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Experience of Professor Huang Shijing’s differential treatment of white matter ischemic lesions based on the theory of brain and kidney |
CHEN Yuxia YU Bin PAN Juhua HUANG Shijing |
Chinese Medicine Research and Development Center, Guang’anmen Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100053, China
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Abstract White matter ischemic lesions is a common pathological change in the brain of the elderly, which is closely related to hypertension, cognitive decline, and ischemic stroke. At present, no effective intervention has been found. Professor Huang Shijing has observed and practiced for many years. It is concluded that the pathological basis of the occurrence and development of ischemic leukoencephalopathy is “kidney deficiency, phlegm blocking blood stasis”, and “brain and kidney failure” is an important part of its pathogenesis. Centering on this pathogenesis, it is proposed that special attention should be paid to the role of “communicating brain and kidney” in treatment on the basis of “tonifying kidney and filling marrow, resolving phlegm and removing blood stasis”. A lot of clinical results have been achieved, which provides a new idea for the prevention and treatment of many kinds of encephalopathies. This paper systematically expounds Professor Huang Shijing’s experience in differential diagnosis and treatment of ischemic leukoencephalopathy based on the theory of brain and kidney.
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[1] 林晶,王迪龙,邱宝山,等.新型脑白质病变动物模型及其脑小血管的病理学研究[J].中国神经精神疾病杂志,2016,42(11):680-684.
[2] Wu X,Ya J,Zhou D,et al. Pathogeneses and Imaging Features of Cerebral White Matter Lesions of Vascular Origins [J]. Aging Dis,2021,12(8):2031-2051.
[3] 黄鹏展,迟晓玲,邱海丽,等.益肾通络化浊汤治疗缺血性脑白质病轻度认知障碍的临床观察[J].中国中医药科技,2017,24(5):640-641.
[4] 崔远武,张连城,李强,等.中医“肾脑系统”的初步构建[J].天津中医药,2015,32(3):142-145.
[5] 郑洪新,谢晚晴.肾藏象理论的系统结构[J].中国中医基础医学杂志,2015,21(11):1339-1341,1424.
[6] 武峻艳,王杰.从“肾脑相关”看“作强之官”[J].中华中医药杂志,2017,32(9):4198-4200.
[7] 武峻艳,王杰,张俊龙.肾脑相关理论探讨[J].中医杂志,2016,57(20):1711-1714.
[8] 张新普,薛丹,李敏,等.针灸促进脑功能可塑性作用的中医基础理论研究——五脏、经络与脑的相关性探析[J].四川中医,2017,35(5):50-52.
[9] 李文杰,康小荣,孙元培.银杏酮酯滴丸治疗缺血性脑白质病的疗效及部分作用机制研究[J].中药材,2021,44(2):465-469.
[10] 朱心怡,王雨晴,李楠楠,等.基于“络损髓伤”理论治疗缺血性脑白质病分析[J].中西医结合心脑血管病杂志,2021,19(7):1217-1221.
[11] 李会琪,何剑波,张恒,等.脑梗塞患者认知障碍与中医证候及脑白质疏松相关性分析[J].陕西中医,2013,34(10):1275-1276.
[12] 丁镜波.314例脑白质病变患者MRI影像学与临床特点的回顾性分析[J].世界中西医结合杂志,2014,9(8):873-875.
[13] 葛永利,王玉敏,王洪权.脑小血管病与氧化应激[J].中国老年学杂志,2018,38(2):469-473.
[14] 辛明蔚,刘雁峰,骆斌,等.交通心肾法对老龄雌鼠下丘脑-垂体-卵巢ER的影响[J].中医药学报,2014,42(6):45-47.
[15] 侯赋成,殷梅.脑白质病变的病理学及发病机制的研究进展[J].临床神经病学杂志,2018,31(4):310-313.
[16] 韩露露,黄世敬.缺血性脑白质病的中医治疗进展[J].辽宁中医杂志,2019,46(4):866-868.
[17] 翟吴剑文,黄世敬.中医治疗脑白质病变研究进展[J].辽宁中医杂志,2020,47(12):195-198.
[18] 杨凤梅,强睿,徐曼曼,等.补益药治疗缺血性脑白质病的研究进展[J].医学研究杂志,2021,50(7):155-158.
[19] 史宝光,于嵩,王玥,等.基于“肾脑相济”理论探讨电针疗法对SAMP8小鼠神经元内尼氏小体的影响[J].吉林医学,2017,38(12):2203-2205.
[20] 王旭,王玥,于嵩,等.基于“肾脑相济”理论的电针疗法对痴呆小鼠脑内β-淀粉样蛋白及中性内肽酶表达的影响[J].针刺研究,2018,43(1):20-23.
[21] 盛望,李旭华,胡国恒,等.肾脑复元汤对阿尔茨海默病模型大鼠学习记忆及凋亡相关蛋白的影响[J].世界中西医结合杂志,2017,12(8):1072-1076.
[22] 张帅,韦云,李浩.基于肾脑相关理论探讨阿尔茨海默病患者中枢神经再生[J].中医杂志,2018,59(2):120-123.
[23] 于文涛,赵润生,高维娟,等.补肾活血方对血管性痴呆大鼠脑海马脑源性神经生长因子介导的PI3K/AKT信号通路的影响[J].中药药理与临床,2018,34(3):141-146.
[24] 牛天童,刘广志.中药对阿尔茨海默病鼠模型作用机制的研究进展[J].中国医药,2021,16(12):1903-1906.
[25] 邢维昊,张婕,巫晓宇,等.脑源性神经营养因子与神经炎症在神经退行性疾病中的作用研究进展[J].中国医药科学,2022,12(10):21-24.
[26] 王洋,赵健,王迪,等.基于肠道菌群探讨中药防治阿尔茨海默病的研究进展[J].中国医药导报,2022,19(3):38-42.
[27] 江泳秋,蔡超群.通窍活血汤联合加兰他敏对阿尔茨海默病患者脑干诱发电位及认知功能的影响[J].中国当代医药,2021,28(4):192-195. |
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