differences were statistically significant (P＜0.05). There was no significant difference in the total incidence of complications between two groups (P＞0.05). Conclusion Continuous ACB analgesia combined with press needle can effectively relieve postoperative pain in patients with total knee arthroplasty, promote early active functional exercise in patients, reduce the use of analgesic drugs, shorten length of hospitalization， and improve patient satisfaction, which is worthy of clinical promotion and use.
2023 Vol. 20 (13): 113-117 [
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Influencing factors of recovery agitation during general anesthesia in patients with advanced gastric cancer
YANG Shasha WU Yanfei▲
DOI: 10.20047/j.issn1673-7210.2023.13.27
Objective To observe the occurrence of recovery agitation during general anesthesia in patients with advanced gastric cancer, and to analyze its influencing factors. Methods The clinical data of 125 patients with advanced gastric cancer who received general anesthesia in the First Affiliated Hospital of Xinjiang Medical University from March 2021 to March 2022 were analyzed. According to the occurrence of recovery agitation during general anesthesia, they were divided into agitation group and non-agitation group. The related factors affecting the occurrence of recovery agitation during general anesthesia in patients with advanced gastric cancer were analyzed. Results Recovery agitation occurred in 31 of 125 patients with advanced gastric cancer during general anesthesia. The proportion of anxiety, diabetes mellitus, and laparotomy, and visual analogue scale (VAS) score in recovery period were higher than those in the non-agitation group, and the proportion of patients with compound epidural block and Dexmedetomidine was lower than that in non-agitation group, and the differences were statistically significant (P＜0.05). Anxiety, diabetes, laparotomy, and VAS score in recovery period were risk factors for recovery agitation during general anesthesia in patients with advanced gastric cancer (OR＞1，P＜0.05); compound epidural block and Dexmedetomidine were protective factors for recovery agitation during general anesthesia in patients with advanced gastric cancer (OR＜1，P＜0.05). Conclusion Anxiety, diabetes, laparotomy, VAS score in recovery period, compound epidural block, and Dexmedetomidine are influencing factors.
2023 Vol. 20 (13): 118-121 [
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Clinical effect of head point cluster acupuncture on spastic hemiplegia after stroke
REN Ting1 WANG Hongxu2 LI Hongyu3 WANG Xue4 ZHU Luwen4 TANG Qiang4
DOI: 10.20047/j.issn1673-7210.2023.13.28
Objective To analyze the treatment of spastic hemiplegia after stroke by surface electromyographic signal, and to explore the clinical effect of head point cluster acupuncture on hemiplegia after stroke. Methods A total of 62 patients with stroke spastic hemiplegia who were admitted to the Second Affiliated Hospital of Heilongjiang University of Chinese Medicine from October 2020 to June 2021 were selected and divided into control group and experimental group according to random number table method, with 31 cases in each group. The control group received routine rehabilitation training, and the experimental group was treated with head point cluster acupuncture based on the rehabilitation training of the control group. Both groups were treated for four weeks. The modified Ashworth scale (MAS), Fugl-Meyer assessment (FMA), Barthel index (BI) of ability to perform activities of daily living, and integrated electromyographic (IEMG) were used to evaluate the efficacy. Results Due to the shedding of one case during the test in the experimental group, 30 cases were included in the final statistical analysis. Compared with before intervention, MAS scores in both groups were decreased after intervention, and those in the experimental group were lower than those in the control group, the differences were statistically significant (P＜ 0.05). Compared with before intervention, FMA and BI scores of the two groups were significantly increased after intervention, and those in the experimental group were higher than those in the control group, the differences were statistically significant (P＜0.05). Compared with before intervention, IEMG of biceps and rectus femoris were decreased in two groups, and those in the experimental group were lower than those in the control group, the differences were statistically significant (P＜0.05). Compared with before intervention, IEMG of triceps and biceps femoris were increased in two groups, and those in the experimental group was higher than those in the control group, the differences were statistically significant (P＜0.05). Conclusion Head point cluster acupuncture can effectively reduce the muscle tension of stroke patients with spastic hemiplegia and improve their motor function and ability of daily living.
2023 Vol. 20 (13): 122-125,139 [
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Exploration the medication rules of Professor Bai Yanping in treatment of vitiligo based on data mining
LIU Jiayi1 LIU Saisai1 LUO Sha1 LIU Qianwei1 CAI Rui1 BAI Yanping2
DOI: 10.20047/j.issn1673-7210.2023.13.29
Objective To analyze the medication rules of Professor Bai Yanping in the treatment of vitiligo based on data mining technology. Methods The Chinese medicine prescriptions for vitiligo treated by Professor Bai Yanping in China-Japan Friendship Hospital from April 2010 to September 2020 were collected. The frequency, classification, efficacy, four nature, five flavours, and channel tropism of Chinese medicine were analyzed descriptively. The potential drug combinations were explored through association rules and cluster analysis, and data visualization was realized through network diagram. Results A total of 535 prescriptions and 221 Chinese medicines were included in the study. In terms of drug natures, warm drugs were the main drugs, followed by cold and plain drugs. In the aspect of drug flavours, bitter drugs were the most, followed by sweet and pungent drugs. In the aspect of drug channel tropism, the frequency of drugs entering liver channel was the highest. In the classification of Chinese medicine, tonifying deficiency medicine was the most used. The most commonly used drug for treatment was Psoraleae Fructus. Forty-one drug combinations of vitiligo were obtained by association rule analysis. Two potential new prescriptions were obtained by cluster analysis. Conclusion The medication rules obtained in this study is consistent with professor Bai Yanping’s theory of treating vitiligo based on treating from etiology of deficiency, treatment with both attack and supplementation, nourishing blood and dispelling wind, ridding the body of white， and harmonizing yin and yang, the efficacy of which is remarkable.
2023 Vol. 20 (13): 126-130 [
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Experience of Professor Huang Shijing’s differential treatment of white matter ischemic lesions based on the theory of brain and kidney
CHEN Yuxia YU Bin PAN Juhua HUANG Shijing
DOI: 10.20047/j.issn1673-7210.2023.13.30
White matter ischemic lesions is a common pathological change in the brain of the elderly, which is closely related to hypertension, cognitive decline, and ischemic stroke. At present, no effective intervention has been found. Professor Huang Shijing has observed and practiced for many years. It is concluded that the pathological basis of the occurrence and development of ischemic leukoencephalopathy is “kidney deficiency, phlegm blocking blood stasis”, and “brain and kidney failure” is an important part of its pathogenesis. Centering on this pathogenesis, it is proposed that special attention should be paid to the role of “communicating brain and kidney” in treatment on the basis of “tonifying kidney and filling marrow, resolving phlegm and removing blood stasis”. A lot of clinical results have been achieved, which provides a new idea for the prevention and treatment of many kinds of encephalopathies. This paper systematically expounds Professor Huang Shijing’s experience in differential diagnosis and treatment of ischemic leukoencephalopathy based on the theory of brain and kidney.
2023 Vol. 20 (13): 131-134 [
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Reflection on inheritance and innovation of moxibustion of intangible cultural heritage
JI Chenyang1 WANG Liuqing2 ZHAI Xu1 GAO Rongrong3
DOI: 10.20047/j.issn1673-7210.2023.13.31
This paper combs the origins and representatives of typical characteristic moxibustion schools such as Bagui acupuncture and moxibustion school, Lingnan moxibustion school, Chengjiang school, Lu’s acupuncture and moxibustion school, golden needle plum blossom school, and Xujiang moxibustion school, and summarizes the characteristic academic thoughts and contributions of the schools. This article proposes to promote the development of standardized “key technical equipment for moxibustion” based on the inheritance of characteristic ideas such as “heat syndrome valued moxibustion”, “moxibustion sensation transmission and acupoint sensitization”, and proposes three countermeasures for the inheritance and development of intangible moxibustion: standardize the evaluation criteria for intangible cultural heritage of characteristic moxibustion methods; build a theoretical system and inheritance platform; carrying out teaching inheritance and exploring the service mode of combining medical treatment and nursing. Adhere to eliminating falsehood and preserving authenticity, maintain integrity and innovate, and provide ideas for the inheritance, innovation, and international development of intangible cultural heritage moxibustion methods.
2023 Vol. 20 (13): 135-139 [
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Clinical effect of Chaihu Guizhi Longgu Muli Decoction combined with tiaoshen kaiyu acupuncture on post stroke depression
HUANG Jing ZHANG Yining PANG Xiuyu
DOI: 10.20047/j.issn1673-7210.2023.13.32
Objective To investigate the clinical effect of Chaihu Guizhi Longgu Muli Decoction combined with tiaoshen kaiyu acupuncture on post stroke depression. Methods A total of 126 patients with post stroke depression admitted to Heilongjiang College of Traditional Chinese Medicine from June 2021 to June 2022 were selected and they were divided into three groups by random number table method, with 42 cases in each group. The decoction group was treated with routine therapy+Chaihu Guizhi Longgu Muli Decoction orally, the acupuncture group was treated with routine therapy+tiaoshen kaiyu acupuncture, and the combined group was treated with routine therapy+Chaihu Guizhi Longgu Muli Decoction orally+tiaoshen kaiyu acupuncture, with 15 days as a course of treatment, and three courses of treatment. The symptom score, depression score, serological index level, clinical efficacy, and adverse reaction rate of patients were evaluated. Results After treatment, the scores of symptoms and depression in the three groups decreased, and those in the combined group were lower than those in the decoction group and acupuncture group (P＜0.05); after treatment, serum levels of homocysteine, microtubule-associated protein, and ubiquitin carboxy-terminal hydrolase L1 in three groups were decreased, and those in the combined group were lower than those in the decoction group and acupuncture group (P＜0.05). The clinical efficacy of combination group was better than that of decoction group and acupuncture group (P＜0.05). There was no significant difference in the incidence of adverse reactions among the three groups (P＞0.05). Conclusion Chaihu Guizhi Longgu Muli Decoction combined with tiaoshen kaiyu acupuncture has a significant effect on post stroke depression, can improve the clinical symptoms of patients, inhibit brain damage, and has good safety.
2023 Vol. 20 (13): 140-143,165 [
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Professor Liu Deshan’s clinical experience in distinguishing and treating abnormal taste by traditional Chinese medicine
XU Anqi1 SONG Min1 LIU Yang1 LIU Zhenguo1 SHI Zhenpeng1 LIU Deshan2
DOI: 10.20047/j.issn1673-7210.2023.13.33
Abnormal taste refers to the abnormal taste and odor in the human body. Western medicine is easy to produce drug resistance, and the drug is easy to relapse, and there are certain limitations. Professor Liu Deshan believes that the pathogenesis of abnormal taste is always attributed to the dysfunction of the spleen and stomach or other zang-fu organs, which is a symptom of the disease of the zang-fu organs reflected in the mouth through the meridians and collaterals. Sweet taste is often treated from the dampness and heat of the spleen and stomach, sour taste is often treated from the stagnation of the spleen and stomach, bitter taste is often treated from the stagnation of the bile organs, and spicy taste is often treated from the heat of the lung and stomach. In addition, attention should be paid to grasp the differentiation of cold and heat, deficiency and excess when the syndrome is present. With the addition and subtraction of the syndrome, the disease is treating both manifestation and root cause, which have good effect, then broaden the idea for the treatment of abnormal taste. This paper summarizes clinical thinking of Professor Liu Deshan in the treatment of sweet taste, sour taste, bitter taste, and spicy taste, in order to provide experience for treatment of abnormal taste by traditional Chinese medicine. Last but not least, a typical medical case is attached for peer’s reference.
2023 Vol. 20 (13): 144-147 [
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Application value of spectral CT imaging in the differential diagnosis of parotid basal cell adenoma and pleomorphic adenoma
LUO Bing LIN Jingxing GUO Li ZHANG Lili ZENG Chenglong PAN Aizhen XU Zhifeng▲
DOI: 10.20047/j.issn1673-7210.2023.13.34
Objective To investigate the application value of spectral CT imaging in the differential diagnosis of parotid basal cell adenoma (BCA) and pleomorphic adenoma (PA). Methods A total of 37 cases of parotid BCA and PA diagnosed pathologically in the Foshan First People’s Hospital, Guangdong Province from October 2018 to August 2021 were collected, including 17 cases in BCA group and 20 cases in PA group. All patients underwent maxillofacial plain and dual-phase enhanced energy spectral scans using Discovery CT scanner, the iodine concentration (IC), monochromatic CT value of 40, 70, 100 keV, and 140 keV were measured and recorded respectively, and the spectral curve slope were obtained; the differential diagnosis of BCA and PA was evaluated by receiver operating characteristic curve. Results There was statistical significance in tumor morphology of two groups (P＜0.05). In arterial stage, monochromatic CT value of 40 keV, spectral curve slope K1 and IC in BCA group were higher than those in PA group, and the differences were statistically significant (P＜0.05); in venous stage, monochromatic CT values of 40, 70 keV, spectral curve slope K1, K2, and K3, and IC in BCA group were higher than those in PA group, and the differences were statistically significant (P＜0.05). The cut-off value of arterial stage spectral curve slope K1 for the diagnosis of BCA and PA was 1.19, the area under the curve was 0.994, the sensitivity was 94.1%, and the specificity was 100%. Conclusion The use of spectral CT imaging technology can effectively differentiate the diagnosis of BCA and PA, and provide an important reference for clinical.
2023 Vol. 20 (13): 148-151 [
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Imaging features of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusions
Yusufu Rouzi Aihemaiti Tuohuti ZHANG Tao ZHANG Xu CHEN Jie
DOI: 10.20047/j.issn1673-7210.2023.13.35
Objective To explore the imaging features of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusions. Methods Clinical data of 15 renal cell carcinoma patients associated with XP11.2 translocation/TFE3 gene fusion confirmed by pathological examination in the People’s Hospital of Xinjiang Uygur Autonomous Region from March 2016 to November 2021 were collected. CT and MRI data of the tumor were analyzed and the imaging features were evaluated. Results All lesions involved the renal cortex and medulla, and two cases of hydronephrosis were caused by involvement of the renal pelvis; six cases were complicated with calcification, including four cases of annular or arc-shaped calcification and two cases of nodular or dotted calcification; necrosis and cystic change were observed in ten cases; pseudocapsule was seen in six cases, including incomplete capsule in two cases; lymph nodes metastasis were found in renal hilum and retroperitoneum in four cases. T1 weighted imaging showed equal or slightly low signal in four cases and high signal in one case; T2 weighted imaging signals of three cases were uneven, showing equal or slightly high signals; diffusion-weighted imaging presents uniform or non-uniform high signal; and the apparent diffusion coefficient diagram showed a significantly low signal. After enhanced scanning of the fifteen patients, six cases had significant enhancement in the cortical phase, sustained enhancement in the medulla phase and significant clearance in the delayed phase; nine cases had mild to moderate enhancement in the cortical and medulla phases, and slight clearance in the delayed phase. Conclusion Renal cell carcinoma associated with Xp11.2 translocation/ TFE3 gene fusions has certain CT and MRI characteristics, which is helpful to improve the diagnosis rate of this disease.
2023 Vol. 20 (13): 152-155 [
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Analysis on immune checkpoint inhibitor therapy-associated autoimmune encephalitis based on the US Food and Drug Adverse Event Reporting System
WU Tingxi1 XU Chang2 ZHANG Yang3 SHI Yanfeng4 GUO Heng3 XU Bei1 ZHAO Zhigang1
DOI: 10.20047/j.issn1673-7210.2023.13.36
Objective To evaluate the risk of immune-associated encephalitis (AIE) caused by immune checkpoint inhibitors (ICI) based on the US Food and Drug Adverse Reaction Reporting System. Methods Adverse event reports of ICI (including Navulizumab, Parbolizumab, Attilizumab, Abvizumab, Duvarizumab, Cemiplimab, Ipimimumab, and Tremelimumab) were collected from FAERS database from 1Q2011 to 4Q2021. The risk, occurrence time, patient outcome, and ICI reintroduction of AIE adverse events were evaluated by ROR. Signal was considered to exist when the number of reported adverse events related to the target drug was ≥ 3 and the lower limit of 95% ROR signal was ≥ 1. Results A total of 865 adverse events of AIE were reported, involving 234 patients receiving ICI therapy. The signal emerged in Nivolumab, Pembrolizumab, Atezolizumab, Durvalumab, Nivolumab with Ipilimumab, and durvalumab with Tremelimumab, with Durvalumab having the strongest signal (ROR 95% CI: 40.97 [25.70-65.31]). Nivolumab plus ipilimumab had a higher risk of AIE compared to Nivolumab monotherapy (ROR 95% CI: 33.16 [25.49-43.15]), with a shorter period of onset of time(median 60 days). More than 70% of patients with ICI-associated AIE required hospitalization or prolonged hospital stay, with a fatality rate of 18.80% (44 cases). No reports of ICI resumption were collected. Conclusion The risk of AIE induced by ICI is different, and ICI-associated AIE tended to occur within three months after ICI treatment, which should attract clinical attention.
2023 Vol. 20 (13): 156-160 [
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Clinical distribution and drug resistance analysis of Stenostomonas maltophilia
WANG Shibo1 GAO Yanjun2 SHI Like1 LI Jihong1 WANG Yue1 DONG Xing1 WANG Liyi1 JIA Yuan1
DOI: 10.20047/j.issn1673-7210.2023.13.37
Objective To analyze the clinical distribution and resistance of Stenotrophomonas maltophilia. Methods Stenotrophomonas maltophilia was isolated from hospitalized patients in the Second Hospital of Hebei Medical University from January 2019 to December 2021, and the clinical distribution, specimen sources, and drug sensitivity tests of stenotrophomonas maltophilia were retrospectively analyzed through WHONET 5.6 system. Results A total of 966 strains of Stenotrophomonas maltophilia were isolated from January 2019 to December 2021, and the detection rate of gram-negative bacilli was 2.54%. The department with the highest detection rate was pediatric internal medicine. The proportion of Stenotrophomonas maltophilia in respiratory department was the highest (30.85%). The majority of patients with Stenotrophomonas maltophilia infection were elderly patients over 60 years old, accounting for 57.04%. A total of 771 strains of Stenotrophomonas maltophilia were isolated from sputum specimens, accounting for 79.81%. The drug susceptibility test results showed that the drug resistance rates of Stenotrophomonas maltophilia to Minocycline, Cotrimoxazole, and Levofloxacin were 2.60%, 10.40% and 13.50%, respectively; the drug resistance rate to ceftazidime was 70.9%. The drug susceptibility results of Stenotrophomonas maltophilia from different samples showed that the drug resistance rates of stenotrophomonas maltophilia in lavage fluid, urine and blood samples were higher than those in sputum samples to Minocycline, Cotrimoxazole, Levofloxacin, and Ceftazidime. Conclusion Stenotrophomonas maltophilia mainly came from respiratory department, mainly sputum. The susceptible population is the elderly with high drug resistance. Clinicians should reasonably select antibiotics according to the results of drug sensitivity to reduce the generation and prevalence of drug-resistant strains.
2023 Vol. 20 (13): 161-165 [
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Relationship between high-quality Party building and high-quality deve-lopment in public hospitals
REN Jing* PAN Junhua*
DOI: 10.20047/j.issn1673-7210.2023.13.38
High-quality development is a concept first proposed at the 19th National Congress of the Communist Party of China. It originally referred to high-quality economic development. Later, this concept has gradually become a guiding principle for development in various fields. In June 2021, the General Office of the State Council issued the Opinions on Promoting the High-quality Development of Public Hospitals, which clarified that public hospitals should continue to advance in the direction of high-quality development. Public hospitals implement the president responsibility system under the leadership of the Party Committee, in order to realize the effective leadership of the Party on high-quality development, it is necessary to clarify the relationship between high-quality Party building and high-quality development, and improve the understanding of the relationship from their respective contents, operating characteristics, and results, in order to correctly handle the relationship between the two in the work, leading the direction of high-quality development of the hospital with high-quality political construction, guaranteeing high-quality development practice of the hospital with high-quality organization construction, and creating high-quality development environment of the hospital with high-quality style construction.
2023 Vol. 20 (13): 166-169 [
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Effects of medical counseling games on children with hidden penis and their families
JIN Lihong1 LI Danting2 FANG Jingjing1 YU Linjun1 HU Wenhui3▲
DOI: 10.20047/j.issn1673-7210.2023.13.39
Objective To analyze the effects of medical counseling games on children with hidden penis and their families. Methods A total of 130 children with latent penis and their families admitted to Taizhou Hospital of Zhejiang Province from January to August 2022 were studied. According to the random envelope method, the patients were divided into control group (using conventional nursing intervention) and observation group (using medical counseling game combined with conventional nursing intervention), with 65 cases in each group. Before and after the intervention, the modified yale preoperative anxiety scale (m-YPAS) and the anxiety scores of their families on the state-trait anxiety inventory (STAI), the compliance behavior of children, the facial expression, legs, activity crying, and consolability (FLACC), the health knowledge of their families and the postoperative recovery status were compared between the two groups. Results Before surgery, the scores of m-YPAS and STAI were lower in the two groups than at admission, and those in the observation group were lower than those in the control group (P＜0.05); on discharge day, compliance behavior score in two groups was higher than that at admission, and observation group was higher than control group (P＜0.05); 6 h after surgery, 12 h after surgery and before discharge, the FLACC scores of the two groups was compared in time and between groups, and the differences were statistically significant (P＜0.05). Compared within the group, the FLACC scores of the two groups at 12 h after surgery was higher than that at 6 h after surgery, and the FLACC score before discharge was lower than that at 6 h after surgery (P＜0.05), the FLACC score of observation group was lower than that of control group at different time (P＜0.05). The family members of the observation group had better knowledge of health than the control group (P＜0.05); the time of getting out of bed and discharge in observation group were shorter than those in control group (P＜0.05). The total complication rate of observation group was lower than that of control group (P＜0.05). Conclusion Medical counseling games can reduce the preoperative anxiety of children with occult penis surgery and their parents, improve the compliance behavior of children, and their families’ grasp of health knowledge, reduce the degree of postoperative pain of children, promote postoperative recovery, and have clinical reference significance.
2023 Vol. 20 (13): 170-175 [
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Nursing intervention effect of HFMEA mode after hepatocellular carcinoma perfusion embolization intervention
TANG Fen1 XU Xuan1 LIU Huilian1 YU Xiaoxiang2▲
DOI: 10.20047/j.issn1673-7210.2023.13.40
Objective To explore the nursing intervention effect of healthcare failure mode and effect analysis(HFMEA) mode after hepatocellular carcinoma perfusion embolization intervention. Methods A total of 184 patients with liver cancer who underwent perfusion embolization interventional surgery in Qinhuai Medical District, Eastern Theater Command General Hospital from January 2021 to December 2021 were selected as the study objects. The patients were divided into intervention group and conventional group according to the admission odd-even number, with 92 cases in each group. The intervention group adopted nursing intervention measures based on HFMEA model, and the conventional group adopted routine nursing intervention measures. The changes of cancer-induced fatigue score, quality of life score, serum alpha-fetoprotein (AFP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and C-reactive protein (CRP) before and after intervention were compared between the two groups, and the occurrence of toxic and side effects were compared between the two groups. Results After intervention, somatic fatigue score, emotional fatigue score, cognitive fatigue score, and total cancer-related fatigue score in both groups were lower than before intervention, and those of the intervention group were lower than those of the conventional group (P＜0.05); after intervention, the physical status, social/family status, emotional status, functional status, and total quality of life score in both groups were higher than before intervention, and those of the intervention group were higher than those of the conventional group (P＜0.05). After intervention, the values of AFP, ALT, AST, and CRP in both groups were lower than before intervention (P＜0.05). During embolization chemotherapy, the degree of nausea and vomiting reaction in the intervention group was significantly lower than that in the conventional group, and the difference was statistically significant (P＜0.05). Conclusion The nursing intervention based on HFMEA model can significantly improve the quality of life, reduce the degree of cancer fatigue, and reduce the degree of toxic and side effects after the interventional operation of liver cancer perfusion embolization.
2023 Vol. 20 (13): 176-179,188 [
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Effect of seamless overall intervention on intraoperative hypothermia in patients undergoing laparoscopic surgery for cervical cancer
WANG Jingyun SONG Miao ZHANG Bin CHEN Jia ZHANG Qian▲
DOI: 10.20047/j.issn1673-7210.2023.13.41
Objective To explore the effect of seamless overall intervention on intraoperative hypothermia in patients undergoing laparoscopic surgery for cervical cancer. Methods A total of 138 patients with cervical cancer who received extensive laparoscopic hysterectomy plus pelvic lymph node dissection in Jiangsu Provincial People’s Hospital from January 2020 to December 2021 were selected, according to random number table method, they were divided into study group and control group, with 69 cases in each group. The study group received seamless holistic care, and the control group received routine care. Intraoperative temperature changes, operation-related indexes and incidence of adverse events were compared between the two groups. Results There were statistically significant differences between the two groups in intraoperative temperature change, time point comparison and interaction (P＜0.05). Further pair-based comparison, intra-group comparison: the intraoperative body temperature of study group at 90 min was higher than that at 60 min after surgery, but lower than that at other time periods, and the highest body temperature at the end of surgery, the difference was statistically significant (P＜0.05); there was statistical significance in body temperature of control group at different time periods (P＜0.05). Comparison between groups: the body temperature of the study group was higher than that of the control group at 30, 60, 90 min， and after operation, the differences were statistically significant (P＜0.05). The postoperative resuscitation time and bowel sound recovery time of the study group were shorter than those of the control group, the differences were statistically significant (P＜0.05). The incidence of intraoperative hypothermia and postoperative chills and restlessness in the study group were lower than that in the control group, the differences were statistically significant (P＜0.05). Conclusion The implementation of seamless holistic nursing for patients undergoing cervical cancer surgery can help to maintain the body temperature level within the conventional range, reduce the risk of intraoperative hypothermia, chills and agitation during postoperative anesthesia recovery, and shorten the postoperative recovery time of recovery and bowel sounds.
2023 Vol. 20 (13): 180-183 [
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Application value of phased nursing based on the change rule of compliance curve in hemodialysis of patients with end stage renal disease
XIANG Meiling1 XIE Runyue1▲ LIU Qingyan2
DOI: 10.20047/j.issn1673-7210.2023.13.42
Objective To explore the application value of phased nursing based on the change rule of compliance curve in hemodialysis of patients with endstage renal disease. Methods A total of 94 patients with end stage renal disease who received hemodialysis treatment in Ningguo People’s Hospital of Anhui Province from June 2020 to April 2022 were selected, according to the simple random number table method, the patients were divided into control group and study group, with 47 cases in each group. The control group received routine care, on the basis of the control group, the study group adopted phased nursing based on the law of compliance curve change. Negative emotions and sleep quality, treatment compliance, total complication rate， and patient satisfaction were compared between the two groups before and after intervention. Results After intervention, the scores of Hamilton depression scale, Hamilton Anxiety scale and Pittsburgh sleep quality index in two groups were lower than those of before intervention, and those in the study group were lower than those in the control group (P＜0.05); the treatment compliance of the study group was better than that of the control group (P＜0.05); the total complication rate of study group was lower than that of control group (P＜0.05). The patient satisfaction of study group was better than that of control group (P＜0.05). Conclusion During hemodialysis for patients with end stage renal disease, phased nursing based on the change rule of compliance curve is helpful to relieve their negative emotions, improve treatment compliance, reduce the risk of complications, improve sleep quality and improve patient satisfaction.
2023 Vol. 20 (13): 184-188 [
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Value of CPOT scoring - oriented nursing intervention on prevention and control of delirium in patients with mechanical ventilation
QI Lijuan LI Min YANG Biao
DOI: 10.20047/j.issn1673-7210.2023.13.43
Objective To explore the value of critical-care pain observation tool (CPOT) scoring oriented nursing intervention in the prevention and control of delirium in patients with mechanical ventilation. Methods A total of 72 patients with mechanical ventilation admitted to Fuyang Cancer Hospital of Anhui Province from January 2020 to April 2022 were selected and divided into control group and observation group according to random number table method, with 36 cases in each group. Control group was treated with routine delirium prevention and control measures, and observation group was treated with CPOT scoring-oriented nursing on the basis of control group. The incidence of delirium, duration of delirium, incidence of adverse reactions such as unplanned extubation, man-machine confrontation, duration of mechanical ventilation, and length of ICU stay were compared between the two groups. Results The delirium incidence in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). The incidence of unplanned extubation and man-machine confrontation in observation group was lower than control group, and the difference was statistically significant (P＜0.05). There were no significant differences in the proportions of ventilator- associated pneumonia, infusion extravasation, tube biting and sputum aspiration obstruction between the two groups (P＞0.05). Delirium duration in the observation group was lower than that in the control group, and the difference was statistically significant (P＜0.05). There was no significant difference in mechanical ventilation time and ICU stay time between the two groups (P＞0.05). Conclusion The CPOT scoring-oriented nursing intervention applied to mechanical ventilation patients can promote the reduction of delirium risk, reduce the incidence of unplanned extubation and man-machine confrontation, and reduce delirium duration. It is an early nursing supplement for delirium prevention in mechanical ventilation patients, but has no significant effect on mechanical ventilation duration and ICU stay time.
2023 Vol. 20 (13): 189-192 [
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Application effect of postoperative functional rehabilitation nursing in patients with rotator cuff injury
LI Yan LI Jing WANG Manman WU Jie ZHANG Xinxin LI Yuqian SUN Wanwan
DOI: 10.20047/j.issn1673-7210.2023.13.44
Objective To explore the application effect of postoperative functional rehabilitation nursing in patients with rotator cuff injury. Methods Eighty patients with rotator cuff injury treated in Bozhou People’s Hospital of Anhui Province from April 2020 to January 2022 were selected. The reference group received routine nursing intervention after surgery, and the study group strengthened functional rehabilitation nursing on the basis of routine nursing. Both groups were treated for 16 weeks. The recovery time and the recovery effect of joint function were compared between the two groups. Results After intervention, the mean postoperative pain duration and shoulder function recovery time of the study group were shorter than those of the reference group, and the differences were statistically significant (P＜0.05); At 8 and 16 weeks after intervention, ADL, shoulder range of motion, muscle strength score and total score of shoulder joint function between the two groups showed no statistical significance (P＞0.05), while the difference of each score time was statistically significant (P＜0.05). The pain score of the study group at 8 and 16 weeks after intervention was lower than that of the reference group. ADL, shoulder motion score and total score were all in the control group, and the differences were statistically significant (P＜0.05). Conclusion Postoperative functional rehabilitation nursing for patients with rotator cuff injury can effectively accelerate the speed of rehabilitation and improve the effect of joint function recovery.
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